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"Associate Program Director of the General clinical research Center and Columbia Presbyterian Medical Center. Board-certified in Pediatric Endocrinology, he has a longstanding interest in clinical research relating to alterations of energy expenditure to body weight. He has worked with other experts in a clinical study regarding the role of leptin and body composition. Dr. Rosenbaum has just completed a pilot study designed to examine the effects of supervised exercise and nutritional and health education on metabolic risk factors for type II diabetes mellitus in children." - Deirdre Imus, Growing Up Green: Baby and Child Care: Volume 2 in the Bestselling Green This! Series (Green This!) (Get the book.)

"That's called basic research. clinical research may be very hands-on, with patients actively involved in experiments, or it may be applied, with a researcher comparing biological samples from patients—for example, blood or muscle tissue—to those from healthy comparison subjects. In this way, scientists can discover differences that might lead to an understanding of the biology of the disease. Another kind of clinical research consists of doing drug trials." - Benjamin H. Natelson, M.D., Your Symptoms Are Real: What to Do When Your Doctor Says Nothing Is Wrong (Get the book.)

"As a result of clinical research that found that the consumption of L. casei What Is Superficial Bladder Cancer? Superficial bladder cancer is a common term used to describe a tumor or mass of cells on the surface of the bladder. This type of cancer can be removed surgically with good success rates; however, it has a high recurrence rate. i--1 Shirota significantly reduced the recurrence of cancer in the bladder. In a clinical trial, patients who had been treated for superficial bladder cancer were given L. casei Shirota with positive results. L." - Allison Tannis, Probiotic Rescue: How You can use Probiotics to Fight Cholesterol, Cancer, Superbugs, Digestive Complaints and More (Get the book.)

"Richard Wurtman is a neuroscience professor and former director of MIT's clinical research Center, and Dr. Judith Wurtman is a research scientist, director of the women's health program at the MIT clinical research Center, and author of The Serotonin Solution and Managing Your Mind and Mood Through Food." - Connie Bennett, C.H.H.C. with Stephen T. Sinatra, M.D., Sugar Shock!: How Sweets and Simple Carbs Can Derail Your Life-- and How YouCan Get Back on Track (Get the book.)

"It was possible, its advocates said, to believe that the symptoms of illness "meant" something, that bodies could speak—but to do so while still believing in statistics, modern clinical research, and laboratory physiology. What this meant in practice was that American psychosomatic medicine focused less on holistic concepts of mind-body unity and more on exploring the effects of particular psychological factors on particular diseases." - Anne Harrington, The Cure Within: A History of Mind-Body Medicine (Get the book.) "The paper had two goals: on the one hand, it argued for a new understanding of placebos and their effects; on the other, it urged the adoption of a new research methodology to remove (among other things) the distorting influence of placebo effects from clinical research settings. For Beecher, placebos were not harmless humbugs, psychotherapy by other means offered to patients who could not otherwise be helped." - Anne Harrington, The Cure Within: A History of Mind-Body Medicine (Get the book.)

"A recent study, published in Drugs and Experimental clinical research, showed that carnitine supplementation improved quality of life and life expectancy in patients who had suffered a heart attack. Another study, published in American Heart Journal, indicated improvements in survival associated with carnitine supplementation in patients with heart failure. These studies and many others support carnitine's role in protecting and enhancing cardiovascular health." - Steven V. Joyal, What Your Doctor May Not Tell You About Diabetes: An Innovative Program to Prevent, Treat, and Beat This Controllable Disease (Get the book.)

"Board-certified in Pediatric Endocrinology, he has a longstanding interest in clinical research relating to alterations of energy expenditure to body weight. He has worked with other experts in a clinical study regarding the role of leptin and body composition. Dr. Rosenbaum has just completed a pilot study designed to examine the effects of supervised exercise and nutritional and health education on metabolic risk factors for type II diabetes mellitus in children. He is working on an NIH/NIDDK-funded grant in human obesity. Susan Sencer, M.D." - Deirdre Imus, Growing Up Green: Baby and Child Care: Volume 2 in the Bestselling Green This! Series (Green This!) (Get the book.)

