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"CHAPTER 8 FLAVONOIDS AS NUTRACEUTICALS JEN-KUN LIN1 AND MENG-SHIH WENG Institute of Biochemistry and Molecular Biology, College of Medicine, National taiwan University, No. 1, Section 1, Jen-ai Road, Taipei, taiwan 'Corresponding author; E-mail: jklin@ha.mc.ntu.edu.tw 1. INTRODUCTION "Nutraceutical" is a term coined in 1979 by Stephen DeFelice (DeFelice, 1992). It is defined "as a food or parts of food that provide medical or health benefits, including the prevention and treatment of disease." - Erich Grotewold, The Science of Flavonoids (Get the book.)

"The main tea growers throughout the world are India, China, Kenya, Sri Lanka, Indonesia, Turkey, taiwan, Japan, Nepal, and Bangladesh. Why Should I Drink Tea? Tea is a good source of flavonoids called catechins, which are important antioxidants that can help prevent certain types of diseases. The major catechins, found mostly in green tea, include: epigallocatechin-3-gallate (EGCG), epigallocatechin (EGC), epicatechin-3-gallate (ECG), and epicat-echin (EC). EGCG is the most abundant and widely studied tea polyphenol, and EGCG and ECG have the highest radical-scavenging activity." - David W. Grotto, RD, LDN, 101 Foods That Could Save Your Life! (Get the book.)

"Genetic variations of apolipoprotein A5 gene is associated with the risk of coronary artery disease among Chinese in taiwan. Atherosclerosis 185, 143-149. 145. Lai, C. Q., Corella, D., Demissie, S., et al. (2006). Dietary intake of n-6 fatty acids modulates effect of apolipoprotein A5 gene on plasma fasting triglycerides, remnant lipoprotein concentrations, and lipoprotein particle size: The Framing-ham Heart Study. Circulation 113, 2062-2070. 146. Elosua, R., Ordovas, J. M., Cupples, L. A., et al. (2006)." - Ann M. Coulston and Carol J. Boushey, Nutrition in the Prevention and Treatment of Disease (Get the book.) "Epidemiologic study of age-related cataracts among an elderly Chinese population in Shih-Pai, taiwan. Ophthalmology 110(6), 1089-1095. 26. Mukesh, B. N., Le, A., Dimitrov, P. N., Ahmed, S., Taylor, H. R., and and McCarty, C. A. (2006). Development of cataract and associated risk factors: the Visual Impairment Project. Arch. Ophthalmol. 124, 79-85. 27. West, S. K, Duncan, D. D., Munoz, B., et al. (1998). Sunlight exposure and risk of lens opacities in a population-based study: the Salisbury Eye Evaluation project. JAMA 280, 714-718. 28. Taylor, H. R., West, S. K., Rosenthal, F. S., et al." - Ann M. Coulston and Carol J. Boushey, Nutrition in the Prevention and Treatment of Disease (Get the book.)

"Mercury has also been detected in several products made in China and taiwan. When a patient turned up in his office with mercury poisoning, Dr. Christopher Lam, chair at the department of chemical pathology at Hong Kong's Prince of Wales Hospital, examined her skin whitening cream and found mercury levels 65,000 times higher than amounts allowed in the US. Follow-up product tests conducted by Lam found mercury in eight of 38 skin whitening creams made in China and taiwan. Some of the products were labeled "mercury free." - Stacy Malkan, Not Just a Pretty Face: The Ugly Side of the Beauty Industry (Get the book.)

"Today, Yakult milk product can be found in many countries around the world, including Australia, Europe and taiwan. In Japan, one can find dozens of probiotic products on supermarket shelves, ranging from fortified milks to candy containing Lactobacilli and Bifidobacterium strains. In Chapter 18, we'll take a closer look at some of these products available on supermarket shelves. The probiotic food trend is evident around the world. Most popular in Japan, probiotics are consumed to a lesser degree in Europe." - Allison Tannis, Probiotic Rescue: How You can use Probiotics to Fight Cholesterol, Cancer, Superbugs, Digestive Complaints and More (Get the book.)

