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NaturalPedia > Concepts > Trials
Quotes about Trials from the world's top natural health / natural living authors
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"So far, results from the human trials have been consistent with the animal trials and with other studies conducted in countries such as China. Widespread acceptance of ECT could provide cancer patients with a less invasive alternative to surgery, radiation and chemotherapy treatments, potentially at a lower cost and with fewer side effects. For information on ECT clinical trials, call:
• City of Hope National Medical Center, 626-359-8111." - Bottom Line Books, Uncommon Cures For Everyday Ailments (Get the book.)
| "These results are not atypical; Prozac had to go through ten clinical trials in order to accomplish four trials with a marginally better cure rate than a placebo.19 Two trials is what the Food and Drug Administration requires for proof of efficacy; currently drug companies can conduct many trials before they can produce two that show that their drug is marginally more effective than a placebo." - Dawson Church, The Genie in Your Genes: Epigenetic Medicine and the New Biology of Intention (Get the book.)
| "Mosholder found evidence of increased risk of suicidal thoughts principally upon a review of twenty-two pediatric trials, involving 4,250 children.137 He found "74 of the 2298 children taking antidepressants had a 'suicide related event' compared with 34 of the 1952 children taking placebos."138 Over one hundred events occurred in the trials that were labeled by the drug company sponsors as "possibly suicide-related," ranging from hanging and overdose to cutting and slapping. Forty-seven patients were hospitalized; none completed a suicide attempt." - Jonathan W. Emord, The Rise of Tyranny (Get the book.)
| "CARDIOVASCULAR DISEASE: Over fifty trials, including human intervention trials, have shown that consumption of soy products improves cholesterol ratios, and reduces total cholesterol and LDL cholesterol, especially in individuals with elevated cholesterol.
Tips on Using Soy
SELECTION AND STORAGE:
• Dried soybeans can be purchased in prepackaged containers and bulk bins.
• Edamame can be purchased frozen or precooked. Edamame should be deep green and firm with no bruised pods. Fresh edamame may be available seasonally in natural food and specialty markets." - David W. Grotto, RD, LDN, 101 Foods That Could Save Your Life! (Get the book.)
| "Analyzing the combined results of fifteen clinical trials that used inert tablets as placebo controls, Beecher determined that the effect of these placebos was profound: on average, placebos affected about a third of patients in the placebo group (though there was great variability across the trials), and in certain instances produced "gross physical change[s]" that could "exceed those attributable to potent pharmacological action."68
Recognizing that placebo effects were powerful, however, was not the same thing as saying they were therapeutically useful." - Anne Harrington, The Cure Within: A History of Mind-Body Medicine (Get the book.)
| "CARDIOVASCULAR DISEASE: Over fifty trials, including human intervention trials, have shown that consumption of soy products improves cholesterol ratios, and reduces total cholesterol and LDL cholesterol, especially in individuals with elevated cholesterol.
Tips on Using Soy
SELECTION AND STORAGE:
• Dried soybeans can be purchased in prepackaged containers and bulk bins.
• Edamame can be purchased frozen or precooked. Edamame should be deep green and firm with no bruised pods. Fresh edamame may be available seasonally in natural food and specialty markets." - David W. Grotto, RD, LDN, 101 Foods That Could Save Your Life! (Get the book.)
| "Five of five trials showed successful treatment of hay fever.
• Five of seven trials showed faster recovery of bowel function after abdominal surgery.
• Four of six trials showed improvement in rheumatological disease.
• Eighteen of twenty trials found positive results in treating pain or trauma.
• Eight of ten trials showed positive results with mental or psychological problems." - William Collinge, The American Holistic Health Association Complete Guide to Alternative Medicine (Get the book.)
| "People who show negative results are eliminated from the trials so their results don't show up in the study. Some of the data are outright falsified, and in fact, the people running these clinical trials know if they don't produce positive results, they probably won't get any other contract work in the pharmaceutical industry at all. So, these trials are scientific fraud, and yet the mainstream media reports on them as if they are scientific fact, and in doing so, the media propagates all of these myths and perpetuates brain spam." - Mike Adams, Spam Filters for Your Brain (Get the book.)
| "Some managed care plans actually refuse to allow patients to participate in clinical trials because they fear complications from the trials.
