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"Lactate sensitivity or an increased responsiveness to lactate might provoke anxiety symptoms. Niacinamide supplementation appears to increase the conversion of lactate to pyruvate, reducing lactate levels in the blood, which would reduce many anxiety symptoms (especially panic). HIV Infection: Dr M.F. Murray of Harvard University has done extensive research on niacinamide as a potential AIDS preventive factor. He has found a marked similarity between pellagra and AIDS." - Abram Hoffer, PhD, MD, FRCP(C) and Dr. Jonathan Prousjy, DPHE, DSC, ND, FRSH, Naturopathic Nutrition: A Guide to Nutrient-rich Food & Nutritional Supplements for Optimum Health (Get the book.)

"Alternatively, the final reaction product of two subsequent reactions can be determined: pyruvate kinase ADP + phosphoenolpyruvate -<->- ATP + pyruvate In a last step, pyruvate is metabolized by lactate dehydrogenase to yield lactate: lactate dehydrogenase Pyruvate + NADH -<--——NAD + lactate Although the above methods can be used for quantifying compounds in botanical material, the exact determination of digitalis glycosides in blood and plasma is even more important." - Dr. Michael Heinrich, Joanne Barnes, Simon Gibbons and Elizabeth M. Williamson, Fundamentals of Pharmacognosy and Phytotherapy (Get the book.)

"Medical Hypotheses 56: 693-94, 2001] Of interest are plant molecules that inhibit lactate dehydrogenase. For example resveratrol, a red wine molecule, markedly reduces lactate dehydrogenase levels. [Cardiovascular Research 47:549-55, 2000; Acta Pharmacology Sin 24:703-10, 2003] Diallyl trisulfide, a breakdown product of allicin from garlic, also inhibits lactate dehydrogenase. [Biofactors 21:171-4, 2004] Querce-tin, a plant extract often obtained from onions, also inhibits production of lactic acid." - Bill Sardi, You Don't Have to be Afraid of Cancer Anymore (Get the book.)

"Treatment with schisandra reduced the horses' heart rate and respiratory frequency, increased plasma glucose, and decreased lactate levels. In an earlier study (Ahumada et al. 1989) involving thoroughbred horses, a single dose of extract equivalent to 192 grams of schisandra produced similar results. The racehorses were on average 1.8 seconds faster over 800 meters. It was postulated that schisandra may cause a lower synthesis of lactate in muscles under anaerobic conditions and also stimulate lactate clearance by the liver. z." - David Winston, RH(AHG), and Steven Maimes, Adaptogens: Herbs for Strength, Stamina, and Stress Relief (Get the book.)

"Another group was given only the calcium lactate. Bone density was significantly reduced after one year in the calcium-only group, while the estriol-plus-calcium group had a 1.66 percent increase in bone density, using the DXA scan again.141 A third Japanese study compared 50- to 65-year-old women and elderly women who received either estriol, 2 mg/day, plus 1 g/day calcium lactate or 2 mg/day of estriol alone for 10 months.142 Increases of about 5 percent in the lumbar spine were seen in both age groups of women who took the estriol and the calcium." - Tori Hudson, N.D., Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness (Get the book.)

"Alternatively, the final reaction product of two subsequent reactions can be determined: pyruvate kinase ADP + phosphoenolpyruvate -<->- ATP + pyruvate In a last step, pyruvate is metabolized by lactate dehydrogenase to yield lactate: lactate dehydrogenase Pyruvate + NADH -<--——NAD + lactate Although the above methods can be used for quantifying compounds in botanical material, the exact determination of digitalis glycosides in blood and plasma is even more important." - Dr. Michael Heinrich, Joanne Barnes, Simon Gibbons and Elizabeth M. Williamson, Fundamentals of Pharmacognosy and Phytotherapy (Get the book.)

"L-Carnitine Fumarate also blocked the production of harmful lactate and toxic fatty acids. The Newly Updated Carnitine Family: AminoCarnitines A new generation of carnitines has been developed based upon research and the resulting elegant chemical manufacturing technology. This amounts to a USP validated process that allows the molecular bonding of certain amino acids with certain carnitine derivatives. I will describe the various forms of carnitine to explain the reasoning that has gone into this expanding technology in this section." - Stephen T. Sinatra, M.D., The Sinatra Solution Metabolic Cardiology (Get the book.)

