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"Gueriguian's concerns about liver toxicity. The FDA approved Rezulin in February 1997, and brisk sales soon earned it "blockbuster" status. However, reports of fatal liver toxicity due to Rezulin soon started to appear. Notwithstanding reports of deaths in the United States as well as in Japan, and the withdrawal of the drug from the United Kingdom because of liver toxicity in December 1997, Dr. Eastman and his colleagues decided to continue treating volunteers in the Diabetes Prevention Program study with Rezulin." - John Abramson, Overdosed America: The Broken Promise of American Medicine (P.S.) (Get the book.)

"Dandelion is well-known for its beneficial effects on liver problems, including cirrhosis, jaundice, hepatitis, gallstone removal, and liver toxicity. Dr. David Peterson, a licensed, practicing medical herbalist in Great Britain, once wrote that the high insulin content of the root may be regarded as something "to prescribe for people with diabetes mellitus." Heinerman suggests 3 capsules of dried root each day." - Gabriel Cousens, There Is a Cure for Diabetes: The Tree of Life 21-Day+ Program (Get the book.)

"It is merely a pigment and is not a sign of liver toxicity. Carotenes are not toxic. Carotenes Mixed, natural carotenes, 75,000 III twice daily 25,000-50,000 III for prevention (see treatment plans) Vitamin A. Studies have shown that dietary vitamin A protects against cervical cancer. Women with lower scrum levels and dietary intakes of total vitamin A are significantly more likely to have dysplasia or carcinoma in situ than women with a higher intake of these nutrients." - Tori Hudson, N.D., Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness (Get the book.) "Immediate-release niacin is recommended, as sustained-release niacin has been associated with severe liver toxicity in doses of more than 2 grams per day. Niacin can also exacerbate elevated serum glucose levels in diabetics and can worsen gout. Niacin in doses of more than 1 gram per day are best taken under the guidance of a physician, with monitoring of liver-function tests. Niacin (Nicotinic Acid) 500 mg 1-3 times per day Paxitethine. Pantethine is the activated form of vitamin B5 (pantothenic acid) and a key component of coenzyme A (CoA)." - Tori Hudson, N.D., Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness (Get the book.)

"One such agent, triglitazone, which offers a novel way to enhance endogenous insulin efficiency, has already been withdrawn from the market because of liver toxicity. Should physicians leap to prescribe similar drugs as soon as they are released? Hardly. The ukpds group published a secondary analysis in 2000, torturing the same data to derive an association that is more consistent with their preconceived notion that treating the high blood glucose in type 2 diabetes treats the patient in some meaningful way." - Nortin M. Hadler MD, Worried Sick: A Prescription for Health in an Overtreated America (Get the book.)

"There was a small increase in heart attacks among some who took it, and there were some who registered increased liver toxicity. But the coronaries were largely linked to the observation that the Vioxx patients were not taking aspirin anymore, which was linked with decreased heart attacks; it wasn't Vioxx that was the culprit, Merck insisted. And the liver toxicity was simply something that could be controlled by good physician monitoring. This, of course, somewhat mitigated the drug's pharmaco-economic benefits, but that cavil fell on deaf ears." - Greg Critser, Generation Rx: How Prescription Drugs are Altering American Lives, Minds, and Bodies (Get the book.)

"Parsley extract was also found to have a protective effect comparable to the diabetic medication, glibor-nuride, against liver toxicity caused by diabetes. CANCER: Myristicin, a phytochemical that has been isolated in parsley, is an effective inhibitor of tumors in mice. Tips on Using Parsley SELECTION AND STORAGE: • Parsley comes in both dried and fresh forms. • Choose fresh parsley that does not have wilted or yellow leaves—a sure sign that it is not fresh! • Trim off any wilted parts before storing fresh parsley refrigerated in a plastic bag." - David W. Grotto, RD, LDN, 101 Foods That Could Save Your Life! (Get the book.)

