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"Because of these tentatively positive results, two large studies were conducted, the Deutsche nicotinamide Intervention Study and the European nicotinamide Diabetes Intervention Trial (ENDIT); neither found significant benefit. However, in the face of some of the above studies, if my child had Type-1 diabetes, I would certainly add nicotinamide to the mix because of its minimal toxicity, and the fact that it is inexpensive. A dosage of 2,000 mg a day would cost around $7.00 a month. Dosage: The typical dosage used is 500-1,000 mg three times a day, taken with food." - Gabriel Cousens, There Is a Cure for Diabetes: The Tree of Life 21-Day+ Program (Get the book.)

"Niacin Coenzyme forms are: nicotinamide Adenine Dinucleotide (NAD) nicotinamide Adenine Dinucleotide Phosphate (NADP) Niacin can be made in the body from the essential amino acid tryptophan. When tryptophan is consumed in excess of protein needs, one sixtieth of the excess tryptophan can be converted to niacin. The niacin equivalent (NE) of food includes the niacin present plus the amount of niacin that can be made from tryptophan. In some foods, the tryptophan content is more important than the niacin content in providing niacin equivalents." - Dr. Steve Blake, Vitamins and Minerals Demystified (Get the book.)

"His Stanford colleague Michael Kohane, an expert in fruit flies, had been studying the effects of supplements of nicotinamide adenine din-ucleotide (NAD) on his fruit fly specimens. An important cofactor for enzymes, NAD helps in energy metabolism within cells by transporting hydrogen, which is essential in setting the fly's built-in timer for larval development. Energy availability also directly affects an organism's fitness." - Lynne McTaggart, The Intention Experiment: Using Your Thoughts to Change Your Life and the World (Get the book.)

"Vitamin B3 comes as two basic types— niacin (also called nicotinic acid) and niacinamide (also called nicotinamide). Got that straight? Don't worry about it. Doctors generally recommend inositol hexaniacinate (a form of the nicotinic acid) for individuals who need large amounts of niacin, as it has not been shown to be toxic in larger amounts. While possibly not as effective as plain niacin, it does appear to lower cholesterol. Niacinamide, the alternative source of vitamin B3, offers no benefit in cholesterol management." - Jonny Bowden, Ph.D., C.N.S., The Most Effective Natural Cures on Earth: The Surprising, Unbiased Truth about What Treatments Work and Why (Get the book.)

"Niacin used in supplements and as food fortification is usually in the form of nicotinamide (niacinamide), which has no flushing effect. Nicotinic acid (niacin) is also available as a supplement, but should be kept to small doses to avoid flushing." - Dr. Steve Blake, Vitamins and Minerals Demystified (Get the book.) "Niacin. (c) nicotinamide. (d) All of the above. 5. Riboflavin helps reactivate this important antioxidant: (a) Tryptophan. (b) Cobalamin. (c) Biotin. (d) Glutathione. 6. Part of our niacin requirement can be met by dietary: (a) Tryptophan. (b) Lysine. (c) Methionine. (d) Leucine. 7. Niacin deficiency can cause: (a) Blindness. (b) Pellagra. (c) Beriberi. (d) Scurvy. 8. Which B vitamin makes up a large part of coenzyme A? (a) Pantothenic acid. (b) Tryptophan. (c) Thiamin. (d) Biotin. 9. Coenzyme A is an important part of: (a) Energy production. (b) The TCA cycle." - Dr. Steve Blake, Vitamins and Minerals Demystified (Get the book.) "You may recall that nicotinamide is a form of niacin, vitamin B3. Iron as an Antioxidant Cells need protection from any accumulation of hydrogen peroxide. Hydrogen peroxide can cause free radical damage inside cells. Certain enzymes that contain heme can catalyze reactions that neutralize the free radical hydrogen peroxide. Hydrogen peroxide is converted to water and oxygen, as shown in Figure 11-3. In this case, iron in heme acts as an antioxidant. A Free Radical Enzymes containing heme Figure 11-3 Enzymes containing heme catalyze the conversion of hydrogen peroxide to water and oxygen." - Dr. Steve Blake, Vitamins and Minerals Demystified (Get the book.)

