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"St John's Wort before initiating selegiline. MAJOR RISK Amiodarone: Concurrent use may result in reduced amiodar-one levels. Clinical Management: Concurrent use of amiodarone and St. John's Wort is not recommended. Given the extended half-life of amiodarone, potential for drug interaction may exist even after discontinuation of amiodarone. Amsacrine: Concurrent use may result in reduced effectiveness of amsacrine. Clinical Management: Avoid concomitant use of St. John's Wort and amsacrine." - Thomson Healthcare, Inc., PDR for Herbal Medicines, Fourth Edition (Get the book.)

"They specifically investigated whether st john's wort was more effective than a placebo, whether it was as effective as standard antidepressant drugs, and whether it had fewer side effects than those drugs. When the results of the trials were put together, they showed that st john's wort extracts were significantly better than placebo. Fifty-five per cent of patients given st john's wort found that their symptoms improved, whereas only 22 per cent of patients in the placebo group showed improvement." - Nicola Reavley, The New Encyclopedia of Vitamins, Minerals, Supplements and Herbs (Get the book.)

"A couple of years ago, for example, a $6 million study found the herbal remedy st john's wort was less effective than a placebo, apparently as a vindication of conventional medicine. While the herb had managed to help only 24% of cases of moderate to severe depression, the placebo scored 32%. It later emerged that Zoloft was also part of the trial and had helped 25%.14 The clinical difference is not that impressive - and it is getting worse. " - Jacky Law, Big Pharma: Exposing the Global Healthcare Agenda (Get the book.)

"Linde K et al., st john's wort for depression - An overview and meta-analysis of randomized clinical trials. In: Brit Med J 313(7052):253-258. 1996. Lopez-Bazzocchi I, Hudson JB, Towers GHN, Antiviral activity of the photoactive plant pigment hypericin. In: Photochem Photobiol 54:95-98. 1991. Maisenbacher P, Johanniskrautol. In: DAZ 132(6):281. 1992. Mathic C, Ourrison G, (1964) Phytochemistry 3:115, 133, 377, 379. Miiller WE, Schafer C, Johanniskraut In-vitro-Studie iiber Hypericum-Extrakt, Hypericin und Kampferol. In: DAZ 136(13):1015-1022. 1996." - Joerg Gruenwald, Ph.D., PDR for Herbal Medicines (Get the book.)

"For hot flushes, Kitty Campion recommends rosemary, spearmint, mugwort, st john's wort, 6 As you can see, this recipe is for a vegan cake. People who are not vegans might want to add organic free range eggs. People might also want to add apple juice as a sweetener and some first cold-pressed organic olive oil. The recipe is taken from a leaflet produced by Wellfoods Ltd., Unit 6, Mapplewell Business Park, Mapplewell, Barnsley, South Yorkshire, S75 6BP. http:Wwww.bake-it.com. 7 Robbins J. Reclaiming Our Health: Exploding the medical myth and embracing the source of true healing." - Martin J. Walker, HRT Licensed to Kill and Maim: The Unheard Voices of Women Damaged by Hormone Replacement Therapy (Get the book.)

"Acute neuropathy after exposure to sun in a patient treated with st john's wort. Lancet 352(9134):1121-1122. 1998. Brantner A, Kartnig T, Quehenberger F. Vergleichende phytochemische Untersuchungen an Hypericum perforatum L., und Hypericum maculatum (Crantz). Sci Pharm 62:261-276. 1994. Breidenhach T, Hoffmann MW, Becker T, et al: Drug interaction of St. John's Wort with cyclosporine (letter). Lancet 355(9218): 1912. 2000. Breidenbach T, Kliem V, Burg M, et al: Profound drop of cyclosporin A whole blood trough levels caused by St. John's Wort (Hypericum perforatum)." - Thomson Healthcare, Inc., PDR for Herbal Medicines, Fourth Edition (Get the book.) "DeMott K. st john's wort tied to serotonin syndrome. Clin Psychiatry 26:28. 1998. Denke A, Schempp H, Weiser D, et al: Biochemical activities of extracts from hypericum perforatum L. 5th communication: dopamine- beta-hydroxylase product quantification by HPLC and inhibition by hypericins and flavonoids. Arzneim-Forsch Drug Res 50(5):415-419. 2000. DeSmet PM, Touw DJ. Safety of St. John's Wort (Hypericum perforatum) (letter). Lancet 355(9203):575-576. 2000. DeSmet PA, Nolen W. St. John's Wort as an antidepressant. BMJ 313:241-242. 1996. Dimpfel W, Schober F, Mannel M." - Thomson Healthcare, Inc., PDR for Herbal Medicines, Fourth Edition (Get the book.) "Linde K, Mulrow CD, Berner M, et al. st john's wort for depression (Review). Cochrane Database of Systematic Reviews 2. CD000448: 2005. Linde K, Knuppel L. Large-scale observational studies of hypericum extracts in patients with depressive disorders—a systematic review. Phytomed; 12: 148-157. 2005. Linde K, Ramirez G, Mulrow CD, et al: St. John's Wort for depression - an overview and meta-analysis of randomized clinical trials. BMJ 313(7052):253-258. 1996. Lopez-Bazzocchi I, Hudson JB, Towers GN. Antiviral activity of the photoactive plant pigment hypericin. Photochem Photobiol 54(l):95-98." - Thomson Healthcare, Inc., PDR for Herbal Medicines, Fourth Edition (Get the book.)