"The products themselves continue to be manufactured entirely in East and South-East Asia (specifically, in China, Indonesia, the Philippines, Malaysia, Singapore, taiwan, and Thailand). In marketing terms, however, Haw Par Healthcare Limited fairly successfully makes the best of both worlds, East and West. Its corporate literature asserts: 'Tiger Balm is not an ancient Chinese concoction, but a modern efficacious medication." - Roberta Bivins, Alternative Medicine?: A History (Get the book.)

"A similar study was carried by out researchers at the National Yang Ming Medical College and National Research Institute of Chinese Medicine in Taipei, taiwan. In this instance, the Qigong master alternately sent positive and negative intention to boar sperm cells and human fibroblast cells, which make up the connective tissue of the body. After 2 minutes of negative intention, the growth rates and protein synthesis of the cells decreased dramatically by 22-53 percent." - Lynne McTaggart, The Intention Experiment: Using Your Thoughts to Change Your Life and the World (Get the book.)

"It worked well enough in taiwan (Li-Chen et al. 2006) to tantalize some in Britain (Frost and Stewart-Brown 2006). I am bemused. Pressing on the tender spots of patients with back pain was considered diagnostic of disease by Osier and by many who welcome "fibromyalgia" into their belief systems and therapeutic envelopes (chapter 10). But then again, there are those who think that small and inconsistent effects in multiple randomized trials justify the use of some herbs to treat low back pain (Gagnier et al. 2007)." - Nortin M. Hadler MD, Worried Sick: A Prescription for Health in an Overtreated America (Get the book.)

"On the math section, Naperville scored sixth, behind only Singapore, Korea, taiwan, Hong Kong, and Japan. As a whole, U.S. students ranked eighteenth in science and nineteenth in math, with districts from Jersey City and Miami scoring dead last in science and math, respectively. "We have huge discrepancies among our school districts in the United States," says Ina Mullis, who is a codirector of TIMSS. "It's a good thing that we've at least got some Napervilles — it: shows that it can be done." - John J. Ratey, MD, Spark: The Revolutionary New Science of Exercise and the Brain (Get the book.)

"Stevia is approved as a food source in South and Central America, Korea, taiwan, Japan, and China, and as such, is used as a sweetener in many food products.11 However, in the United States and Canada, probably due in large part to concerns raised by the sugar industry about potential competition, to date, stevia is approved only as a food supplement. It is available at most healthfood stores. ANTIBIOTIC ALTERNATIVES Colloidal Silver A colloid consists of minute particles that float within a liquid despite the pull of gravity; they remain suspended." - Ron Garner, Conscious Health: A Complete Guide to Wellness Through Natural Means (Get the book.)

"Taipei (TEYE-PAY, TEYE-BAY) Capital of taiwan and largest city in the country, located in northern taiwan. * In 1949, Taipei became the headquarters of Chiang Kai-shek's Chinese Nationalists, who had been forced to flee mainland China. Taiwan Island in the Pacific Ocean near the mainland of southern China; seat of the Republic of China. Its capital and largest city is Taipei. When the Chinese communists came to power on the mainland, the Nationalist government of Chiang Kai-shek and some of his army took refuge on taiwan." - E. D. Hirsch, The Dictionary of Cultural Literacy (Get the book.)

"Institute of Pharmacology, College of Medicine, National taiwan University, Taipei, taiwan. jklin@ha.mc.ntu.edu.tw Van Horn, Linda; Ph.D, RD for the Nutrition Committee. "Fiber, Lipids, and Coronary Heart Disease" Year Published: 1997 Product Code: 71-0113. A Statement for Healthcare Professionals From the Nutrition Committee, American Heart Association. 1997;95:2701-2704. PC Oat Beta Glucan (Schiff), NSC-24 Immune Enhancer (Nutritional Supply Corp.), Maitake Bio-Beta-Glucan (Nature'sAnswer). Biorklund, M.; van Rees, A.; Mensink, R.P.; Onning, G. " - Jan Lovejoy, Get Balanced-the Natural Way to Better Health with Superfoods (Get the book.)

"He had earned a four-year degree in acupuncture from a school in the Netherlands, and over the years his interest in nontraditional healing methods had prompted him to learn classical homeopathy and travel around Southeast Asia, taiwan, and China to study traditional Chinese medicine (TCM). He had been instrumental in creating clinical and ethical standards for the acupuncture profession in Australia, and now his school was about to be folded into Melbourne's Victoria University as the first degreed acupuncture program in the state of Victoria." - Peter h. Fraser and Harry Massey, Decoding the Human Body-Field: The New Science of Information as Medicine (Get the book.)

