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"Although the new-generation diabetes drugs were introduced with great fanfare, in some cases their side-effect profile turned out to be troubling and in some cases even more deadly than the older drugs. SECOND-GENERATION TREATMENTS When sulfonylureas went off patent, the next generation of diabetes drugs, the thiazolidinediones, entered the scene. Thiazolidinediones, also called glitazones, act on peroxisome proliferator-activated receptors (PPARs) sitting on the DNA of cells. These drugs have a number of effects, including regulation of metabolism." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"Eastman announced that Rezulin had been selected as one of the two diabetes drugs to be included in the study—a real victory for Warner-Lambert, the manufacturer of Rezulin. Also in 1996 Warner-Lambert submitted Rezulin to the FDA for approval, and it became the first diabetes drug to be given an accelerated review. The medical officer evaluating the new drug application, Dr. John L. Gueriguian, was a 19-year veteran of the FDA." - John Abramson, Overdosed America: The Broken Promise of American Medicine (P.S.) (Get the book.) "His review recommended that Rezulin not be approved: the drug appeared to offer no significant advantage over other diabetes drugs already on the market, and it had a worrisome tendency to cause inflammation of the liver. Warner-Lambert executives "complained about Gueriguian to the higher-ups at the FDA." Dr. Gueriguian was then removed from the approval process for this drug. When the Advisory Committee met to decide on the approval of Rezulin, they were not informed of Dr. Gueriguian's concerns about liver toxicity." - John Abramson, Overdosed America: The Broken Promise of American Medicine (P.S.) (Get the book.)

"SECOND-GENERATION TREATMENTS When sulfonylureas went off patent, the next generation of diabetes drugs, the thiazolidinediones, entered the scene. Thiazolidinediones, also called glitazones, act on peroxisome proliferator-activated receptors (PPARs) sitting on the DNA of cells. These drugs have a number of effects, including regulation of metabolism. Glitazones reduce sugar production by the liver and increase the sensitivity of cells to insulin. Side effects include infections, headaches, anemia, fluid retention, weight gain, and, more rarely, liver failure or cardiac events." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"I consider most oral diabetes drugs inappropriate. The studies back in the 1970s showed that all the oral diabetes medications available at that time increased the risk of heart attack and death from heart disease, compared to placebo. Many of the diabetic drugs we have today are simply first cousins of those prescribed years ago. Avandia?which rakes in 2.1 billion dollars in revenue per year - doesn't do anybody any good and has recently showed to dramatically increase risk of heart attacks." "Does this worsen their conditions? " Dr. Whitaker: "Yes." - Kenneth W Thomas, Ron Gilbert, Gerd Schaller, Side Effects: The Hidden Agenda of the Pharmaceutical Drug Cartel (Get the book.)

"Research has in fact shown that diabetes drugs increase your risk of heart attack by a whooping 250 percent! Some diabetes drugs are less dangerous than others, but regardless, they are still dangerous enough to consider avoiding them. For example, the widely used diabetes drug Avandia has recently been linked to a greater risk of heart attack and, possibly, death, according to the New England Journal of Medicine (May 21, 2007)." - Andreas Moritz, Timeless Secrets of Health & Rejuvenation: Unleash The Natural Healing Power That Lies Dormant Within You (Get the book.)

"But you'll never see conventional medicine talk about a diabetes cure, unless of course it happens to be promoting one of Big Pharma's new diabetes drugs. The diabetes industry, meanwhile, claims to be searching for a cure for the disease. That's sort of like spending millions of dollars searching for a cure for "lawn discoloration disease" when all you need to do is water the grass. But talk of such simple cures isn't tolerated in conventional medicine today. The origins of fictitious disease There is a curious tendency in conventional medicine to name a set of symptoms a disease." - Mike Adams, Natural Health Solutions (Get the book.)

"Bonus: Metformin is less likely than other diabetes drugs to cause weight gain. Nausea and other gastrointestinal side effects are usually temporary. •Sulfonybureas, such as glipizide (Glucotrol) and glyburide (Glynase), stimulate the pancreas to produce more insulin. Side effects include low blood sugar and weight gain. These drugs are frequently combined with metformin, resulting in an additional decrease in A1C. •Thiazolidinediones, such as pioglitazone (Actos) and rosiglitazonte (Avandia), increase the body's sensitivity to insulin." - Bottom Line Health, Bottom Line's Health Breakthroughs 2007 (Get the book.)

