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"Effects of Omega-3 polyunsaturated fatty acids on Depression. Severus WE. Herz, 2006 December, 31 (Suppl. 3):69-74. Recent epidemiological and clinical research has indicated that omega-3 polyunsaturated fatty acids "may well represent a major advance in the treatment of depression." Treatment of Depression: Time to Consider Folic Acid and Vitamin B12. Cop-pen A; Bolander-Gouaille C. Journal of Psychopharmacology, 2005 January, 19(l):59-65. This study suggested that both folic acid (800 microg daily) and vitamin B12 (1 mg daily) should be included in the treatment of depression." - Gary Null and Amy McDonald, The Food-Mood Connection: Nutrition-based and Environmental Approaches to Mental Health and Physical Wellbeing (Get the book.)

"The Gruppo Italiano per lo Studio della Soprawivenza nell'Infarto Miocardico (GISSI) Prevenzione Trial assessed 11,324 Italians after a heart attack and randomly assigned them to take polyunsaturated fatty acids, vitamin E, both, or neither.15 The polyunsaturated fatty acids led to a reduction in heart attacks and related events, but vitamin E had no effect. The ATBC study showed an increase in strokes with vitamin E." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"These are not as bad for you as saturated fats, and they contain healthy essential fatty acids (discussed later), but they aren't healthy in large quantities. polyunsaturated fatty acids contain more than one double bond along the fatty acid chain. Replacing saturated fatty acids in the diet with polyunsaturated fatty acids (PUFAs) from vegetable oils will lower both total cholesterol and LDL levels and decrease blood pressure.52 However, it may also lower HDL. The third general type of fat is monounsatu-rated fat. These fats contain one double bond." - Tori Hudson, N.D., Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness (Get the book.)

"All the diabetic red blood cell membranes were lower in polyunsaturated fatty acids. Plasma phospholipids, triglycerides, and cholesterol esters were also impaired, suggesting there is an impairment of polyunsaturated fatty acid metabolism in diabetes. This suggests that in non-insulin-dependent diabetes impaired insulin activity may be both a cause and an effect of membrane polyunsaturated fatty acid composition. It is complicated, but the point is to show that Type-2 diabetes is associated with dysfunctional fat metabolism." - Gabriel Cousens, There Is a Cure for Diabetes: The Tree of Life 21-Day+ Program (Get the book.)

"Pancreatic Cancer Because a number of polyunsaturated fatty acids have been shown to inhibit the growth of malignant cells in lab experiments, researchers investigated whether fatty acids modify the growth of human pancreatic cancer. To do so, they studied lauric, stearic, palmitic, oleic, linoleic, alpha-linolenic, gamma-linolenic, arachidonic, docosahexaenoic (DHA) and eicosapentaenoic (EPA) acids and the effect of each fatty acid on cell growth." - Freedom Press, Natural Cancer Cures: The Definitive Guide to Using Dietary Supplements to Fight and Prevent Cancer (Get the book.) "Pancreatic Cancer When researchers tested the effects of polyunsaturated fatty acids on malignant cells, they found all of the PUFAs tested had an inhibitory effect. EPA, found in fish and formed from alpha-linolenic acid in flax, was the most effective. (Refer to page 87, Pancreatic Cancer, for more details on this study." - Freedom Press, Natural Cancer Cures: The Definitive Guide to Using Dietary Supplements to Fight and Prevent Cancer (Get the book.)

"In another study, extracts of n-3 polyunsaturated fatty acids also led to a significant reduction in heart attacks in men with heart disease.51 Contrary to public opinion and to what you read in the papers, however, omega-3 fatty acids will not prevent heart disease. A recent analysis of 41 studies of omega-3 fatty acids with a total of 36,913 participants52 showed no reduction in cardiovascular events or total mortality with omega-3 supplementation using fish oils and other supplements. There was a 7% increase in cancer, which was not statistically significant." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.) "The polyunsaturated fatty acids led to a reduction in heart attacks and related events, but vitamin E had no effect. The ATBC study showed an increase in strokes with vitamin E. Three other studies, involving observations of tens of thousands of people, the Cambridge Heart Association Antioxidant Study (CHAOS),16 the Heart Outcomes Prevention Evaluation (HOPE) study,17 and the Women's Health Study,18 also failed to find a protective effect for vitamin E on heart disease." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"In addition to total fat recommendations, dietary reference intakes have been formulated for essential polyunsaturated fatty acids (PUFA). There is evidence that docosahexaenoic acid modulates insulin resistance and that it is vital for fetal neurovisual development [53]. The consumption of omega-3 fatty acids in pregnant women continues to be below the recommendation. In a study by Thomas et al., the consumption of omega-3 fatty acids and fiber was increased in women with GDM after nutrition intervention [54]." - Ann M. Coulston and Carol J. Boushey, Nutrition in the Prevention and Treatment of Disease (Get the book.)

