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"BIOFLAVONOIDS Bioflavonoids (or just flavonoids) have been referred to as vitamin P. Bioflavonoids are not vitamins and are not essential for life. Bioflavonoids are excellent antioxidants found in many plant foods. As potent antioxidants, they protect us from arterial damage and cancer formation. Parsley and elderberry have the highest content of bioflavonoids. COENZYME Q10 Coenzyme Q10 is not a vitamin, but plays many necessary biological roles in the body. It can be synthesized in the body and so it cannot be considered a vitamin."
- Dr. Steve Blake, Vitamins and Minerals Demystified (Get the book.)

"For example, quercetin seems to be a more effective photoprotectant than kaempferol because it is a more effective antioxidant (Ryan et al, 2001, 2002). Another enzymatic innovation that appears to have occurred at this stage is the evolution of flavonol synthase. All orders of land plants, including bryophytes, produce flavonols, which are produced from dihydroflavonols by one or more flavonol synthase (FLS) enzymes (Figures 7.1 and 7.2). FLS is derived from the 2-oxoglutarate-dependent dioxygenase gene family (Holton et al, 1993)."
- Erich Grotewold, The Science of Flavonoids (Get the book.)

"The flavonoid-sensitive tyrosine aminopeptidase activity was associated with low-affinity binding of NPA and the purified protein involved was identified as AtAPMl (Murphy et al, 2000, 2002). AtAPMl is a dual-function aminopeptidase and trafficking protein, and both functions may be involved in regulation of auxin transport (see Sections 2.3 and 2.5). Another flavonoid-binding activity also was observed in fractions with a high affinity for NPA. These were the plasma membrane phosphoglycoproteins (PGPs) (Murphy et al, 2002) (see Section 2.5)."

- Erich Grotewold, The Science of Flavonoids (Get the book.)

"Oxmore quercetin in the root tip than wild type (Peer et al, 2001). Auxin transport in tt4 is faster than in wild type, while transport in tti is slower (Peer et al, 2004). This is likely due to flavonoid regulation of auxin loading and efflux into the auxin transport stream at the apices. One mechanism through which flavonols may be acting is the plasma membrane P-glycoproteins (PGPs). The alglycone flavonol quercetin can bind to the first A TP-binding fold ofPGPs, which inhibits auxin efflux (Ferte et al., 1999; Geisler et al., 2005)."

- Erich Grotewold, The Science of Flavonoids (Get the book.)

"MAPK cascades in other systems (see Section 2.1). AtPTENl is a pollen-specific protein that is required for normal pollen development (Gupta et al., 2002). AtPTENl is a homolog of the mammalian PTEN protein that regulates cell division and polarization (Perandones et al., 2004; Waite et al., 2005). AtPTENl encodes a dual phosphatase acting on both phosphopeptides and phosphoinositol in vitro. As such, MAPK pathway components and phosphatidyl inositol-3,4,5-triphosphate (PIP3), which thereby inhibits AKT/PKB, may be endogenous AtPTEN substrates. AtPTENl also may regulate the MAPK pathway."

- Erich Grotewold, The Science of Flavonoids (Get the book.)

"FLAVONOIDS their imperfect memories. I realized that if I wanted to get Sardinian red wine isnt the a sense of the authentic Sardinian only place to find flavonoids. lifestyle, I needed to spend time Brightly colored fruits and with someone younger who was vegetables and dark chocolate still working and living in the tradi- also conta,n ^em- Studies tional way."
- Dan Buettner, The Blue Zones: Lessons for Living Longer From the People Who've Lived the Longest (Get the book.)

"Flavonoids include quercetin, which promotes insulin secretion and is a potent inhibitor of sorbitol accumulation. Quercetin has been found in vitro to inhibit sorbitol accumulation in human lenses,121 and has been found to slow the course of cataract formation.122'123 Other flavonoids include naringin and hespertin; both have been found to be aldose reductase inhibitors, therefore protecting against the accumulation of sorbitol."
- Gabriel Cousens, There Is a Cure for Diabetes: The Tree of Life 21-Day+ Program (Get the book.)