"These mechanisms are similar to how the diabetes drugs acarbose and metformin work to decrease blood sugar, but vinegar is cheaper and safer than those medications. Other Foods That Help Your Blood Sugar and Weight drate-digesting enzymes, including amylase, sucrase, lactase, and maltase. When these enzymes are blocked, sugar and starches pass through the digestive tract much the same way that indi- Use vinegar liberally in salad dressings and in other dishes. It helps to regulate blood sugar and Vinegar, blood sugar, and insulin. Recent research by separate teams of U.S." - Jack Challem, Stop Prediabetes Now: The Ultimate Plan to Lose Weight and Prevent Diabetes (Get the book.) "Some diabetes drugs reduce blood-sugar levels but do not prevent the progression of prediabetes to diabetes. According to a report in the New England Journal of Medicine, people taking ramipril (Altace) to treat prediabetes benefited from improved blood-sugar levels; however, the drug did not reduce their risk of developing diabetes or dying. Early in 2007, Eli Lilly, the maker of Zyprexa (noted previously) agreed to pay a total of $1.2 billion to 28,500 people who took the drug for bipolar disease or schizophrenia. The drug had gained a reputation for promoting both obesity and diabetes." - Jack Challem, Stop Prediabetes Now: The Ultimate Plan to Lose Weight and Prevent Diabetes (Get the book.)

"Unlike some other oral diabetes drugs, it doesn't lead to weight gain and may even help people get their weight under control. It can be dangerous, however, for people with kidney disease. They should not take the drug, and everyone on metformin should have their kidney function monitored regularly (at least once a year). People with congestive heart failure should not take metformin, either. Metformin has two nasty side effects that patients must know about. One, lactic acidosis, is rare, but it is a medical emergency if it occurs. Lactic acidosis can be lethal." - Joe Graedon, M.S. and Teresa Graedon, Ph.D., Best Choices From the People's Pharmacy (Get the book.)

"You can reverse these things and go on to live a life free of type 2 diabetes and without needing insulin injections or diabetes drugs. There are some cases in which people have gone so far down the road with advanced type 2 diabetes that they may find it extremely challenging, or maybe even impossible to reverse it. I acknowledge that such extreme cases do exist, however; the vast majority of people who have been diagnosed with diabetes are clearly within the window of potential reversal if they just start working on that reversal today." - Mike Adams, Natural Health Solutions (Get the book.)

"A high-fiber diet has been shown to work better in controlling diabetes than the diet recommended by the ADA, and may control blood sugar levels as well as oral diabetes drugs.21 In this study, the increase in dietary fiber was accomplished exclusively through the consumption of foods naturally high in fiber—such as leafy green vegetables, granola, and fruit—to a level beyond that recommended by the ADA. No fiber supplements were given." - Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D., The Natural Pharmacy: Complete A-Z Reference to Natural Treatments for Common Health Conditions (Get the book.)

"Lara put her back on both of her original diabetes drugs, Amaryl and Glucophage. In real life, however, Conception Morgado was a fundamentally changed woman with a fundamentally altered liver, and she would never quite return to the fulfilling, active life she once led. She was plagued with two debilitating conditions: a chronic upper-abdomen pain and endless fatigue. She no longer could walk her grandson to school, or make wedding gowns, or even, many days, cook for Lazarro. As Dr." - Greg Critser, Generation Rx: How Prescription Drugs are Altering American Lives, Minds, and Bodies (Get the book.)

"Some diabetes drugs are less dangerous than others, but regardless, they are still dangerous enough to consider avoiding them. For example, the widely used diabetes drug Avandia has recently been linked to a greater risk of heart attack and, possibly, death, according to the New England Journal of Medicine (May 21, 2007). An analysis pooling the results of several dozen studies, encompassing some 28,000 patients, showed that Avandia, which is manufactured by GlaxoSmithKline, causes a 43 percent higher risk of heart attack. The U.S." - Andreas Moritz, Timeless Secrets of Health & Rejuvenation: Unleash The Natural Healing Power That Lies Dormant Within You (Get the book.)

"The pharmaceutical database, Pharmaprojects, found 300 diabetes drugs in development in 2004, three times as many as eight years ago.36 Insulin is a protein that has traditionally been given by injection because other routes were not suitable. Oral insulin does not survive in the digestive system, for example, and insulin given transdermally would not provide diabetics with the capability to give themselves precisely measured doses." - Jacky Law, Big Pharma: Exposing the Global Healthcare Agenda (Get the book.)

