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Hesperetin sources, health benefits and uses

Monday, September 11, 2017 by

Hesperetin is a flavonoid that is most abundant in citrus fruits, and is a form of the glycoside hesperidin. It is the main compound in lemons and oranges. Hesperetin has a molecular formula of C16H14O6 and has a molecular weight of 302.28. This makes the compound a relatively big and heavy flavonoid, although a quick glance at its structure will show its vast stability and durability.

It is this property that makes hesperetin useful in medicine. The compound is a known vasodilator and is applied as a treatment for hypertension. Pharmacologists have noted an 80 percent decrease in cholesteryl ester mass and apoB secretion (two factors in high blood pressure) in mice models injected with hesperetin.

Because hesperetin can be easily extracted through citrus cultivation, many people can supplement their diet with this flavonoid through tablets or pills. You may also opt to take hesperetin naturally by drinking orange juice with pulp or eating the more membranous parts of citrus fruits.

Medicinal uses for hesperetin

This flavonoid contains antioxidant, anti-inflammatory, hypolipidemic, and anti-carcinogenic properties. Its primary function is to reduce the activity of cholesterol-producing genes, particularly receptors of LDL (low-density lipoprotein). Said simply, hesperetin reduces the amount of bad cholesterol in the body by decreasing the secretion of apoB-containing lipoproteins while enhancing the reuptake of these lipoproteins.

The citrus bioflavanoid can also work together with other compounds to enhance chemopreventive efficacy, especially those targeted at nephrotoxicity and renal carcinogenesis (liver and kidney cancer). Hesperetin reduces the damage caused by oxidative stress and neutralizes reactive oxygen species. This protects proteins, tissues, and DNA from radiation and toxins (which would be typical among cancer patients who decide to undergo chemotherapy). There is also evidence to suggest that hesperetin directly disrupts radical scavenging activity which prevents DNA damage.

Additionally, hesperetin lowers inflammation in the body by suppressing the production of certain proteins and enzymes that cause the body to become stressed. This, in turn, reduces the risk of developing cardiovascular disorders like high blood pressure and heart attack. Mice models who were administered daily hesperetin showed healthier heart tissue compared to those who were not.

Heart ailments often coincide with the risk of diabetes. Hesperetin is also proficient in lowering glucose levels, preventing either condition. The flavonoid increases adiponectin, a protein responsible for fat energy production. People with increased levels of adiponectin are able to reduce fat accumulation through improved blood vessel function.

Consequently, hesperetin can likewise be used for weight loss. Hesperetin increases a person’s metabolic rate. One study suggested that a combination treatment of G-hesperidin (a water-soluble form of hesperidin) and caffeine significantly reduced body fat in humans.

Other conditions that can be treated with hesperetin include:

  • Allergies
  • Anxiety
  • Brain Damage
  • Chronic Venous Insufficiency
  • Depression
  • Hemorrhoids
  • Insomnia
  • Neuropathic Pain
  • Osteoporosis

Body systems supported by hesperetin

Hesperetin helps your liver and kidneys function properly. Its antioxidant effects also imply that the flavonoid can also support the entire immune system.

Where to learn more


Hesperetin is a form of hesperidin and is found in most citrus fruits. It is an efficient vasodilator and can be used in cancer prevention and treatment.

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