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Quotes about Alloxan from the world's top natural health / natural living authors

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"The Textbook of Natural Medicine calls alloxan a "potent beta cell toxin." It is unfortunate that the FDA still allows companies to use it to process foods we eat. Research also shows that we are able to reverse the effects of alloxan with vitamin E. According to Dr. Gary Null's Clinicians' Handbook of Natural Healing, vitamin E effectively protected lab rats from the harmful effects of administered alloxan. In support of that, researchers have found that among rats that are genetically susceptible to IDDM, feeding wheat gluten will cause 40 percent of the subjects to develop IDDM." - Gabriel Cousens, There Is a Cure for Diabetes: The Tree of Life 21-Day+ Program (Get the book.)

"In animal models of type 1 diabetes, beta cells are destroyed by administering compounds that generate free radicals (such as nitrosamines and alloxan, a drug often used to create diabetes in experimental animals because of its free-radical-damaging effects on beta cells). Recently, researchers decided to see what would happen if they gave the animals fish oil before receiving the diabetes-inducing drug alloxan. They discovered that the fish oils prevented chemically induced type 1 diabetes." - Michael T. Murray, Beat Diabetes Naturally: The Best Foods, Herbs, Supplements, and Lifestyle Strategies to Optimize Your Diabetes Care (Get the book.)

"Unfortunately, most consumers are unaware of alloxan and its potentially fatal link to diabetes because these facts are not well publicized, are hidden by FDA approval, and certainly doctors and the food industry are not informing parents that they and their children are being poisoned by white flour containing alloxan. Diabetes and Chemical Poisoning. Source: (http://imva.info/) 27 Consumer Reports (Feb. 2006): 28 Genetically Engineered Food Biotech, Biotechnology, GMO, Genetically Modified (www.organicconsumers.org/gelink.html) 29 Health Hazards of Genetically Manipulated Foods; www." - Mark Sircus, Transdermal Magnesium Therapy (Get the book.)

"Gary Null's Clinicians' Handbook of Natural Healing, vitamin E effectively protected lab rats from the harmful effects of administered alloxan. In support of that, researchers have found that among rats that are genetically susceptible to IDDM, feeding wheat gluten will cause 40 percent of the subjects to develop IDDM. Several other groups of rats with the same genetic inclination to develop IDDM were fed gluten-free diets, and only 10-15 percent developed IDDM. Further, the rate and severity of diabetes could be manipulated by varying the amount of gluten in the diet." - Gabriel Cousens, There Is a Cure for Diabetes: The Tree of Life 21-Day+ Program (Get the book.) "There is a food environment characterized by heavy marketing of excitotoxin-rich processed junk foods, refined carbohydrates such as white sugar and white flour with alloxan, heavy use of animal fats and trans fats, agrochemical-laden foods, and heavy-metal toxicity. These characteristics combine to result in a negative synergy that has precipitated diabetes at pandemic levels, when it was relatively rare before 1940. This is not an accident—the Culture of Death is an active and thoughtless Crime Against Wisdom." - Gabriel Cousens, There Is a Cure for Diabetes: The Tree of Life 21-Day+ Program (Get the book.)

"It is known, for example, that many chemicals—including alloxan, paraquat, and certain chemotherapeutic agents60—can stimulate excessive production of oxy radicals in the nuclei of beta cells. It is also recognized that higher levels of circulating lipid peroxide correlate with worse symptoms of diabetes61—indicating that free radicals are at work. Also, as we will see in the next chapter, anti-oxidants have been shown to ease the symptoms of diabetes. Cataracts. Ultraviolet radiation in sunlight causes free radical activity which damages the eye's lens." - Hari Sharma, Freedom from Disease: How to Control Free Radicals, a Major Cause of Aging and Disease (Get the book.)