"They no longer go to taiwan and ask the locals to "make this." Now, they go to taiwan to see what the locals are making that they can sell back home. More and more, U.S. companies don't even participate at the design stage. "What we are seeing," says Paul Craig Roberts, is the "rapid transformation of America into a 3rd world economy."5 American firms are increasingly left with only brands to market. But even those won't last forever, after customers realize that the real innovation, design, and manufacture genius is overseas." - William Bonner, Addison Wiggin, Empire of Debt: The Rise of an Epic Financial Crisis (Get the book.)

"Studies comparing populations in parts of the world other than mainland China have not supported a link between selenium deficiency and DCM,36'37 except in taiwan.38 Moreover, no clinical trials outside of China have explored the effects of supplementation with selenium for people with DCM, nor is there reason to believe that selenium supplementation would help most people outside of China and taiwan suffering from cardiomyopathy." - Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D., The Natural Pharmacy: Complete A-Z Reference to Natural Treatments for Common Health Conditions (Get the book.)

"Shoei-Yn Lin-Shiau, Institute of Pharmacology, College of Medicine, National taiwan University for her inspiring discussion during the preparation of this article. 8. REFERENCES Afaq, F., Adhami, V. M, Ahmad, N, and Mukhtar, H, 2003, Inhibition of ultraviolet B-mediated activation of nuclear factor KB in normal human epidermal keratinocytes by green tea constituent (-)-epigallocatechin-3-gallate, Oncogene, 22:1035-1044. Agarwal, C, Singh, R. P., Dhanalakshmi, S., Tyagi, A. K, Tecklenburg, M., Sclafani, R. A., and Agarwal, R." - Erich Grotewold, The Science of Flavonoids (Get the book.)

"March 1984 to March 1989; taiwan a 468.1% stock price increase from May 1986 to May 1991; and Thailand a 430.7% stock price increase over the same period. Most of these price increases came during the period 1982-87, as the world experienced a recovery from the Great Recession of 1981. In all of these countries, the stock market was already down from its peak by December 1996, before there was any hint of the Asian financial crisis. It appears that the collapse of a speculative bubble in these countries preceded the crisis and was part of the ambience that produced the crisis." - Brian Fagan, Floods, Famines, and Emperors: El Nino and the Fate of Civilizations (Get the book.) "Taiwan stock market, the biggest one-year decline on our list. The third-largest one-year price increase, of 384.6%, occurred in Venezuela between January 1990 and January 1991. This price surge came on the heels of a severe economic slump that had produced an economic growth rate of -8%, an unemployment rate of 10%, and inflation of 85% in 1989.5 Then the Iraqi occupation of Kuwait (from August 1990 to February 1991) resulted in an interruption of Persian Gulf oil supplies, a rapid rise in international oil prices, and increased demand for Venezuelan oil." - Brian Fagan, Floods, Famines, and Emperors: El Nino and the Fate of Civilizations (Get the book.) "During the year of the highest speculative increase in taiwan, October 1986 to October 1987, there were some impressive "new era" reasons for optimism. Booming exports had pushed economic growth rates into the double-digit range, and it was widely predicted that with this steep growth trajectory the economy would soon be producing such high-tech items as computer chips. The new affluence was visible everywhere: expensive foreign cars cruised the streets of Taipei and businessmen freely downed $100 bottles of wine at glamorous new restaurants." - Brian Fagan, Floods, Famines, and Emperors: El Nino and the Fate of Civilizations (Get the book.)

"Through his family's many contacts in Korea, Japan, taiwan, and Hong Kong, he set up operations in Southeast Asia to develop metalworking industries. He traveled a great deal, and whether at home or on the road, he continued to be—his own description—a "glutton." "I was gaining weight," he says, "but since I had my clothes tailor-made in Hong Kong, I'd have a suit made every trip, and didn't really notice that the old suits didn't fit." - Caldwell B. Esselstyn, Jr., M.D., Prevent and Reverse Heart Disease (Get the book.)