"The flavonoids usually appear to be most potent in fruits or in sweet vegetables, probably because the sugars help the flavonoids to be absorbed. Providing the orange and yellow colors in citrus fruits (for example), the flavonoids are antioxidants and also help the absorption of vitamin C. The main discovery to date is that they seem to help prevent cancers, but different flavonoids have different roles. Taxifolin and rutin are two important flavonoids in citrus fruits, including oranges and grapefruits."
- Judith Wills, The Food Bible (Get the book.)

"I also recommend pantothenic acid, which is vitamin B5, and vitamin C, which should be taken with quercetin, the bioflavonoid. The flavonoids are very powerful oxidants and healing agents. They have antiviral properties and antiyeast properties. They are great for people with Candida, fatigue, and chronic infections. Ninety percent of the vitamin C you take is not utilized unless you take the bioflavonoids with it. I take issue on this point with Linus Pauling, whom I greatly respect. I've yet to see where vitamin C taken by itself is maximally utilized."
- Gary Null and Amy McDonald, The Food-Mood Connection: Nutrition-based and Environmental Approaches to Mental Health and Physical Wellbeing (Get the book.)

"Flavonoids: flavonoids are a group of polyphenolic compounds commonly found in nearly all plants, in which they are concentrated in the seeds, bark, flowers, peel, or skin. There are over 4,000 known flavonoids and many occur in common beverages like tea, coffee, beer, wine, and fruit juices. These include red- and blue-pigmented anthocyanidins; the white and pale-yellow compounds rutin, quercetin, and kaempferol; citrus bioflavonoids; and green tea polyphenols. Most medicinal herbs are also rich in flavonoids, such as ginkgo (Ginkgo biloba) and milk thistle (Silybum marianum)."
- J. E. Williams, Viral Immunity: A 10-Step Plan to Enhance Your Immunity against Viral Disease Using Natural Medicines (Get the book.)

"The nutritional benefits of flavonoids include the increase of intracellular vitamin C levels, a decrease in the leakiness and breakage of small blood vessels, the prevention of easy bruising, and immune system support—all of great benefit in diabetes.126 Bilberry, grapeseed, and ginkgo are important plant sources of flavonoids. Essential Fatty Acids (EFAs) The essential fatty acids also play a very important role, which is why I am very hesitant to encourage dietary fat intake that is too low to get the benefits of EFAs. In diabetes the essential fatty acid metabolism is impaired."
- Gabriel Cousens, There Is a Cure for Diabetes: The Tree of Life 21-Day+ Program (Get the book.)

"Bilberry fruit contains flavonoids known as anthocyanidins, plant pigments that have excellent antioxidant properties. They scavenge damaging particles in the body known as free radicals, helping to prevent or reverse damage to cells. Antioxidants have been shown to help prevent a number of long-term illnesses such as heart disease, cancer, and the eye disorder called macular degeneration. Bilberry also contains vitamin C, another antioxidant. Anthocyanidins found in bilberry fruit may also be useful for people with vision problems."

- Gabriel Cousens, There Is a Cure for Diabetes: The Tree of Life 21-Day+ Program (Get the book.)

"It is thought that the flavonoids reduce leukotrienes, potent vasoconstrictors, and contain prostacyclins that vasodilate and inhibit blood stickiness. This benefit is only found in dark chocolate, however. Milk chocolate binds to the antioxidants in chocolate and makes them unavailable. It is also higher in fat content. Dark chocolate, with 70 percent cocoa or more, also known as bittersweet or semisweet chocolate, contains little or no added sugar and is made from cocoa butter, which has a neutral or even beneficial effect on cholesterol."
- Tori Hudson, N.D., Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness (Get the book.)

"Bilberry, grapeseed, and ginkgo are important plant sources of flavonoids. Essential Fatty Acids (EFAs) The essential fatty acids also play a very important role, which is why I am very hesitant to encourage dietary fat intake that is too low to get the benefits of EFAs. In diabetes the essential fatty acid metabolism is impaired. The Delta-6 desaturatase enzyme, which is necessary to convert linoleic acid to gamma linolenic acid (GLA), is inhibited in diabetes."
- Gabriel Cousens, There Is a Cure for Diabetes: The Tree of Life 21-Day+ Program (Get the book.)

