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"In lab experiments using LDL isolated from adult blood samples, they found that increasing amounts of three phytoestrogens (genis-tein, daidzein, and equol) inhibited LDL oxidation; this protective effect was even more powerful when ascorbic acid (vitamin C) was present, too. Genis-tein and daidzein are the isoflavones found in soy and soy products. Pairing soy with citrus sounds like a partnership that can't miss." - Elaine Magee, Food Synergy: Unleash Hundreds of Powerful Healing Food Combinations to Fight Disease and Live Well (Get the book.)

"Widely occurring isoflavones include daidzein, genistein, formono-netin, and biochanin A, which are noted for their estrogenic properties. Y if °H OH 0 Fig. 7.53. Daidzein Fig. 7.54. Genistein Daidzein daidzein is a widely distributed isoflavone that is especially abundant in the Lamiaceae. As discussed in chapter 9, it is an effective phytoestrogen. Table 7.9. Plants Containing Daidzein PLANT PLANT PART Genista tinctoria (dyer's broom) Shoot Glycine max (soy) Seed Phaseolus coccineus (scarlet runner bean) Whole plant Psoralea corylifolia (babchi) Root Pueraria lobata, P." - David Hoffman, FNIMH, AHG, Medical Herbalism: The Science Principles and Practices Of Herbal Medicine (Get the book.)

"They studied the effects of a special red clover extract, Rimostil, containing Clovone, a specific blend of isoflavones (biochanin A, formononetin, genistein, and daidzein), on serum lipids, bone density, and endometrial thickness in postmenopausal women.119 Fifty postmenopausal women were randomly assigned to receive either 28.5 mg, 57.0 mg, or 85.5 mg of Rimostil for six months, followed by two months of a placebo. Bone density was measured at baseline, three months, and six months using a DXA scan. (Lipid levels and uterine lining thickness were also measured in this study." - Tori Hudson, N.D., Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness (Get the book.) "Soy is the only dietary source of daidzein, which is a nonsteroidal estrogen-like molecule. Soy also increases the menstrual cycle length by one to five days, especially the follicular phase. This may have a positive effect on bone density due to longer exposure to elevated estrogen levels. Soy appears to have a proestrogen effect on bone in some experimental evaluations. The bone density of ovariectomized rats for which soy replaced casein in the diet was compared to another group that received estrogen." - Tori Hudson, N.D., Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness (Get the book.) "The two main isoflavones of soy are genistein and daidzein. Isoflavones have a unique ability to weakly bind to estrogen receptors in the body and seem to have both a weak estrogen effect as well as an antiestrogen effect, depending on the tissue involved and the dose consumed. There are hundreds of studies on soy and dozens on hot flashes, some showing effect and others not, making it difficult to make conclusions." - Tori Hudson, N.D., Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness (Get the book.) "One group received one tablet of a standardized extract of red clover (26 mg biochanin A, 16 mg formononetin, 1 mg genistein, and 0.5 mg daidzein), and the other received a placebo. This trial lasted one year, and 86 women in the red clover group and 91 in the placebo group completed the study. Dietary calcium and vitamin D were similar in both groups. At the end of 12 months, women in the red clover group had less bone loss of the lumbar spine than women in the placebo group. Bone density decreased by 1.08 percent in the red clover group and by 1.86 percent in the placebo group." - Tori Hudson, N.D., Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness (Get the book.)

"Using a series of tyrosine kinase inhibitors, Paul Bernasconi (1996) found that genistein, but not daidzein, could displace and compete with NPA binding to membrane vesicles, thus introducing a model of flavonoid modulation of the phosphorylation state of regulatory proteins and/or lipids associated with auxin efflux. Bernasconi also showed that calmodulin antagonists, protein serine/threonine kinase inhibitors, and phosphatase inhibitors lacked the activity seen with flavonoids and tyrosine kinase inhibitors. Using wild-type and flavonoid-deficient mutants of Arabidopsis, Murphy et al." - Erich Grotewold, The Science of Flavonoids (Get the book.)

"It is unclear which bacterial strain is involved in equol production [61, 62] and whether the ability to convert daidzein to equol can be induced in nonproducers [63]. V. METHODOLOGY FOR STUDYING INTESTINAL MICROFLORA A. Conventional Methodology and Its Limitations Our present knowledge of intestinal microflora is largely based on classical approaches of cultivation, direct microscopic observation, and biochemical analysis [64]. Results obtained using these conventional methodologies have improved our understanding of the intestinal microflora." - Ann M. Coulston and Carol J. Boushey, Nutrition in the Prevention and Treatment of Disease (Get the book.)