"Increase good fat consumption. polyunsaturated fatty acids found in plants and some animals, e.g., fish, support healthy inflammation in the body and may reduce inflammation associated with lesion development. 3. Increase fiber intake. This will help inhibit the uptake of cholesterol from the intestinal tract. About 95% of cholesterol in bile acids is re-absorbed in the intestinal tract and recycled. 4. Inhibit liver synthesis of cholesterol. This is how the pharmaceutical family of drugs called statins target high cholesterol levels." - Allison Tannis, Probiotic Rescue: How You can use Probiotics to Fight Cholesterol, Cancer, Superbugs, Digestive Complaints and More (Get the book.) "Fatty Inflammation Dietary lipids, especially long-chain polyunsaturated fatty acids, e.g., omega-3 and omega-6 fatty acids, control immune function. These fats may change the ability of microbes to attach to the intestinal mucus lining. Good fats in the diet are another way to help control immune reactions associated with allergies, and promote a healthy intestine. Summary There are more than 400 species of bacteria in the gastrointestinal tract. Only 30 to 40 of these species account for 99% of the microbes that make up the microflora of the human intestinal tract." - Allison Tannis, Probiotic Rescue: How You can use Probiotics to Fight Cholesterol, Cancer, Superbugs, Digestive Complaints and More (Get the book.)

"The fish story: A diet-heart hypothesis with clinical implications: n-3 polyunsaturated fatty acids, myocardial vulnerability, and sudden death. Circulation 107, 2632-2634. 104. Multiple Risk Factor Intervention Trial Research Group. (1982). Multiple risk factor intervention trial. Risk factor changes and mortality results. JAMA 248, 1465-1477. 105. Hu, F. B., Bronner, L., Willett, W. C., et al. (2002). Fish and omega-3 fatty acid intake and risk of coronary heart disease in women. JAMA 287, 1815-1821. 106. Morris, M. C., Manson, J. E., Rosner, B., Buring, J. E., Willett, W." - Ann M. Coulston and Carol J. Boushey, Nutrition in the Prevention and Treatment of Disease (Get the book.)

"Research does show that when you increase the ratio of polyunsaturated fatty acids to saturated fatty acids, there is an improved insulin binding.60 Rats fed high-fat diets became insulin resistant. Saturated fatty acids caused the most deterioration. Linolenic acid (LA) caused the least problem. The use of omega-3 from flaxseed oil normalized insulin function in the saturated fatty acid group. Research has also shown that the higher the amount of saturated fatty acids in the cell membrane, the more insulin resistance there is." - Gabriel Cousens, There Is a Cure for Diabetes: The Tree of Life 21-Day+ Program (Get the book.)

"USES Fish oils, rich in essential omega-3 long chain polyunsaturated fatty acids, appear to have numerous health benefits, including reduced risk of heart attack and certain cancers, enhanced brain functioning, and cellular health. It has also been shown to inhibit cachexia, or abnormal weight loss from muscle wasting caused by cancer, and to prolong the life of those with cancer. HOW TO USE Fish oil in a high-quality supplement form may be the easiest and safest way to obtain essential omega-3 fatty acids." - Freedom Press, Natural Cancer Cures: The Definitive Guide to Using Dietary Supplements to Fight and Prevent Cancer (Get the book.)

"Research shows that increasing membrane fluidity by taking in higher levels of dietary polyunsaturated fatty acids, especially the omega-3s, actually increases the number of insulin receptors, therefore increasing insulin activity. Research52,53 suggests that in Type-2, we have hyperinsulinemia and insulin resistance in approximately 75 percent of Type-2 diabetics in the initial phases. The elevated levels of insulin happen because insulin function is not working." - Gabriel Cousens, There Is a Cure for Diabetes: The Tree of Life 21-Day+ Program (Get the book.) "They ate basically a plant-source diet (a chimpanzee diet) and their fat intake was less than 30 percent. The polyunsaturated fatty acids also require a certain balance. The significance we have hypothesized about the kinds of fats, between cis being transferred to trans, appears in some research49'50,51 that shows there are abnormal membrane phospholipid profiles in cooked fat, which is of major significance in both Type-1 and Type-2 diabetes. Insulin stimulates and glucagon inhibits a particular enzyme, which influences the availability of polyunsaturated fats for membrane incorporation." - Gabriel Cousens, There Is a Cure for Diabetes: The Tree of Life 21-Day+ Program (Get the book.)

