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"Chondroitin stimulates the production of proteoglycans and hyaluronic acid and inhibits proteolytic enzymes, which destroy cartilage. Glucosamine and chondroitin are often combined and sold in health-food stores. One placebo-controlled study in older males with osteoarthritis of the knee showed no difference in pain ratings between patients treated with glucosamine and those treated with placebo.34 Glucosamine was also associated with more side effects, including loose stools, nausea, heartburn, and headache." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"The GAG studies with published trials include PPS (pentosan polysulfate sodium) Elmiron,13-19 heparin,20 and hyaluronic acid (Cystostat).21 These studies showed treatment efficacy over placebo for each of these treatments. No studies have been published on over-the-counter preparations of chondroitin sulfates and glucosamine preparations; however, a link has been established between chondroitin and IC.22 A GAG in the form of N-acetyl glucosamine or glucosamine sulfate can be used as part of a multifactorial approach to repair the bladder epithelium." - Tori Hudson, N.D., Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness (Get the book.) "Intravesical heparin, hyaluronic acid, and intravesical PPS are other options. Experimental therapies are being explored, including electrical nerve stimulation to activate the inhibitory circuits and decrease the sensation of pain, intravesical injection of botulinium toxin, gene therapy, and nerve growth-factor inhibitors. Surgical interventions are currently considered a last resort. These include surgical removal of visible ulcers, laser denervation, or removing a part of the colon and attaching it to the bladder to increase bladder capacity." - Tori Hudson, N.D., Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness (Get the book.)

"Chondroitin stimulates the production of proteoglycans and hyaluronic acid and inhibits proteolytic enzymes, which destroy cartilage. Chondroitin and glucosamine are often given in combination for osteoarthritis. Most of the earlier studies of glucosamine and chondroitin were performed by manufacturers and were not well controlled." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"It is based on the natural biodegradable ingredient hyaluronic acid, the effectiveness of which is well-documented (10). In fact, restylane has been shown to be more effective than collagen in double blind clinical trials six months after injection by dermatologists in the naso-labial folds, wrinkles that run from the bridge of the nose to the corners of the mouth (). It's also cheaper than collagen. Injections that combined restylane and the prescription drug Botox (botulinum toxin) were also reported to be more effective than injections of either product alone. 9. Peptides." - Samuel S. Epstein, Randall Fitzgerald, Toxic Beauty: How Cosmetics and Personal Care Products Endanger Your Health . . . And What You Can Do about It (Get the book.) "The anti-wrinkling agent restylane, or Perlane, used in products made by Sweden's Q-Med, incorporates a natural biodegradable ingredient called hyaluronic acid that has been shown to be both safe and effective. Botox injections have been in use long enough to be considered relatively safe, but must be injected by a qualified dermatologist. Chapter Ten: Products Targeting Everyone Imagine for a moment that you are in your bathroom in the morning, beginning your daily routine. First, you use the toilet, and then spray an air freshener." - Samuel S. Epstein, Randall Fitzgerald, Toxic Beauty: How Cosmetics and Personal Care Products Endanger Your Health . . . And What You Can Do about It (Get the book.)

"Hyaluronic acid is the main component of this extracellular matrix. hyaluronic acid solutions have remarkable viscosity and tensile properties. When no pressure is applied to the solution, it is highly viscous and rigid. If pressure is applied, the water is squeezed out and the strands move past one another. Thus, hyaluronic acid solutions behave as biological shock absorbers in connective tissue. hyaluronic acid plays an important role in tissue hydration, lubrication, and cellular function, and is able to hold more water than any other natural substance." - David Hoffman, FNIMH, AHG, Medical Herbalism: The Science Principles and Practices Of Herbal Medicine (Get the book.)

"Does hyaluronic acid promote or accelerate the spread of cancer? ... 424 Melatonin: The sleep hormone that prolongs survival... 425 Melatonin as cancer therapy ... 427 Supplemental melatonin helps overcome symptoms during cancer treatment... 427 What impairs melatonin production? ... 427 Melatonin and chemotherapy side effects... 428 Cancer patients and sleep problems ... 428 Melatonin enhancement... 428 Does melatonin enhancement really protect against cancer? ... 428 Zeolites ... 429 Probiotics (beneficial bacteria) and cancer..." - Bill Sardi, You Don't Have to be Afraid of Cancer Anymore (Get the book.)

