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"One particular antioxidant currently under study, alpha li-poic acid, has been shown to help in the treatment of multiple sclerosis by balancing T-cell activity and has also been found to help lessen symptoms in those with diabetic neuropathy. Alpha lipoic acid has such a profound effect, says Mullin, because it penetrates into the central nervous system, offering protection from the kind of free-radical damage that is often seen in multiple sclerosis and other neurological autoimmune diseases. Again, work carefully with your doctor and/or nutritionist." - Donna Jackson Nakazawa, The Autoimmune Epidemic (Get the book.)

"GAMMA LINOLENIC ACID (GLA) GLA reportedly can reverse nerve damage to peripheral nerves in patients with diabetic neuropathy. GLA regulates insulin, and seems to protect against diabetic heart, eye, and kidney damage. GLA has an insulin-sparing activity that allows insulin to be more effective. Diets that are relatively high in linoleic acid appear to decrease the progression of microangiopathy in diabetics.137 Excellent sources are evening primrose oil and flax seed oil." - Gabriel Cousens, There Is a Cure for Diabetes: The Tree of Life 21-Day+ Program (Get the book.) "A high dose, about 600 mg per day, is needed to improve diabetic neuropathy.131 ALA's primary effect is its antioxidant reaction. In summary, ALA improves blood sugar metabolism, reduces glycosylated protein, improves blood flow to peripheral nerves, and actually stimulates the regeneration of nerve fibers.132'133'134'135 Research has shown that ALA increases insulin sensitivity. In one study, seventy-four patients with Type-2 diabetes were randomly assigned to receive either a placebo or 600,1,200, or 1,800 mg a day of ALA." - Gabriel Cousens, There Is a Cure for Diabetes: The Tree of Life 21-Day+ Program (Get the book.) "We have used it along with the total program in helping to reverse diabetic neuropathy. Dosage: We recommend a form of B-12 that is vegan, made from bacteria. It is called Nano B complex. Anyone on this diet is well advised to take it protectively. We need about 6 meg twice a day as a minimum. BIOTIN Biotin is another vitamin that seems to be important for carbohydrate fat and protein metabolism. A plant-source-only diet seems to increase the intestinal bacteria in a way to enhance biotin synthesis and absorption." - Gabriel Cousens, There Is a Cure for Diabetes: The Tree of Life 21-Day+ Program (Get the book.) "VITAMIN B-6 Vitamin B-6 is very helpful in reversing diabetic neuropathy, and protects against peripheral nerve degeneration. Diabetics with neuropathy have been shown to be deficient in B-6 and benefit from supplementation.94 It seems to also inhibit glycosylation of proteins.95 It also helps with magnesium metabolism. Dosage: With regard to gestational diabetes, a study published in the British Medical Journal showed that women taking 100 mg of B-6 reversed the condition in twelve of the fourteen women." - Gabriel Cousens, There Is a Cure for Diabetes: The Tree of Life 21-Day+ Program (Get the book.)

"Lower doses have shown benefit in type 2 diabetic patients in the context of painful peripheral diabetic neuropathy. No side effects have been reported from the use of benfotiamine. Carnosine and Its Precursors Carnosine is a molecule (dipeptide) composed of two amino acids, beta-alanine and histidine. Carnosine is valuable because it helps inhibit accelerated aging by interfering with glycation, thus protecting against glycation-induced damage and acting as an antioxidant to fight oxidative stress. Evidence of carnosine's antiglycation abilities has been seen in several studies." - Steven V. Joyal, What Your Doctor May Not Tell You About Diabetes: An Innovative Program to Prevent, Treat, and Beat This Controllable Disease (Get the book.) "About half of the more than 82,000 lower limb amputations performed in the United States each year are for people with diabetic neuropathy. The tragedy of amputation can be prevented in many cases if more attention is paid to the first signs of infection in the feet (see "Caring for Your Feet," page 58). Sensory neuropathy can also result in muscle weakening or wasting (amyotrophy). If the nerve cells responsible for stimulating certain muscles are destroyed, the muscles decrease in strength and size." - Steven V. Joyal, What Your Doctor May Not Tell You About Diabetes: An Innovative Program to Prevent, Treat, and Beat This Controllable Disease (Get the book.) "Peripheral Neuropathy The foot is the body part most commonly affected by peripheral diabetic neuropathy. Peripheral neuropathy can also affect the legs, arms, and hands. The nerve damage may first appear as discomfort, tingling, extreme sensitivity to touch, loss of coordination or balance, numbness, or the sensation of getting needle pricks and may graduate to severe pain or cramps followed by the disappearance of the pain and/or numbness." - Steven V. Joyal, What Your Doctor May Not Tell You About Diabetes: An Innovative Program to Prevent, Treat, and Beat This Controllable Disease (Get the book.) "This recent study confirmed the results of a 1999 study that showed significant improvements in neuropathy scores after only three weeks in type 2 diabetic patients suffering from painful peripheral diabetic neuropathy. These patients received up to 320 mg of benfotiamine daily, with greater benefits seen in the high-dose group. Benfotiamine provides tremendous benefit by stopping the accumulation of sugar-derived compounds called triosephos-phates that gather in blood and nerve cells and damage them." - Steven V. Joyal, What Your Doctor May Not Tell You About Diabetes: An Innovative Program to Prevent, Treat, and Beat This Controllable Disease (Get the book.)

