Chlorantraniliprole — toxicity, side effects, diseases and environmental impacts

Friday, December 08, 2017 by

Chlorantraniliprole is a member of the anthranilic diamine class of insecticides. This insecticide affects insect ryanodine receptors, which means it interrupts normal muscle contraction. Chlorantraniliprole acts against a wide range of insects including many species of moths, leafrollers, armyworms, caterpillars, white grubs, and beetles. Applications must be timed to the most susceptible insect state, and it is often used during egg hatching or on newly hatched larva.

Synthetic in origin, chlorantraniliprole appears as a fine crystalline off-white powder. It is usually supplied as a suspension concentrate or as water-dispersible granules.

Chlorantraniliprole’s trade names and identifiers include:

  • 500008-45-7
  • Rynaxpyr
  • Chlorantranilipol
  • DPX-E2Y45
  • CHLOANTRANILIPROLE
  • UNII-622AK9DH9G
  • 622AK9DH9G
  • CHEMBL399318
  • CHEBI:67113
  • 3-bromo-N-(4-chloro-2-methyl-6-((methylamino)carbonyl)phenyl)-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide
  • 3-bromo-N-[4-chloro-2-methyl-6-(methylcarbamoyl)phenyl]-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide
  • 3-Bromo-N-[4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl]-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide
  • 3-bromo-N-{4-chloro-2-methyl-6-[(methylamino)carbonyl]phenyl}-1-(3-chloro-2-pyridinyl)-1H-pyrazole-5-carboxamide
  • 5-bromo-N-[4-chloro-2-methyl-6-(methylcarbamoyl)phenyl]-2-(3-chloropyridin-2-yl)pyrazole-3-carboxamide
  • Chlorantraniliprole [ISO]
  • HSDB 7877
  • 3-bromo-N-(4-chloro-2-methyl-6-(methylcarbamoyl)phenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide
  • C18H14BrCl2N5O2
  • SCHEMBL29551

List of known side effects

Chlorantraniliprole causes serious eye irritation. It may also cause respiratory irritation. It is very toxic to aquatic life, with long-lasting effects.

Neither chlorantraniliprole nor the formulated products Coragen/Acelepryn and Altacor were very toxic in acute oral, dermal, or inhalation exposure studies in laboratory animals. It is also worth mentioning that neither the active ingredient nor the formulated products were irritating to skin and eyes (tested on rabbits) nor skin sensitizers (tested on guinea pigs).

Researchers did not note any oncogenic effects in rat or mouse chronic feeding studies. This compound was also negative in a number of genotoxicity studies. The Environmental Protection Agency (EPA) classified chlorantraniliprole as “not likely to be carcinogenic to humans.” The EPA did not conduct a worker exposure and risk assessment for these chlorantraniliprole products because the toxicological database does not indicate systemic toxicity concerns for short-term and intermediate-term dermal and inhalation exposures.

In addition, the EPA concluded that post-application risks to workers, residents, and children would be negligible due to the low toxicity of chlorantraniliprole.

Body systems affected by chlorantraniliprole

Exposure to chlorantraniliprole can irritate the eyes.

Items that can contain chlorantraniliprole

Chlorantraniliprole is used to control various kinds of pests on a range of crops including potatoes and cotton. It is used to control pests such as cabbage loopers (which has developed a resistance to most pesticides), corn borers (grain pests), armyworms (caterpillars that attack rice), and cutworms (moth larvae that are nocturnal and feed on plants). Chlorantraniliprole is applied on plants such as potatoes, grapes, and cotton.

Some manufacturers and suppliers of products containing this active ingredient are:

  • DuPont
  • Syngenta
  • Scotts Company

Some products using chlorantraniliprole include:

  • Acelepryn
  • Coragen
  • DuPont E2Y45 SC
  • Altacot
  • Ferterra
  • Prevathon

How to avoid chlorantraniliprole

Always wear proper protective gear when handling chlorantraniliprole. In the event of a fire, wear a self-contained breathing apparatus and use personal protective equipment. In an area heavily exposed to small fires, let the fire burn itself out if conditions permit since water may increase the area contaminated by chlorantraniliprole. Cool containers or tanks of chlorantraniliprole with water spray and control runoff.

Do not apply chlorantraniliprole in a way that will come into contact with workers or other persons, either directly or through drift. Only protected handlers may be in the area during application.

Wear items of protective clothing such as non-absorbent gloves (not leather or fabric), rubber footwear (not canvas or leather), a hat, goggles, or a dust-mist filter. If no specific clothing is required, gloves, long-sleeved shirts and long pants, and closed shoes are recommended.

Where to learn more

Summary

Chlorantraniliprole is a member of the anthranilic diamine class of insecticides. This insecticide affects insect ryanodine receptors, which means it interrupts normal muscle contraction.

Chlorantraniliprole causes serious eye irritation. It may also cause respiratory irritation. It is very toxic to aquatic life, with long-lasting effects.

Chlorantraniliprole is used to control various kinds of pests on a range of crops including potatoes and cotton. It is used to handle pests such as cabbage loopers, corn borers, armyworms, and cutworms.

Sources include:

PMEP.CCE.Cornell.edu[PDF]

PubChem.NCBI.NLM.NIH.gov

SiteM.Herts.AC.uk



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