"Ongoing clinical research by Dr. Jaquelyn McCandless of low-dose naltrexone is in progress. Preliminary results indicate improvements in mood, cognition, and social relatedness in some children. A small percentage showed side effects of irritability, agitation, and restlessness. I also sometimes employ low-dose naltrexone as an immune modulator. It appears to help keep the immune system functioning at the proper level, without becoming underactive or overactive." - Kenneth Bock, Healing the New Childhood Epidemics: Autism, ADHD, Asthma, and Allergies: The Groundbreaking Program for the 4-A Disorders (Get the book.)

"Probiotics improve immunity and prevent diarrhea according to clinical research. Probiotics likely play a role in colic and L. reuteri is known to reduce crying times in these infants. Probiotics may reduce the risk of children developing allergic diseases later in life and may play a role in reducing respiratory-related illnesses. Research to date has found supplementing probiotics in infant formulas to be safe and effective in infants as young as four months of age. Prebiotics may be of particular benefit to infants as their microflora is predominantly Bifidobacteria." - Allison Tannis, Probiotic Rescue: How You can use Probiotics to Fight Cholesterol, Cancer, Superbugs, Digestive Complaints and More (Get the book.) "The connection between probiotics and cholesterol does not only appear to work theoretically but also appears to be supported by clinical research. Watch for more research in this area in the future. Probiotics may help your heart by doing more than lowering cholesterol. A controlled, randomized, double-blind study involving 36 male smokers who consumed 50,000 CFUs of L. plantarum had a decrease in oxidative stress and inflammation. Thus, L. plantarum appears to effectively reduce some heart disease risk factors." - Allison Tannis, Probiotic Rescue: How You can use Probiotics to Fight Cholesterol, Cancer, Superbugs, Digestive Complaints and More (Get the book.)

"So, let's examine some of the clinical research to see the impact L-carnitine can have in CHF therapy. L-carnitine plays a role in the utilization of fatty acids and glucose in the heart. However, the relationship between carnitine availability in heart tissue, carnitine metabolism in the heart, and left ventricular function had not been fully studied." - Stephen T. Sinatra, M.D., The Sinatra Solution Metabolic Cardiology (Get the book.)

"Between 1996 and 2002, the portion of the public who distrusted information from clinical research professionals shot up, from 28 percent to 75 percent.91 The New York Times noted that by 2005, consumers seemed to be less confident in drug marketing. "A lot of the demand that the industry has created over the years has been through promotion, and for that promotion to be effective, there has to be trust," said Richard Evans, an analyst at Sanford C. Bernstein & Company, an investment research company. "That trust has been lost." - Charles Barber, Comfortably Numb: How Psychiatry Is Medicating a Nation (Get the book.)

"Niacin or vitamin B3 has been shown in clinical research to be effective in 87.5 percent of women with menstrual cramps.14 Niacin was given in 100 mg doses twice daily throughout the month, and then every two to three hours during the periods of menstrual cramps. Although a sometimes uncomfortable niacin flush could easily occur at the escalated dosing, none of the women in the study stopped the medication due to the flushing. Interestingly, the women who received no relief of their menstrual cramps were frequently the women who reported no flushing." - Tori Hudson, N.D., Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness (Get the book.)

"Experimental study designs provide the greatest accuracy in describing cause and effect, and for this reason are considered the "gold standard" in clinical research. However, experimental study designs are rarely the first type of design used when testing a new clinical activity. Commonly an experimental study will be preceded by a series of descriptive, correlational, and quasi-experimental trials, often in that order. In experimental designs, treatments are randomly assigned to patients. Pretest-Post-Test Control Group Design." - John Boik, Cancer & Natural Medicine: A Textbook of Basic Science and Clinical Research (Get the book.) "To date, very little clinical research has been conducted on the majority of complementary therapies, and it is simply too early to make many judgments. Since so little is known about the anticancer effects of complementary therapies, their use should, in general, be focused toward research. 1.4 RESEARCH ON COMPLEMENTARY MEDICINE As already stated, the clinical efficacies of natural anticancer agents are largely unknown." - John Boik, Cancer & Natural Medicine: A Textbook of Basic Science and Clinical Research (Get the book.)

