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NaturalPedia > Tamoxifen
Quotes about Tamoxifen from the world's top natural health / natural living authors
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"Two flavors are available. One, tamoxifen, effectively blocks the receptor. tamoxifen is an agent used to treat breast cancer and has been studied in large trials on the prevention of breast cancer (which discerned marginal and balancing risks and benefits). One concern in these trials was that blocking the estrogen receptor would predispose to osteopenia, if not osteoporosis. That concern did not materialize, surprisingly. There is another compound, raloxifene (marketed as Evista), which is structurally similar to tamoxifen and also binds estrogen receptors." - Nortin M. Hadler MD, Worried Sick: A Prescription for Health in an Overtreated America (Get the book.)
| "Taxol is not to be confused with tamoxifen, however, which is a first-line hormone therapy often used in premenopausal patients. tamoxifen has also gained favor as a preventative
Modern Mammograms—At the Mall
drug; Taxol treatment follows diagnoses of cancer.
Current guidelines recommend Taxol for patients who have advanced breast and ovarian cancer. Ask your doctor or oncologist if it is appropriate in your case." - Bottom Line Books, Uncommon Cures For Everyday Ailments (Get the book.)
| "In animal studies, flaxseed increased the effectiveness of the breast cancer drug tamoxifen, but no clinical trials on the flaxseed interaction with tamoxifen, or other breast cancer drugs, have been conducted on breast cancer patients. German research, meanwhile, has linked plant lignan intake and a reduced risk of breast cancer. Studies there have found that premenopausal women eating a high level of lignans experienced a 64 percent reduction in breast cancer risk.
Food sources of lignans besides ground flaxseed include whole grain cereals, berries, vegetables, and fruits in general." - Elaine Magee, Food Synergy: Unleash Hundreds of Powerful Healing Food Combinations to Fight Disease and Live Well (Get the book.)
| "Taxol is not to be confused with tamoxifen, however, which is a first-line hormone therapy often used in premenopausal patients. tamoxifen has also gained favor as a preventative
Modern Mammograms—At the Mall
drug; Taxol treatment follows diagnoses of cancer.
Current guidelines recommend Taxol for patients who have advanced breast and ovarian cancer. Ask your doctor or oncologist if it is appropriate in your case." - Bottom Line Books, Uncommon Cures For Everyday Ailments (Get the book.)
| "Consider the anti-cancer drugs that cause cancer. tamoxifen, for example, is a common drug prescribed to high-risk women to prevent breast cancer, and it is usually taken for five years. However, research conducted in Israel found that tamoxifen can cause cancer instead. According to a study published in the International Journal of Gynecological Cancer, the treatment of breast cancer with tamoxifen results in an increased risk of uterine cancer incidence and mortality. Merely substituting one cancer for another is not a treatment option that should be offered to cancer patients." - Andreas Moritz, Timeless Secrets of Health & Rejuvenation: Unleash The Natural Healing Power That Lies Dormant Within You (Get the book.)
| "Drug's track record: Year FDA approved drug for this use, 1999 (first approved for treating breast cancer, 1982)
What you need to do when taking tamoxifen:
1. Have a yearly gynecologic examination (with a Pap smear).
2. Check up yearly blood tests.
3. Use birth control (do not get pregnant).
TAMOXIFEN STUDY FACTS
Who was in the study? 13,175 women age 35 and older who previously had lobular carcinoma in situ OR whose 5 year risk of breast cancer was calculated to be 1.7% or greater
Length of study 6 Years
Women NOT TAKING Tamoxifen
Women TAKING Tamoxifen
How drug might help?" - Richard A. Deyo M.D. M.P.H., Donald L. Patrick, Hope or Hype: The Obsession with Medical Advances and the High Cost of False Promises (Get the book.)
| "In animal studies, flaxseed increased the effectiveness of the breast cancer drug tamoxifen, but no clinical trials on the flaxseed interaction with tamoxifen, or other breast cancer drugs, have been conducted on breast cancer patients. German research, meanwhile, has linked plant lignan intake and a reduced risk of breast cancer. Studies there have found that premenopausal women eating a high level of lignans experienced a 64 percent reduction in breast cancer risk.