"Decreased insulin sensitivity and liver toxicity can result from daily amounts over 2000 mg. However, niacin in the form of nicotinic acid can cause "niacin flush" in amounts as low as 35 mg. Nicotinic acid can dilate the capillaries, causing a brief tingling and flushing of the skin. Summary for Niacin—Vitamin B3 Main function: energy metabolism. RDA: men, 16 mg; women, 14 mg (niacin equivalent). No toxicity has been reported from food; flushing has been reported above 35 mg in the nicotinic acid form; no effects have been noted below 2000 mg of niacinamide. Deficiency disease: pellagra." - Dr. Steve Blake, Vitamins and Minerals Demystified (Get the book.)

"Donepezil inhibits acetylcholinesterase without causing liver toxicity. In one study, 431 patients with AD were randomized to one year of donepezil or placebo. Compared to placebo, donepezil was shown to delay symptoms of cognitive-function decline in Alzheimer's patients by five months. After one year, Mini Mental Status Exam (MMSE), a thirty-point scale that measures memory and cognitive function scores went from 17 to 18 with donepezil and remained at seventeen with placebo, a difference that was not statistically significant." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.) "Troglitazone was found to be effective in the prevention of type 2 diabetes in at-risk patients but was associated with high rates of liver toxicity. In one trial, 7 out of 585 treated patients had liver elevations ten times that of normal levels, high enough to be potentially associated with fatal liver damage.2 Based on these results, the study was concluded in 1998 and the drug was taken off the market in 2000." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.) "After the withdrawal of troglitazone because of its liver toxicity, piogli-tazone (Actos) and rosiglitazone (Avandia) were the only glitazones used for treating patients with type 2 diabetes, either alone or in combination with metformin or with sulfonylureas. Avandamet is a combination of rosi-glitazone and metformin. Many doctors use glitazones in combination with insulin, which improves glucose control while decreasing the amount of insulin required." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"The side effects of thiazolidinediones (TZDs) include fluid retention and liver toxicity. The latter complication requires that you have regular monitoring of your liver function. Several significant warnings about TZDs emerged in 2007. In February of that year, the manufacturers of Avandia (rosi-glitazone) reported that in their study of more than 4,300 patients with type 2 diabetes, significantly more women who took rosiglitazone experienced fractures of the foot, hand, or upper arm than did women who were taking metformin or glyburide." - Steven V. Joyal, What Your Doctor May Not Tell You About Diabetes: An Innovative Program to Prevent, Treat, and Beat This Controllable Disease (Get the book.)

"Notwithstanding reports of deaths in the United States as well as in Japan, and the withdrawal of the drug from the United Kingdom because of liver toxicity in December 1997, Dr. Eastman and his colleagues decided to continue treating volunteers in the Diabetes Prevention Program study with Rezulin. Only after Audrey LaRue Jones, a 55-year-old high school teacher, died of liver failure in May 1998 did Rezulin stop being given to the volunteers in the study. Warner-Lambert maintained that Rezulin was not responsible for the liver failure that led to her death." - John Abramson, Overdosed America: The Broken Promise of American Medicine (P.S.) (Get the book.)

"The study originally included a fourth limb on triglitazone but, as I mentioned in chapter 3, the fda withdrew that drug in 1998 because of liver toxicity. The intensive program started with a sixteen-session curriculum taught one-to-one covering diet, exercise, and behavior modification. Monthly individual and group sessions for reinforcement followed this. After three years, more impressive progression in glucose intolerance was demonstrated in the placebo group compared to the other two, with the lowest incidence in the lifestyle group." - Nortin M. Hadler MD, Worried Sick: A Prescription for Health in an Overtreated America (Get the book.)

"The agency censored a scientific paper by Misbin that revealed the liver toxicity of Rezulin, denying him the right to publish it in a medical journal. "One of my supervisors said something to me that I have never forgotten," Misbin told reporter Michael Scherer, "that we have to maintain good relations with the drug companies because they are our customers."93 FDA aimed to silence its internal critics through intimidation. Lutwak, Gueriguian, and Misbin were all made subjects of a criminal investigation by FDA's Internal Affairs office." - Jonathan W. Emord, The Rise of Tyranny (Get the book.)

