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Orotic acid sources, health benefits and uses

Thursday, September 28, 2017 by

Ingesting orotic acid leads to a basal rate of orotic acid excretion in urine, as fasting lessens the occurrence of bowel movements by 50 percent. However, most urinary orotic acid is processed in the body, where it becomes an intermediate in the pathway for the synthesis of pyrimidine nucleotides. Orotic acid is then converted to uridine monophosphate (UMP) by UMP synthase, a multifunctional protein with both orotate phosphoribosyltransferase and orotidylate decarboxylase.

One major process that occurs during pyrimidine nucleotide synthesis is the mutation of the multifunctional protein UMP synthase, thus making it impossible for orotic acid to convert to UMP and to other pyrimidines, thus resulting in an accumulation of orotic acid in the urine.

Until scientists were able to figure out that orotic acid could be synthesized by the body, it was called vitamin B13. Foods that are rich in orotic acid are milk and other dairy products and vegetables such as beets and carrots.

Orotic acid also comes in the form of a health supplement, which is produced through laboratory procedures. The recommended daily intake of orotic acid for adults is 300 milligrams. Pregnant women, lactating mothers, and people who are under great deals of stress every day are encouraged to increase their orotic acid intake.

Even though orotic acid obviously provides the body with a ton of medicinal and health benefits, a deficiency of the nutrient doesn’t necessarily result to chronic illnesses or conditions. However, overdosing on orotic acid could lead to liver and intestinal upset, allergic dermatitis, nausea, and vomiting.

Medicinal uses for orotic acid

Orotic acid can address vitamin B12 or cobalamin deficiency.

Orotic acid is good for the skin. It is used as an ingredient in cosmetic products to foster skin health.

Orotic acid is essential to the manufacture and maintenance of adenosine triphosphate (ATP) levels in body cells. High amounts of ATP are needed in order for the optimum functioning of the heart and the brain, and for preventing fatigue and exhaustion.

Orotic acid is also important in the synthesis of methionine, which is very much needed for the growth of new blood vessels in the body. Orotic acid also aids the exchange of folic acid (vitamin B9) and panthothenic acid (vitamin B5). It even boosts amino acid assimilation, thereby improving protein synthesis in conjunction with other vitamins.

Like folic acid, orotic acid can positively impact the development of the fetus in the womb by guarding it against pre-natal diseases like neural tube.

Body systems supported by orotic acid

Orotic acid is good for the cardiovascular system. It is said to have therapeutic effects to alleviate the symptoms of myocardial degeneration – which is also called cardiomyopathy and which is a heart ailment that enlarges the heart and makes it rigid — especially the severity of calcific changes. Orotic acid ingestion results in partial electrical stabilization of failing hearts and the prevention of heart lesions.

It guards the heart against atherosclerosis by protecting the elasticity of blood vessel walls and preventing the formation of cholesterol plaques.

Orotic acid is good for the central nervous system. It can prevent multiple sclerosis, which disrupts the flow of information within the brain.

Orotic acid is good for the excretory system. It positively affects the regeneration of liver cells and aids in the production of bilirubin, which is a yellow compound that normally transpires in the normal catabolic pathway that breaks down heme in vertebrates. It also prevents fatty liver as it contains hepatoprotective properties.

Orotic acid is good for the immune system. It prevents immunodeficiency.

Orotic acid is good for the muscular system. It ensures the proper occurrence of anabolic processes, thereby stimulating the growth of muscle tissues.

Where to learn more


Orotic acid is good for the cardiovascular, nervous, excretory, immune, and muscular systems.

Orotic acid can address vitamin B12 or cobalamin deficiency.

Orotic acid is good for the skin.

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