"Casein, calcium phosphate, and lactate in yogurt act as buffers in the acidic environment of the stomach, thus protecting a portion of the microbial lactase from degradation and allowing the delivery of intact cells to the small intestine [87, 88]. In the duodenum, once the intact bacterial cells interact with bile acids, they are disrupted, allowing substrate access to enzyme activity. Yogurt consumption results in enhanced digestion of lactose and improved tolerance [55, 85, 89-91]. In 1984, Kolars et al." - Ann M. Coulston and Carol J. Boushey, Nutrition in the Prevention and Treatment of Disease (Get the book.)

"Furthermore, if people who get panic attacks are injected with lactate, severe panic attacks are produced. In normal individuals nothing happens. So it appears that individuals with anxiety may be sensitive to lactate. In other words, lactate may be causing their anxiety. Reducing the level of lactate is a critical goal in the treatment of anxiety and panic attacks. Therapeutic Considerations The natural approach to anxiety builds upon the recommendations given for stress in the chapter Stress Management. After all, anxiety is usually a symptom of severe stress." - Michael T. Murray, N.D., Joseph E. Pizzorno, N.D., Encyclopedia of Natural Medicine, Revised Second Edition (Get the book.)

"One way it does this is by raising levels of lactate in the body, which promotes anxiety. Vitamin B3 enhances the breakdown of lactate. One or two cups of coffee a day are not a problem for most people. Yet five to ten cups daily can be, as can fewer cups of a high-caffeine brew, such as Starbucks. Starbucks' beverages contain extremely large amounts of caffeine. A twelve-ounce cup of Starbucks coffee has 195 mg of caffeine, or a little more than 16 mg per ounce." - Jack Challem, The Food-Mood Solution: All-Natural Ways to Banish Anxiety, Depression, Anger, Stress, Overeating, and Alcohol and Drug Problems--and Feel Good Again (Get the book.)

"Several forms have been synthesized; among them are fumarate, tartrate, citrate, lactate, and amino carnitines, new molecules with specific amino acids attached to carnitine molecules. The carnitines referred to as AminoCarnitines?have already been successfully introduced within the last few years. These are combinations of L-carnitine with What Are AminoCarnitines? ?The accumulated body of scientific literature shows that L-carnitine precursors such as glycine, arginine, taurine, and lysine are related to L-carnitine's metabolic performance. ?" - Stephen T. Sinatra, M.D., The Sinatra Solution Metabolic Cardiology (Get the book.) "Remember, increased lactate can be toxic to the normal functioning heart.) These results, too, suggest that carnitine is doing something to improve the metabolism in the ischemic zones of the myocardium. Next, we'll be looking at other chronic and acute ischemic heart conditions where carnitine levels may be depleted: heart attack and heart failure. Later, I'll discuss other cardio protective effects that occur when carnitine is supplemented, such as a reduction in total cholesterol and triglyceride levels." - Stephen T. Sinatra, M.D., The Sinatra Solution Metabolic Cardiology (Get the book.)

"Use calcium lactate or calcium chelate form (do not use lactate form if you are allergic to dairy products). Needed to balance with calcium and relax the muscles. Melatonin Start with 1.5 mg daily, taken 2 hours or less before bedtime. If this is not effective, gradually increase the dosage until an effective level is reached (up to 5 mg daily). A natural hormone that promotes sound sleep. Use it only occasionally and do not give it to children. Helpful Vitamin B complex As directed on label. Helps to promote a restful plus extra state." - Phyllis A. Balch, CNC, Prescription for Nutritional Healing, 4th Edition: A Practical A-to-Z Reference to Drug-Free Remedies Using Vitamins, Minerals, Herbs & Food Supplements (Get the book.)

