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"One recent study showed a delay in cognitive decline from mild cognitive decline to Alzheimer's in the first year but no effect after three years.8 Based on the evidence, in 2006 the British National Institute of Clinical Excellence (NICE) recommended that donepezil not be used for the treatment of severe or mild Alzheimer's because its modest efficacy did not justify its side effects and expense." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"Dementia and cognitive decline. Starting EPT after age 65 is not recommended for the prevention of dementia or cognitive decline. The Women's Health Initiative memory study showed an increase in the risk of dementia during the five years in women 65 and older.145 It is not yet clear as to whether ET or EPT can prevent dementia when hormones are started during perimenopause or early postmenopause. Premature Menopause and Premature Ovarian Failure." - Tori Hudson, N.D., Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness (Get the book.)

"One recent study showed a delay in cognitive decline from mild cognitive decline to Alzheimer's in the first year but no effect after three years.8 Based on the evidence, in 2006 the British National Institute of Clinical Excellence (NICE) recommended that donepezil not be used for the treatment of severe or mild Alzheimer's because its modest efficacy did not justify its side effects and expense." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"An Open Trial of Plant-Source Derived Phosphatidylserine for Treatment of Age-Related cognitive decline. Schreiber S, et al. Israel Journal of Psychiatry and Related Sciences, 2000, 37(4):302-307. In this study of 15 healthy older adults with age-related memory impairment, the authors determined that 300 milligrams per day of plant-source derived phosphatidylserine improved memory after 12 weeks. Pharmacological Effects of Phosphatidylserine Enzymatically Synthesized from Soybean Lecithin on Brain Functions in Rodents. Sakai M; et al." - Gary Null and Amy McDonald, The Food-Mood Connection: Nutrition-based and Environmental Approaches to Mental Health and Physical Wellbeing (Get the book.) "Alpha-lipoic acid in combination with other mitochondrial nutrients such as acetyl-L-carnitine and coenzyme Q10 has been shown to improve mitochondrial and cognitive decline in older adults. Long-term Effects of Cognitive Training on Everyday Functional Outcomes in Older Adults Willis, SJ; et al. Journal of the American Medical Association, 2006, 296:2805-2814. This large study concluded that cognitive training resulted in improved cognitive abilities in elderly patients. Coenzyme Q10 Modulates Cognitive Impairment Against Intracerebroven-tricular Injection of Streptozotocin in Rats." - Gary Null and Amy McDonald, The Food-Mood Connection: Nutrition-based and Environmental Approaches to Mental Health and Physical Wellbeing (Get the book.) "In recent years, chemical exposure has increasingly been linked to a variety of "subclinical" mental health symptoms (behavior changes, cognitive decline) as well as neurodevelopmental disorders, such as autism, attention deficit disorder (ADD), and mental retardation. "The human brain is a precious and vulnerable organ," says Philippe Grand-jean, adjunct professor at Harvard School of Public Health and the study's lead author. "And because optimal brain function depends on the integrity of the organ, even limited damage may have serious consequences...." - Gary Null and Amy McDonald, The Food-Mood Connection: Nutrition-based and Environmental Approaches to Mental Health and Physical Wellbeing (Get the book.)