"Journal National Cancer Institute 82: 672-76, 1990] The use of high-dose nicotinamide (niacinamide), which does not cause flushing and side effects as niacin does, improves oxygen flow to tumors. Patients with advanced cancers given 5,600 milligrams of nicotinamide experienced an increase in delivery of oxygen to tumor cells. [Cancer Research 57: 5261-64, 1997] Co-treatment using niacin and radiation therapy is more promising than radiation alone. Vitamin B6 and cancer The available data on the role of vitamin B6 and cancer is limited." - Bill Sardi, You Don't Have to be Afraid of Cancer Anymore (Get the book.)

"It's ironic, but in 1979, shortly after the original patent for Valium expired, research scientists for Hoffmann-LaRoche, the company that made Valium, published an article entitled 'Nicotinamide is a brain constituent with benzodiazepine-like actions' That means niacinamide—nicotinamide is the British version of the name—acts like Valium and Valium-category drugs in the brain." "Valium is the stuff I damn near got addicted to. Could I get hooked on niacinamide?" "No. Niacinamide is one form of vitamin b3. Without it for long enough, we'd literally drop dead." - Jonathan V. Wright, M.D. and Alan R. Gaby, M.D., Natural Medicine, Optimal Wellness: The Patient's Guide to Health and Healing (Get the book.)

"The first of these studies—the Deutsche nicotinamide Intervention Study—did not show much of an effect with 1.2 grams of niacinamide daily, while results from the larger study, the European nicotinamide Diabetes Intervention Trial (ENDIT), are not yet available.7 While we don't believe that niacinamide will work for all recent-onset type 1 diabetes patients or offer an effective prevention strategy on its own in most cases, it may work for some." - Michael T. Murray, Beat Diabetes Naturally: The Best Foods, Herbs, Supplements, and Lifestyle Strategies to Optimize Your Diabetes Care (Get the book.)

"These include creatine, nicotinamide,44 and n-acetylcysteine.45 But lest you think that all this protection is just important for old brains, it appear:; that loss of energy production and oxidative stress are critical components of little autistic brains as well.4'' So all across the age spectrum and all across the spectrum of different diseases that affect the brain (and almost everything else), we must focus on keeping our free radicals and oxidative stress in check and our mitochondria healthy. A BRAIN WITHOUT ENERGY I want :o share a very important story with you." - Mark Hyman MD, The UltraMind Solution: Fix Your Broken Brain by Healing Your Body First (Get the book.)

"For the patients I work with, I give 3000 milligrams per day of either nicotinic acid or nicotinamide, which are both forms of vitamin B3." Other nutrients include vitamin C, vitamin B6, and manganese. "I also use vitamin C at the same dose level and sometimes a lot more because vitamin C is a very good water-soluble antioxidant," Dr. Hoffer explains. "It is considered the foremost, the most active water-soluble antioxidant present in the human body. That's extremely important." Manganese is used to protect against tardive dyskinesia. Dr." - Gary Null and Amy McDonald, The Food-Mood Connection: Nutrition-based and Environmental Approaches to Mental Health and Physical Wellbeing (Get the book.)

"The effects of nicotinamide supplementation on angiogenesis in humans has yet to be demonstrated. nicotinamide also decreases blood flow resistance in tumors, and subsequently, lowers the intratumor vascular pressure (Lee et al, 1992). The method by which nicotinamide produces this effect is not understood. Since high vascular pressure limits the uptake of drugs by a tumor, it may be possible, under certain conditions, to use nicotinamide to increase the efficacy of anticancer drugs. 3.4 NATURAL AGENTS THAT INHIBIT ANGIOGENESIS A number of natural agents exhibit antiangiogenic properties." - John Boik, Cancer & Natural Medicine: A Textbook of Basic Science and Clinical Research (Get the book.)

"However, in the face of some of the above studies, if my child had Type-1 diabetes, I would certainly add nicotinamide to the mix because of its minimal toxicity, and the fact that it is inexpensive. A dosage of 2,000 mg a day would cost around $7.00 a month. Dosage: The typical dosage used is 500-1,000 mg three times a day, taken with food. Those at risk for developing Type-1 diabetes, or those who have already been diagnosed, are well advised to use niacinamide. The research has shown that it is most helpful either before or in the initial phases, i.e." - Gabriel Cousens, There Is a Cure for Diabetes: The Tree of Life 21-Day+ Program (Get the book.)