"Two of these isoflavones, genistein and daidzein, act as both antioxidants and estrogens that when consumed in foods may help contribute to reducing the risk of coronary heart disease as well as protecting against breast or prostate cancer as part of an overall healthy lifestyle. Adding soy to your diet, as suggested in The SuperFoodsRx Diet, usually is a health plus if only because it provides a protein source—and a complete protein at that—that has a lower and healthier fat content than meat, the protein it usually replaces." - Wendy Bazilian, DRPH, MA, RD, Steven Pratt, MD, Kathy Matthews, Superfoods Rx Diet: Lose Weight with the Power of SuperNutrients (Get the book.)

"The main isoflavones found in soy include genistein, daidzein, and glycitein [227, 228]. Although a few epidemiologic studies assessed the intake of dietary phytoestrogens, particularly isoflavones, and found inverse associations with prostate cancer risk [62, 224, 229, 230], analytical epidemiologic data on this topic are limited [231]." - Ann M. Coulston and Carol J. Boushey, Nutrition in the Prevention and Treatment of Disease (Get the book.) "However, because the plasma half-lives of the isoflavones genistein and daidzein are short (6 to 8 hours) [15], the timing of soy consumption in relation to urine or blood sampling may under- or overestimate isoflavone exposure. Metabolism of isoflavones is also linked to the health of colonic bacterial populations, and therefore the effects of diet and drugs on the colonic environment may influence plasma and urinary levels. Dietary exposure to flavonoids and other polyphenols can be monitored by measuring parent compounds and metabolites in urine or plasma [16, 17]." - Ann M. Coulston and Carol J. Boushey, Nutrition in the Prevention and Treatment of Disease (Get the book.)

"Genistein and daidzein are two types of isoflavones in soy. Isoflavones are flavonoid and act asphytostrogons, which are useful in treating cancer. When fermented, they have been shown to slow skin cancer, leukemia, and lung, prostate, colon, and breast cancers. Genistein and daidzein can be found in your health food store in capsule form. Tests also show these two nutrients, along with many other nutrients in fermented soy, can definitely help other diseases such as Parkinson's disease, muscular dystrophy, hepatitis, and the list goes on." - Gregory, A. Gore, Defeat Cancer (Get the book.)

"Of the flavonoids and isoflavonoids tested in this sensitive assay, the order of estrogenicity was genistein > kaempherol > naringenin > apigenin > daidzein > biochanin A > formononetin > luteolin > flsetin > catechin/taxifolin > hesperetin (Miksicek, 1995). Some properties of soy isoflavones, such as preventing osteoporosis (Anderson, 1999) and lowering cholesterol levels (Lichtenstein, 1998), may suggest an estrogen-related mechanism. Isoflavones are believed to exert their effects through ER signaling pathway because of the structural similarity to estrogen." - Erich Grotewold, The Science of Flavonoids (Get the book.)

"Soy contains built-in insecticides called isoflavones (genistein and daidzein). Isoflavones are estrogen-like substances that have the same effect in the body as estrogen, and eating soy can make a person estrogenic, contributing to problems such as cancer, irritability and mood swings, fat gain from the waist down, fibrocystic breast disease, and uterine fibroids.24'25,26 Isoflavones decrease thyroid hormone production. This can stunt children's growth. Hypothyroid is associated with raised serum cholesterol and tends to create fatigue and obesity." - Gabriel Cousens, There Is a Cure for Diabetes: The Tree of Life 21-Day+ Program (Get the book.)

"Humans who eat three soy bars (containing 12 mg genistein and 7 mg daidzein each) daily for 2 weeks could increase the plasma isoflavone level and the resistance of LDL to Cu-catalyzed oxidation (Tikkanen et al, 1998). Other studies in humans found that chronic red wine consumption (400 ml/day) reduced the susceptibility of LDL to lipid peroxidation catalyzed by Cu (Fuhrman et al, 1995). Similarly, a small but significant increase in the lag time of LDL oxidation was observed after 4 weeks of black tea consumption (600 ml/day) (Ishikawa et al, 1997). 3." - Erich Grotewold, The Science of Flavonoids (Get the book.)

"Numerous studies have found that soy products • increase the risk of breast cancer in women, brain damage in both men and women, and abnormalities in infants • contribute to thyroid disorders, especially in women • promote kidney stones (because of excessively high levels of oxalates which combine with calcium in the kidneys) • weaken the immune system • cause severe, potentially fatal food allergies • accelerates brain weight loss in aging users Soy products contain; • Phytoestrogens (isoflavones) genistein and daidzein, which mimic and sometimes block the hormone estrogen." - Andreas Moritz, Cancer Is Not A Disease - It's A Survival Mechanism (Get the book.)