• Health Care Fairs
u.
sed to be, the only way to keep up with what was truly going on in the business of natural healing was to ask your holistic healer or an MD interested in holistic healing about what he or she learned at the last alternative medicine convention." - Bottom Line Books, Uncommon Cures For Everyday Ailments (Get the book.)
| "This was the first time that blind, controlled trials were used in psychiatric research history, a design adopted on the advice of Dr Bud Fisher, a member of the Canadian Department of Health. The first two trials studied the benefits of a yeast nucleotide preparation in the treatment of schizophrenia. Results were negative. The remaining six focused on vitamin B-3, both niacin and niacinamide. These trials were followed by one double-blind confirmatory report by J.R. Wittenborn3 and many other reports in the clinical literature." - Dr. Abram Hoffer, MD, FRCP (C) and Dr. Harold D. Foster, PhD, Feel Better, Live Longer with Vitamin B-3 (Get the book.)
| "Over one hundred events occurred in the trials that were labeled by the drug company sponsors as "possibly suicide-related," ranging from hanging and overdose to cutting and slapping. Forty-seven patients were hospitalized; none completed a suicide attempt. Mosholder additionally found that only 3 in 15 pediatric depression trials included sufficient evidence of efficacy, raising the question of whether any of these drugs were effective in children." - Jonathan W. Emord, The Rise of Tyranny (Get the book.)
| "After the first studies, which were just case reports, showed remarkable rates of recovery for anorexics and bulimics, we started to do control trials. One of the first was to see whether in fact there was a difference in taste perception between those who are deficient in zinc and those who are not. We wrote a paper that was presented at the American College of Nutrition in 1986 and published in Nutrients and Brain Function in 1987, demonstrating that in fact patients who have zinc deficiency are unable to taste the zinc solution." - Gary Null and Amy McDonald, The Food-Mood Connection: Nutrition-based and Environmental Approaches to Mental Health and Physical Wellbeing (Get the book.)
| "One drug company, GlaxoSmithKline, started trials on a H5N1 vaccine in the spring of 2006 in Germany and Belgium using an adjuvant to enhance its effect. Adjuvant technology means a lower amount of vaccine is needed per dose. That might increase the number of doses available. The vaccine still has to be effective and safe, however. Initial results from the trials, designed to test safety and measure immune response, are expected by the flu season of 2006-2007.
There's another concern." - J. E. Williams, Beating the Flu: The Natural Prescription for Surviving Pandemic Influenza and Bird Flu (Get the book.)
| "Clinical trials have demonstrated the benefits. "PS was able to turn back the clock on memory loss by 12 years," Dr. Kidd says. "That is, in matching up names and faces. People were testing at about 64 years of age and at the end of the trial, they were testing 52 years of age. So it actually turned back the clock on a measurable aspect of memory loss. It can also benefit persons who have motor problems and tremors as well as hallucinatory dysfunction. It seems to be very good for mood as well." - Gary Null and Amy McDonald, The Food-Mood Connection: Nutrition-based and Environmental Approaches to Mental Health and Physical Wellbeing (Get the book.)
"Depression_
A Meta-Analytic Review of Double-Blind, Placebo-Controlled trials of Antidepressant Efficacy of Omega-3 Fatty Acids. Lin PY; Su KP. Journal of Clinical Psychiatry, 2007 July, 68(7):1056-1061.
In their review of recent literature, the authors determined that omega-3 polyunsaturated fatty acids (PUFAs) can significantly improve depression in patients with clearly defined depression and bipolar disorder.
Effects of Omega-3 Polyunsaturated Fatty Acids on Depression. Severus WE. Herz, 2006 December, 31 (Suppl. 3):69-74."
- Gary Null and Amy McDonald, The Food-Mood Connection: Nutrition-based and Environmental Approaches to Mental Health and Physical Wellbeing (Get the book.)
| "Two trials is what the Food and Drug Administration requires for proof of efficacy; currently drug companies can conduct many trials before they can produce two that show that their drug is marginally more effective than a placebo.