"One half of a grapefruit contains more than 150 phytonutrients, mostly flavonoids, believed to help the body fight against aging, allergies, infection, cancer, ulcers, and heart disease. Home Remedies Most of the home remedies utilize the grapefruit seed versus the fruit. Grapefruit seed extract is thought to be useful in treating external skin conditions, especially fungal-related conditions such as athlete's foot, jock itch, and dandruff. Throw Me a Lifesaver!"
- David W. Grotto, RD, LDN, 101 Foods That Could Save Your Life! (Get the book.)

"Flavonoids are a group of polyphenolic compounds commonly found in nearly all plants, in which they are concentrated in the seeds, bark, flowers, peel, or skin. There are over 4,000 known flavonoids and many occur in common beverages like tea, coffee, beer, wine, and fruit juices. These include red- and blue-pigmented anthocyanidins; the white and pale-yellow compounds rutin, quercetin, and kaempferol; citrus bioflavonoids; and green tea polyphenols. Most medicinal herbs are also rich in flavonoids, such as ginkgo (Ginkgo biloba) and milk thistle (Silybum marianum)."
- J. E. Williams, O.M.D., Viral Immunity (Get the book.)

"Finally, catnip and other mints are also rich in flavonoids, and several studies have now shown how important flavonoids are. Although flavonoids have only recently been praised for their properties, V^llUUSiJNLJ ntKBS 1HA1 neat they were identified decades ago. Albert Szent-Gyorgyi, the researcher who first discovered vitamin C in 1928, was also a champion of flavonoids. He called them vitamin P. Green Pharmacy for Cataracts There are a number of herbs that can help prevent cataracts. V\V Bilberry (Vaccinium myrtillus)."
- James A. Duke, Ph.D., The Green Pharmacy: New Discoveries in Herbal Remedies for Common Diseases and Conditions from the World's Foremost Authority on Healing Herbs (Get the book.)

"They all contain flavonoids which help to reduce the buildup of cholesterol and plaque in the arteries. Adding these foods and drinks to your diet may prevent arterial damage or stop the buildup you already have from progressing. CLOGGED ARTERIES, HIGH CHOLESTEROL ?How a High-Fat Food Might Help If you don't eat avocados because they're so high in fat, it's time to rethink that."
- Bottom Line Books, Uncommon Cures For Everyday Ailments (Get the book.)

"Inhibition of Bacterial Mutagenesis by Citrus flavonoids," Planta Med, 62(3), June 1996, p. 222-226. Results of this study showed that citrus flavonoids and catechins inhibit invasion of mouse M04 cells into embryonic chick heart fragments in vitro. —M. Bracke, et al., "Effect of Catechins and Citrus flavonoids on Invasion in Vitro," Clin Exp Metastasis, 9(1), January-February 1991, p. 13-25. General Results of this study indicated that colonic secretions can be modulated by dietary citrus flavonoids in vitro. —T.D. Nguyen & A.T."
- Gary Null, Ph.D., The Clinician's Handbook of Natural Healing (Get the book.)

"The term flavonoid derives from the Latin flavus meaning "yellow" because the flavonoids are responsible for the yellow, red, white, and blue pigments in plants. Phenolics include isoflavones, which are higher in legumes and especially soybeans than any other plants; coumestans, with one known estrogenic member (coumestrol) that is approximately six times more estrogenic than the isoflavones;35' 36 and lignans, high in grains and cereals and highest in flaxseed."
- Tori Hudson, N.D., Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness (Get the book.)

"In food, the following fruits and vegetables pack the highest concentrations of antioxidants: • Fruits: prunes (the most by far), raisins, blueberries, blackberries, strawberries, raspberries, plums, oranges, red grapes, and cherries • Vegetables: kale, spinach, brussels sprouts, alfalfa sprouts, broccoli florets, beets, red bell peppers, onions, corn, and eggplant Antioxidant compounds found in fruits and vegetables include flavonoids. They have impressive benefits for the whole body, particularly the cardiovascular system."
- Stephen Sinatra, M.D. and James C., M.D. Roberts, Reverse Heart Disease Now: Stop Deadly Cardiovascular Plaque Before It's Too Late (Get the book.)

"Many polyphenols such as flavonoids do not inhibit iron absorption. Only the polyphenols with gallic acid, which are often found in tannins, have been found to interfere with iron absorption. Iron absorption can be reduced by drinking beverages with tannic acid, such as wine, tea, or coffee during or within two hours of a meal. Spices such as oregano can also reduce iron absorption. Vitamin C greatly reduces the inhibiting effects of oxalates and tannins."
- Dr. Steve Blake, Vitamins and Minerals Demystified (Get the book.)