"Gut bacterial metabolism of the soy isoflavone daidzein: Exploring the relevance to human health. Exp. Biol. Med. 230, 155-170. 63. Vedrine, N., Mathey, J., Morand, C, Brandolini, M., Davicco, M.-J., Guy, L., Remesy, C, Coxam, V., Manach, C. (2006). One-month exposure to soy isoflavones did not induce the ability to produce equol in postmenopausal women. European J. Clin. Nutr. 60, 1039-1045. 64. O'Sullivan, D. (2000). Methods for analysis of the intestinal microflora. Curr. Issues Intest. Microbiol. 1, 39-50. 65. Franks, A. H., Harmsen, H. J. M., Raangs, G. C, Jansen, G. J., Schut, F." - Ann M. Coulston and Carol J. Boushey, Nutrition in the Prevention and Treatment of Disease (Get the book.)

"Genis-tein and daidzein are the isoflavones found in soy and soy products. Pairing soy with citrus sounds like a partnership that can't miss. SMART FATS AND VITAMINS You might be wondering, Are there actually fats that are smart* Smart fats, as I fondly refer to them, are dietary fats that offer health benefits without harming the body like the other "bad" fats (namely, saturated and trans fats). In this book we'll focus on two smart fats in particular: omega-3 fatty acids and monounsaturated fats. Monounsaturated fats lower LDL cholesterol levels and reduce the risk of heart disease." - Elaine Magee, Food Synergy: Unleash Hundreds of Powerful Healing Food Combinations to Fight Disease and Live Well (Get the book.)

"Comparison of the urinary excretion rates of daidzein and two daidzein328 metabolites in individuals over a 3-day period following soya challenge3 Mean (SD) excretion (umol) per 3 days Metabolite <8 umol equol >25 umol equol (n = 8) (n = 4) Daidzein 23.05 (12.43) 14.95 (6.69) Equol 1.53 (2.60) 64.89 (59.23) O-Dma 21.72 (17.93) 6.97 (6.47) "Individuals are grouped as either low equol producers (less than 8 umo/ in 3 days) or high equol producers (over 25 umo/ in 3 days) Note: Equol is substantially more oestrogenic than daidzein or O-Dma Other studies have found the following." - Simon Mills and Kerry Bone, Principles and Practice of Phytotherapy: Modern Herbal Medicine (Get the book.)

"The red clover supplement is known to contain four isoflavones that are important in an Asian diet: biochanin A, genistein, formononetin, and daidzein. This is powerful evidence for red clover, thus indicating the use of Flor-Essence as an aid in prostate cancer treatment. A growing number of physicians are recognizing the importance of natural adjuncts to therapy and are recommending the use of Flor-Essence. Michael Schachter, M.D., F.A.C.A.M." - Freedom Press, Natural Cancer Cures: The Definitive Guide to Using Dietary Supplements to Fight and Prevent Cancer (Get the book.)

"Soybeans contain two isoflavones, genistein and daidzein, that appear to have beneficial effects on bone. Administering eithet of these compounds3 or a soy-based diet4 to rats partially prevented the loss of bone resulting from surgical removal of the ovaries. Preliminary studies in humans also suggest that ingesting soy products may help prevent osteoporosis.5 Nutritional Supplements The importance of calcium for healthy bones is well known. Numerous double-blind studies have shown that supplementing with calcium slows the rate of bone loss in postmenopausal women." - Jonathan V. Wright, M.D. and Alan R. Gaby, M.D., Natural Medicine, Optimal Wellness: The Patient's Guide to Health and Healing (Get the book.) "Ipriflavone is metabolized in the body into daidzein, one of the osteoporosis-preventing compounds found in soy. Numerous studies have shown that supplementing with ipriflavone (200 mg, 3 times per day) can prevent bone loss in postmenopausal women."-20-21 Because ipriflavone appears to be quite safe, it may be a viable alternative to some of the drugs currently being used to treat osteoporosis. Ipriflavone inhibits an enzyme (cytochrome P450) that breaks down certain drugs. Therefore, this compound could potentially interact with other medications." - Jonathan V. Wright, M.D. and Alan R. Gaby, M.D., Natural Medicine, Optimal Wellness: The Patient's Guide to Health and Healing (Get the book.)

"Reviewed by Marks andRifkind, 1991 Daidzein Daidzein is an isoflavone found in legumes such as Pueraria lobata (ge gen) and in soy products. daidzein induced differentiation in B16 melanoma and HL-60 human leukemia cells. Jing and Han, 1992; Jingetal., 1993; Han, 1994 Docosahexaenoic acid (DHA) Docosahexaenoic acid (DHA), a component offish oil, markedly accelerates retinoic acid-induced differentiation in human leukemic (HL-60) cells. The effect appears to be due to the ability of DHA to alter plasma membrane fluidity." - John Boik, Cancer & Natural Medicine: A Textbook of Basic Science and Clinical Research (Get the book.)