"Some studies have considered metabolic differences in cerebral glucose between men and women as an important factor in cognitive decline. These studies have only shown a decreased parietal activity in early-onset dementia of AD, independent of a gender effect [42]. Another aspect regarding differences in prevalence of AD among men and women focuses on the roles of estrogen and testosterone in disease pathogenesis, and there are a number of lines of evidence suggesting that estrogen deficiency, following menopause, may contribute to the etiology of AD in women [43, 44]." - Ann M. Coulston and Carol J. Boushey, Nutrition in the Prevention and Treatment of Disease (Get the book.) "As is well known, with aging there is an increase in the number of multiple co-occurring chronic conditions, including cognitive decline and dementia. Because the proportion of the population in the United States and other nations that are aged continues to increase, cognitive and motor deficits are growing rapidly. Cognitive impairment and dementia are major causes of disability in our nation, and their financial impact and long-term care costs are enormous. The major cause of dementia is Alzheimer's disease (AD). Aging clearly results in declines in brain size, weight, and function [4-6]." - Ann M. Coulston and Carol J. Boushey, Nutrition in the Prevention and Treatment of Disease (Get the book.) "The decreased incidence [45] and a delay in the onset [46] of AD among women on hormone replacement therapy following menopause [47] has also contributed to a belief that these agents may play a relevant role in brain function and cognitive decline associated with aging [48]. However, a decline in estrogen or testosterone does not explain why males with Down's syndrome are at significantly higher risk of developing AD-type changes and at an earlier age than their female counterparts [49]." - Ann M. Coulston and Carol J. Boushey, Nutrition in the Prevention and Treatment of Disease (Get the book.) "We have reviewed studies that have shown reversals in age-related cognitive and motor behaviors with fruit or vegetable supplementation [91] and have increased signaling and prevented cognitive decline in APP/PSI mice [283]. In the case of AD, there is an inverse correlation between the intake of wine flavonoids [284] or fruit and vegetable intake [285] and the development of dementia." - Ann M. Coulston and Carol J. Boushey, Nutrition in the Prevention and Treatment of Disease (Get the book.)

"Moreover, neither quetiapine nor risperidal were effective for the treatment of agitation in elderly demented patients, and quetiapine was associated with a more rapid cognitive decline over time than was placebo. As I mentioned above, antipsychotic drugs should not be used to control the behavior of elderly people unless they are really suffering from psychosis (e.g., seeing or hearing-things that aren't there); they have not been shown to be helpful, and they increase the risk of death." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.) "Rivastigmine delayed the cognitive decline of AD and led to a five-point difference from placebo on the seventy-item ADAS-Cog.10 These results are no better than those of donepezil or any of the other Alzheimer's drugs. Side effects are headache, nausea, diarrhea, insomnia, and dizziness. GALANTAMINE Galantamine (Reminyl) is an acetylcholinesterase inhibitor that modulates the nicotinic acetylcholine receptor. This receptor binds the neurotransmitter acetylcholine, which plays a critical role in learning and memory." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"It may be characterized by hallucinations, delusions, abnormal thought processes, abnormal movements, disrupted speech, social withdrawal, emotional distress, lack of motivation, and cognitive decline. Subtypes include catatonic, paranoid, disorganized, and undifferentiated schizophrenia. Psychotic symptoms generally begin in adolescence or early to mid-adulthood. Schizophrenia is associated with a higher rate of substance abuse and suicide than that which occurs in the general population." - Gary Null and Amy McDonald, The Food-Mood Connection: Nutrition-based and Environmental Approaches to Mental Health and Physical Wellbeing (Get the book.)

"Higher intake of niacin from food has been shown in some research to be associated with a slower annual rate of cognitive decline. Foods like eggs, liver, fish, and broccoli are great sources. Bottom line: Eat your fruits and vegetables, but don't forget your fats and protein. The Power of the Crossword Puzzle Much has been written about mental aerobics, brain teasers, and other ways of keeping your brain young. Obviously all that good press for mental gymnastics has had an impact (what other possible reason could there be for the popularity of Sudoku?)." - Jonny Bowden, Ph.D., C.N.S., The Most Effective Natural Cures on Earth: The Surprising, Unbiased Truth about What Treatments Work and Why (Get the book.) "Basic Brain Nutrition 101 Back in 2003, reports from the Chicago Health and Aging Project started documenting the powerful effects that nutrients can have on cognitive decline and Alzheimer's disease. The project was a study of common chronic health problems of older persons, and especially of risk factors for "The sad realities of dementia being epidemic and treatments for dementia still so limited make it a moral imperative to explore all possibilities for relief " —Parris Kidd, Ph.D., biochemist and nutritionist Alzheimer's disease." - Jonny Bowden, Ph.D., C.N.S., The Most Effective Natural Cures on Earth: The Surprising, Unbiased Truth about What Treatments Work and Why (Get the book.)

