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"Mosholder discovered evidence that antidepressant drugs (serotonin reuptake inhibitors (SSRIs)), including Paxil, Zoloft, and Effexor, could increase the risk of suicidal thoughts in children.135 FDA had assigned Mosholder the task of evaluating claims of an association between antidepressants and suicidal behavior in children in June of 20 03.136 Dr. Mosholder found evidence of increased risk of suicidal thoughts principally upon a review of twenty-two pediatric trials, involving 4,250 children." - Jonathan W. Emord, The Rise of Tyranny (Get the book.)

"The symptoms of depression in older adults may include agitation, anxiety, memory problems, social withdrawal, decreased appetite, confusion, loss of l63 interest in normally pleasurable activities, prolonged grief, reduced energy, and suicidal thoughts. Because these symptoms are present in many other conditions, accurate diagnosis is difficult. Among other mental health problems in older adults are anxiety, and alcohol and substance abuse. In a given year, more than 11 percent of people aged fifty-five and older meet the criteria for an anxiety disorder. Phobias are the most common type." - Gary Null and Amy McDonald, The Food-Mood Connection: Nutrition-based and Environmental Approaches to Mental Health and Physical Wellbeing (Get the book.)

"Another disturbing trend that came from this analysis was the change in suicidal thoughts over time. In the U.S. there are 24.5 million doctor visits for depression per year, a 70% increase from fifteen years ago. Sixty-nine percent of these visits result in a prescription for an antidepressant. The analysis showed that the risk of suicidal thinking and suicide itself has been gradually increasing over the years. It is unclear whether this is the result of an increase in the number of antidepressant prescriptions by primary-care physicians or other causes." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.) "A recent meta-analysis of studies of adults taking SSRIs showed no increase in suicidal thoughts or attempts, while there was a 57% increase in nonfatal self-harm with SSRIs that was of borderline statistical significance. However, another metaanalysis showed a greater than twofold increase in fatal and nonfatal suicide attempts in patients on SSRI vs. placebo, and in those on SSRIs compared to other nonmedication treatments. The risk was 5.6 per 1,000 patient years (the number of years people take the drug times the number of patients)." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"The patients were no less depressed after taking Paxil than after taking placebos, and the incidence of emotional lability (including suicidal thoughts) was twice as high (3.2 percent versus 1.5 percent). The United Kingdom Medicines and Healthcare Products Regulatory Agency promptly advised that Paxil no longer be prescribed for patients under the age of 18. When all of the evidence is considered, "breakthrough" is not exactly the first word that comes to mind to describe the effectiveness and safety of the new antidepressant drugs." - John Abramson, Overdosed America: The Broken Promise of American Medicine (P.S.) (Get the book.) "When the manufacturer of Paxil performs nine clinical studies on the treatment of adolescents for depression and finds that Paxil is no more effective than placebos and, in fact, significantly increases the frequency of "emotional lability" (including suicidal thoughts and attempts), it's no problem. The company publishes one study that shows a benefit, fails to publish the other eight, and markets away. When British drug authorities spill the beans? No problem." - John Abramson, Overdosed America: The Broken Promise of American Medicine (P.S.) (Get the book.)

"The partial hospitalization staff identified him as suffering from "anxiety, depression, grief and loss, and suicidal thoughts." As I've so often seen in retrospect, he quickly deteriorated on the Zoloft. This is consistent with FDA's new warnings about children undergoing "clinical worsening" on antidepressants (see chapter 3). Andy's behavior became increasingly difficult, puzzling, and strange. He sat in the family van and used his cell phone to call his parents in the house asking to go to the airport. He wanted to go on a trip." - Peter Breggin, Medication Madness: A Psychiatrist Exposes the Dangers of Mood-Altering Medications (Get the book.) "It more specifically warns about "central nervous system stimulation which may lead to tremors, restlessness, anxiety, lightheadedness, confusion, hallucinations, paranoia, depression, nightmares, insomnia, and rarely, suicidal thoughts and acts. These reactions may occur following the first dose." That little string of words reflects untold numbers of nightmarish personal experiences. These reactions are consistent with the overstimulation of the brain and the mind that appear in many of our cases of medication madness." - Peter Breggin, Medication Madness: A Psychiatrist Exposes the Dangers of Mood-Altering Medications (Get the book.)