"A new form called inositol hexaniacinate also prevents the flushing, and lowers cholesterol without observed liver toxicity. This is not to say that liver toxicity cannot occur, but it is extremely rare. Herbs Each of the thousands of herbs of which we know contains numerous phytochemicals— including flavonoids, sterols, and special chemicals peculiar to each plant. It is important to remember that many of these complex compounds have not been adequately studied, and some can be quite toxic, possibly even resulting in death." - Russell L. Blaylock, M.D., Health and Nutrition Secrets (Get the book.)

"Heating unsaturated fats (those liquid at room temperature) at high temperatures produces trans fatty acids, which create toxic free radicals in the body that result in cancer, aging, birth defects and liver toxicity. The presence of heated fats in the bloodstream lowers blood cell capacity to carry oxygen and also blocks capillaries with fat globules. Fatty deposits then accumulate on the vascular walls and contribute to atherosclerosis and other forms of heart disease. Cardiovascular disease is currently the number one killer of Americans, with cancer coming in a close second." - Susan E. Schenck, The Live Food Factor: The Comprehensive Guide to the Ultimate Diet for Body, Mind, Spirit & Planet (Get the book.)

"In addition, there have been more than 100 patients hospitalized with liver toxicity caused by the drug. Since June 5th, there have been at least five additional deaths from liver damage associated with the use of this drug reported to the FDA for a total of at least 26 deaths from liverfailure. The total number of reports received by the FDA in which liver toxicity was associated with troglitazone is more than 560 since March, 1997, when the drug was first marketed." - Mike Adams, Natural Health Solutions (Get the book.)

"When Morgan Spurlock of documentary Supersize Me fame ate at McDonald's every day for a month, he developed liver toxicity, impotence, depression, and obesity, and he physically craved the junk food he was eating (probably related to the strange effects that high-fat foods can have on your brain). The amount of soda in a 7-Eleven "Double Gulp" drink is sixty-four ounces, and contains forty-eight tablespoons of sugar. A day of McDonald's meals contains one pound of sugar. A pound! No wonder we are swelling like balloons." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"While it is much safer than niacin, there is still some risk of liver toxicity. It should be used with caution, especially in those with a history of hepatitis, alcohol abuse and other liver disorders. It is a good idea to obtain a baseline liver function test and to repeat these after three weeks of therapy. The risk of liver toxicity is extremely low. Garlic Extract Should contain 10 mg of 0.8 percent alliin or a total of 4,000 ug of allicin potential for the total daily dose. Always buy quality brands." - Russell L. Blaylock, M.D., Health and Nutrition Secrets (Get the book.)

"The bottom line is that the issues of kava's safety and efficacy have been studied extensively, including a statistical review of seven human clinical trials, published in the Journal of Clinical Psychopbarmacology, which indicated no significant advetse effects related to kava use and liver toxicity. Exercise: Move or Die No one likes to hear this, but it's true. If you don't move, you die. Exercise fundamentally changes every system and function in your body." - Jon Barron, Lessons from The Miracle Doctors: A Step-by-Step Guide to Optimum Health and Relief from Catastrophic Illness (Get the book.)

"ADVERSE EFFECTS Kava has recently been removed from the food and supplement market in a number of countries, including Canada, due to concerns about kava-related liver toxicity.27'28 The reports to date have all been case reports of varying degrees of quality that describe liver toxicity, including cirrhosis, hepatitis and liver failure in patients ingesting kava.27"30 It is not clear if these effects are dose-related or related to long-term use or specific extracts of kava only." - Heather Boon, BScPhm, PhD and Michael Smith, BPharm, MRPharmS, ND, The Natural Medicine Guide to the 50 Most Common Medicinal Herbs (Get the book.)