"Kumari K, Augusti KT, Antidiabetic effects of S-methylcystein sulphoxide on alloxan diabetes. In: PM 61(l):72-74. 1995. Kupidlowska E, Bieniak B, Ruchirawat A, Zobel AM. Influence of methyl derivatives of coumarin on mitotic activity and ultrastructure of meristemic cells of Allium cepa root tips. Phytomedicine 2 (3); 275-281. 1996 Lancaster JE, Shaw ML. Gamma-Glutamyl Peptides in the Biosynthesis of S-Alk(en)yl-L-Cysteine Sulphoxides (Flavour Precursors) in Allium. Phytochemistry 28; 455-460. 1989 Paradiz J. Assessement of damage to irridated onion (Allium cepa L.) by cytogenic analyses." - Thomson Healthcare, Inc., PDR for Herbal Medicines, Fourth Edition (Get the book.) "Hypoglycemic Effects: Oral administration of an infusion or decoction of olive leaf exerted a hypoglycemic effect in normoglycemic rats and in animals made diabetic with alloxan (Gonzalez et al. 1992). In another experimental model of diabetes, induced by streptozotocin, olive leaf failed to lower blood glucose levels or prevent glucosuria and ketonu-ria, but it did reduce circulating levels of liver enzymes and minimized histopathologic abnormalities in both the kidneys and liver (Onderoglu et al, 1999)." - Thomson Healthcare, Inc., PDR for Herbal Medicines, Fourth Edition (Get the book.) "Pharmacological sequential trials for the fractionation of components with hypoglycemic activity in alloxan diabetic mice from Ginseng radix. J Pharm Dyn; 4:402-409. 1981. Kitigawa I, Yaligali Zasshi 103:612. 1983. Kobayashi S et al. Inhibitory actions of phospholipase A(2) and saponins including ginsenoside R(bl) and glycyrrhizin on the formation of nicotinic acetylcholine receptor clusters on cultured mouse myotubes. Phytother Res; 4:106-111. 1990. Konno C, Murakami M, Oshima Y et al. Isolation and hypoglycemic activity of panaxans Q, R, S, T, and U, glycans of Panax ginseng roots." - Thomson Healthcare, Inc., PDR for Herbal Medicines, Fourth Edition (Get the book.)

"Kumari K, Augusti KT, Antidiabetic effects of S-methylcystein sulphoxide on alloxan diabetes. In: PM 61(l):72-74. 1995. Liakopoulou-Kyriakides M et al., (1985) Phytochemistry 24: 600 and 1593. Maugh TH, (1979) Science 204:293. Spare CG, Virtanen Al, (1963) Acta Chem Scand 17:641. Tverskoy L, Dmetriev A, Kozlovsky A, Grodzinsky D, Two phytoalexins from Allium-cepa bulbs. In: PH 30:799. 1991. Vollhardt BR, Zwiebelolmazerat (z.B. Alligerol). In: Intern Praxis 32(1):201. 1992. Wagner H, Bayer Th, Dorsch W, Das antiasthmatische Wirkprfnzip der Zwiebel (Allium cepa L.). In: ZPT 9(6): 165. 1988." - Joerg Gruenwald, Ph.D., PDR for Herbal Medicines (Get the book.)

"In another study utilizing alloxan diabetic rabbits and one human patient, gymnema brought down the fasting blood glucose levels, together with serum cholesterol and triglyceride levels, while improving serum protein levels. The hypoglycemic action took several weeks to develop. Oral administration in normal rats apparently has no significant effect, but only in rats made hyperglycemic experimentally (alloxan, anterior pituitary-treated, tolbutamide, adrenaline)." - Michael Friedman, ND, Fundamentals of Naturopathic Endocrinology (Get the book.)

"Recently, researchers decided to see what would happen if they gave the animals fish oil before receiving the diabetes-inducing drug alloxan. They discovered that the fish oils prevented chemically induced type 1 diabetes. The mechanisms responsible for this effect are related to improved cell membrane function leading to enhanced antioxidant status and suppression of the formation of inflammatory compounds known as cytokines.24 Nitrates Clear links between increased levels of nitrate from dietary sources and water and an increased risk for type 1 diabetes has been established." - Michael T. Murray, Beat Diabetes Naturally: The Best Foods, Herbs, Supplements, and Lifestyle Strategies to Optimize Your Diabetes Care (Get the book.)

"Alloxan induces irreversible diabetes mellitus after 24 hours following its administration and the condition proves to be chronic by laboratory tests after seven days. Experimental Model of Induction of Diabetes Mellitus in Rats; Acta Cir. Bras, vol.18 no.spe S o Paulo 2003 (www.scielo.br/ scielo.php?pid=S0102-86502003001100009&script=sci_arttext&tlng=en) 26 Researchers who are studying diabetes commonly use the chemical to induce the disorder in lab animals." - Mark Sircus, Transdermal Magnesium Therapy (Get the book.)

"Rabbits induced with diabetes with alloxan showed the same results. In tests in humans with both Type I and Type II diabetes, Gymnema was shown to be effective. Gymnema extract was able to reduce blood glucose, glycated hemoglobin, glycosylated plasma proteins, increased C-peptide levels, and conventional diabetic drug therapy.These effects are not noted with standard conventional therapy. All patients developed secondary hypoglycemic symptoms and had to have their drug dosages reduced after several weeks." - Robert Redfern, The Miracle Enzyme Is Serrapeptase (Get the book.)