Food sources of lignans besides ground flaxseed include whole grain cereals, berries, vegetables, and fruits in general." - Elaine Magee, Food Synergy: Unleash Hundreds of Powerful Healing Food Combinations to Fight Disease and Live Well (Get the book.)
| "Black tea polyphenol theaflavins inhibit aromatase activity and attenuate tamoxifen resistance in HER2/neu-transfected human breast cancer cells through tyrosine kinase suppression, Eur J Cancer, 40: 2165-2174. Way, T. D, Kao, M. C, and Lin, J. K., 2005, Degradation of HER2/neu by apigenin induces apoptosis through cytochrome c release and caspase-3 activation in HER2/neu-overexpressing breast cancer cells, FEBS Lett, 579: 145-152. Welshons, W. V, Thayer, K. A., Judy, B. M., Taylor, J. A., Curran, E. M., and vom Saal, F. S., 2003,
Large effects from small exposures. I." - Erich Grotewold, The Science of Flavonoids (Get the book.)
| "Her oncologist also urged her to take tamoxifen, a drug that reduces risk of recurrences. But tamoxifen also impairs fertility, and Sorenson, who had no children, wanted to keep that option open.
"I agonized over the decision and finally decided not to take the tamoxifen, but I kept worrying that I'd made a bad decision," she recalls. Then she went to Commonweal, and in a seminar on cancer care, learned that even without tamoxifen, by European standards, she'd already been treated fairly aggressively. "That eased my mind," she says." - Kevin Trudeau, Natural Cures (Get the book.)
| "In fact, tangeretin and tamoxifen used together display additive anticancer effects in the test tube.90 However, a study performed on mice demonstrated that tamoxifen inhibited breast cancer growth while tangeretin did not.91 Furthermore, adding tangeretin to tamoxifen completely neutralized tamoxifen's benefit. This appears to be a good example, illustrating that test tube results do not necessarily apply to living organisms. One possible explanation is that test tube doses are often far higher than those used in animal and human studies, but it is likely to be more complex than that." - Richard Harkness, The Natural Pharmacist: Your Complete Guide to Reducing Cancer Risk (Get the book.)
| "The action is similar to tamoxifen, which blocks cellular binding sites in the body for estrogen.
ARBs appear to help in heart failure and kidney disease, but we haven't seen any research showing significant benefit for coronary artery disease.
Beta Blockers
For patients with coronary artery disease or heart failure, beta blockers can be lifesavers. They are among the most effective and safest drugs we have in cardiology.
These medications block the beta sympathetic limb of the autonomic nervous system, the part responsible for gearing up your body for action." - Stephen Sinatra, M.D. and James C., M.D. Roberts, Reverse Heart Disease Now: Stop Deadly Cardiovascular Plaque Before It's Too Late (Get the book.)
| "Medications that can interfere with T4 activation NSAIDs (nonsteroidal anti-inflammatory drugs such as Ibuprofen and Naprosyn), birth control pills, oral estrogen, chemotherapy (interferon, 5FU, tamoxifen, 6-mercaptopurine), most antidepressants and sleeping pills, beta-blockers, lithium, phenytoin, amiodarone, and theophylline.
5. Toxins, including pesticides, mercury, fluoride, radiation, alcohol, caffeine, cigarette smoke, and phthalates (chemicals added to plastics, often emitted when heating or microwaving plastics).
6. Thyroid antibodies These are discussed below." - Phuli Cohan, The Natural Hormone Makeover: 10 Steps to Rejuvenate Your Health and Rediscover Your Inner Glow (Get the book.)
| "This drug, according to the media, was 'a refined version of HRT' and 'a cousin of tamoxifen', which appeared, according to Eli Lilly and various HRT supporters, 'to combine the benefits of tamoxifen and HRT with none of their disadvantages'. The drug was claimed to have an oestrogen effect on some tissues but not on others.34
Maggie Turtle's friend in the North, Professor David Purdie, suggested that the drug could be used by women in the long term after the menopause." - Martin J. Walker, HRT Licensed to Kill and Maim: The Unheard Voices of Women Damaged by Hormone Replacement Therapy (Get the book.)
| "If flaxseed produces the same effects as anti-estrogens such as tamoxifen, it has the potential for use in both breast cancer treatment and prevention."