"It contains vitamin C from acerola berries; herbal extracts of elder flower, green tea, grape seed, and horsetail; citrus and cranberry bioflavonoids; hyaluronic acid; zinc sulfate; and essential oils of lavender, rose geranium, and sweet lavender. Vita Synergy for Men from The Synergy Company. This is a combination nutritional supplement that contains a balanced blend of all major vitamins and minerals, trace elements, and a variety of herbal extracts used to support men's health. • Wellness Formula from Source Naturals. This supplement is designed to support optimal health in cold weather." - Phyllis A. Balch, CNC, Prescription for Nutritional Healing, 4th Edition: A Practical A-to-Z Reference to Drug-Free Remedies Using Vitamins, Minerals, Herbs & Food Supplements (Get the book.)

"Approved by the US Food and Drug Administration (FDA), Res-tylane is a bioengineered, nonanimal, stabilized hyaluronic acid. It is almost identical to a substance found naturally in the body, making it safe to have repeat procedures. I like to combine Restylane treatments with Botox. Although many people associate Botox skin injections with the "frozen" look sometimes seen on the faces of film stars, I prefer to use it more judiciously to relax muscles and give the face a destressed look. Note: I do not recommend silicone injections to smooth the skin." - Bottom Line Health, Bottom Line's Health Breakthroughs 2007 (Get the book.)

"High-Tech Skin Care Options: Injectable hyaluronic acid, Botox, and Laser Surgery Hyaluronic Acid Injections Hyaluronic acid (HA) has been used in cataract surgery for over twenty-five years, injected into the eyeball to keep it from collapsing during surgery. It is also used to lubricate the joints of arthritic patients, marketed under the name Hyaloronan. Recently, injectable HA has begun to be used as a wrinkle filler. Traditionally, collagen (or your own fat) was injected into the deep folds on either side of your nostrils to lessen these lines." - Garcia Oz, Sharyn Kolberg, The Healthy High-tech Body (Get the book.)

"The blend of glycerin, ceramides, cholesterol, and hyaluronic acid will help normal to dry skin look and feel very good. However, even better performance would be possible if CeraVe had added antioxidants. Other than that, every other aspect should make your skin very happy. CETAPHIL (SKIN CARE ONLY) CETAPHIL AT-A-G LANCE Strengths: Inexpensive; their original, often-recommended Gentle Skin Cleanser; mostly fragrance-free products; affordable and widely available; offers complete ingredient lists on its Web site." - Paula Begoun and Bryan Barron, Don't Go to the Cosmetics Counter Without Me, 7th Edition (Get the book.)

"An alternative is injections of hyaluronic acid, a building block of healthy cartilage that quite a few of my patients have benefited from. A variation on this is prolotherapy. It consists of an injection into the joint of an irritant such as a sugar solution to create more collagen growth, which stabilizes the joint. This can stop the degenerative process and eliminate the pain." - Hyla Cass, M.D., Supplement Your Prescription: What Your Doctor Doesn't Know About Nutrition (Get the book.)

"Drubaix I; Maraval M; Robert L; Robert AM. hyaluronic acid (hyaluronan) levels in pathological human saphenous veins. Effects of procyanidol oligomers. Pathol Biol (Paris) Jan;45(l):86-91. 1997. Facino MR, Carini M, Aldini G, et al. Free radicals scavenging action and anti-enzyme activities of procyanidines from Vitis viniferct: a mechanism for their capillary protective action (German). Arzneimittelforschung; 44(5):592-601. 1994. Frankel EN, Kanner J, German JB et al. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet; 34(8843)1:454-457. 1993." - Thomson Healthcare, Inc., PDR for Herbal Medicines, Fourth Edition (Get the book.) "An in vitro study determined that procyanidins inhibit the activities of some proteolytic enzymes (collagenase, elastase) involved in the degradation of the main structural components of the extra-vascular matrix, collagen, elastin, and hyaluronic acid (Facino et al, 1994). Cytotoxic Effects: One study reported a Grape Seed extract exhibited cytotoxicity toward some cancer cells (Joshi et al, 1998). An abstract reported that Grape Seed extract exerted a chemopreventive effect on adenomas polyposis coli gene mutation-associated intestinal adenoma formation." - Thomson Healthcare, Inc., PDR for Herbal Medicines, Fourth Edition (Get the book.)