"But when there is a deficiency in B vitamins, then pyruvic acid is converted into lactate. Because most of the B vitamins have been removed from refined white sugar and carbohydrates, consumption of these items upsets the pyruvate-to-lactate ratio and increases the amount of lactic acid in the bloodstream. These elevated levels of lactate lead to anxiety. When you exercise vigorously without breathing properly, or in a stuffy, poorly ventilated environment, and the muscles can't access enough oxygen to burn glucose, then the body reacts anaerobically and lactate builds up." - Barnet Meltzer, M.D., Food Swings: Make the Life-Changing Connection Between the Foods You Eat and Your Emotional Health and Well-Being (Get the book.)

"The use of supplemental creatine speeds up regeneration of adenosine triphosphate, which increases energy availability during exercise, thereby buffering lactate and reducing muscle pain. The main side effect of chronic use is weight gain. Herbs and Other Plant Life One of the most popular means of self-medication is the use of herbs and other plant products that are sold over the counter as supplements. Some medications, like digitalis, which is used in the treatment of heart failure, are derived from plants whose beneficial properties have been known for many centuries." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"Another physical effect of meditation is a decrease in blood lactate. lactate is a substance secreted by the muscles, and it contributes to feelings of anxiety. In a fascinating experiment, one group of patients with anxiety disorder was injected with lactate. Another group, with the same disorder, was injected with a placebo. Almost every patient in the group that got the lactate quickly experienced an anxiety attack. None of the people in the placebo group experienced such an attack." - Dharma Singh Khalsa, M.D., Brain Longevity: The Breakthrough Medical Program that Improves Your Mind and Memory (Get the book.)

"Niacinamide supplementation appears to increase the conversion of lactate to pyruvate, reducing lactate levels in the blood, which would reduce many anxiety symptoms (especially panic). HIV Infection: Dr M.F. Murray of Harvard University has done extensive research on niacinamide as a potential AIDS preventive factor. He has found a marked similarity between pellagra and AIDS." - Abram Hoffer, PhD, MD, FRCP(C) and Dr. Jonathan Prousjy, DPHE, DSC, ND, FRSH, Naturopathic Nutrition: A Guide to Nutrient-rich Food & Nutritional Supplements for Optimum Health (Get the book.)

"Less anaerobic metabolism translates into a reduction in its metabolite, lactate, and a culprit agent in the vicious anginal syndrome. So let's move on, because for those with suspected heart attack, L-carnitine's protective qualities are worth knowing about! Carnitine and Myocardial Infarction When a blood clot forms and gets stuck in a coronary artery, it's a disaster! These clots probably originate at a plaque rupture site, where platelets stick and attach themselves. This is often the start of an acute coronary, or heart attack—what we used to call a coronary thrombosis." - Stephen T. Sinatra, M.D., The Sinatra Solution Metabolic Cardiology (Get the book.)

"Perhaps the most significant biochemical disturbance noted in patients with anxiety and panic attacks is an elevated blood lactate level and an increased lactate-to-pyruvate ratio. lactate (the soluble form of lactic acid) is the final pathway in the breakdown of blood sugar (glucose) when there is a lack of oxygen. Nutrition appears to play a key role in the increased lactate-to-pyruvate ratio seen in patients with anxiety. According to Melvyn Werbach, M.D." - Michael T. Murray, N.D., The Healing Power of Herbs: The Enlightened Person's Guide to the Wonders of Medicinal Plants (Get the book.)

"For example resveratrol, a red wine molecule, markedly reduces lactate dehydrogenase levels. [Cardiovascular Research 47:549-55, 2000; Acta Pharmacology Sin 24:703-10, 2003] Diallyl trisulfide, a breakdown product of allicin from garlic, also inhibits lactate dehydrogenase. [Biofactors 21:171-4, 2004] Querce-tin, a plant extract often obtained from onions, also inhibits production of lactic acid. [Xenobiotica 33:587-602, 2003; Physiology Chemistry Physics 7:473-5, 1975] This may be a primary reason for reported anti-cancer effects of these herbs." - Bill Sardi, You Don't Have to be Afraid of Cancer Anymore (Get the book.)