These studies support the work of French researchers who recently found that low levels of alpha-linolenic acid (ALA, found predominantly in flax) predict increased risk of breast cancer. The study was published in the February 2000 issue of the European Journal of Cancer." - Freedom Press, Natural Cancer Cures: The Definitive Guide to Using Dietary Supplements to Fight and Prevent Cancer (Get the book.)
| "If the comparison had been with Herceptin, anastrozole would not have looked so good. But tamoxifen gives a more direct comparison to glean what we are paying for: £100 million ($180 million) for the advances since tamoxifen as outlined above. In affluent countries, that may seem like a good use of taxpayers' money, because what is more precious than health? But no one knows what taxpayers think because there is no way of knowing and very little serious debate beyond simply demanding greater access to life-saving drugs." - Jacky Law, Big Pharma: Exposing the Global Healthcare Agenda (Get the book.)
| "Thus, both compounds were anti-estrogenic; however, flax performed its activities without tamoxifen's tissue toxicity (including uterine cancer risks).
CLINICAL CASES Breast cancer
Could a flaxseed muffin or two a day keep breast and prostate cancer at bay? Maybe so, according to a Canadian study in which women ate a muffin a day—with 50 grams of ground flaxseed. The researchers found there was a "slowing down in tumor growth" in breast cancer patients who ate the flaxseed muffins." - Freedom Press, Natural Cancer Cures: The Definitive Guide to Using Dietary Supplements to Fight and Prevent Cancer (Get the book.)
| "With at least 100,000 women taking tamoxifen at any time, the switch could cost £100 million.39
Tamoxifen shows how if medicine moves forward in small, incremental steps, prices take strides in an ever steeper ascent. The drug is a British invention that has been used for more than 20 years with huge success, cutting in half the number of women whose breast cancers returned after treatment. Its performance is now outclassed on virtually every measure by the latest so-called aromatase inhibitors, of which anastrozole is just one." - Jacky Law, Big Pharma: Exposing the Global Healthcare Agenda (Get the book.)
| "While I still had to have a double mastectomy in late June and am on tamoxifen, all my nodes were clear (and they took out 33!); also, the tumor was quite small (1.7 cm). I have every reason to believe that the cancer was contained and probably shrank due to Essiac.
"Additionally, while taking Essiac, a large mole on my back, which was taking on the odd texture and coloration of a skin cancer, completely disappeared. The mole itself had been there unchanged for several years; there was nothing else I did that can explain its disappearance."
Eileen B." - Freedom Press, Natural Cancer Cures: The Definitive Guide to Using Dietary Supplements to Fight and Prevent Cancer (Get the book.)
| "This study also showed that tamoxifen (a drug used in women at risk for breast cancer or to prevent breast cancer recurrence) effects were increased, not decreased. A Japanese study indicates that black cohosh inhibits breast cancer cells.
Black cohosh is available in tinctures, tablets, and capsules. The usual dose is 40 to 80 mg daily (2 to 4 ml of tincture, three times daily), but be aware that since its full effects may not be felt for two to three weeks, it is not much help if you need immediate relief. It works best over the long term." - Phuli Cohan, The Natural Hormone Makeover: 10 Steps to Rejuvenate Your Health and Rediscover Your Inner Glow (Get the book.)
| "However, estriol may reduce the negative effects of the cancer drug tamoxifen for women already diagnosed with breast cancer.152
Prescribing Estriol. Estriol seems to be helpful in treating many of the symptoms of menopause such as hot flashes. However, the jury is still out as to whether estriol will protect you from conditions such as osteoporosis and if it provides any heart disease protection or adverse cardiovascular effects. Women who currently have breast cancer or who are survivors must weigh the benefits and risks after being provided with well-balanced information." - Tori Hudson, N.D., Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness (Get the book.)
"In addition, in vitro studies have shown that black cohosh did not cause increase in proliferation of estrogen receptor positive breast cancer cells, and it had an additive effect of inhibiting proliferation when given with the antiestrogen drug tamoxifen.118120 A very recent study demonstrates that black cohosh inhibits the growth of human breast cancer cells."
The other area that has received a lot of attention in the last two years is whether black cohosh has adverse effects on liver function."
- Tori Hudson, N.D., Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness (Get the book.)
| "BREAST CANCER: A mouse study showed that flaxseed may enhance the effectiveness of the cancer drug tamoxifen in halting the growth of breast cancer. Women with high levels of enterolactone (a weak phytoestrogen), linked to high lignan intake from foods like flax, have been shown to experience a fifty-eight percent reduction of breast cancer risk.