"So he and another colleague, who was an expert in clinical research, tested patients' balance before and after they completed their course of massage treatment. To provide a comparison, they also tested untreated CFS and FM patients and healthy people on two occasions separated by several weeks. If massage improved balance, we would expect to find better balance scores on the second trial than on the first. Since the comparison groups had no specific treatment between their two balance tests, we would expect similar scores on the two tests. The graph on page 193 shows the data." - Benjamin H. Natelson, M.D., Your Symptoms Are Real: What to Do When Your Doctor Says Nothing Is Wrong (Get the book.)

"Thus in 1917, for example, the US medical periodical Medical Times carried a lengthy transcript of a paper on Ayurvedic medicine presented by Dr Sarat Chandra Ghose to the 1916 Eight Annual Meeting of the American Association of clinical research. The paper lauded Ayurveda's glorious past?Hindu medicine attained a very high level of perfection when the rest of the world was almost in its infancy... long before western medical science came into existence'." - Roberta Bivins, Alternative Medicine?: A History (Get the book.)

"And the actual work of doing laboratory and clinical research is incredibly slow even when everything is working beautifully. So when I tell interested patients that there is not much new since the last visit, I can understand the disappointment. However, that's the way research goes—by microsteps, until all of a sudden the little bits of information add up to allow the researcher to make a discernible step forward. These statements are true of research in general, but even more so for illnesses with no bio-markers." - Benjamin H. Natelson, M.D., Your Symptoms Are Real: What to Do When Your Doctor Says Nothing Is Wrong (Get the book.)

"Still in the early stages of clinical research, shark cartilage, especially in the frozen, concentrated form known as Comitris?and CarTCell? shows promise as a cancer treatment. HISTORY With the discovery of shark cartilage's anti-angiogenic activity, it has become popular for treatment of conditions such as osteo and rheumatoid arthritis, lupus, and cancer. Many companies began manufacturing shark cartilage into a powder or pill form supplement, however, not all supplements are created equally." - Freedom Press, Natural Cancer Cures: The Definitive Guide to Using Dietary Supplements to Fight and Prevent Cancer (Get the book.)

"A review of all of the clinical research on the use of probiotics in people with ulcerative colitis suggests that high-dose, multi-strain probiotic mixtures are more effective at reducing inflammation and increasing remission length than single probiotic strains. Of note, the probiotic Escherichia coli has also been used in a number of clinical trials and reportedly maintains remission in ulcerative colitis patients. Pouchitis Patients with ulcerative colitis sometimes have part of their colon removed to treat the disease." - Allison Tannis, Probiotic Rescue: How You can use Probiotics to Fight Cholesterol, Cancer, Superbugs, Digestive Complaints and More (Get the book.)

"The advertising firms quickly showed what potent partners their clinical research operations could be for drug companies eager to boost sales. The story of a pain reliever called Bextra provides a case in point. Pharmacia, the drugs manufacturer, had asked the FDA in 2001 to approve Bextra to treat both the chronic pain of arthritis and the more acute pain that follows surgery. The regulators agreed to approve the drug to treat arthritis but refused to allow the company to sell it for more intense pain. The regulators' decision upset Pharmacia's marketing plans." - Melody Petersen, Our Daily Meds: How the Pharmaceutical Companies Transformed Themselves into Slick Marketing Machines and Hooked the Nation on Prescription Drugs (Get the book.)

"In most spheres of medicine, new practice is certified through carefully designed clinical research. But it's hard to imagine a control group of patients (who get no treatment) in the emergency room, and its even harder to imagine a randomized "double-blind" design (in which neither the patient nor the physician knows who has or has not received treatment). The next day, we met after work for dinner at our favorite bistro. "Did you know that the homicide rate declined between I960 and 2000?" asked Fran. I looked at her without comprehension." - Gerald E. Markle and Frances B. McCrea, What If Medicine Disappeared? (Get the book.)