"Omega-3 Fatty Acids Omega-3 fatty acids are polyunsaturated fatty acids (PUFAs). They include linolenic acid (LNA), found in high concentrations in purslane, a green, leafy vegetable, and flax seed. Eicosapentanoic acid (EPA) and docosahexanoic acid (DHA) are the animal omega-3 fats in fish and fish oils and organ meat. DHA is your brain's dominant fatty acid; it makes up about 40 percent of the fat in your brain." - James Dowd and Diane Stafford, The Vitamin D Cure (Get the book.)

"The monounsaturated fats and polyunsaturated fatty acids such as alpha-linolenic acid and other omega-3 fatty acids in addition to higher dose proteins do not require a significant insulin release for metabolism. A Program for Professional or World-Class Athletes ?Multivitamin/mineral foundation program with 1 gram of fish oil ?Coenzyme Q\q\ 300-360 mg ?L-carnitine: 2,000-3,000 mg ?D-ribose: 15-20 grams ?Magnesium: 800 mg Note: Most athletes are also deficient in vitamin E and an additional 400-800 units of mixed vitamin E compounds and especially gamma-tocopherol is recommended." - Stephen T. Sinatra, M.D., The Sinatra Solution Metabolic Cardiology (Get the book.)

"Archaeological evidence in the form of fish bones and mounds of shellfish found transcontinentally appears to confirm this assumption, and from that we may infer that human biology is well attuned to, and even reliant on, the polyunsaturated fatty acids of the omega-3 (also known as n-3) series fatty acids drawn from aquatic sources and leafy green vegetation (vegetation produces n-3 fatty acids through photosynthesis).5 Indeed, n-3 fatty acids are today called essential because human beings cannot produce them on their own and must acquire them from their diets." - Peter J. Whitehouse and Daniel George, The Myth of Alzheimer's: What You Aren't Being Told About Today's Most Dreaded Diagnosis (Get the book.)

"This author hypothesized that schizophrenia could be a low-grade systemic inflammatory disease originating in the perinatal period, and suggested that perinatal supplementation with long-chain polyunsaturated fatty acids may help prevent subsequent development of the disorder. ?¦¦ High-dose Glycine Added to Olanzapine and Risperidone for the Treatment of Schizophrenia. Heresco-Levy U; et al. Biological Psychiatry, 2004 January, 55(2):165-171. This double-blind, placebo-controlled, six-week crossover treatment trial determined that ." - Gary Null and Amy McDonald, The Food-Mood Connection: Nutrition-based and Environmental Approaches to Mental Health and Physical Wellbeing (Get the book.) "Recent epidemiological and clinical research has indicated that omega-3 polyunsaturated fatty acids "may well represent a major advance in the treatment of depression." Treatment of Depression: Time to Consider Folic Acid and Vitamin B12. Cop-pen A; Bolander-Gouaille C. Journal of Psychopharmacology, 2005 January, 19(l):59-65. This study suggested that both folic acid (800 microg daily) and vitamin B12 (1 mg daily) should be included in the treatment of depression." - Gary Null and Amy McDonald, The Food-Mood Connection: Nutrition-based and Environmental Approaches to Mental Health and Physical Wellbeing (Get the book.) "The authors contend that a functional deficiency of certain long-chain polyunsaturated fatty acids may contribute to ADHD. They propose a treatment protocol with this in mind. Autism Spectrum Disorders_ Children with Autism: Effect of Iron Supplementation on Sleep and Ferritin. Dosman CF; Brian JA; et al. Pediatric Neurology, 2007 March, 36(3):152-158. An 8-week open-label trial with oral iron supplementation was conducted to assess the link between low serum ferritin and sleep disturbance in children with autism spectrum disorder." - Gary Null and Amy McDonald, The Food-Mood Connection: Nutrition-based and Environmental Approaches to Mental Health and Physical Wellbeing (Get the book.)

"The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina. Prog Retin Eye Res 2005 Jan; 24(1):87-138. Savitha S, Panneerselvam C. Mitochondrial membrane damage during aging process in rat heart: Potential efficacy of L-carnitine and DL alpha lipoic acid. Mech Ageing Dev 2006; 127(4):349-55. Schulze MB et al. Fiber and magnesium intake and incidence of type 2 diabetes: A prospective study and meta-analysis. Arch Intern Med2007 May 14; l67(9):956-65. Sethumadhavan S, Chinnakannu P." - Steven V. Joyal, What Your Doctor May Not Tell You About Diabetes: An Innovative Program to Prevent, Treat, and Beat This Controllable Disease (Get the book.)

