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"This is known as bioavailability. Pharmaceutical-grade products ensure proper bioavailability. That is, the substance can be used by the body at the dose stated. Many supplements differ in price depending upon their bioavailability. Some products seem like a better deal, but your body may be able to absorb only a portion of the supplement. If melatonin never worked for you and/or you are having mela-tonin-deficient symptoms, you may want to ask a compounding pharmacist to make a dose of 0.1 mg and gradually increase the dose by 0." - Phuli Cohan, The Natural Hormone Makeover: 10 Steps to Rejuvenate Your Health and Rediscover Your Inner Glow (Get the book.)

"Certain nutritional yeast products are fortified with chromium and have good bioavailability. TOXICITY OF CHROMIUM As noted above, hexavalent chromium is known to cause cancer and skin irritation. There have been no convincing reports of toxicity from the trivalent chromium in food or supplements. Therefore, the Food and Nutrition Board has not set an upper level for chromium. Several studies have shown a lack of side effects from supplementation of 1000 meg for several months. People with kidney or liver disease should be cautioned to take lower doses." - Dr. Steve Blake, Vitamins and Minerals Demystified (Get the book.)

"While there have been many clinical studies using these preparations, there are very few published reports, in either human subjects or animal models, comparing the absorption or the bioavailability of the coenzyme Qio in these products. There are many coenzyme Qi0 supplements available commercially, but they are not equally bioavailable. As a fat-soluble compound, coenzyme Q10 is poorly absorbed in water and follows the same pathway of intestinal absorption as other fats that are consumed." - Stephen T. Sinatra, M.D., The Sinatra Solution Metabolic Cardiology (Get the book.)

"Ubiquinol has a higher bioavailability compared to ubiquinone. Unpublished data. Kapoor D et al. Androgens, insulin resistance and vascular disease in men. Clin Endocrinol (Oxf) 2005 Sep; 63(3):239-50. Khan A et al. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care 2003 Dec; 26(12):3215-18. Kim MJ et al. Inhibitory effects of epicatechin on interleukin-1-beta-induced inducible nitric oxide synthase exptession in RINm5F cells and rat pancreatic islets by down-regulation of NF-kappaB activation. Biochem Pharmacol2004 Nov 1; 68(9): 1775-85. Kono S et al." - Steven V. Joyal, What Your Doctor May Not Tell You About Diabetes: An Innovative Program to Prevent, Treat, and Beat This Controllable Disease (Get the book.)

"In addition to their estrogenic activity, many of these plant compounds can interfere with steroid metabolism and bioavailability, and also modulate the activity of enzymes, such as tyrosine kinase and topoisomerase, which are crucial to the ability of cancer cells to proliferate and spread throughout the body. Although the researchers cautioned that more studies are necessary, the use of dietary milled flaxseed as a means of reducing risk of prostate cancer appears promising." - Freedom Press, Natural Cancer Cures: The Definitive Guide to Using Dietary Supplements to Fight and Prevent Cancer (Get the book.)

"Raj Chopra, develops the "Biosolv" process, allowing for greater bioavailability of supplemental CoQ10 in the body. 1997 CoQ10 hits textbooks of mainstream cardiology. 1997-2004 Continued research into role of CoQ10 in cardiovascular health and mitochondrial diseases. 2004 Canadian government places ubiquinone on statin labels as a precaution. 2005 Blood levels of CoQ10 much higher when taken twice daily compared to once-a-day dosing of same amount. 2006 Introduction of Ubiquinol QH?by Kaneka. Photograph of Raj Chopra, Stephen T. Sinatra, M.D., and Fred Crane, Ph.D." - Stephen T. Sinatra, M.D., The Sinatra Solution Metabolic Cardiology (Get the book.)

"We've seen no studies that suggest that tablets, capsules, liquid, and gel caps provide different levels of bioavailability. The chart on page 54 shows a sampling of what's available. And one important caveat: you don't need to pay more than about $50 a year for your vitamin D supplements (of course, the cost depends on the size of your D dose). For links to vitamin D retailers, go to www.thevitamindcure.com. Stay Away from Too Much Vitamin A When you're shopping for vitamin D, avoid supplements with vitamin A in them." - James Dowd and Diane Stafford, The Vitamin D Cure (Get the book.)