"Andrew Mosholder, a psychiatrist at the FDA who reviewed data collected from SSRI trials in childhood depression, became concerned about an increase in suicidal thoughts, but was specifically excluded by his superiors at the FDA from attending an FDA advisory panel meeting on drug treatment of childhood depression. As described in The Lancet (April 24, 2004, "Depressing Research"), after reviewing the evidence from clinical trials conducted by the drug companies, the Medicines and Healthcare Products Regulatory Agency (MHRA) of the United Kingdom (U.K." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.) "In my clinical experience as a psychiatrist, I have found there to be a real but small risk of a condition called akathisia, a feeling of internal restlessness and agitation, associated with changes in doses of SSRIs, which can lead to suicidal thoughts and behavior. No one has yet shown that SSRIs increase the rates of completed or "successful" suicides in either adults or children. But one reason for the increased agitation is that the recommended starting dose is often too high. I recommend starting at half the recommended dose and moving patients up very gradually." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"In children and adolescents, less common side effects may also include: Agitation, excessive menstrual bleeding, frequent urination, hyperactivity, mania or hypomania (inappropriate feelings of elation and/or rapid thoughts), nosebleeds, personality changes (sometimes extreme), rage, suicidal thoughts, and thirst. While you are taking fluoxetine you may need to be monitored for worsening symptoms of depression and/or suicidal thoughts especially at the start of therapy or when doses are changed." - Dr. David W. Tanton; Ph.D., A Drug-Free Approach To Healthcare, Revised Edition (Get the book.)

"The Cassidys' lawsuit, filed in federal court in Pittsburgh, charged that Diane Cassidy's doctor prescribed the antidepressant Prozac to her for weight loss and that the drug caused suicidal thoughts that led her to slash her wrists and overdose on a painkiller. She suffered intracranial bleeding from the painkiller, which left her paralyzed on one side and mentally impaired, according to the lawsuit, which sought $4.84 million in tangible damages. The Cassidys were represented by Houston trial lawyer Andy Vickery, who has negotiated settlements of several Prozac cases against Lilly." - Gary Null and Amy McDonald, The Food-Mood Connection: Nutrition-based and Environmental Approaches to Mental Health and Physical Wellbeing (Get the book.)

"Some people come to me holding this extreme position, because the AD label has a way of driving suicidal thoughts. In this woman's case, and in each such instance I encounter in my practice, I attempted to persuade her to think more positively about the trajectory of her condition, and emphasized the variability of the clinical course of brain aging. I reminded her that even if the worst-case scenario played out and she declined quickly, she might become more serene and at peace with her condition, losing the desire to commit suicide in the process." - Peter J. Whitehouse and Daniel George, The Myth of Alzheimer's: What You Aren't Being Told About Today's Most Dreaded Diagnosis (Get the book.) "Clearly when brain aging hits earlier than we expect it to, and especially when it features prominent behavioral symptoms such as aggressiveness and suicidal thoughts, it is impossible to call a person's situation normal. Statistically speaking, it is not normal to be so demented at sixty-six, whereas the onset of some dementia in one's eighties, nineties, or beyond is more or less the normal expectation." - Peter J. Whitehouse and Daniel George, The Myth of Alzheimer's: What You Aren't Being Told About Today's Most Dreaded Diagnosis (Get the book.)

"In 2004, the FDA ordered that antidepressants carry a "black box" warning, the government's strongest warning, alerting consumers to the risk of increased suicidal thoughts and behavior among children and teens taking them. Research data, previously unpublished, revealed that children given antidepressants were almost twice as likely to have suicidal thoughts and behaviors as those who took placebos." - Bruce E. Levine, Surviving America's Depression Epidemic: How to Find Morale, Energy, and Community in a World Gone Crazy (Get the book.)