"Replacing saturated fatty acids in the diet with polyunsaturated fatty acids (PUFAs) from vegetable oils will lower both total cholesterol and LDL levels and decrease blood pressure.52 However, it may also lower HDL. The third general type of fat is monounsatu-rated fat. These fats contain one double bond. Monounsaturated fatty acids, as found in olive oil, show either no effect on HDL or an increase in HDL, thereby promoting a better effect than either PUFAs or saturated fats. Of all the types of fat, monounsaturated is the healthiest for your heart." - Tori Hudson, N.D., Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness (Get the book.)

"Monounsaturated fatty acids have only one double bond, while polyunsaturated fatty acids have two or more double bonds. Monounsaturated fatty acids are further distinguished by the position of the double bond - omega-3 (on the third carbon), omega-6 on the sixth carbon, and so on. Oleic acid, the main fatty acid in olive oil, is a monounsaturated fatty acid as it has a single double bond. Common polyunsaturated fatty acids found in plant foods are linoleic and linolenic acids. Because of the double bonds, plant fats usually occur as oils, while animal fats tend to be solid." - Ben-Erik van Wyk, Food Plants of the World: An illustrated guide (Get the book.)

"Dietary polyunsaturated fatty acids and Depression: When Cholesterol Does Not Satisfy." American Journal of Clinical Nutrition (1995): 62:1-9. left for us all to be eating more of them (except perhaps deer and feral pigs), and certainly not enough wild fish. Fortunately, however, a few of the most nutritious fish species, including salmon, mackerel, sardines, and anchovies, are well managed and in some cases even abundant. Don't overlook those oily little fish. B E THE KIND OF PERSON WHO TAKES SUPPLEMENTS." - Michael Pollan, In Defense of Food: An Eater's Manifesto (Get the book.)

"The major benefit of these polyunsaturated fatty acids called omega-3s, in particular DHA (docosahex-anenoic acid) and EPA (eicosapentaenoic acid), is that they make blood platelets less "sticky" thus protecting circulatory health, they may promote cognitive functioning, and there's also a growing body of evidence that they may reduce the inflammatory process in the entire body. It's this latter benefit—reducing inflammation—that seems to most benefit those trying to lose weight." - Wendy Bazilian, DRPH, MA, RD, Steven Pratt, MD, Kathy Matthews, Superfoods Rx Diet: Lose Weight with the Power of SuperNutrients (Get the book.)

"All the polyunsaturated fatty acids tested had an inhibitory effect, with EPA (found in fish and formed from alpha-linolenic acid in flax) being the most potent. Monounsaturated (e.g., olive oil) or saturated fatty acids (found in beef and dairy) were not inhibitory. "The ability of certain fatty acids to inhibit significantly the growth of three human pancreatic cancer cell lines in vitro at concentrations which could be achieved in vivo suggests that administration of such fatty acids may be of therapeutic benefit in patients with pancreatic cancer," reported researchers." - Freedom Press, Natural Cancer Cures: The Definitive Guide to Using Dietary Supplements to Fight and Prevent Cancer (Get the book.)

"Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction. Circulation. 2002;105: 1897-1903. Singh RB, et al. Effect of an Indo-Mediterranean diet on progression of coronary artery disease in high risk patients. Lancet. 2002; 360:1455-1461. Surette ME, Koumenis IL, Edens MB, Tramposch KM, Clayton B, Bowton D, Chilton FH. Inhibition of leukotriene biosynthesis by a novel dietary fatty acid formulation in patients with atopic asthma: a randomized, placebo-controlled, parallel-group, prospective trial. Clin Ther Mar. 2003; 25(3):972-979. Suzuki S et al." - David W. Grotto, RD, LDN, 101 Foods That Could Save Your Life! (Get the book.)

"When nutrition researchers talk about polyunsaturated fatty acids, they are often referring primarily to linoleic acid—a fatty acid found in nuts and seeds and most vegetable oils. In animal research, the consumption of polyunsaturated fatty acids increases the risk of some cancers.61 However, in humans, most,62'63,64 though not all,65 reports do not find an association between polyunsaturates and cancer risks. Sugar A preliminary study has reported an association between an increasing intake of sugar or sugar-containing foods and an increased risk of gallbladder cancer." - Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D., The Natural Pharmacy: Complete A-Z Reference to Natural Treatments for Common Health Conditions (Get the book.)

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