"They'd rather just keep people in a lifelong state of diabetes and make sure they keep buying more insulin and diabetes drugs, both of which enrich drug companies. I've researched diabetes groups, cancer groups, and heart associations. Based on what I found, I've come to the opinion that virtually none of them are interested in actually curing or preventing disease. They push screening and "treatment" (with drugs, of course), but never prevention or cures. One exception to this is the group Breast Cancer Action (www.BCaction." - Mike Adams, Natural Health Solutions (Get the book.)

"Exenatide is among the most expensive diabetes drugs. APPENDIX 2 INGREDIENTS THAT MAY BE NEW TO YOU The recipes in this book use simple ingredients that are available just about anywhere, but a few include ingredients that may be unfamiliar. If you cannot find them at your favorite stores, see Appendix 3 for some convenient online sources. AGAVE NECTAR Agave nectar (or syrup) is a mild-flavored liquid sweetener made from the blue agave cactus plant." - Neal D. Barnard and Bryanna Clark Grogan, Dr. Neal Barnard's Program for Reversing Diabetes: The Scientifically Proven System for Reversing Diabetes Without Drugs (Get the book.)

"It may control blood sugar alone or be combined with other diabetes drugs to improve blood sugar control. Common side effects include diarrhea, nausea and vomiting, flatulence, fatigue, indigestion, and headache. Avoid guar gum in low-fat foods (salad dressing, frozen desserts, etc.), because it reduces metformin's absorption and effectiveness. Downside: Lactic acidosis, a rare reaction, requires emergency medical attention and can be fatal. Cost: Approximately $90 to $120 per month; generic $65 to $100 showed that Actos has a better effect on several measures of cholesterol and blood lipids." - Joe Graedon, M.S. and Teresa Graedon, Ph.D., Best Choices From the People's Pharmacy (Get the book.)

"Ampicillin (omnipen, others) • Calcium-containing antacids (Tums) • Calcium-blocking blood pressure drugs such as Calan and Cardizem Certain other blood pressure drugs such as reserpine (Diupres) Epinephrine (EpiPen) Indomethacin (Indocin) Insulin • Oral diabetes drugs such as Micronase • Quinidine (Quinidex) MY OBSERVATION: The three items underlined above are typical medications commonly used to treat the potential side effects associated with both the statins, Zocor" and Colestipol, which Al was also taking. Drug #2: Colestid?" - Dr. David W. Tanton; Ph.D., A Drug-Free Approach To Healthcare, Revised Edition (Get the book.) "Oral Contraceptives * Antidepressants * Antacids • Blood pressure medications * Asthma medication * Diuretics • diabetes drugs * Blood thinning drugs * Aspirin 9. A surprising number of women are placed on Synthroid? (and normally left on the drug), yet we also find the warning that: "Postmenopausal women on long-term Synthroid" therapy may suffer a loss of bone density, increasing the danger of osteoporosis [brittle bones]" (http://www.healthsquare.com/newrx/svn1421.htm). Hand Tremors Nervousness Chest pain Headache Hyperactivity Tremors Palpitation 1 A'^ 10." - Dr. David W. Tanton; Ph.D., A Drug-Free Approach To Healthcare, Revised Edition (Get the book.)

"Oral Contraceptives * Antidepressants * Antacids • Blood pressure medications * Asthma medication * Diuretics • diabetes drugs * Blood thinning drugs * Aspirin 9. A surprising number of women are placed on Synthroid? (and normally left on the drug), yet we also find the warning that: "Postmenopausal women on long-term Synthroid" therapy may suffer a loss of bone density, increasing the danger of osteoporosis [brittle bones]" (http://www.healthsquare.com/newrx/syn1421 .htm). 10. Most importantly, the majority of diabetics are hypothyroid (requiring thyroid medication)." - Dr David W Tanton, Ph.D., Antidepressants, Antipsychotics, And Stimulants - Dangerous Drugs on Trial (Get the book.)