"Paxil is a shorter-acting Prozac, but I don't use it in children, because even though it's generally calming, it occasionally creates the paradoxical reaction of triggering agitation, and even prompting suicidal thoughts. Atypical Antipsychotic Medications for Autism After antidepressants, this type of medication is the second most frequently applied in the treatment of autism. In a recent study, 29 percent of all drugs used for autism were antipsychotics." - Kenneth Bock, Healing the New Childhood Epidemics: Autism, ADHD, Asthma, and Allergies: The Groundbreaking Program for the 4-A Disorders (Get the book.)

"Guilt: believing you "just can't do anything right" or that you are a burden to others ?Suicidal thoughts or attempts Cognitive-behavioral therapy is based on the idea that your thoughts—and not external factors such as people or events?drive your behaviors and feelings. Therefore, you can change the way you think so that you will feel and behave better." - Steven V. Joyal, What Your Doctor May Not Tell You About Diabetes: An Innovative Program to Prevent, Treat, and Beat This Controllable Disease (Get the book.)

"One more point: TADS reported suicidal thoughts in 7% who took Prozac compared with 4% in the placebo group. The authors concluded (perhaps a bit defensively) that: "despite calls to restrict access to medications, medical management of [major depression] with Prozac, including careful monitoring for adverse events, should be made widely available, not discouraged.38 This conclusion received a cautious endorsement—"as is usually the case with good research, the study provides not only important answers, but also raises several important questions"—from a JAMA editorial in the same issue." - Gerald E. Markle and Frances B. McCrea, What If Medicine Disappeared? (Get the book.)

"In the letter, Wyeth warned health care professionals that clinical studies had found a heightened risk of hostility and suicidal thoughts in children and teenagers taking its drug. The company wrote, "You should be alert to signs of suicidal ideation in children and adolescent patients prescribed Effexor." Extreme agitation was one of those signs. In October 2004, a little more than three years after Justin died, the Food and Drug Administration issued a warning to health professionals and the public." - Shannon Brownlee, Overtreated: Why Too Much Medicine Is Making Us Sicker and Poorer (Get the book.)

"He concluded, overall, that children in the studies who took antidepressants were on average twice as likely to have suicidal thoughts as those on placebo.14 Mosholder's findings were leaked to the media. FDA Internal Affairs then began a criminal investigation of Mosholder.141 In the Summer of 2003 Britain's Medicines and Healthcare Products Regulatory Agency prohibited the prescription of the SSRI drug Paxil (sold in Britain under the name Seroxat) to depressed patients." - Jonathan W. Emord, The Rise of Tyranny (Get the book.) "Mosholder found evidence of increased risk of suicidal thoughts principally upon a review of twenty-two pediatric trials, involving 4,250 children.137 He found "74 of the 2298 children taking antidepressants had a 'suicide related event' compared with 34 of the 1952 children taking placebos."138 Over one hundred events occurred in the trials that were labeled by the drug company sponsors as "possibly suicide-related," ranging from hanging and overdose to cutting and slapping. Forty-seven patients were hospitalized; none completed a suicide attempt." - Jonathan W. Emord, The Rise of Tyranny (Get the book.)

"This was based on a study done of data from 24 trials involving more than 4,400 patients taking antidepressants.195 suicidal thoughts were most prevalent during the first few months of starting the prescription. The warning on the drug even suggests that the child be watched closely during that time period for any bad signs. And in addition, that the doctor see the child weekly during the first four weeks. Doesn't that speak loudly of the dangers of the drug? Isn't that enough of a warning that something is wrong with this picture?" - Kenneth W Thomas, Ron Gilbert, Gerd Schaller, Side Effects: The Hidden Agenda of the Pharmaceutical Drug Cartel (Get the book.) "As well, "it is estimated that between 10% and 25% of SSRI users experience akathisia,119 often in conjunction with suicidal thoughts, hostility and violent behavior." As if that isn't bad enough, antidepressants can accumulate in the lungs, so that if a second antidepressant is prescribed, they may be released in toxic levels.120 Anti-hypertensive medications are blood-pressure reduction pills. Non-steroidal anti-inflammatory medications are those that reduce joint pain, used in the treatment of gout, arthritis and other inflammations." - Kenneth W Thomas, Ron Gilbert, Gerd Schaller, Side Effects: The Hidden Agenda of the Pharmaceutical Drug Cartel (Get the book.) "Or have suicidal thoughts. But isn't this a better choice than depression? How about something even worse? Serotonergic205 enhancing drugs are known to produce the Serotonin Syndrome, which is a 204 Filidei, "New Mental Health Initiative Forwards Psychiatry's Brave New World," The Communication Line, Clearwater, Florida: Creative Communications & Designs, Inc, 2004 205 Activated by or capable of liberating serotonin, especially in transmitting nerve impulses very dangerous and potentially fatal side effect." - Kenneth W Thomas, Ron Gilbert, Gerd Schaller, Side Effects: The Hidden Agenda of the Pharmaceutical Drug Cartel (Get the book.)