"There are three forms of niacin available: nicotinic acid, nicotinamide, and inositol hexaniacinate. Nicotinic acid can decrease triglycerides and raise HDL cholesterol, but this requires high doses (typically 1.5 to 3 g daily), which can cause flushing and liver toxicity. (As a general precaution, anyone who takes more than 2 g of niacin daily or more than 500 mg at the same time as statins should undergo periodic liver function tests.) Nicotinic acid may also worsen glycemic control." - Steven V. Joyal, What Your Doctor May Not Tell You About Diabetes: An Innovative Program to Prevent, Treat, and Beat This Controllable Disease (Get the book.) "Effect of standard nicotinamide in the prevention of type 1 diabetes in first-degree relarives of persons wirh type 1 diabetes. Autoimmunity 2006 Jun; 39(4):333-40. Cauley JA et al. Effects of estrogen plus progestin on risk of fracture and bone mineral density: The Women's Health Initiative randomized trial. JAMA 2003 Oct 1; 290(13):1729-38. Colhoun HM et al. On behalf of the CARDS investigators. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): Multicentre randomised placebo-controlled trial." - Steven V. Joyal, What Your Doctor May Not Tell You About Diabetes: An Innovative Program to Prevent, Treat, and Beat This Controllable Disease (Get the book.)

"Antioxidant cosmeceutical ingredients include vitamins such as B-5 (and its synthetic derivative panthenol), C, E, and nicotinamide; lycopene; polyphenols such as coffeeberry in coffee plant fruit and resveratrol in grapes; genistein, the isoflavone in soy milk and fermented soy; EGCG (epigallocatechin-3-gallate); pycnogenol, an extract of French marine pine bark; grape seed extract; and DMAE, found in cold-water fish, particularly salmon. 6. Tyrosinase Inhibitors." - Samuel S. Epstein, Randall Fitzgerald, Toxic Beauty: How Cosmetics and Personal Care Products Endanger Your Health . . . And What You Can Do about It (Get the book.)

"Because of these interesting results, several pilot studies were designed to see if nicotinamide was a viable way to prevent Type-1 diabetes from manifesting, or after manifesting, to prevent the beta cells from further destruction or reduce the rate of destruction. In these studies seven participants were given 3 grams of niacinamide. After six months, five patients in the niacinamide group and two in the placebo group were not needing insulin. Their blood glucose levels and HgbAlc levels were normal." - Gabriel Cousens, There Is a Cure for Diabetes: The Tree of Life 21-Day+ Program (Get the book.)

"The effects of nicotinamide supplementation on angiogenesis in humans has yet to be demonstrated. nicotinamide also decreases blood flow resistance in tumors, and subsequently, lowers the intratumor vascular pressure (Lee et al, 1992). The method by which nicotinamide produces this effect is not understood. Since high vascular pressure limits the uptake of drugs by a tumor, it may be possible, under certain conditions, to use nicotinamide to increase the efficacy of anticancer drugs. 3.4 NATURAL AGENTS THAT INHIBIT ANGIOGENESIS A number of natural agents exhibit antiangiogenic properties." - John Boik, Cancer & Natural Medicine: A Textbook of Basic Science and Clinical Research (Get the book.)

"Nicotinamide: A large single dose of another B vitamin, nicotinamide, enhanced the cancer cell-killing ability of the conventional drug, L-PAM. This enhancement was at its maximum when nicotinamide was given one hour before L-PAM injections. In fact, it more than doubled the effectiveness of the drug. It also more than tripled the time that the chemotherapy stayed in the bloodstream. As the dose of nicotinamide was decreased, the enhancement of L-PAM was also reduced, British scientists reported (10)." - Ralph W. Moss, Ph.D., Cancer Therapy: The Independent Consumer's Guide To Non-Toxic Treatment & Prevention (Get the book.)

"Take 100 mg twice a day of coenzyme Q10 (CoQ10), an antioxidant that may be beneficial in treating hypovolemic and septic shock and may improve blood flow. nicotinamide (a form of vitamin B3) taken at 2-4 g a day may help protect against bacterial endotoxin, which causes septic shock. Glutamine added to parenteral nutrition (nutrients given through the veins when someone cannot take oral nutrition) may protect the intestines and prevent complications from septic shock. If a dose can be tolerated, take 20-30 mg in divided doses. Consult a naturopathic physician about parenteral administration." - Marshall Editions, 1000 Cures for 200 Ailments: Integrated Alternative and Conventional Treatments for the Most Common Illnesses (Get the book.)

