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"Other Names: Bitterghaap, Ghaap, Kalahari cactus, P57 actions and pharmacology COMPOUNDS Ten new C(21)-steroidal derivatives, namely gordonosides A-L were isolated from a chloroform extract of the aerial parts of hoodia gordonii. Compounds are based on 3beta,14beta-dihydroxy-pregn-5-en-17-betaone aglycone. Hoodigosides A-K (1-11), 11 new oxypregnane glycosides and a previously reported oxypregnane glycoside P57AS3 were isolated from the aerial parts of hoodia gordonii. The structures of these 12-O-beta-tigloyl isoramanone glycosides were determined."
- Thomson Healthcare, Inc., PDR for Herbal Medicines, Fourth Edition (Get the book.)

"One of the most popular ingredients to hit the supplement scene is the appetite suppressant hoodia gordonii, a cactus found in the Kalahari Desert. The story the manufacturers are pitching is that Hoodia is eaten by African Bushmen to control their hunger as they travel through the desert. Now this is the stuff of sales and marketing legend. Surely, if it comes from a far-off, mysterious land and works for the Bushmen, it will work in our toxic, overstuffed society. Some manufacturers even suggest that the nonexistent rate of obesity in indigenous populations is a result of eating Hoodia."
- Craig Pepin-Donat, The Big Fat Health and Fitness Lie (Get the book.)

"There are said to be as many as 20 species of the Hoodia plant, but only the hoodia gordonii variety grown in the Kalahari Desert of South Africa has evidence to support its appetite suppressing qualities. This makes it very difficult to come by, but there are many more Hoodia products on the market than can possibly be sustained by this rare plant using the exact species and portion of the plant said to provide benefits. Greedy manufacturers can use any of the Hoodia species and still lawfully claim that their product contains one hundred percent Hoodia."

- Craig Pepin-Donat, The Big Fat Health and Fitness Lie (Get the book.)

"A steroidal glycoside with anorectic activity in animals, termed P57AS3 (P57), was isolated from hoodia gordonii and found to have homologies to the steroidal core of cardiac glycosides. EFFECTS Hoodigosides A-K were tested for cytotoxicity and antioxidant activities in cell-based assays where they were found to be inactive. P57AS3 (P57), an oxypregnane steroidal glycoside, is the only reported active constituent from this plant as an appetite suppressant. Intracerebroventricular (i.e.v."
- Thomson Healthcare, Inc., PDR for Herbal Medicines, Fourth Edition (Get the book.)

"Unproven Uses: hoodia gordonii is traditionally used in South Africa for its appetite suppressant properties. Paradoxically, it is also used as appetite stimulant. Hoodiais also used for indigestion, hypertension, diabetes, stomachache, abdominal pain, and peptic ulceration. contraindications None are known. precautions and adverse reactions No reliable information is available. Safety in pregnancy and nursing has not been established. drug interactions No human drug information is available. dosage No information is available."

- Thomson Healthcare, Inc., PDR for Herbal Medicines, Fourth Edition (Get the book.)

"New oxypregnane glycosides from appetite suppressant herbal supplement hoodia gordonii. Steroids. 2007 Jun;72(6-7):524-34. Rader JI, Delmonte P, Trucksess MW. Recent studies on selected botanical dietary supplement ingredients. Anal Bioanal Chem. 2007 Mar 28. Van Wyk B-E, Gericke N (2000) People's Plants: a guide to useful plants of southern Africa. Briza Publications, Pretoria."

- Thomson Healthcare, Inc., PDR for Herbal Medicines, Fourth Edition (Get the book.)

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