"The industry also had internal documents and data suggesting the drugs could trigger agitation, along with suicidal thoughts and behavior, yet the published literature said SSRIs were "effective" in children and adolescents and "well-tolerated," medical-speak for safe.t Even Justin's mother, a trained health care provider, hadn't a clue that her son's agitation might be a devastating side effect that could provoke him to suicide, until she received the "Dear Doctor" letter from Wyeth. "The medical community thinks these drugs are safe and effective," she says. " - Shannon Brownlee, Overtreated: Why Too Much Medicine Is Making Us Sicker and Poorer (Get the book.)

"Five of the six ghost-written articles that concerned pediatric psychopharmacology failed to mention that 9 percent of the children in trials experienced suicidal thoughts or took an action toward suicide.85 All of which is to say that the industry has invaded the academy, and the academy has only been too happy to let them in. The New England Journal of Medicine has a sensible policy requiring its authors to list their financial relationship with the drug companies. The only problem is that the policy can be somewhat impractical." - Charles Barber, Comfortably Numb: How Psychiatry Is Medicating a Nation (Get the book.)

"Now SSRIs carry a warning that they may increase the risk of suicidal thoughts and actions in children and adolescents, a finding that is still in question. And stories are coming out about the difficulty of withdrawing from this class of drugs, especially from venlafaxine (Effexor). Recently, I started treating a successful entrepreneur whose life was a mess. He and his wife were separated because he'd had an affair, and he'd also lost his business. He came to me to find out more about an issue that had cropped up in couple's therapy, where it became clear that he suffered from ADHD." - John J. Ratey, MD, Spark: The Revolutionary New Science of Exercise and the Brain (Get the book.)

"While you are taking fluoxetine you may need to be monitored for worsening symptoms of depression and/or suicidal thoughts especially at the start of therapy or when doses are changed. Your doctor may want you to monitor for the following symptoms: anxiety, panic attacks, difficulty sleeping, irritability, hostility, impulsivity, severe restlessness, and mania (mental and/or physical hyperactivity). These symptoms may be associated with development of worsening symptoms of depression and/or suicidal thoughts or actions. After you stop taking fluoxetine, your body may need time to adjust." - Dr. David W. Tanton; Ph.D., A Drug-Free Approach To Healthcare, Revised Edition (Get the book.)

"For others, SSRIs can trigger akathisia and suicidal thoughts. t Eli Lilly, the maker of Prozac, has data showing that 38 percent of people who take the drug become "activated," a term that includes varying degrees of agitation. But those data are considered "proprietary," and they have surfaced only once during a court case before a judge ordered them sealed. pediatric prescriptions for antipsychotics, powerful drugs that were developed to treat such serious psychiatric conditions as schizophrenia, mania, and bipolar disorder." - Shannon Brownlee, Overtreated: Why Too Much Medicine Is Making Us Sicker and Poorer (Get the book.)

"Those publications found Prozac actually reduced the chance of suicidal thoughts as well as suicide.28 The FDA committee voted unanimously in favor of Lilly's position. BOX #11-1 A Tragic Lesson for Lilly's Chairman Lilly knew Prozac could increase the risk of suicide, but Lilly's chief scientist and spokesman Leigh Thompson also knew that if they acknowledged the Prozac-suicide link, "Lilly could go down the tubes," to use Thompson's own words as found in a memo Thompson never dreamed would be seen by others." - Dr. Timothy Scott, America Fooled: The Truth About Antidepressants, Antipsychotics and How We've Been Deceived (Get the book.)

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