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"On the other hand, the suppressive effects of flavones, such as chrysin and apigenin, on the expression of the high affinity IgE receptor FceRI, which plays a central role in the IgE-mediated allergic response (Yano et al., 2005) has been demonstrate. 3.2. Genistein and daidzein Genistein and daidzein (isoflavones derived from soybeans) have been shown to inhibit the development of both hormone- and non-hormone-related cancers, including mouse models of breast, prostate, and skin cancer." - Erich Grotewold, The Science of Flavonoids (Get the book.)

"One is a bioflavonoid called chrysin, and another is Nettle Root. They will bond to and remove aromatase, and thus prevent the testosterone to estrogen conversion. I personally use a men's formula produced by the Life Extension Foundation called Super MiraForte?with chrysin, which also contains other cofactors beneficial for men. The non-profit organization maintains high quality standards for all their products. They not only issue grants for research in various areas of longevity, but are also fighting to preserve our freedom of access to nutrients." - Dr. David W. Tanton; Ph.D., A Drug-Free Approach To Healthcare, Revised Edition (Get the book.)

"COMPOUNDS: POPLAR LEAF BUDS Flavonoids: (particularly in the glutinous coating of the buds, also yielding propolis) including chrysin, tectochrysin, galen-gine, izalpinine, galangin-3-methyl ether, kaempferol-3-methyl ether, pinocembrin, pinocembrin-7-methyl ether, apigenin Glycosides and esters yielding salicylic acid: including salicin, populin Volatile oil: chief components alpha- and beta-caryophyllene EFFECTS: POPLAR LEAF BUDS Poplar buds have antiphlogistic, antibacterial, and wound healing effects." - Thomson Healthcare, Inc., PDR for Herbal Medicines, Fourth Edition (Get the book.)

"COMPOUNDS: POPULI GEMMA Glycosides and esters yielding salicylic acid: including, among others, salicin, populin Volatile oil: chief components alpha- and beta-caryophyllene Flavonoids: including, among others, chrysin, tectochrysin, galengin, izalpinine, galangin-3-methyl ether, kaempferol-3-methyl ether, pinocembrin, pinocembrin-7-methyl ether, apigenin (in the sticky coating of the buds, also yielding propolis) EFFECTS: POPULI GEMMA The buds are antibacterial and are vulnerary." - Joerg Gruenwald, Ph.D., PDR for Herbal Medicines (Get the book.)

"Constituents Citric acid, flavonoids (apigenin, luteolin, quercitin, rutin, chrysin), glycosides, alkaloids (harman, har-mine, harmaline, harmol, harmalolsterols), sitosterol, stigmasterol, serotonin, sugars, gum Energetic Correspondences • Flavor: bitter • Temperature: cool • Moisture: dry • Polarity: yin • Planet: Sun/Venus/Neptune • Element: water Contraindications Large doses may cause nausea and vomiting. Avoid large doses during pregnancy. Unripe fruits have some level of toxicity and should not be consumed." - Brigitte Mars, A.H.G., The Desktop Guide to Herbal Medicine: The Ultimate Multidisciplinary Reference to the Amazing Realm of Healing Plants, in a Quick-study, One-stop Guide (Get the book.)

"The pure chemical (found in very small doses in the herb, and available in therapeutic doses only from chrysin products) also has up to thirty times the relaxant effect of chlordiazepoxide or diazepam. chrysin also interacts with an enzyme that acts to transform testosterone molecules into estrogen molecules. This ability makes chrysin especially useful for men who suffer conditions caused by excessive estrogen levels, such as gynecomastia (enlargement of the breasts), and for individuals of both sexes with diminished sex drive." - Phyllis A. Balch, CNC, Prescription for Herbal Healing: An Easy-to-Use A-Z Reference to Hundreds of Common Disorders and Their Herbal Remedies (Get the book.)

"Very preliminary research suggests that chrysin may emerge as a useful anxiolytic agent, that it might aid in the control of morphine withdrawl and that it might have some chemopre-ventive properties in cardiovascular disease and cancer. RESEARCH SUMMARY Chrysin's ability to inhibit the aromatization of androstenedione and testosterone to estrogens has been demonstrated in the laboratory. chrysin has been shown to be among the most potent of the natural and synthetic flavone inhibitors of human estrogen aromatase." - Sheldon Saul Hendler and David Rorvik, PDR for Nutritional Supplements (Get the book.)

"Chrysin, also known as flavone X, inhibits aromatase, an enzyme responsible for breaking down testosterone into estrogen, thereby helping to maintain higher testosterone levels. chrysin can be taken alone or used along with other testosterone-boosting agents, such as androstenedione and DHEA. There are few human studies on chrysin; however, European Olympic athletes who took 1 to 3 grams of chyrsin reportedly experienced a 30 percent increase in testosterone." - Earl Mindell, R.Ph., Ph.D., Earl Mindell's Supplement Bible: A Comprehensive Guide to Hundreds of NEW Natural Products that Will Help You Live Longer, Look Better, Stay Heathier, ... and Much More! (Get the book.)