"Active Constituents Kudzu root is high in isoflavones, such as daidzein, as well as isoflavone glycosides, such as daidzin and puerarin. Depending on its growing conditions, the total isoflavone content varies from 1.77 to 12.0%, with puerarin in the highest concentration, followed by daidzin and daidzein.2 As is the case with other flavonoid-like substances, the constituents in kudzu root are associated with improved microcirculation and blood flow through the coronary arteries. A widely publicized 1993 animal study showed that both daidzin and daidzein inhibit the desire for alcohol." - Schuyler W. Lininger, Jr. DC, The Natural Pharmacy: Complete Home Reference to Natural Medicine (Get the book.)

"Red clover contains several isoflavones including genistein and daidzein. Initial research studies suggest that genistein could be connected to breast cancer tumor growth, senility, brain aging, and slowed thyroid activity. More research is needed to confirm or disprove these findings. The University of Pittsburgh Cancer Institute recentiy discovered that red clover may also have high estrogenic activity - a possible risk for breast cancer. If your family history or personal history includes breast cancer, don't try red clover. Stay dry with evening primrose oil." - The Editors of FC&A, Unleash the Inner Healing Power of Foods (Get the book.)

"Effect of daidzein on antiarrhythmia]. Zhongguo Zhong Yao Za Zhi 2003;28(9):853-856. Yin ZZ, Zeng GY. [Pharmacology of puerarin. V. Effects of puerarin on platelet aggregation and release of 5-HT from platelets], Zhongguo Yi Xue Ke Xue Yuan Xue Bao 1981 ;3 Suppl 1:44-47. Yu Z, Zhang G, Zhao H. [Effects of Puerariae isoflavone on blood viscosity, thrombosis and platelet function]. Zhong Yao Cai 1997;20(9):468-469. Zhang G, Fang S. [Antioxidation of Pueraria lobata isoflavones (PLIs)]. Zhong Yao Cai 1997;20(7):358-360. Zhang GQ, Hao XM, Dai DZ, et al." - Thomson Healthcare, Inc., PDR for Herbal Medicines, Fourth Edition (Get the book.)

"If you're not a tofu fan, and your feeling about soy is just soy-so, it is available in pill and powdered supplement form with daidzein and other isoflavones. One soy protein shake or two soy concentrate supplement tablets (containing 10 mg. genistein and daidzein) is what I would recommend. DAIDZEIN: Works with genistein to block enzymes that promote tumor growth. May be especially beneficial to women in controlling the effects of potent estrogens that could stimulate the growth of breast cancer cells. Helps reduce blood-alcohol levels and relieve hangovers (see section 205)." - Earl Mindell, Earl Mindell's Vitamin Bible for the 21st Century (Get the book.)

"Daidzein In a study of more than 1,000 synthetic and natural compounds thought to induce differentiation, the isoflavone daidzein was highly potent in inducing differentiation in human leukemia HL-60 cells. Differentiation was induced at approximately 40 uM. Jing etal., 1993 Induced differentiation in HL-60 cells. Han, 1994 Induced differentiation in B16 melanoma cells at a concentration of approximately 40 to 150 uM. Jing and Han, 1992 14.6.6 Induction of Differentiation Studies of the effects of the isoflavones genistein and daidzein on differentiation are summarized in Table 14.5." - John Boik, Cancer & Natural Medicine: A Textbook of Basic Science and Clinical Research (Get the book.)

"Bradyrhizobium japonicum in soybeans (Kosslak et al., 1987) and 7,4'-dihydroxyflavone induced nodulation by Rhizobium leguminosarum bv. trifolii in white cover (Orgambide et al., 1994). Secreted NOD factors (/V-acetylchitooligosaccharides) also alter apoplastic pH and initiate a Ca2+ cascade, which is thought to either initiate or repress defense responses in the plant (Felle et al, 2000). Nodulation is initiated when the bacteria invade the root and is completed when a vascular bundle is formed in the nodule." - Erich Grotewold, The Science of Flavonoids (Get the book.)

"Genistein Daidzein daidzein is a widely distributed isoflavone that is especially abundant in the Lamiaceae. As discussed in chapter 9, it is an effective phytoestrogen. Table 7.9. Plants Containing Daidzein PLANT PLANT PART Genista tinctoria (dyer's broom) Shoot Glycine max (soy) Seed Phaseolus coccineus (scarlet runner bean) Whole plant Psoralea corylifolia (babchi) Root Pueraria lobata, P. phaseoloides (kudzu) Root Trifolium pratense (red clover) Flower Ulex europaeus (gorse) Aerial parts Genistein This isoflavone occurs in clover (Trifolium spp." - David Hoffman, FNIMH, AHG, Medical Herbalism: The Science Principles and Practices Of Herbal Medicine (Get the book.)

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