Modern surgery is amazing—yet sometimes unnecessary
The many studies that fail to show that the drug is helpful are called "file drawer studies," because they're quietly filed in dusty corners and never submitted to the FDA or medical journals—though Kristol was able to obtain them to include in his meta-analysis." - Dawson Church, The Genie in Your Genes: Epigenetic Medicine and the New Biology of Intention (Get the book.)
| "Included are assessments of essential fatty acids, the niacin flush test and treatment trials using supplementation with eicos-apentaenoic acid.
Supplementation with a Combination of Omega-3 Fatty Acids and Antioxidants (Vitamins E and C) Improves the Outcome of Schizophrenia. Arvindakshan M; Ghate M; et al. Schizophrenia Research, 2003 August 1, 62(3):195-204.
Oral supplementation with a mixture of eicosapentaenoic acid (EPA)/docosa-hexaenoic acid (DHA) and antioxidants (vitamin E/C) over a four-month period proved beneficial to schizophrenic patients." - Gary Null and Amy McDonald, The Food-Mood Connection: Nutrition-based and Environmental Approaches to Mental Health and Physical Wellbeing (Get the book.)
| "The US National Research Council also concluded that the REG trials could not be explained by chance.28
An effect size is a figure which reflects the actual size of change or outcome in a study. It is arrived at by factoring in such variables as the number of participants and the length of the test. In some drug studies, it is arrived at by dividing the number of people who have had a positive effect from the drug by the total number of participants in the trial. The overall effect size of the PEAR database was 0.2 per hour.20 Usually an effect size between 0.0 to 0.3 is considered small, a 0." - Lynne Mctaggart, The Field - The Quest for the Secret Force of the Universe (Get the book.)
| "Or how many oncologists stand up for their cancer patients and protect
4 Confirmation of deficient mismatch repair (dMMR) as a predictive marker for lack of benefit from 5-FU based chemotherapy in stage II and III colon cancer (CC): a pooled molecular reanalysis of randomized chemotherapy trials. (D. J. Sargent, S. Marsoni, S. N. Thibodeau, et al. them against chemotherapy treatment which they know can cause them to die far more quickly than if they received no treatment at all?" - Andreas Moritz, Cancer Is Not A Disease - It's A Survival Mechanism (Get the book.)
| "One set of trials involved a fascinating phenomenon called scopolamine amnesia. It seems that if you administer a chemical called scopolamine (by injection or by mouth) to people, they will very quickly experience near-total amnesia. They just forget everything. It's remarkable—all information skills, including memory, attention, and learning, just seem to disappear. The chemical is harmless, the effect is only temporary, and it wears off in a few hours, but it allows researchers to do all sorts of clever studies." - Jonny Bowden, Ph.D., C.N.S., The Most Effective Natural Cures on Earth: The Surprising, Unbiased Truth about What Treatments Work and Why (Get the book.)
| "Along with trials evaluating the health benefits of available cancer screening modalities," the authors conclude, "investigations into potential undesirable consequences of cancer screening are also warranted."31
Iatrogenesis is an issue. It is a mistake to assume the safety of a procedure, especially if it is even minimally invasive.32 Any and all screening that uses radiation increases the patient's risk of cancer.33 The 1996 Task Force admits that radiation probably contributed to "a small number" of new cases of cancer." - Gerald E. Markle and Frances B. McCrea, What If Medicine Disappeared? (Get the book.)
"One meta-analysis, which included more than 47,000 subjects from five major outcome trials since 2002, concluded that statins reduced major coronary events by 27%, stroke by 18% and all-cause morality by 15%. Benefits accrued to both men and women, those with and without high blood pressure, diabetics and nondiabetics, and particularly for smokers.19
An editorial in the New England Journal of Medicine asserted that statins are effective in the treatment of stable coronary heart disease."
- Gerald E. Markle and Frances B. McCrea, What If Medicine Disappeared? (Get the book.)
"Therefore, statins have not been shown to provide an overall health benefit in primary prevention trials."14
Thus, we arrive at two conclusions about statins and primary prevention: they have some small affect on morbidity (illness), but none on mortality.