"Doctors perform a wide range of treatments for wrinkles, including facial peels; cosmetic skin surgery; laser resurfacing; local injections with purified botulinum toxin (Botox), collagen injections, or new soft-tissue fillers such as hyaluronic acid (Restylane); and fat transfers, to name a few. Many, if not all, of these treatments can cause unpleasant side effects. If you are considering medical treatment for this condition, do plenty of research and discuss your options with a qualified dermatologist. XEROPHTHALMIA See under eye problems." - Phyllis A. Balch, CNC, Prescription for Nutritional Healing, 4th Edition: A Practical A-to-Z Reference to Drug-Free Remedies Using Vitamins, Minerals, Herbs & Food Supplements (Get the book.)

"Wound Healing Effects: hyaluronic acid (HA), which is synthesized by fibroblasts, promotes proliferation of epithelial cells. Oral glucosamine may enhance HA synthesis, thus accelerating healing and minimizing scarring in fresh wounds (McCarty 1996). clinical trials Knee PainJOsteoarthritis Results continue to vary among studies investigating the efficacy of glucosamine for the treatment of knee osteoarthritis." - Thomson Healthcare, Inc., PDR for Herbal Medicines, Fourth Edition (Get the book.) "The sulfate salt of glucosamine forms half of the disaccharide subunit of keratan sulfate, which is decreased in osteoarthritis, and of hyaluronic acid, which is found in both articular cartilage and synovial fluid (Leffler et al 1999). Supplemental glucosamine is generally used to reduce pain and immobility associated with osteoarthritis, especially in the knee joint. The supplements are usually derived from crab shells, although a corn source is also available. Most studies of osteoarthritis have used the sulfate form of glucosamine (D'Ambrosio et al 1981; Pujalte et al 1980)." - Thomson Healthcare, Inc., PDR for Herbal Medicines, Fourth Edition (Get the book.)

"This forms a gel-like matrix in which proteins are embedded and through which water, oxygen, and solutes have to pass to get to the cells. hyaluronic acid is the main component of this extracellular matrix. hyaluronic acid solutions have remarkable viscosity and tensile properties. When no pressure is applied to the solution, it is highly viscous and rigid. If pressure is applied, the water is squeezed out and the strands move past one another. Thus, hyaluronic acid solutions behave as biological shock absorbers in connective tissue." - David Hoffman, FNIMH, AHG, Medical Herbalism: The Science Principles and Practices Of Herbal Medicine (Get the book.)

"Lancet 359: 2131-39, 2002] Arthritis is another prominent problem with aromatase inhibitors, caused by the lack of estrogen and the resultant decline in the production of hyaluronic acid, a joint-cushioning molecule. [Arthritis Rheumatism 52:2594-8, 2005] Since aromatase inhibitors lower circulating estrogen levels to almost unrecordable levels in postmenopausal women, women taking them may experience rapid withering of their bones, and more fractures and face being bedridden." - Bill Sardi, You Don't Have to be Afraid of Cancer Anymore (Get the book.)

"We may add a nutrient such as hyaluronic acid. hyaluronic acid signals genes to help synthesize new cells as well as act as a connective tissue raw material itself.676 Our goal is not only to reduce pain but also to improve the response to exercise, especially to find a level of support that helps a person do strength-training exercise. When we can get a person with fibromyalgia onto a strength-training program and get a good response to that program, we can fix their problem." - Byron J. Richards, CCN, Mastering Leptin: The Leptin Diet, Solving Obesity and Preventing Disease, Second Edition (Get the book.)

"In addition, limited in vitro and in vivo studies have shown that topically applied soybean seed extract increases collagen and hyaluronic acid synthesis in aging skin (Sources: Photochemistry and Photobiology, May-June 2005, pages 581-587; and Journal of Cosmetic Science, September-October 2004, pages 473-479), but that is true of lots of antioxidants, not just soy." - Paula Begoun and Bryan Barron, Don't Go to the Cosmetics Counter Without Me, 7th Edition (Get the book.)