"DESCRIPTION Chrysin belongs to the flavone class of flavonoids. chrysin is found naturally in various plants including the Pelargonium species, which are germanium-like plants; the Passiflora or passion flower species, which include tropical passion fruit; and the Pinaceae species, including pine trees. Chrysin, principally obtained from the plant Passiflora coerulea, is marketed as a nutritional supplement and is especially popular among male body builders and other athletes because of its possible action in inhibiting the conversions of androgens to estrogens." - Sheldon Saul Hendler and David Rorvik, PDR for Nutritional Supplements (Get the book.)

"Propolis contains 55% Resinous and Balsamic substances, 30% bee Wax, 10% ethereal and aromatic oils, 5% Pollen, antibiotics, with Vitamins B Complex*, B1, B2, C, the widest range of (30) Bioflavonoids of any food substance including Galangin, Kaempferol, and Quercetin; Vitamin E, Amino acids, Enzymes, all the essential Minerals Iron, Calcium, Manganese, Silicon, and Trace minerals; essential oils; and Cinnamic acid, cinnamyl alcohol, caffeic acid, chrysin, isalpinin, isoferulic acid, pinocembrin, sinapic acid, tectochrysin, over 30 active components have been identified." - Joseph E. Mario, Anti-Aging Manual: The Encyclopedia of Natural Health (Get the book.)

"Stem-bark gave the flavonoids oroxylin A, baicalein, its 7-glucuronide, scutellarein and its 7-rutinoside, chrysin and p-coumaric acid. Seeds gave another flavone, oroxindin. Heartwood yielded beta-sitosterol and isofla-vone, prunetin. Bark of the root gave chrysin, baicalein and oroxylin. Bark also contained dihydrobaicalcein. A decoction of bark showed good diuretic activity in rats, comparing favourably with potassium acetate, and being more potent than urea." - C. P. Khare, Indian Herbal Remedies: Rational Western Therapy, Ayurvedic and Other Traditional Usage, Botany (Get the book.)

"Aside from testosterone therapy under a physician's care, an herbal product that can help the body produce testosterone naturally is the bioflavonoid chrysin (5,7-dihydroxyflavone), which is found in the a passionflower plant (Passiflora coerula). Another useful herbal is an extract made from nettle root (Urtica dioica). The latter binds to SHBG better than testosterone, which helps increase the body's level of "free" testosterone. Make sure you use a product made from the root, not the stems and leaves." - Phyllis A. Balch, CNC, Prescription for Nutritional Healing, 4th Edition: A Practical A-to-Z Reference to Drug-Free Remedies Using Vitamins, Minerals, Herbs & Food Supplements (Get the book.) "Aside from testosterone therapy under a physician's care, there is an herbal product, the bioflavonoid chrysin, extracted from the plant Passiflora coerula (a type of passionflower), which can help the body produce testosterone naturally. Another useful herbal is an extract made from nettle root (Urtica dioica). This binds to SHBG better than testosterone does, thus helping to increase the body's level of free testosterone. If you choose to try this remedy, make sure you use a product made from the root, not the stems and leaves." - Phyllis A. Balch, CNC, Prescription for Nutritional Healing, 4th Edition: A Practical A-to-Z Reference to Drug-Free Remedies Using Vitamins, Minerals, Herbs & Food Supplements (Get the book.)

"If tests on chrysin bear out their promise, men would have an inexpensive natural supplement that would: • Increase free testosterone • Decrease excess estrogen • Produce a safe antianxiety effect Chrysin is sold to bodybuilders by commercial supplement companies that do not know whether or not their product is modulating testosterone and estrogen levels favorably in men. The Life Extension Foundation, on the other hand, has conducted studies to evaluate chrysin's effects (when it is combined with piperine to enhance absorption) on aging men. Nettle." - Gary Null, Gary Null's Power Aging (Get the book.)

"I personally use a men's formula produced by the Life Extension Foundation called Super MiraForte?with chrysin, which also contains other cofactors beneficial for men. The non-profit organization maintains high quality standards for all their products. They not only issue grants for research in various areas of longevity, but are also fighting to preserve our freedom of access to nutrients. Although many aren't aware of the fact, that is becoming more and more of a threat. Vested interests would like very much to prevent our access to vitamins in sufficient quantity to have any real benefit." - Dr. David W. Tanton; Ph.D., A Drug-Free Approach To Healthcare, Revised Edition (Get the book.)