"The executives' plan was for the doctors to talk about how Neurontin eased a type of pain suffered by diabetes patients called diabetic neuropathy The Proworx executives told the doctors what they wanted their presentations to include. They also explained to the doctors that Proworx had created slides that could be used in their presentations. The doctors told the executives they understood what the company wanted. They declined to use the slides, however, and said they would write their own speeches." - Melody Petersen, Our Daily Meds: How the Pharmaceutical Companies Transformed Themselves into Slick Marketing Machines and Hooked the Nation on Prescription Drugs (Get the book.)

"Vitamin D and chronic pain from diabetic neuropathy Years ago, a guest at our health resort suffered from painful diabetic neuropathy, a disease of nerve damage associated with diabetes. He stayed for several months, and at the end of that time was pain-free. I felt that this was due to our plant-based diet, and there is little doubt that it was a factor. However, recent research has convinced me that the vitamin D gained from exposure to the Southern Utah sunshine was also important: fifty-one patients with type-two diabetes and neuropathic pain had average serum levels of only 18 ng/ml." - Marc Sorenson, Solar Power For Optimal Health (Get the book.)

"So although there appears to be some benefit from ALA, study results vary, and it is not clear that it has lasting benefit in the case of diabetic neuropathy. Diet and Behavior Type 2 diabetes, yet another disease caused by modern living, can be treated by changing the way we live. It might seem like everyone knows that lifestyle changes are important, but many of us just find it too difficult to implement them." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"The Capsaicin Study Group: Effect of treatment with capsaicin on daily activities of patients with painful diabetic neuropathy. Diabetes Care 15,159-165,1992. 18. Chad, D: Med World News, February 27,1989. 19. Tandan R, et al.: Topical capsaicin in painful diabetic neuropathy. Controlled study with long-term follow-up. Diabetes Care 15, 8-14,1992. 20. Tandan R, et al.: Topical capsaicin in painful diabetic neuropathy. Effect on sensory function. Diabetes Care 15,15-18,1992. 21. Basha KM and Whitehouse FW: Capsaicin: A therapeutic option for painful diabetic neuropathy." - Michael T. Murray, N.D., The Healing Power of Herbs: The Enlightened Person's Guide to the Wonders of Medicinal Plants (Get the book.)

"In a three-week German study, 328 patients with type 2 diabetes and diabetic neuropathy received either intravenous ALA or a placebo. The study found a statistically significant improvement in the pain, tingling, and disability related to neuropathy in those who got the ALA. This study also looked at seventy-three of the participants who had type 2 diabetes and cardiac neuropathy and who had taken either oral ALA or placebo. Those who had taken ALA showed an improvement in measures of cardiac heart-rate conductance." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"Vitamin D and diabetic neuropathy Years ago, one of the guests at our health resort told us that he suffered from very painful diabetic neuropathy, a disease of nerve damage caused by chronically high blood sugar associated with diabetes. He stayed for several months, and at the end of that time, he was pain free. I had felt that his progress was due to our plant-based, low-fat diet, and there is little doubt that the diet was a factor." - Marc Sorenson, Solar Power For Optimal Health (Get the book.)