"Gymnema Sylvestre (GS) Animal experiments have shown that animals which have their Beta cells destroyed by alloxan are able to regenerate Beta cells after a few months when taking GS, a herb grown in India. The Beta cell is the cell that produces insulin. Diabetics needing insulin treatment (Type 1) have been able to decrease their insulin after GS therapy. Antibetic: This compound contains 10 herbs including GS, all of which have been tested and found to exhibit a lowering of the blood sugar. Antibetic has brought about a fall in blood sugar in many patients." - James A. Howenstine, A Physician's Guide to Natural Health Products That Work (Get the book.)

"The experimental severity of the disease can be increased or decreased by varying the dose of alloxan. Glycans from the mushroom Ganoderma lucidum produce significant hypoglycemia in alloxan-induced diabetes in animals. They appear to operate through a unique mechanism, probably affecting glycogen or glucose metabolism.141 Ganoderan B, one of these glycans, has been shown to elevate plasma insulin levels and increase the activities of hepatic glucokinase, phosphofruc-tokinase, and glucose-6 phosphate dehydrogenase." - David Hoffman, FNIMH, AHG, Medical Herbalism: The Science Principles and Practices Of Herbal Medicine (Get the book.)

"Results found both plants taken as a powder had significant hypoglycemic effects in rabbits other than those treated with alloxan. —M.S. Akhtar, et al., "Effects of Portulaca Oleracae (Kulfa) and Taraxacum Offinale (Dhud-hal) in Normoglycaemic and Alloxan-Treated Hyperglycaemic Rabbits," J.P.M.A., 35, July 1985. General This extensive review articlenotes numerous clinical studies supporting the use of Dandelion in treating conditions including liver problems, hepatitis, gallstones, kidney trouble, and weight loss." - Gary Null, Ph.D., The Clinician's Handbook of Natural Healing (Get the book.)

"One of the substances added during the bleaching process is alloxan, which destroys the beta cells of the insulin-producing pancreas. After bleaching, white flour often has dough conditioners added that reduce the need for kneading. White flour can remain in the grocery store at room temperature almost indefinitely without becoming rancid, a boon for retailers but not for consumers. This fake food, with little or negative nutritional value, is an integral part of more than 90 percent of the baked products sold." - Dianne Onstad, Whole Foods Companion: A Guide For Adventurous Cooks, Curious Shoppers, and lovers of natural foods (Get the book.)

"Kimura M, et al: Pharmacological sequential trials for the fractionation of components with hypoglycemic activity in alloxan diabetic mice from ginseng radix. / Pharm Dyn 4, 402-409,1981. 32. Kimura M, et al: Effects of hypoglycemic components in ginseng radix on blood insulin level in alloxan diabetic mice and on insulin release from perfused rat pancreas. / Pharm Dyn 4, 410-417,1981. 33. Yamamoto M and Uemura T: Endocrinological and metabolic actions of P. ginseng principles. Proceeding 3rd International Ginseng Symposium, 1980, Korean Ginseng Research Institute, pp. 115-119. 34." - Michael T. Murray, N.D., The Healing Power of Herbs: The Enlightened Person's Guide to the Wonders of Medicinal Plants (Get the book.)

"Hypoglycaemic and anti-hyperglycaemic effects of Trigonella foenum-graecum leaf in normal and alloxan induced diabetic rats, Journal of Ethnopharmacology, 58: 149-155. 9. Okabayashi, Y., Taui, S., Fijisaiwa, T, Koide, M., Hasegawa, H., Nakamusa, T, Fujii, M., and Otsuki, M., 1990, Effect of Gymnema sylvestre on glucose homeostasis in rats, Diabetes Research Clinic Practice, 9: 143. 10. Chandalia, M., Garg, A., Lutjohan, D., el al., 2000. Beneficial effects of high dietary fibre in patients with type 2 diabetes niellitus, New England Journal of Medicine, 342: 1392-1398. 11. Yongchaiyuda, S." - Amarjit S. Basra, Handbook of Medicinal Plants (Get the book.) "HYPOGLYCEMIC ACTIVITY Many natural drugs are used in traditional medicine as antidiabetics, and several active compounds have been identified by in vivo bioassay using experimental diabetic animals induced by alloxan or streptozotocin (STZ) or by using the oral sucrose tolerance test (an animal model of insulin-dependent diabetes mellitus) and by in vitro bioassay testing glucose transport activity. Prevention of hyperglycemia and hyperinsulinemia by retardation of glucose uptake by the small intestine is one successful approach to improving insulin resistance in diabetes mellitus." - Amarjit S. Basra, Handbook of Medicinal Plants (Get the book.)