"Besides, a significant percentage of cabg patients died before they could leave the hospital, about half had a stormy recovery, nearly that many had memory loss at a year, and half suffered cognitive decline at five years that was beyond that observed in their birth cohort. But it's not easy to give up a belief. Besides, there is a small subset, about 3 percent of all patients, with a particular blockage that is helped. Treated medically, only 65 percent of this subset survived for five years; 85 percent if they survived cabg." - Nortin M. Hadler MD, Worried Sick: A Prescription for Health in an Overtreated America (Get the book.)

"A large study in Italy titled cognitive decline in the elderly: A double-blind, placebo-controlled multi-centered study on efficacy of phosphatidylserine administration followed 494 elderly subjects over six months, all of whom had moderate to severe mental decline. One group received 300 mg a day of PS, the other received a placebo. The PS group performed significantly better in both mental function and measures of behavior. Interestingly, symptoms of depression also improved, a finding that has been suggested by another study on elderly women. Steven Bratman, M.D." - Jonny Bowden, Ph.D., C.N.S., The Most Effective Natural Cures on Earth: The Surprising, Unbiased Truth about What Treatments Work and Why (Get the book.)

"Starting EPT after age 65 is not recommended for the prevention of dementia or cognitive decline. The Women's Health Initiative memory study showed an increase in the risk of dementia during the five years in women 65 and older.145 It is not yet clear as to whether ET or EPT can prevent dementia when hormones are started during perimenopause or early postmenopause. Premature Menopause and Premature Ovarian Failure. Women who have the onset of menopause early, and especially prior to age 40, have lower risks of breast cancer, but earlier onset of bone loss and CHD." - Tori Hudson, N.D., Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness (Get the book.)

"Moreover, as we face an epidemic of cognitive decline and impairment among the aging populations, berries in particular, have been shown to lessen the risk of these dreaded conditions related to the brain and cognition. Tomatoes, a featured actor of the health-promoting Mediterranean diet, have demonstrated health benefits, particularly in relation to certain types of cancers as well as heart disease. For those reasons alone these SuperFoods would be critical additions to anyone's diet." - Wendy Bazilian, DRPH, MA, RD, Steven Pratt, MD, Kathy Matthews, Superfoods Rx Diet: Lose Weight with the Power of SuperNutrients (Get the book.)

"The first human reports on this question suggest that estrogen is not an essential ingredient for exercise to protect against cognitive decline. In one study, physiologist Jennifer Etnier, who is now at the University of North Carolina at Greensboro, administered tests of mental processing speed and executive function to 101 postmenopausal women and compared the results to their reported levels of regular aerobic activity. Those who were more physically active had higher scores regardless of whether they had been undergoing HRT." - John J. Ratey, MD, Spark: The Revolutionary New Science of Exercise and the Brain (Get the book.) "Among those with the least cognitive decline over a four-year period, three factors turned up: education, self-efficacy, and exercise. The first two weren't so surprising, but Cotman was curious about the last. "I got to thinking about what the heck was really going on," he says. "The assumption was that exercise didn't act on the brain, but my take on it was that somehow it had to be the brain." - John J. Ratey, MD, Spark: The Revolutionary New Science of Exercise and the Brain (Get the book.) "What gets lost in the question of whether exercise helps menopausal women with hot flashes is the big picture, namely that it guards against heart disease, diabetes, breast cancer, and cognitive decline. The physical symptoms of menopause exacerbate the mood symptoms, and there's no question exercise helps in this regard. One woman told me that the most frustrating part of aging is that she feels like her body is out of control. She gained weight, suffered hot flashes and high blood pressure, and her vision deteriorated. On top of that, she feels anxious and depressed at times." - John J. Ratey, MD, Spark: The Revolutionary New Science of Exercise and the Brain (Get the book.) "Fundamentally, cognitive decline and all neurodegenerative diseases stem from dysfunctional and dying neurons; it's a communication breakdown. Research on aging revolves primarily around the effort to "restore the nerve cells' ability to communicate and stay alive," Mattson points out. "If you can do that, then you can prevent their degeneration and therefore prevent the disease." As the synaptic activity decreases and dendrites retract, the capillaries feeding the brain shrink back as well, restricting blood flow." - John J. Ratey, MD, Spark: The Revolutionary New Science of Exercise and the Brain (Get the book.)