"Chemistry: phenolic glycosides: isoferulic acid, ferulic acid, caffeic acid, prenylferulate, prenylcaffeate, pinocembrin, pinostrobin, pinobanksin, chrysin, benzyl-(e)-caffeate, galangin, isosakuranetin, phenylethyl-(e)-caffeate, kaempferol, salicin, salicortin, salireposide, populin, temuloidin, and tremulacin Medicinal Uses: Although phenolic glycoside content differs slightly from Aspen (Populus tremuloides) and Balsam Poplar (Populus balsamifera), Cottonwood's uses are very similar. The bark tea is a reliable, broadly acting antiinflammatory agent." - Charles W. Kane, Herbal Medicine of the American Southwest (Get the book.)

"The nutrients tested included various combinations of chrysin, nettle root, maca, ginger root, muira puama, and zinc, along with piperine to enhance the absorption of the chrysin. The results from the first pilot study showed that nine out of 10 men experienced a significant reduction in serum estradiol (estrogen) levels after only 30 days, compared to baseline. In this brief study, total testosterone increased in seven out of 10 men, but free testosterone increased in only four of the 10 men studied. Other blood parameters were not statistically altered." - The Life Extension Editorial Staff, Disease Prevention and Treatment (Get the book.)

"It is also a source of an antioxidant chemical known as chrysin, which helps the body conserve testosterone. It does not cause the body to produce more testosterone, but, by conserving the testosterone already in the body, it can have the effect of increasing testosterone levels. A wide range of potential therapeutic applications of chrysin are currently being investigated." - Phyllis A. Balch, CNC, Prescription for Herbal Healing: An Easy-to-Use A-Z Reference to Hundreds of Common Disorders and Their Herbal Remedies (Get the book.) "Both passionflower and chrysin products can cause drowsiness, and both increase the effects of both alcohol and psychoactive drugs such as sedatives and tranquilizers. You should not use passionflower if you take an MAO inhibitor. Nor should you take passionflower during pregnancy, because it may stimulate the uterine muscles. Women seeking to become pregnant should not take chrysin. Adults over the age of sixty-five and children between the ages of two and twelve should take only low-strength preparations, and you should not give this herb in any form to a child under two years of age." - Phyllis A. Balch, CNC, Prescription for Herbal Healing: An Easy-to-Use A-Z Reference to Hundreds of Common Disorders and Their Herbal Remedies (Get the book.) "Chrysin also interacts with an enzyme that acts to transform testosterone molecules into estrogen molecules. This ability makes chrysin especially useful for men who suffer conditions caused by excessive estrogen levels, such as gynecomastia (enlargement of the breasts), and for individuals of both sexes with diminished sex drive. At the same time that it keeps testosterone from being transformed into estrogen, however, it blocks some (but not all) of the receptors on cells that cause them to respond to estrogen, blunting the effects of excess estrogen." - Phyllis A. Balch, CNC, Prescription for Herbal Healing: An Easy-to-Use A-Z Reference to Hundreds of Common Disorders and Their Herbal Remedies (Get the book.)

"Clinical data confirm the usefulness of this species for the conditions mentioned above, but the compounds responsible for the activity are not definitively known. chrysin and other flavonoids have been shown to be biologically active, and consequently the flavonoids Fig. 9.6 Microscopic appearance of passion flower herb (Passiflorae herba) showing (a) typical fragment of the lower epidermis of a leaf with some calcium oxalate structures along the small veins, (b) sickle-shaped long unicellular trichomes and (c) the unusual pollen." - Dr. Michael Heinrich, Joanne Barnes, Simon Gibbons and Elizabeth M. Williamson, Fundamentals of Pharmacognosy and Phytotherapy (Get the book.) "Constituents The active constituents are not known, but the flavonoids are thought to be important, particularly chrysin and related compounds. These include schaftoside, isoschaftoside, orientin, homoorientin, vitexin, isovitexin, kaempferol, luteolin, quercetin, rutin, saponaretin and saponarin. Alkaloids of the harman type are present in low amounts (the presence of harmine, harmaline, harmol and harmalol has been disputed) as well as p-carbolines. 8-Pyrone derivatives, including maltol and ethylmaltol, sterols, sugars and gums are present but their relevance to the activity is not known." - Dr. Michael Heinrich, Joanne Barnes, Simon Gibbons and Elizabeth M. Williamson, Fundamentals of Pharmacognosy and Phytotherapy (Get the book.) "Sedative effects are attributed at least in part to the flavonoid, particularly chrysin, content. Recent research has demonstrated other pharmacological actions in animals, which may lead to new indications (e.g. aphrodisiac, antitussive and anti-asthmatic activities). There are few clinical studies of passiflora; however, a preliminary double-blind randomized trial using 36 patients with generalized anxiety showed that the extract to be as effective as oxazepam but with a lower incidence of impairment of job performance." - Dr. Michael Heinrich, Joanne Barnes, Simon Gibbons and Elizabeth M. Williamson, Fundamentals of Pharmacognosy and Phytotherapy (Get the book.) "Constituents It contains flavonoids including baicalin, baicalein, wogonin, chrysin, oroxylin A, skullcapflavones I and II, and others (Fig. 24.4). Pharmacological effects and clinical efficacy-Used for a wide variety of ailments, particularly fevers, infections, jaundice, thirst and nosebleeds, and as an antidote and sedative. Baicalin is anti-inflammatory and antiallergic; it inhibits the formation of lipoxygenase products and, to a lesser extent, cyclo-oxygenase products in leukocytes." - Dr. Michael Heinrich, Joanne Barnes, Simon Gibbons and Elizabeth M. Williamson, Fundamentals of Pharmacognosy and Phytotherapy (Get the book.)