"This may be due to rapid conversion of the nicotinamide to nicotinic acid in the body. When the dose is too high for both forms of the vitamin, the patients will suffer from nausea at first, and if the dose is not reduced, from vomiting. These side effects may be used to determine what is the optimum dose. When they do occur, the dose is reduced until it is just below the nausea level. With children, the first indication may be loss of appetite. If this does occur, the vitamin must be stopped for a few days and then may resumed at a lower level." - Abram Hoffer, PhD, MD, FRCP(C) and Dr. Jonathan Prousjy, DPHE, DSC, ND, FRSH, Naturopathic Nutrition: A Guide to Nutrient-rich Food & Nutritional Supplements for Optimum Health (Get the book.)

"As the dose of nicotinamide was decreased, the enhancement of L-PAM was also reduced, British scientists reported (10). Nicotinamide also increased the antitumor activity of another conventional anticancer drug, cisplatin. Survival time of mice more than doubled in a group receiving both substances. Yet nicotinamide by itself showed no antitumor activity. Pathological changes in cells were partially prevented "by a single protective dose" of the vitamin. Toxicity of the drug was also "partially reversed" by the vitamin." - Ralph W. Moss, Ph.D., Cancer Therapy: The Independent Consumer's Guide To Non-Toxic Treatment & Prevention (Get the book.)

"I advised him to start Ben on nicotinamide 3 g daily. Children today suffer from a large number of serious behavioral and learning disorders, which are caused primarily by the food that they eat. A few months later, George called me again. He wanted to know whether I would be interested in his son's response. He then told me that they were no longer worried because Ben was normal. Two months after he started on the vitamin, the clinic giving him remedial reading discharged him as well. He had not responded to their program the previous 6 months." - Abram Hoffer, PhD, MD, FRCP(C) and Dr. Jonathan Prousjy, DPHE, DSC, ND, FRSH, Naturopathic Nutrition: A Guide to Nutrient-rich Food & Nutritional Supplements for Optimum Health (Get the book.)

"Roots are rich in minerals and various vitamins, including nicotinamide (850 ug) and vitamin C (30 mg). Notes Canola oil is low in erucic acid and glyco-sinolates. It can be esterified to make biodiesel. Brassica nigra black mustard Black mustard flowers and fruit Black mustard seeds Description This is an erect annual herb of up to 1 m in height with deeply lobed lower leaves and narrowly oblong upper leaves. Small yellow flowers are followed by smooth, beaked capsules that split open when they ripen to release the black to reddish brown seeds." - Ben-Erik van Wyk, Food Plants of the World: An illustrated guide (Get the book.)

"Optimal doses of nicotinamide considerably improved the symptoms of anxiety. By the time he was 24 years old, he entered medical school and his anxiety worsened. He was so upset by his inability to just "go with the flow," or "feel comfortable in my own skin" that he again sought the help of a psychiatrist. This time the psychiatrist assessed and diagnosed him with social phobia, panic disorder, dysthymia, and mild agoraphobia. He was started on Zoloft (sertraline HCI) 50 mg daily." - Abram Hoffer, PhD, MD, FRCP(C) and Dr. Jonathan Prousjy, DPHE, DSC, ND, FRSH, Naturopathic Nutrition: A Guide to Nutrient-rich Food & Nutritional Supplements for Optimum Health (Get the book.)

"Nutritional value The fruits are low in energy yield (about 20-30 kcal per 100 g) but are rich in minerals, nicotinamide and other vitamins. notes The dry fruit of the smooth luffa (vegetable sponge) has become an important article in export trade, especially for the European and USA markets. Lupinus albus white lupin • Egyptian lupin White lupin Description Erect annual herbs with digitate leaves and attractive flower clusters producing hairy pods with large, usually white seeds. Four large-seeded lupins are of direct importance as human and animal food: the white lupin, blue lupin (L." - Ben-Erik van Wyk, Food Plants of the World: An illustrated guide (Get the book.)

"Vitamin B3 comes in two basic forms—niacin (also called nicotinic acid) and niacinamide (also called nicotinamide). A variation on niacin, called inositol hexaniacinate, is also available in supplements. Since it has not been linked with any of the usual niacin toxicity in scientific research, some doctors recommend inositol hexaniacinate for people who need large amounts of niacin. Where is it found? The best food sources of vitamin B3 are peanuts, brewer's yeast (page 480), fish, and meat. Some vitamin B3 is also found in whole grains. Who is likely to be deficient?" - Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D., The Natural Pharmacy: Complete A-Z Reference to Natural Treatments for Common Health Conditions (Get the book.)

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