"Coffee consumption is inversely associated with cognitive decline in elderly European men: the FINE study., Eur / Clin Nutr. 2006 Aug 16. Folsom AR, Parker ED, Pereira MA. Coffee consumption and risk of type 2 diabetes mellitus: an 11 -year prospective study of 28,812 postmenopausal women. Arch Intern Med. 2006 Jun 26;166(12):1311-1316. Klatsky AL, Morton C, Udaltsova N, Friedman GD. Coffee, cirrhosis, and transaminase enzymes. Arch Intern Med. 2006 Jun 12;166( 11): 1190—1195. Lee WJ, Zhu BT." - David W. Grotto, RD, LDN, 101 Foods That Could Save Your Life! (Get the book.)

"Likewise, a high intake of alpha-linoleic acid, an N-6 fatty acid, has been shown to increase cognitive decline in the elderly when compared to control patients, in one study.580 Patients on higher N-3 fatty acid diets showed reduced cognitive decline. Of particular importance is the finding that DHA plays a major role in synaptic function and synaptic protection against excitotoxicity. The greatest and earliest damage in Alzheimer's disease involves the synapse." - Russell L. Blaylock, M.D., Health and Nutrition Secrets (Get the book.)

"Add to that the incteased risk of stroke and the cognitive decline associated with bypass surgery. "Caveat emptor," said Fran. "Let the buyer beware." I could only shake my head. It turns out that stenting and cabbages don't work, but not because of—as previously believed—various technical deficiencies. They don't work because the very model of why a heart attack occurs was incorrect. The old idea was this: "coronary disease is akin to sludge building up in a pipe." - Gerald E. Markle and Frances B. McCrea, What If Medicine Disappeared? (Get the book.)

"We know that even people with prediabetes have a higher risk of cognitive decline, poor memory, and loss of brain function.17 So when you have that soda, some imaginary barrier does not protect your brain. How could we really believe that our brains could tolerate half a pound of sugar a day on average and be healthy? There are many other examples of how great an influence the body (and what you put in your body) can have on your brain, some more of which you will learn about over the course of this book. But here is the bottom line . . . All broken brains have their root in the body." - Mark Hyman MD, The UltraMind Solution: Fix Your Broken Brain by Healing Your Body First (Get the book.) "Scientific advances over the last few decades have given us the tools to prevent, stop, and even reverse cognitive decline and address all the mood disturbances that come with swings in blood sugar and insulin. While there are some new medications that can help, such as Glu-cophage and Actos, they have side effects and are only a Band-Aid unless used with a comprehensive nutritional, exercise, and stress management plan that is the foundation of the UltraMind Solution I provide in Part III." - Mark Hyman MD, The UltraMind Solution: Fix Your Broken Brain by Healing Your Body First (Get the book.) "However, insulin resistance doesn't lead only to cognitive decline, memory impairment, dementia, and Alzheimer's. Other Problems Created by Insulin Resistance It is well known that depression is more common in diabetics, but a Finnish study of young men found that those who had the worst insulin resistance had an almost threefold risk of having severe depression.7 One of my patients, a physician, was morbidly obese and had tried everything from liquid diets to gastric bypass, all of which failed." - Mark Hyman MD, The UltraMind Solution: Fix Your Broken Brain by Healing Your Body First (Get the book.)

"Having adequate amounts of all the B vitamins, especially folic acid and vitamin B6, is also critical for protection against homocysteine and cognitive decline. All work together nicely to reduce homocysteine levels and protect against anemias as well as mental disorders. In 2004 the Nutrition Research Newsletter reported a "memory" study done in Switzerland, where participants were divided into groups with varying stages of cognitive problems." - Jonny Bowden, Ph.D., C.N.S., The Most Effective Natural Cures on Earth: The Surprising, Unbiased Truth about What Treatments Work and Why (Get the book.)

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