"The active principle of shilajit is fulvic acid, which improves the bioavailability of important trace minerals, and there is some feeling that it creates regeneration in the pancreatic cells. It is known as an adaptogen and should be taken mostly during the winter. COCCINIA INDICA Coccinia indica seems to have a blood glucose lowering effect that operates on the same mechanism as bitter melon.185'186 GINGKO BILOBA Gingko biloba has membrane-stabilizing flavones and anthocyanides, which seem to protect against retinopathy." - Gabriel Cousens, There Is a Cure for Diabetes: The Tree of Life 21-Day+ Program (Get the book.)

"The enzymes improved the bioavailability of both proteins and carbohydrates in the lumen of the small intestine, not only under impaired digestive conditions, but also in healthy human digestion. Glucose availability was increased fourfold in the "perfect" digestive system and by seven times in the impaired digestion model. Proteins were twice as bio-available in the impaired digestive process. The activity of any digestive enzyme supplement in the small intestine "presupposes that the enzymes survive the acidity of the stomach." - Tom Bohager, Everything You Need to Know About Enzymes to Treat Everything from Digestive Problems and Allergies to Migraines and Arthritis (Get the book.)

"Many supplements differ in price depending upon their bioavailability. Some products seem like a better deal, but your body may be able to absorb only a portion of the supplement. If melatonin never worked for you and/or you are having mela-tonin-deficient symptoms, you may want to ask a compounding pharmacist to make a dose of 0.1 mg and gradually increase the dose by 0.1 mg every two to three nights until your sleep is deep and restful." - Phuli Cohan, The Natural Hormone Makeover: 10 Steps to Rejuvenate Your Health and Rediscover Your Inner Glow (Get the book.)

"Breast milk has excellent bioavailability of zinc, although zinc content falls off after the first six months of breastfeeding. CHILD ZINC DEFICIENCY Infectious diarrhea results in the deaths of millions of children each year. Mild zinc deficiency can increase the susceptibility of children to infectious diarrhea. Unfortunately, diarrhea reduces zinc absorption, worsening the problem. Zinc supplementation can be added to oral rehydration therapy to significantly increase survival with persistent childhood diarrhea." - Dr. Steve Blake, Vitamins and Minerals Demystified (Get the book.)

"Dosage and Bioavailability Several studies have validated Astaxanthin's bioavailability. Many animal models have found Astaxanthin throughout the bodies of rodents while human studies measuring blood levels of Astaxanthin have proven that this carotenoid is absorbed by humans through oral consumption (Osterlie, et al, 2000 and Mercke, et al, 2003). But we have to look closely at a number of factors to understand the correct dosage level for humans." - Bob Capelli, ASTAXANTHIN: Natural Astaxanthin, King of the Carotenoids (Get the book.)

"The bioavailability of coenzyme Q]0 plays a major role in supplement activity. Hydrosoluble forms of coenzyme Ql0 are more highly absorbed than powder forms and contribute more significantly to elevated blood levels. (Adapted from Miles MV, etal. Nutrition Research, 2002;22:919-929.) the appropriate solubilization techniques. The following graphs (see Figure 4.5 below) summarize the results of these two clinical studies, and demonstrate the higher blood levels of Q-Gel over standard coenzyme Qio preparations over time." - Stephen T. Sinatra, M.D., The Sinatra Solution Metabolic Cardiology (Get the book.)

"Animal products have the highest levels of zinc and also have a high bioavailability; please refer to Graph 12-1." - Dr. Steve Blake, Vitamins and Minerals Demystified (Get the book.)