"Momordica charantia (bitter gourd or melon) Nelumbo nucifera (sacred lotus) Opuntia ficus-indica (prickly pear) Panax ginseng (ginseng) Psidium gujava (guava) Syzygium cumini (jambul) Trigonella foenum-graecum (fenugreek) Vernonia amygdalina (bitter leaf) Testing of plants for hypoglycemic properties is based on inducing diabetes in animals with toxins (such as alloxan) and evaluating the hypoglycemia or glucose tolerance produced by a plant extract compared with that of a standard, such as tolbutamide. alloxan causes selective necrosis of the pancreatic islet P cells." - David Hoffman, FNIMH, AHG, Medical Herbalism: The Science Principles and Practices Of Herbal Medicine (Get the book.)

"Lipid membrane peroxidation turns Lipids into aldehydes, lipofusc in, andperoxidesto T-cell failure,herpes,cancer,atherosclerosis, emphysema, infectious disease, osteoporosis, and diabetes (from oxy-radical damage in pancreas Beta-cells from chemicals alloxan, paraquat, and chemotherapy chemicals). Free radicalscauseprogeria/extremelyrapidaging before puberty, from lack of free radical-scavenging Enzymes (controlled with Horseradish enzyme Peroxidase). The Major Histocompatibility Complex (MHC) regulates the SOD and Glutathione-Peroxidase radical response team." - Joseph E. Mario, Anti-Aging Manual: The Encyclopedia of Natural Health (Get the book.)

"Momordica charantia (bitter gourd or melon) Nelumbo nucifera (sacred lotus) Opuntia ficus-indica (prickly pear) Panax ginseng (ginseng) Psidium gujava (guava) Syzygium cumini (jambul) Trigonella foenum-graecum (fenugreek) Vernonia amygdalina (bitter leaf) Testing of plants for hypoglycemic properties is based on inducing diabetes in animals with toxins (such as alloxan) and evaluating the hypoglycemia or glucose tolerance produced by a plant extract compared with that of a standard, such as tolbutamide. alloxan causes selective necrosis of the pancreatic islet P cells." - David Hoffman, FNIMH, AHG, Medical Herbalism: The Science Principles and Practices Of Herbal Medicine (Get the book.)

"Among the effects demonstrated by animal experimentation are the following: CNS-stimulating effects; protective effects against various harmful agents such as ionizing radiation, infections, and toxins (lead salts, alloxan); protection from exhausting physical and psychological stresses; effects on carbohydrate and lipid metabolism and on RNA and protein biosynthesis; and immune-stimulating effects. It is difficult to draw any inferences from these studies regarding the efficacy of ginseng in humans." - volker schulz and Rudolf Hansel, Rational Phytotherapy: A Reference Guide for Physicians and Pharmacists (Get the book.) "Mathew PT, Augusti KT (1973) Studies of the effect of allicin (diallyl disulphide-oxide) on alloxan diabetes: Part I - Hypopglycaemic action & enhancement of serum insulin effect 8c glycogen synthesis. Indian J Biochem Biophys 10: 209-212. McCrindle BW, Helden E, Conner WT (1998) Garlic extract therapy in children with hypercholesterolemia. Arch Pediatr Adolesc Med 152:1089-1094. Nakagawa S, Masamoto K, Sumiyoshi H, Harada H (1984) Acute toxicity test of garlic extract. J Toxicol Sci 9: 57-60. Neil A, Silagy C (1994) Garlic: its cardio-protective properties. Curr Opinion Lipid 5: 6-10." - volker schulz and Rudolf Hansel, Rational Phytotherapy: A Reference Guide for Physicians and Pharmacists (Get the book.)

"Pharmacological sequential trials for the fractionation of components with hypoglycemic activity in alloxan diabetic mice from ginseng radix. J Pharm Dyn 1981; 4: 402-409 32. Kimura M, Waki I, Tanaka O et al. Effects of hypoglycemic components in ginseng radix on blood insulin level in alloxan diabetic mice and on insulin release from perfused rat pancreas. J Pharm Dyn 1981; 4: 410-117 33. Yamamoto M, Uemura T. Endocrinological and metabolic actions of P. ginseng principles. Proceeding 3rd International Ginseng Symposium. Seoul: Korean Ginseng Research Institute. 1980: p 115-119 34." - Michael T. Murray, ND, Textbook of Natural Medicine 2nd Edition Volume 1 (Get the book.)

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