"Outcome studies and other kinds of clinical research about the NES clinical system and Infoceuticals are beginning in earnest. Conversations and visits with such diverse researchers and visionaries as Milo Wolff, Fritz-Albert Popp, and Lynne McTaggart are opening new doors and stimulating new ideas. Peter can barely keep up with his own rush of ideas, but he has always welcomed collaboration and conversation with others. These kinds of encounters will continue and no doubt will stimulate the ongoing refinement of the NES system." - Peter h. Fraser and Harry Massey, Decoding the Human Body-Field: The New Science of Information as Medicine (Get the book.)

"Yet he called for continued clinical research on the drug, offering this remarkable conclusion: "Patients and their families have a compelling need for a basis of hope. If such hope is not offered, they will quickly seek it from the hands of quacks or charlatans." Moertel's assertion was shocking and disturbing. "We should stop deceiving patients," another physician replied in response: "To do less is to be a charlatan or a quack." - Gerald E. Markle and Frances B. McCrea, What If Medicine Disappeared? (Get the book.)

"So a decade ago I stepped back from my life at the bedside (not entirely, since I still see many patients) to carry out a productive clinical research program and do many visiting professorships. However, the many months that I had spent each year in the hospital at the bedside growing increasingly frustrated were sacrificed. I felt compelled to become a reformer. Because of my decades of research regarding workplace health and safety, I was long sought after as a resource for various congressional committees and the like." - Nortin M. Hadler MD, Worried Sick: A Prescription for Health in an Overtreated America (Get the book.)

"In clinical research it's been shown to help lower blood cholesterol, but more to the point, it's also been shown to reduce the symptoms of BPH. Four double-blind, placebo-controlled studies including 519 men and lasting from 4 to 26 weeks concluded that beta-sitosterol significantly improved urological symptoms and flow measures. Nettles (stinging nettles) are frequently combined with other "prostate herbs" like saw palmetto and have long been believed to have a beneficial effect on prostate health." - Jonny Bowden, Ph.D., C.N.S., The Most Effective Natural Cures on Earth: The Surprising, Unbiased Truth about What Treatments Work and Why (Get the book.)

"Minimizing Bias One inescapable fact of clinical research is that individuals respond differently to any given nutritional state, disease context, or treatment intervention. These differences are based in countless genetic variations in receptor binding, enzyme efficiency, gene promotion, and all of the other signaling and response mechanisms of cells and tissues of the body. Additionally, individuals bring different life experiences, different morbidities, differing nutritional status, differing motivations, and differing abilities to adhere to or sustain a given therapeutic intervention." - Ann M. Coulston and Carol J. Boushey, Nutrition in the Prevention and Treatment of Disease (Get the book.) "Results of clinical research trials. Ann. Intern. Med. 119, 688-693. 38. Anderson, J. W., Konz, E. C, Frederich, R. C, and Wood, C. L. (2001). Long-term weight-loss maintenance: a meta-analysis of U.S. studies. Am. J. Clin. Nutr. 74, 579-584. 39. Wing, R. R. (1992). Don't throw out the baby with the bathwater: a commentary on very-low-calorie diets. Diabetes Care 15, 293-296. 40. Wadden, T. A., Sternberg, J. A., Letizia, K. A., Stunkard, A. J., and Foster, G. D. (1989). Treatment of obesity by very low calorie diet, behavior therapy, and their combination: A five-year perspective. Int. J." - Ann M. Coulston and Carol J. Boushey, Nutrition in the Prevention and Treatment of Disease (Get the book.) "Support for this work was also provided by grants from the National Institutes of Health to the University of North Carolina Clinical Nutrition Research Unit (DK56350), the University of North Carolina General clinical research Center (RR00046), and the Center for Environmental Health and Susceptibility (ES10126). References 1. Gordon, N. (1997). Nutrition and cognitive function. Brain Dev. 19, 165-170. 2. Guesry, P. (1998). The role of nutrition in brain development. Prev. Med. 27, 189-194. 3. Mattson, M. P. (2003). Gene-diet interactions in brain aging and neurodegenerative disorders." - Ann M. Coulston and Carol J. Boushey, Nutrition in the Prevention and Treatment of Disease (Get the book.)

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