"Therefore, physicians employing CoQIO as a therapeutic supplement should determine bioavailability through blood testing. Regardless of the brand and form of CoQIO you use, the blood level is the bottom line. Our Recommendations We use the hydrosoluble CoQIO in our practices and take it ourselves. There are multiple brands widely available that use hydrosoluble technology. Look for Q-Gel somewhere on the label. The dosage recommendations listed below are for standard forms of CoQIO, not hydrosoluble." - Stephen Sinatra, M.D. and James C., M.D. Roberts, Reverse Heart Disease Now: Stop Deadly Cardiovascular Plaque Before It's Too Late (Get the book.) "At the time of the writing of this book, maximum bioavailability appears to be achieved by a hydrosoluble processing technology that enhances CoQIO absorption in both water and fat so that it is readily picked up in the bloodstream. Next best are oil-based soft-gel supplements in which the CoQIO is dissolved in an oil medium such as soybean. Recently, a dextrose compound called cyclodextrin has been complexed with CoQ 10 to improve the absorption of the powder-in-capsule supplements. Form is a principal consideration when reading the science or deciding which supplement to choose." - Stephen Sinatra, M.D. and James C., M.D. Roberts, Reverse Heart Disease Now: Stop Deadly Cardiovascular Plaque Before It's Too Late (Get the book.) "Since adequate blood levels and bioavailability of CoQIO are essential to treating very sick people, we offer some additional information designed to make your use of this remarkable supplement the most beneficial for you. The differences in CoQIO forms have created confusion not just among consumers and patients but among physicians as well. CoQIO Blood-Level Research After you swallow a pill, CoQIO travels the same pathway of intestinal absorption as other fats we consume." - Stephen Sinatra, M.D. and James C., M.D. Roberts, Reverse Heart Disease Now: Stop Deadly Cardiovascular Plaque Before It's Too Late (Get the book.) "Sinatra was involved as an investigator in two other studies comparing relative bioavailability of commercially available products, including an oil suspension in a soft-gel capsule, powder-filled capsule, tablet, and hydrosoluble soft-gel capsule (Q-Gel). Each of the studies involved twenty-four healthy adult volunteers. The hydrosolubilized form raised the CoQIO blood level the highest, reaching a therapeutic range above a desired 2.5 pg/ml level within three to four weeks. Further increases developed as time went on." - Stephen Sinatra, M.D. and James C., M.D. Roberts, Reverse Heart Disease Now: Stop Deadly Cardiovascular Plaque Before It's Too Late (Get the book.)

"The consumption of dairy products also reduces zinc bioavailability because of the zinc-binding action of casein and calcium. Zinc Supplements Zinc supplements are available in a number of forms. Zinc gluconate is readily absorbable. Zinc picolinate is also absorbable, but absorption may be offset by increased elimination. Zinc sulfate and zinc acetate are also available as supplements. Zinc Requirements The RDAs have been set for zinc at levels believed to prevent deficiency in most people, as seen in Table 12-1." - Dr. Steve Blake, Vitamins and Minerals Demystified (Get the book.)

"Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers. Regul Toxicol Pharmacol 2006 Aug 17. Hu FB et al. Dietary intake of alpha-linolenic acid and risk of fatal ischemic heart disease among women. Am J Clin Nutr 1999; 69:890-97. Hypponen E et al. Intake of vitamin D and risk of type 1 diabetes: A birth-cohort study. Lancet200\ Nov 3; 358(9292):1500-3. Imparl-Radosevich J et al. Regulation of PTP-1 and insulin receptor kinase by fractions from cinnamon: Implications for cinnamon regulation of insulin signaling." - Steven V. Joyal, What Your Doctor May Not Tell You About Diabetes: An Innovative Program to Prevent, Treat, and Beat This Controllable Disease (Get the book.)

"Obviously, you can't use detergent to "improve" the bioavailability of your drinking water. But you can use magnetics. Magnetizing your drinking water breaks its surface tension, making it wetter and more useable by your body. In addition, there's a strong secondary benefit. Applying a magnetic field to water raises its pH. This is of vital importance as we will see chapter 13. General Recommendations • You need to treat the water that comes into your house to remove the chlorine, fluoride, chemical residues, heavy metals, bacteria, parasites, etc. in your water." - Jon Barron, Lessons from The Miracle Doctors: A Step-by-Step Guide to Optimum Health and Relief from Catastrophic Illness (Get the book.)

"Of course these results were in the laboratory: The author of the study urged caution in applying these results to humans because the bioavailability of the vitamin C would depend on a host of factors. But the finding is yet another compelling argument for the value of adding tea to your diet. Orange Power Oranges have long been one of the favorite SuperFoods. They're sweet and delicious, low in calories, high in fiber, and great traveling companions because they don't have to be washed before eating." - Wendy Bazilian, DRPH, MA, RD, Steven Pratt, MD, Kathy Matthews, Superfoods Rx Diet: Lose Weight with the Power of SuperNutrients (Get the book.)