"However, estriol taken with calcium lactate supplements may help prevent bone loss that occurs during menopause. Estriol and Breast Cancer. Women often opt against conventional HRT because they are afraid that it might put them at risk for breast cancer. Many practitioners and researchers agree that there is a slight increased risk, and delivering the safest possible hormone oprions continues to be a goal. This has led some to study and use estriol for reducing the risk of and treating breast cancer. Henry Lemon, M.D." - Tori Hudson, N.D., Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness (Get the book.) "A third Japanese study compared 50- to 65-year-old women and elderly women who received either estriol, 2 mg/day, plus 1 g/day calcium lactate or 2 mg/day of estriol alone for 10 months.142 Increases of about 5 percent in the lumbar spine were seen in both age groups of women who took the estriol and the calcium. Women of both age groups in the calcium-alone group had a decrease in bone mineral density of the lumbar spine. High doses of estriol, one at 4 to 6 mg/day and one as high as 12 mg/day, were studied in Scotland, but they were not proved protective against bone loss." - Tori Hudson, N.D., Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness (Get the book.) "For this reason, I recommend taking a form of calcium that is already in a soluble and ionized state, such as calcium citrate, calcium lactate, or calcium gluconate. In these ionized products, about 45 percent of the calcium is absorbed from calcium citrate in patients with reduced stomach acid, as compared to 4 percent absorption for calcium carbonate.77 All of these issues make it difficult to choose from the myriad options of form and dosing in calcium supplementation. In general, I would follow the dosages of either the NIH or NAS." - Tori Hudson, N.D., Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness (Get the book.)

"Molecular basis of evolutionary adaptation at the lactate dehydrogenase-B locus in the fish Fundulus heteroclitus, Proc Natl Acad Sci USA 86: 9365-9369 Curir, P., Dolci, M., and Galeotti, F., 2005, A phytoalexin-like flavonol involved in the carnation (Dianthus caryopohyllus)-Fusarium oxysporum f. Sp dianthi pathosystem, JPhytopath 153: 65-67. Dewick, P. M., 1988, Isoflavonoids, in The Flavonoids. Advances in Research Since 1980, Harborne, J. B., ed., Chapman and Hall, London, pp. 125-209. Dias, A. P., Braun, E. L., McMullen, M. D., and Grotewold, E." - Erich Grotewold, The Science of Flavonoids (Get the book.)

"Perhaps the most significant biochemical disturbance noted in patients with anxiety and panic attacks is an elevated blood lactate level and an increased lactate-to-pyruvate ratio. lactate (the soluble form of lactic acid) is the final pathway in the breakdown of blood sugar (glucose) when there is a lack of oxygen. Nutrition appears to play a key role in the increased lactate-to-pyruvate ratio seen in patients with anxiety. According to Melvyn Werbach, M.D." - Michael T. Murray, N.D., The Healing Power of Herbs: The Enlightened Person's Guide to the Wonders of Medicinal Plants (Get the book.)

"Niacinamide supplementation appears to increase the conversion of lactate to pyruvate, reducing lactate levels in the blood, which would reduce many anxiety symptoms (especially panic). HIV Infection: Dr M.F. Murray of Harvard University has done extensive research on niacinamide as a potential AIDS preventive factor. He has found a marked similarity between pellagra and AIDS." - Abram Hoffer, PhD, MD, FRCP(C) and Dr. Jonathan Prousjy, DPHE, DSC, ND, FRSH, Naturopathic Nutrition: A Guide to Nutrient-rich Food & Nutritional Supplements for Optimum Health (Get the book.)

"It was postulated that schisandra may cause a lower synthesis of lactate in muscles under anaerobic conditions and also stimulate lactate clearance by the liver. z./o ntruat nuapiugcm in use Shatavari Shatavari (Asparagus racemosus) has been used topically to treat animal wounds, and fresh or dried shatavari is used to increase animals' milk production. Guduchi and shatavari have been found to protect against chemotherapy-induced bone marrow suppression. Animal studies have shown that this herb can relieve diarrhea, urinary irritation, and coughs and enhance immune function in animals." - David Winston, RH(AHG), and Steven Maimes, Adaptogens: Herbs for Strength, Stamina, and Stress Relief (Get the book.)

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