"Constituents Calcium, chromium, magnesium, potassium, beta-carotene, quercetin, lignan (nordihydroguaiaretic acid), resins, essential oils, saponins Energetic Correspondences • Flavor: extremely bitter, salty • Temperature: cool • Moisture: dry • Polarity: yin • Planet: Saturn • Element: earth Contraindications In 1992, two people using large doses of chaparral in capsule form developed nonviral hepatitis and three others developed other symptoms of liver toxicity. This led the American Herbal Products Association and the U.S." - Brigitte Mars, A.H.G., The Desktop Guide to Herbal Medicine: The Ultimate Multidisciplinary Reference to the Amazing Realm of Healing Plants, in a Quick-study, One-stop Guide (Get the book.) "It elevates iron levels in the blood, slightly decreases respiration, lowers blood pressure, relaxes smooth muscles, and, due to its flavonoid compounds, counters liver toxicity. It works as a monoamine oxidase inhibitor, thereby increasing the availability of dopamine, a neurotransmitter. It also appears to mimic the action of the neurotransmitter GABA (gamma amino butyric acid) in relaxing the body. It is known as a medharasayan remedy, "a promoter of memory and learning." - Brigitte Mars, A.H.G., The Desktop Guide to Herbal Medicine: The Ultimate Multidisciplinary Reference to the Amazing Realm of Healing Plants, in a Quick-study, One-stop Guide (Get the book.)

"The risk of liver toxicity is extremely low. Garlic Extract Should contain 10 mg of 0.8 percent alliin or a total of 4,000 ug of allicin potential for the total daily dose. Always buy quality brands. Vitamin C (as ascorbate) 250-500 mg a day in divided doses on an empty stomach Vitamin C has been shown to lower total cholesterol and triglycerides, and increase HDL. For each 1 percent rise in HDL the risk of heart attack drops by 4 percent." - Russell L. Blaylock, M.D., Health and Nutrition Secrets (Get the book.)

"On the subject of liver toxicity and the growing importance of genetic factors in that field, the highly readable site maintained by Indiana University's Dr. David A. Flockhart (http://medicine.iupm .edu/flockhart/), is a perfect primer, replete with a drug interactions page and pocket chart. Another outstanding resource on the liver and drugs in general is Howard J. Worman's Liver Disorders Sourcebook (Lowell House, 1999), and Dr. Worman's own site at Columbia University (http://cpmcnet.columbia.edu/dept/gi/disliv .html)." - Greg Critser, Generation Rx: How Prescription Drugs are Altering American Lives, Minds, and Bodies (Get the book.)

"Consuming more than 9 g of kava per day has been shown to elevate liver enzymes temporarily; due to concerns about liver toxicity, only use kava under the direction of a medical herbalist. Willow bark, from which aspirin was originally derived, contains mildly anti-inflammatory salicylates. Willow bark is used to relieve pain related to muscle and joint inflammation. Other herbs with pain-relieving properties include meadowsweet, turmeric, and cayenne. Combine equal parts of all herbs, except cayenne, which should make up only 2-5% of the blend." - Marshall Editions, 1000 Cures for 200 Ailments: Integrated Alternative and Conventional Treatments for the Most Common Illnesses (Get the book.)

"Read package inserts carefully for information regarding liver toxicity. Considerations 0) Taking excessive amounts of vitamin A over long periods may cause liver enzyme levels to become elevated. Anyone who has been taking over 50,000 international units of vitamin A daily for over a year should reduce his or her intake or switch to an emulsion form, which is less harmful to the liver. þ If you have hepatitis C, it is best to reduce the iron levels in the body before starting any treatment. High iron levels inhibit therapy for the liver." - Phyllis A. Balch, CNC, Prescription for Nutritional Healing, 4th Edition: A Practical A-to-Z Reference to Drug-Free Remedies Using Vitamins, Minerals, Herbs & Food Supplements (Get the book.) "This drug has been linked directly to skin eruptions, inflammation of the blood vessels, and liver toxicity. If you have kidney problems, treatment with this drug should be carefully monitored. ? Colchicine, a drug derived from the autumn crocus (Colchicum autumnale), is used to both alleviate acute attacks and prevent further attacks from occurring. While often dramatically effective, this drug can cause serious side effects and toxicity, especially when taken in high doses and/or for prolonged periods." - Phyllis A. Balch, CNC, Prescription for Nutritional Healing, 4th Edition: A Practical A-to-Z Reference to Drug-Free Remedies Using Vitamins, Minerals, Herbs & Food Supplements (Get the book.)

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