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Simvastatin – uses, health risks, and side effects at

Tuesday, September 18, 2018 by

Simvastatin is a drug used to reduce low-density lipoprotein (LDL) or bad cholesterol and triglycerides in the blood and to increase the amount of high-density lipoprotein (HDL) or good cholesterol in the blood. It is also used to reduce the risk of stroke, heart attack, and other heart complications in people with diabetes, coronary heart disease, or other risk factors.

Simvastatin belongs to a class of drugs called HMG CoA reductase inhibitors, also known as statins. It works by slowing the production of cholesterol in the body to reduce the amount of cholesterol that may accumulate on the walls of the arteries and block blood flow to the heart, brain, and other parts of the body.

Simvastatin is sold under the brand name Zocor. It comes in tablet form and is taken orally once a day in the evening. It is used together with diet, weight-loss, and exercise to be more effective.

Simvastatin is not appropriate for some people. Tell the doctor if you:

  • Have had an allergic reaction to simvastatin or any other medicines in the past
  • Have liver or kidney problems
  • Are trying to get pregnant, might be pregnant, already pregnant, or breastfeeding
  • Have severe lung disease
  • Regularly drink excessive amounts of alcohol
  • Have an underactive thyroid
  • Have, or have had, a muscle disorder

Known side effects of simvastatin

The common side effects of simvastatin include:

  • Constipation
  • Headache
  • Joint pain
  • Muscle pain or weakness
  • Nausea
  • Stomach pain
  • Upper respiratory infections

Simvastatin also causes serious side effects, such as:

  • Diarrhea
  • Extreme sensitivity to the sun
  • Feeling weak or very tired
  • Jaundice (yellowing of the skin)
  • Kidney failure
  • Liver toxicity
  • Muscle spasms
  • Rash of any kind
  • Rhabdomyolysis (muscle breakdown)
  • Severe allergic reaction, with symptoms such as fever and trouble breathing
  • Severe anemia
  • Severe muscle pain or weakness
  • Severe nausea or vomiting
  • Severe stomach pain
  • Severe swelling of the hands, feet, and ankles

Body systems that may be harmed by simvastatin

The body systems harmed by simvastatin include the musculoskeletal, hepatic, digestive, hematologic, nervous, and cardiovascular systems.

Food items or nutrients that have similar effects to simvastatin

The following food items lower cholesterol like simvastatin:

  • Apples
  • Beans
  • Citrus fruits
  • Eggplants
  • Fatty fish
  • Grapes
  • Nuts
  • Oats
  • Okra
  • Soy
  • Strawberries
  • Vegetable oils, such as canola, safflower, and sunflower oils
  • Whole grains, such as barley and oats

Treatments, management plans for the simvastatin’s side effects

The following are some natural remedies for some of the side effects of simvastatin:

  • Constipation: Natural remedies for constipation include drinking more water, eating more fiber, exercising more, drinking coffee, eating probiotic foods or taking probiotic supplements, eating prunes, and avoiding dairy.
  • Upper respiratory infections: Upper respiratory infections can be treated by inhaling steam, gargling with salt water solution, drinking ginger tea, and eating garlic.

Where to learn more


Simvastatin is a statin drug used to reduce cholesterol and triglycerides in the blood.

Simvastatin commonly causes constipation, headache, joint pain, muscle pain or weakness, nausea, stomach pain, and upper respiratory infections.

Simvastatin may harm the musculoskeletal, hepatic, digestive, hematologic, nervous, and cardiovascular systems.

Simvastatin is sold under the brand name Zocor.

Sources include: 1 2


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