"Manners GD at al. bioavailability of citrus limonoids in humans.} Agric Food Chem. 2003 Iul2;51(14):4156-4161. Pattison DJ, Silman AJ, Goodson NJ, Lunt M, Bunn D, Luben R, Welch A, Bingham S, Poulose SM, Harris ED, Patil BS. Citrus limonoids induce apoptosis in human neuroblastoma cells and have radical scavenging activity. /Nutr. 2005 Apr;135(4): 870-877. Sun J, Chu YF, Wu X, Liu RH. Antioxidant and antiproliferative activities of common fruits. J Agric Food Chem. 2002 Dec 4;50(25):7449-7454. Limes www.fruitsandveggiesmatter.gov Gharagozloo M, Ghaderi A." - David W. Grotto, RD, LDN, 101 Foods That Could Save Your Life! (Get the book.) "BONE DENSITY: Whey protein enhances the bioavailability (absorption) of calcium and is helpful in the prevention of osteoporosis. IMMUNE ENHANCEMENT: Whey enhances a powerful cell protector called glutathione which neutralizes the harmful effects of free radicals. HYPERTENSION: The whey portion of dairy products may be the beneficial part in controlling blood pressure. Studies show that low-fat dairy products are an essential part of a widely accepted optimal diet for lowering blood pressure called the Dietary Approaches to Stop Hypertension, or "DASH" diet for short." - David W. Grotto, RD, LDN, 101 Foods That Could Save Your Life! (Get the book.)

"What you must know to maximize the bioavailability of nutrients in your food... •Iron. This mineral is critical for brain function and helps your immune system operate normally by increasing your resistance to stress and disease. Iron can help you avoid symptoms of fatigue, weakness and irritability. Plant foods are rarely a good source of iron. For example, although spinach is a good source of magnesium, bone-building vitamin K and other important nutrients, the fiber and plant chemicals in the spinach leaf bind to iron, inhibiting the mineral's bioavailability." - Bottom Line Health, Bottom Line's Health Breakthroughs 2007 (Get the book.)

"Factors affecting the bioavailability of soy isoflavones in humans after ingestion of physiologically relevant levels from different soy foods. J. Nutr. 136, 45-51. 60. Karr, S., Lampe, J., Hutchins, A., and Slavin, J. (1997). Urinary isoflavonoid excretion in humans is dose dependent at low to moderate levels of soy-protein consumption. Am. J. Clin. Nutr. 66, 46-51. 61. Atkinson, C, Berman, S., Humbert, O., and Lampe, J. W. (2004). In vitro incubation of human feces with daidzein and antibiotics suggests interindividual differences in the bacteria responsible for equol production. J. Nutr." - Ann M. Coulston and Carol J. Boushey, Nutrition in the Prevention and Treatment of Disease (Get the book.) "To reflect newer information on bioavailability, the RDAs for two nutrients are in different forms than were used in the past: folate is in meg of dietary folate equivalents (DFE) rather than total meg, whereas vitamin E is in mg of a-tocopherol rather than in mg of a-tocopherol equivalents. For folate, the new DFE unit reflects an increased availability of fortification and supplemental forms of folate and thus will tend to increase estimated intakes of this nutrient. The situation is reversed for vitamin E." - Ann M. Coulston and Carol J. Boushey, Nutrition in the Prevention and Treatment of Disease (Get the book.) "The consistency of this relationship across diverse groups and involving various concurrent diet manipulations (with differences in amounts of dietary factors that could alter carotenoid bioavailability) is notable, although considerable interindividual variation in the degree of response is typically observed. Also, nondietary factors that are among the determinants of plasma carotenoid concentrations (e.g." - Ann M. Coulston and Carol J. Boushey, Nutrition in the Prevention and Treatment of Disease (Get the book.)

"These findings are interesting, given the extremely poor bioavailability of theaflavins, and may suggest that the theaflavins are metabolized to a more-bioavailable active metabolite. The membrane protective effects of the phenolics determined by LDH release and trypan blue exclusion assays demonstrated that epicatechin, catechin, and their mixture protect cellular membrane from (3-amyloid-induced cytotoxicity." - Erich Grotewold, The Science of Flavonoids (Get the book.)

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