"Alpha lipoic acid has no effect on glucose levels, but one study has shown it to decrease pain in patients with diabetic neuropathy. ALA does not have known major toxicities. CHROMIUM Chromium is an essential metal whose exact mechanism of action is unknown. Chromium is present in foods, and although the prevalence of chromium deficiency in humans is unknown, it is thought to be rare. Based on animal studies of chromium deficiency showing the development of insulin resistance, chromium has been advocated as a supplement for the treatment of diabetes." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"Alpha-lipoic acid is approved for the treatment of diabetic neuropathy and is available by prescription in Germany. BIOFLAVONOIDS Bioflavonoids (or just flavonoids) have been referred to as vitamin P. Bioflavonoids are not vitamins and are not essential for life. Bioflavonoids are excellent antioxidants found in many plant foods. As potent antioxidants, they protect us from arterial damage and cancer formation. Parsley and elderberry have the highest content of bioflavonoids. COENZYME Q10 Coenzyme Q10 is not a vitamin, but plays many necessary biological roles in the body." - Dr. Steve Blake, Vitamins and Minerals Demystified (Get the book.)

"Other Benefits from This Great Vitamin Vitamin B6 is one of the most utilized vitamins in the body and plays a vital role in managing such critical conditions as asthma, diabetes (especially diabetic neuropathy), and some forms of heart disease. In general, people with asthma have a defect in the metabolism of an amino acid called tryptophan, which is the raw material from which the body makes serotonin—the happy neurotransmitter. This metabolic difficulty may well be the result of low B6 levels." - Jonny Bowden, Ph.D., C.N.S., The Most Effective Natural Cures on Earth: The Surprising, Unbiased Truth about What Treatments Work and Why (Get the book.)

"Venlafaxine (Effexor) and duloxetine (Cymbalta) have been shown to relieve the nerve pain that accompanies shingles and diabetic neuropathy. •Anticonvulsants. Typically used to control seizures, topiramate (Topamax) eases migraines, and gabapentin (Neurontin) is helpful for people who have diabetic neuropathy or shingles pain. If You Think You'll Feel Better, You Will Jon-Kar Zubieta, MD, PhD, associate professor of psychiatry and radiology, University of Michigan Medical School, Ann Arbor. Journal of Neuroscience. Pain relief may be mind over matter." - Bottom Line Health, Bottom Line's Health Breakthroughs 2007 (Get the book.)

"GLA-rich primrose oil has shown promise in relieving diabetic neuropathy. Ounce for ounce, borage oil contains more GLA than primrose, and is less expensive, but studies have shown that it is not as effective as primrose for relieving diabetic neuropathy. Chromium deficiency is linked to impaired glucose metabolism, impaired glucose clearance, a decrease in the number of insulin receptors, and a reduction in binding of glucose to those receptors." - Russell L. Blaylock, M.D., Health and Nutrition Secrets (Get the book.)

"In an attempt to replicate these promising results, a multicenter study was conducted in which 509 patients with diabetic neuropathy received three weeks of intravenous ALA followed by six months of oral ALA or placebo. This time there were no statistically significant differences in ALA vs. placebo in changes in overall symptoms. After three weeks of intravenous ALA or placebo use, however, 120 patients showed a statistically significant change in symptoms." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"Topical capsaicin in painful diabetic neuropathy. Controlled study with long-term follow-up. Diabetes Care. 1992 Jan;15(l):8-14. Zhang W et al. Eular evidence based recommendations for the management of hand osteoarthritis—report of a task force of the Eular Standing Committee for International Clinical Studies Including Therapeutics (ESCISIT). Ann Rheum Dis. 2006 Oct 17. Persimmons www.crfg.org/pubs/ff/persimmon.html Achiwa Y, Hibasami H, Katsuzaki H, Imai K, Komiya T." - David W. Grotto, RD, LDN, 101 Foods That Could Save Your Life! (Get the book.)

"Capsaicin Study Group (1991) Treatment of painful diabetic neuropathy with topical capsaicin. A multicenter, double-blind, vehicle-controlled study. Arch Intern Med 151: 2225-2229. Carson CF, Riley TV (1995) Antimicrobial activity of the major components of the essential oil of Melaleuca alternifolia. J Appl Bact 78: 264-269. Chad DA (1990) Does capsaicin relieve the pain of diabetic neuropathy? Pain 42: 387-388. Chrubasik S, Conradt C, Black A (2003) The quality of clinical trials with Harpagophytum pro-cumbens. Phytomedicine. 10: 613-23 Chrubasik S, Eisenberg E, Balan E et al." - volker schulz and Rudolf Hansel, Rational Phytotherapy: A Reference Guide for Physicians and Pharmacists (Get the book.)