There is one more issue. For any benefit, there also may be a corresponding risk.
Most experts claim that statins are remarkably safe, even over long periods of time; few side effects are noted. Yet one British study warns that "absolute safety of statins has not been demonstrated for patients at low risk of coronary heart disease."
- Gerald E. Markle and Frances B. McCrea, What If Medicine Disappeared? (Get the book.)
| "And it was conducted by a doctor who has been accused of fraud in other trials."
In addition, "None of the studies lasted for more than 6 weeks, and patients frequently rated Prozac as no better than placebo. There are millions of people taking this drug, trusting that clinical trials proved its safety, its efficacy, and long-term benefit, yet there is apparently no such data."
Another important issue that the Breggins pointed out is that:
None of the patients who participated in the Prozac studies were suffering from severe depression." - Dr. David W. Tanton; Ph.D., A Drug-Free Approach To Healthcare, Revised Edition (Get the book.)
| "In a study published in a recent issue of The British Journal of Urology International, researchers from the University of Chicago reviewed the results of nearly 20 trials that tested Permixon, a commercial extract of saw palmetto. The results were overwhelmingly positive, including improved urine flow; reduction of urinary urgency and pain; improved emptying of the bladder; reduction in size of the prostate gland after two years; and significant improvement in quality of life." - Andreas Moritz, Cancer Is Not A Disease - It's A Survival Mechanism (Get the book.)
| "However, to achieve the blood pressure reduction goal in all these trials, the patient was not on a simple, gentle regimen. To the contrary, these patients were taking on average three antihypertensive agents, each agent with its set of problems.
For patients with type 2 diabetes and hypertension, given the trade-offs and uncertainties, the decision to treat or not to treat with hypoglycemic agents is easier. The decision to treat with multiple antihypertensive drugs is challenging; it requires a dialogue." - Nortin M. Hadler MD, Worried Sick: A Prescription for Health in an Overtreated America (Get the book.)
| "Later in the 1990s," according to David Healy, "it became clear that a large number of trials with less favorable results for the SSRIs were simply not reported by the sponsors, the pharmaceutical companies."31
One important and different kind of meta-analysis used the Freedom of Information Act to obtain FDA reviews of every clinical trial—published or unpublished—of SSRIs between 1987 and 1999. On average, placebos were 80% as effective as the SSRIs." - Gerald E. Markle and Frances B. McCrea, What If Medicine Disappeared? (Get the book.)
| "Two trials is what the Food and Drug Administration requires for proof of efficacy; currently drug companies can conduct many trials before they can produce two that show that their drug is marginally more effective than a placebo.
Modern surgery is amazing—yet sometimes unnecessary
The many studies that fail to show that the drug is helpful are called "file drawer studies," because they're quietly filed in dusty corners and never submitted to the FDA or medical journals—though Kristol was able to obtain them to include in his meta-analysis." - Dawson Church, The Genie in Your Genes: Epigenetic Medicine and the New Biology of Intention (Get the book.)
| "Unlike the most basic of scientific trials, his study did not offer the participants the identical treatment.
Even Targ had complained about problems in study design of the very first major prayer study by Randolph Byrd, in which ordinary Christians had been asked to pray for cardiac patients. There was no information about who was taking blood pressure medication, so it was unclear whether prayer or medicine had done the healing. There were no controls for mental attitude during the study. A high number of patients with a positive oudook may have landed in the treatment group." - Lynne McTaggart, The Intention Experiment: Using Your Thoughts to Change Your Life and the World (Get the book.)
| "Only a double-blind clinical trial3 that lasts from four to six months, the gold standard of laboratory testing, can prove the worth of these products, and few such trials have been performed.
The Mayo Clinic issued a warning in June 2007 that cosmeceutical products contain "powerful active ingredients that can affect biological processes," and emphasized how these ingredients have not been subjected to rigorous safety testing." - Samuel S. Epstein, Randall Fitzgerald, Toxic Beauty: How Cosmetics and Personal Care Products Endanger Your Health . . . And What You Can Do about It (Get the book.)
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