COLON CANCER: An animal study found supplementation of flaxseed oil to be effective in preventing colon tumor development whereas corn oil, mostly omega-6 fats, promoted tumor growth." - David W. Grotto, RD, LDN, 101 Foods That Could Save Your Life! (Get the book.)
| "Irradiation of the pelvic or abdominal area can also induce menopause. tamoxifen, another cancer drug used mostly for women who have breast cancer, can either induce menopause in premenopausal women or increase menopause symptoms in postmenopausal women.
Several drugs can induce menopause that is reversible once the drugs are discontinued. These include Lupron and Synarel, which are usually given to suppress menses in the case of endometriosis and to shrink fibroids before surgery." - Tori Hudson, N.D., Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness (Get the book.)
| "I was also put on tamoxifen. I wish I would have known about Flor-Essence then! In November 1997, I was diagnosed with 'terminal bone cancer' all through my bones. A few months later it was also discovered in my liver. My family doctor said I only had months to live. I started taking Flor-Essence tea (two ounces, three times daily) and still do today. The Surrey Cancer Clinic recommended radiation for pain and then chemotherapy because they found it in my liver. They insisted basically without chemo it was no use seeing them anymore!" - Freedom Press, Natural Cancer Cures: The Definitive Guide to Using Dietary Supplements to Fight and Prevent Cancer (Get the book.)
| "However, unlike these cancers, risk factors for endometrial cancer also include tamoxifen use and factors associated with unopposed estrogens [213]. Given the key role that unopposed estrogens play in this disease, it is not surprising that obesity is one of the major nutrition-related risk factors for this cancer [214]. Polycystic ovarian syndrome, which also is more prevalent among overweight and obese women, also is a risk factor for this disease [215].
The link between obesity and endometrial cancer is well established [213, 214, 216, 217]." - Ann M. Coulston and Carol J. Boushey, Nutrition in the Prevention and Treatment of Disease (Get the book.)
"Effect of tamoxifen on venous thromboembolic events in a breast cancer prevention trial. Circulation 111, 650-656.
172. Abrahamson, P. E., Gammon, M. D., Lund, M. J., et al. (2006). General and abdominal obesity and survival among young women with breast cancer. Cancer Epidemiol. Biomarkers Prev. 15, 1871-1877.
173. Borugian, M. J., Sheps, S. B., Kim-Sing, C, et al. (2003). Waist-to-hip ratio and breast cancer mortality. Am. J. Epidemiol. 158, 963-968.
174. Kumar, N. B., Cantor, A., Allen, K., and Cox, C. E. (2000)."
- Ann M. Coulston and Carol J. Boushey, Nutrition in the Prevention and Treatment of Disease (Get the book.)
"Although several such molecules were introduced into clinical medicine before their mechanisms of action were clarified (e.g., tamoxifen), recent years have seen the development of numerous molecules in this class for the intended purpose of treating osteoporosis. As of this writing, only one SERM, raloxifene (Evista), is FDA approved for prevention and treatment of osteoporosis."
- Ann M. Coulston and Carol J. Boushey, Nutrition in the Prevention and Treatment of Disease (Get the book.)
"E to enhance the cytotoxic effects of adriamycin in human prostate cancer, glioma, and HeLa cells; enhance cisplatin, tamoxifen, and decarbazine on human melanoma and parotid acinar carcinoma cells; and promote doxorubicin to inhibit murine leukemia cell lines [118].
Data from large-scale trials with antioxidants are not available, although some smaller studies provide evidence that antioxidant supplementation can increase the efficacy of standard chemotherapies in humans."
- Ann M. Coulston and Carol J. Boushey, Nutrition in the Prevention and Treatment of Disease (Get the book.)
| "The study showed for the first time that adding a reasonable amount of flaxseed (the study used muffins containing 25 grams of flaxseed) for approximately 38 days reduced tumor growth in patients with breast cancer—similar to the benefits seen when the drug tamoxifen is given to patients before breast surgery.
Since then, many more studies have reported similarly favorable results. A randomized, double-blind, placebo-controlled clinical trial at the University of Toronto, for example, tested the effects of flaxseed in postmenopausal women with newly diagnosed breast cancer." - Elaine Magee, Food Synergy: Unleash Hundreds of Powerful Healing Food Combinations to Fight Disease and Live Well (Get the book.)
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