"Vitamin B6 may help prevent diabetic neuropathy, too—along with biotin. For now, the amounts in the 'blood-sugar multiple' should do the job. As we grow older, the absorption of other B-vitamins gets more problematic, so we often add them to the injection along with the B12 and folate." "How about the retinopathy and cataracts? I really don't want anything to happen to my vision." "Besides vitamin B12, magnesium is advisable. There's evidence of low magnesium in diabetic retinopathy and microangiopathy—that's disease of the small blood vessels in the back of the eye and likely elsewhere." - Jonathan V. Wright, M.D. and Alan R. Gaby, M.D., Natural Medicine, Optimal Wellness: The Patient's Guide to Health and Healing (Get the book.) "As early as 1951, vitamin B12 injections were reported to be helpful for diabetic neuropathy. Of 12 patients who received a series of vitamin B12 injections, 7 had complete or almost complete relief of symptoms.11 The treatment seemed to work best when the injections were given frequently. Research has also demonstrated a beneficial effect of evening ptimrose oil (EPO), a source of a fatty acid called gamma-linolenic acid (GLA)." - Jonathan V. Wright, M.D. and Alan R. Gaby, M.D., Natural Medicine, Optimal Wellness: The Patient's Guide to Health and Healing (Get the book.) "GLA can also help prevent diabetic neuropathy. Flaxseed oil does not contain any GLA and hasn't been shown to prevent neuropathy." "Let's see . . . in addition to my digestive aids, there's all that stuff in the 'blood-sugar multiple', inositol hexanicotinate, flaxseed oil, vitamin B12, bilberry, vitamin C, and GLA . . . anything more?" "At least one more, and possibly two. The first is the amino acid taurine. It'll help prevent retinal and heart problems, and very likely help improve gallbladder function. Taurine is frequently low in diabetics." "And the other?" - Jonathan V. Wright, M.D. and Alan R. Gaby, M.D., Natural Medicine, Optimal Wellness: The Patient's Guide to Health and Healing (Get the book.)

"These are Bell's palsy, cancer, diabetic neuropathy, eye function, heart rate variability, HIV, male impotence, and sleep disturbances (regulates melatonin secretion, augments light sensitivity, and normalizes circadian and sleep-wake rhythms). Optimum Dose The frequency and amount of supplemental or injectable vitamin B-12 is dependent upon the serum level desired. Studies have shown that the psychological benefits of vitamin B-12 are best achieved when serum levels range from 1000 to 2000 pg/ml." - Abram Hoffer, PhD, MD, FRCP(C) and Dr. Jonathan Prousjy, DPHE, DSC, ND, FRSH, Naturopathic Nutrition: A Guide to Nutrient-rich Food & Nutritional Supplements for Optimum Health (Get the book.)

"Ginkgo biloba (page 681) Ginkgo biloba extract may prove useful for prevention and treatment of early-stage diabetic neuropathy, though research is at best very preliminary in this area.278 Other herbs that may help are fenugreek (page 676) seeds and eleuthero (page 672) (Siberian ginseng). Mistletoe (page 711) Mistletoe extract has been shown to stimulate insulin release from pancreas cells,279 and animal research found that it reduces symptoms of diabetes." - Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D., The Natural Pharmacy: Complete A-Z Reference to Natural Treatments for Common Health Conditions (Get the book.) "Preliminary133-134 and double-blind135-136-137-138-139 trials have found that supplementing 600-1,200 mg of lipoic acid per day improves insulin sensitivity and the symptoms of diabetic neuropathy. In a preliminary study, supplementation with 600 mg of alpha-lipoic acid per day for 18 months slowed the progression of kidney damage in patients with type 1 and type 2 diabetes." - Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D., The Natural Pharmacy: Complete A-Z Reference to Natural Treatments for Common Health Conditions (Get the book.)

"Her older brother had diabetic neuropathy, sevete nerve pain, and then a leg amputated, and died of a clot after surgery. Her younger brother's had bypass surgery. And your grandmother, your mother's mothet, died of a heart attack. Enough complications to prevent, all right." "I probably forgot to tell you about my grandmother on the other side. She got what she called 'a little sugat' when she was past 70, and finally died of kidney failure. My wife reminded me that kidney failure is another possible complication of diabetes, and to make sure to tell you." "She's right." - Jonathan V. Wright, M.D. and Alan R. Gaby, M.D., Natural Medicine, Optimal Wellness: The Patient's Guide to Health and Healing (Get the book.)

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