"High doses of C would stimulate production of a substance that inhibits the enzyme hyaluronidase, produced by malignant tumours to attack the hyaluronic acid in intercellular cement, weaken their surroundings and allow infiltration. At the same time high-dose C would also strengthen the collagen fibrils in this intercellular cement, thus providing a double defence against angio-genesis. One might speculate that the patient's very high doses of vitamin C may, among other things, have played a crucial anti-angiogenic role in the marrow." - Michael Gearin-Tosh, Living Proof: A Medical Mutiny (Get the book.)

"Healthy and abnormal cells are held in place by collagen and its water-holding gel called hyaluronic acid (HA). In disease states, germs or tumor cells can excite enzymes that break down collagen and HA, facilitating the spread of infection or cancer. It is essential to maintain connective tissue to remain healthy. Experiments have been conducted over the past decade at Harvard Medical School in Massachusetts and the Lawrence Berkeley National Laboratory in California that expand the current understanding of cancer therapy beyond that of just killing cancer cells." - Bill Sardi, You Don't Have to be Afraid of Cancer Anymore (Get the book.)

"An alternative is injections of hyaluronic acid, a building block of healthy cartilage that quite a few of my patients have benefited from. A variation on this is prolotherapy. It consists of an injection into the joint of an irritant such as a sugar solution to create more collagen growth, which stabilizes the joint. This can stop the degenerative process and eliminate the pain. Old-guard NSAIDs include aspirin, naproxen, indomethacin, piroxicam, diclofenac, diflunisal, etodolac, fenoprofen, ketoprofen, ketorolac, mec-lofenamate, nabumetone, tolmetin, and mefenamic acid." - Hyla Cass, Supplement Your Prescription: What Your Doctor Doesn't Know About Nutrition (Get the book.)

"Is it possible, though, that excess estriol might promote lymphona indirectly by increasing hyaluronic acid? No, because lymph glands are not found in the skin, where hyaluronic acid is typically located. Thus, whether they were normal or cancerous, they would never be exposed to high levels of hyaluronic acid.* • Kawatsu R, Ezaki T, Kotani M, Akagi M. Growth-promoting effect of oestriol in a lymphoma lacking estrogen receptors. Br J Cancer. 1989;59:563-568. large-scale, long-term human trials will be necessary to answer the many unanswered questions regarding estriol's role in cancer." - John Morgenthaler and Jonathan V. Wright, Natural Hormone Replacement For Women Over 45 (Get the book.)

"We may add a nutrient such as hyaluronic acid. hyaluronic acid signals genes to help synthesize new cells as well as act as a connective tissue raw material itself.676 Our goal is not only to reduce pain but also to improve the response to exercise, especially to find a level of support that helps a person do strength-training exercise. When we can get a person with fibromyalgia onto a strength-training program and get a good response to that program, we can fix their problem." - Byron J. Richards, CCN, Mastering Leptin: The Leptin Diet, Solving Obesity and Preventing Disease, Second Edition (Get the book.)

"Ordinarily, such an increase in hyaluronic acid might be seen in a positive light, since the body uses this naturally produced substance for keeping skin soft and flexible. It is also the primary lubricant in joints like the knee and hip. The Japanese researchers wondered whether it was actually the hyaluronic acid that was helping the cancer cells grow. To test this hypothesis, they injected the same cancer cells into another group of mice, but instead of giving these mice estriol, they gave them hyaluronic acid. You can guess what happened." - John Morgenthaler and Jonathan V. Wright, Natural Hormone Replacement For Women Over 45 (Get the book.) "They found that within three to five days of the estriol administration, the mice had levels of hyaluronic acid in their skin that were about three times higher than normal. Ordinarily, such an increase in hyaluronic acid might be seen in a positive light, since the body uses this naturally produced substance for keeping skin soft and flexible. It is also the primary lubricant in joints like the knee and hip. The Japanese researchers wondered whether it was actually the hyaluronic acid that was helping the cancer cells grow." - John Morgenthaler and Jonathan V. Wright, Natural Hormone Replacement For Women Over 45 (Get the book.)

"Other good acids include glucuronic acid, which is important in the body to build polysaccharides such as hyaluronic acid vital for connective tissue; chondroitinsulfat acid which is the basic substance in cartilage; mukoitinsulfat acid which is good for our eyes; and also heparin and lactic acid for the colon. These acids bind to toxins in the body and are then flushed out." - Gregory, A. Gore, Defeat Cancer (Get the book.)

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