"Passiflora coerulea has Isoflavone chrysin Flavone X that increases Testosterone for athletes (taken orally); andlpriflavons (7-Isopropoxy Isoflavone). Grape seed polyphenol Leucoanthocyanins counter free radical oxidations and cardiovascular illness, improve Vitamin A's ability to rid free radicals in eye tissues; shown to be 50-200 times better Brain antioxidant than Vitamin E, regulates fine blood flow in the Brain and heart, strengthens capillary permeabil ity in diabetics; inhibits lung and breast cancers. Lignins in Flax(800mg. per kg." - Joseph E. Mario, Anti-Aging Manual: The Encyclopedia of Natural Health (Get the book.)

"Chrysin confers anxiolytic actions without inducing sedation or muscle relaxation; it may be a partial agonist of benzodiazepine receptors.2 chrysin is found in species of Passiflora and Scutellaria. The furanocoumarin phellopterin, from the roots of Angelica dahurica, strongly inhibits the binding of diazepam to central nervous system benzodiazepine receptors in vitro.3 Some extracts inhibit contraction of the rabbit aorta induced by histamine and serotonin in vitro." - David Hoffman, FNIMH, AHG, Medical Herbalism: The Science Principles and Practices Of Herbal Medicine (Get the book.)

"Other studies have reported conflicting findings to those mentioned above.11 chrysin, a monoflavonoid found in a related species (P. caerulea L.), has been shown to exert an anxiolytic action in mice with no subsequent sedation or muscle relaxation. The authors hypothesize that this could be due to its action as a partial antagonist of the central benzodiazepine receptors.19 An increase in the nociceptive threshold and reduction in locomotor activity have been noted in rats following administration of an hydroalcoholic extract of P. incarnata L (160 mg/kg)." - Heather Boon, BScPhm, PhD and Michael Smith, BPharm, MRPharmS, ND, The Natural Medicine Guide to the 50 Most Common Medicinal Herbs (Get the book.)

"Aging is being increasingly viewed as a proinflammatory process, and agents that inhibit chronic inflammation may protect against diseases as diverse as atherosclerosis, senility, and aortic valve stenosis. chrysin is one of many flavonoids being studied as a phyto-extract that may prevent some forms of cancer. If chrysin can boost free testosterone in the aging male by inhibiting the aromatase enzyme, this would provide men with a low-cost natural supplement that could provide the dual antiaging benefits of testosterone replacement and aromatase-inhibiting drug therapy." - The Life Extension Editorial Staff, Disease Prevention and Treatment (Get the book.) "METABOLISM OF SELECTED ESTROGENS DHEA: ETIOCHOLANOLONE -+ ANDROSTERONE ANDROSTENEDIONE ; TESTOSTERONE (Aromatase; inhibited by chrysin) (Aromatase; inhibited by chrysin) Estrone •* .(El) Estradiol (E2) 4-OH-E1 (catechol estrogens) 16a-OH-Ei 2-OH-E1 (16 ALPHA HYDROXYESTRONE) (2 HYDROXYESTRONE) (Binds estrogen receptor, DNA." - The Life Extension Editorial Staff, Disease Prevention and Treatment (Get the book.)

"The less testosterone that is converted, the more there is available to you. chrysin is added to many products used by bodybuilders as part of their muscle-fitness programs. It is also a potent antioxidant and has been shown to reduce inflammation. It may also play a role in moderating the undesirable effects of stress hormones in our body. It appears that this plant compound works best in the presence of piperine (an extract of pepper) or other plant-based bioflavionoids. I recommend a nutraceutical formula by the Life Extension Foundation called MiraForte with chrysin." - Garcia Oz, Sharyn Kolberg, The Healthy High-tech Body (Get the book.)

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