"Antidepressants and diabetes drugs have weight gain as a potential side effect. • Most other medications cause weight gain; they tend to suppress digestive functions. • Soft drinks and sports drinks (high in fructose corn syrup and salt). • Less than adequate amounts of water drunk each day. • Negative responses to stress. • Alcohol consumption. • Unresolved conflicts (impairing digestion). • Fear and other emotional upsets. • Any other weakening influence. Sleep Well—Lose Weight By some estimates, Americans average about six hours of sleep per night." - Andreas Moritz, Timeless Secrets of Health & Rejuvenation: Unleash The Natural Healing Power That Lies Dormant Within You (Get the book.)

"Once you are diagnosed, your physician is pressured from many directions to put you on diabetes drugs to control blood sugar. This guarantees that you will need to visit your physician frequently to renew your prescription, and guarantees the drug company and pharmacy a lifetime customer. All of the diabetes drugs have side effects, and all of them gradually lose their effectiveness, guaranteeing the drug-dependent diabetic the life-threatening side effects of both the drugs and the disease." - Earl L. Mindell, RPh, PhD with Virginia Hopkins, MA, Bottom Line's Prescription Alternatives (Get the book.) "WHAT'S SO BAD ABOUT diabetes drugs? Diabetes is such a profitable business that physicians will put "prediabetic" patients, with only marginally high blood sugar, on diabetes drugs before even trying weight loss and exercise. In fact a big push now by drug companies and diabetes associations (which are funded by the drug companies) is to "identify" the supposed eight million borderline diabetics so they can get them on drugs, too!" - Earl L. Mindell, RPh, PhD with Virginia Hopkins, MA, Bottom Line's Prescription Alternatives (Get the book.)

"In combination with the diabetes drugs, they may lower blood sugar more than expected. This interaction could be troublesome. If you need aspirin or another salicylate as well as one of these diabetes drugs, monitor blood sugar and be alert for symptoms of hypoglycemia. If you notice any, your doctor may wish to adjust the dose of the diabetes drug. Symptoms of Hypoglycemia (Low Blood Sugar) Shaking, sweating, tiredness, low temperature, faintness, palpitations, hunger, headache, confusion, irritability, visual disturbances, and coma." - Joe Graedon and Teresa Graedon, The People's Guide to Deadly Drug Interactions (Get the book.) "Alcohol may have other effects upon diabetes drugs. The person who drinks regularly may not be able to control blood sugar with the usual dose of Orinase (tolbutamide). On the other hand, if a person who doesn't often drink alcohol has several drinks, he or she may have a longer-than-expected effect from Glucotrol, with possible hypoglycemic symptoms. It is suggested that patients taking any of these oral diabetes drugs generally avoid alcohol. Remember that some liquid medicines contain alcohol (see page 154 for a list)." - Joe Graedon and Teresa Graedon, The People's Guide to Deadly Drug Interactions (Get the book.) "INTERACTION The interaction between alcohol and oral diabetes drugs is complicated, and some aspects of this interaction are potentially dangerous. If patients taking Diabinese drink alcohol, they may experience an unpleasant reaction, with symptoms of nausea and vomiting, flushing, sweating, and throbbing headache. Alcohol may have other effects upon diabetes drugs. The person who drinks regularly may not be able to control blood sugar with the usual dose of Orinase (tolbutamide)." - Joe Graedon and Teresa Graedon, The People's Guide to Deadly Drug Interactions (Get the book.)

"What's So Bad about diabetes drugs? Diabetes is such a profitable business that physicians will put "prediabetic" patients, with only marginally high blood sugar, onto diabetes drugs before even trying weight loss and exercise. In fact a big push now by drug companies and diabetes associations (which are funded by the drug companies) is to "identify" the supposed eight million borderline diabetics so they can get them onto drugs too!" - Earl L. Mindell, R.Ph., Ph.D., Prescription Alternatives, Third Edition: Hundreds of Safe, Natural Prescription-Free Remedies to Restore and Maintain Your Health (Get the book.) "Once you are diagnosed, your physician is pressured from many directions to put you on diabetes drugs to control blood sugar. This guarantees that you will need to visit your physician frequently to renew your prescription, and guarantees the drug company and pharmacy a lifetime customer. All of the diabetes drugs have side effects, and all of them gradually lose their effectiveness, guaranteeing the drug-dependent diabetic the life-threatening side effects of both the drug and the disease." - Earl L. Mindell, R.Ph., Ph.D., Prescription Alternatives, Third Edition: Hundreds of Safe, Natural Prescription-Free Remedies to Restore and Maintain Your Health (Get the book.)

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