"Section 1, Jen-ai Road, Taipei, taiwan 'Corresponding author; E-mail: jklin@ha.mc.ntu.edu.tw 1. INTRODUCTION "Nutraceutical" is a term coined in 1979 by Stephen DeFelice (DeFelice, 1992). It is defined "as a food or parts of food that provide medical or health benefits, including the prevention and treatment of disease." Subsequently, several other terms (medical food, functional food, and nutritional supplements) were used." - Erich Grotewold, The Science of Flavonoids (Get the book.)

"Peanut consumption and reduced risk of colorectal cancer in women: a prospective study in taiwan. World J Gastroenterol. 2006 Jan 14;12(2):222-227. Pears www.usapears.com; www.calpear.com Butler LM, Koh WP, Lee HP, Yu MC, London SJ. Dietary fiber and reduced cough with phlegm: A cohort study in Singapore. Am J Respir Grit Care Med. 2004; 170: 279-287. Conceicao de Olivceira M, Sichieri R, and Moura AS. Weight loss associated with a daily intake of three apples or three pears among overweight women. Nutrition. 2003;19:253-256. Mink PJ." - David W. Grotto, RD, LDN, 101 Foods That Could Save Your Life! (Get the book.)

"Researchers in taiwan say they have established for the first time that the mercury compound present as a contaminant in some seafood can damage the insulin-producing cells in the pancreas. In their experiments, Shing-Hwa Liu and colleagues exposed cell cultures of insulin-producing beta cells to methylmercury. They used concentrations of methylmercury at about the same levels as people would consume in fish under the U.S. Food and Drug Administration's recommended limits.20 Contamination of fish is widespread." - Gabriel Cousens, There Is a Cure for Diabetes: The Tree of Life 21-Day+ Program (Get the book.) "ARSENIC Studies out of taiwan and Bangladesh show that individuals who are exposed to higher amounts of arsenic—in their soil and/or drinking water—have a higher independent risk of developing Type-2 diabetes.62,63 Arsenic in tap water is common; this hormone disruptor is suspected of playing a role in diabetes. Arsenic interferes with the action of glucocorticoid hormones, which belong to the same family of steroid hormones as estrogen and progesterone. Glucocorticoids turn on many genes that help regulate blood sugar and even ward off cancer." - Gabriel Cousens, There Is a Cure for Diabetes: The Tree of Life 21-Day+ Program (Get the book.)

"We crossed the taiwan Friendship Bridge spanning the alligator-infested Tempisque River and onto the roughly 80-mile-long finger of land south of the Nicaraguan border along the Pacific coast—the Nicoya Peninsula. "Until very recently, this was one of the most isolated parts of Costa Rica," Luis said. "You can see it's a long way from the highways, and before this bridge was built, most people had to take a ferry to get here." This in fact was our first clue to Nicoya's longevity. Sardinia's Blue Zones had been similarly isolated." - Dan Buettner, The Blue Zones: Lessons for Living Longer From the People Who've Lived the Longest (Get the book.)

"At National Cheng Kung University in taiwan, scientists determined that caffeic acid increases glucose uptake into cells, thus removing it from the bloodstream. When researchers at nearby Taipei Medical College injected caffeic acid into diabetic animals, their glucose levels declined. To enjoy the benefits of coffee berries, look for extracts that are standardized to 50 percent total phenolic acids and 15,000 umol/g of ORAC (oxygen-radical absorbent capacity). The recommended dosage is 100 mg of extract three times daily." - Steven V. Joyal, What Your Doctor May Not Tell You About Diabetes: An Innovative Program to Prevent, Treat, and Beat This Controllable Disease (Get the book.)

"Oolong Teas Oolong teas come mainly from the southeastern coasts of China and taiwan. After being harvested, the leaves are left to wither to remove some of their moisture. They are then rolled by a machine to release their juices, followed by a partial fermenting process and oven firing. The tea's copperish color is somewhere between that of green and black teas. Oolong tea's flavor is milder than that of black tea but stronger than that of green tea. It contains the same cancer-fighting properties as green and black teas. Formosa Oolong. A product of taiwan." - Brigitte Mars, A.H.G., The Desktop Guide to Herbal Medicine: The Ultimate Multidisciplinary Reference to the Amazing Realm of Healing Plants, in a Quick-study, One-stop Guide (Get the book.)

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