"But the plant actually contains dozens of active components (including chloro-genic acid, flavonoids, and xanthones). More recently, researchers have focused on hyperforin, another active ingredient in St. John's Wort. "Hyperforin, rather than hypericin as originally thought, has emerged as one of the major constituents for antidepressant activity," one 2001 article in the Journal of Pharmacy and Pharmacology pointed out. The rich cast of active plant chemicals is undoubtedly why St. John's Wort has been found useful for such a wide variety of conditions besides depression."
- Jonny Bowden, Ph.D., C.N.S., The Most Effective Natural Cures on Earth: The Surprising, Unbiased Truth about What Treatments Work and Why (Get the book.)

"Plant compounds called flavonoids, proanthocyanidins, and antho-cyanidins are all helpful in the treatment of varicose veins. All seem to help strengthen the delicate walls of the veins and capillaries. Foods richest in these substances include berries (blueberries and blackberries) as well as cherries, grapes, and tea. Add these foods to your diet and take a supplement of grape seed extract, which is rich in these compounds. 4. Vitamin C. Vitamin C in combination with a bioflavonoid called hesperidin has been used in research (often with butcher's broom) with good effect."

- Jonny Bowden, Ph.D., C.N.S., The Most Effective Natural Cures on Earth: The Surprising, Unbiased Truth about What Treatments Work and Why (Get the book.)

"Other fruits and vegetables high in flavonoids are raspberries (raspberries are also high in ellagic acid, which is known to kills cancer cells), black and green tea, red wine, red grapes, citrus fruits, cherries, and vegetables such as broccoli, leafy greens, and onions. These types of fruits and vegetables produce more healthy benefits than just flavonoids, so always try and eat fresh and organic. This is very important for your health. Studies show Quercetin has anticancer effects, and helps prevent heart disease by reducing the oxidation of LDL (bad) cholesterol."
- Gregory, A. Gore, Defeat Cancer (Get the book.)

"And the most abundant, most bioavailable, and most studied of these flavonoids is a compound called quercetin. Apples are a significant source of quercetin, which has quite a resume of health benefits. Quercetin—which was called "the most important flavonoid" by the peer-reviewed journal Nutrition in Cancer—is highly antiinflammatory, making it very useful in helping to calm the symptoms of asthma (and allergies). It's found in onions, apples, berries, tea, red wine, and supplements. In one study published in 2002 in the American Journal of Clinical Michael Murray, N.D."
- Jonny Bowden, Ph.D., C.N.S., The Most Effective Natural Cures on Earth: The Surprising, Unbiased Truth about What Treatments Work and Why (Get the book.)

"There are more than 4,000 of these compounds, and they fall into many classes and subclasses including flavonoids, anthocyanins, and isoflavones."

- Jonny Bowden, Ph.D., C.N.S., The Most Effective Natural Cures on Earth: The Surprising, Unbiased Truth about What Treatments Work and Why (Get the book.)

"It is thought that the antioxidants (C, E, carotenes, and flavonoids) found in fruits and vegetables reduce the risk of cardiovascular disease by scavenging free radical species. The antioxidants protect the unsaturated fatty acids from peroxidation, thus prevenring atherosclerosis. Lipid peroxide concenrrations are in fact higher in individuals with atherosclerosis.103 Good dietary sources of carotenes as well as vitamins C and E are green leafy vegetables, yellow-orange fruits and vegetables, red and purple fruits and vegetables, legumes, grains, and seeds."
- Tori Hudson, N.D., Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness (Get the book.)

"Throughout the trial, both groups had continued their usual medications, enabling the researchers to conclude that the flavonoids in pomegranates appear to offer some promising benefits for arterial disease. In a 2005 study, pomegranate power was further confirmed by Italian researchers. They found that the juice significantly reduced the progression of arterial plaque in mice with high cholesterol. They also discovered that juice-bathed coronary artery endothelial cells produced more nitric oxide."
- Stephen Sinatra, M.D. and James C., M.D. Roberts, Reverse Heart Disease Now: Stop Deadly Cardiovascular Plaque Before It's Too Late (Get the book.)

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