"Ginkgo is of questionable use for dementia. st john's wort shows little benefit as an anti-depressant and offers considerable concerns about interactions with licensed drugs. Ginseng and echinacea are expensive, and clinical trials have failed to discern any advantage in them, in particular in ginseng for dementia and in echinacea for the common cold. Saw palmetto may do something if you have prostatism, but it also may not. Phytoestrogen supplements do not banish hot flashes, and guggulipids will not reduce your serum cholesterol." - Nortin M. Hadler, The Last Well Person: How to Stay Well Despite the Health-Care System (Get the book.) "Examples of the science include the articles published by Barrett and colleagues, 'Treatment of the Common Cold with Unrefined Echinacea" (2002); Wilt and colleagues, "Saw Palmetto Extracts for Treatment of Benign Prostatic Hyperplasia" (1998); and Linde and Mulrow, "St John's Wort for Depression" (igg8). The hepatic toxicity of Chaso and Onshido was documented by Adachi and colleagues, "Hepatic Injury in 12 Patients Taking the Herbal Weight Loss Aids" (2003). The Memorial Sloan-Kettering Cancer Center offers a free Web site (www.mskcc." - Nortin M. Hadler, The Last Well Person: How to Stay Well Despite the Health-Care System (Get the book.)

"A combination of valerian root and st john's wort was shown to have equivalent benefits to the drug amitriptyline (Tryptanol) in a randomized, controlled, double-blind study. One hundred and forty-seven outpatients aged between 20 and 65 were given a daily dose of 450-900 mg of valerian and st john's wort concentrates (equivalent to 0.45-0.9 mg total hypericin) or 75-150 mg of amitriptyline over 6 weeks. Benefit was observed for 82% of patients in the herbal group compared to 77% in the amitriptyline group. The total Hamilton Depression Score was reduced from 24.2 to 8." - Simon Mills and Kerry Bone, Principles and Practice of Phytotherapy: Modern Herbal Medicine (Get the book.)

"To restore lacerated nerves - st john's wort. Nettles are a well-known traditional anti-haemorrhagic. If bleeding is serious, control with firm finger pressure. Any one of the following may be used in the form of teas, tinctures, powders, etc. Bowels. Ladies Mantle, Avens, Horsetail, Shepherd's Purse. Tormentil, Raspberry leaves, Yarrow, Cranesbill. Bilberry. Gums. Tea. Equal parts: Horsetail, st john's wort. (Maria Treben) Or:- Paint gums with Tincture Myrrh, Blood root, Goldenseal or Marigold. Post-partum. (After child-birth) Goldenseal BHP (1983); Lady's Mantle BHP (1983). Lungs." - Thomas Bartram, Bartram's Encyclopedia of Herbal Medicine: The Definitive Guide (Get the book.)

"In contrast to the studies described above, a randomized, double-blind trial comparing 1800 mg daily of st john's wort extract LI 160 to 150 mg daily of imipramine in 209 severely depressed patients from 20 psychiatric centers reported that both were equally effective (Hamilton Depression Scales) over the 6 week treatment period.8 MISCELLANEOUS EFFECTS One randomized, double-blind, placebo-controlled, 6-week study (n=151) reported that St." - Heather Boon, BScPhm, PhD and Michael Smith, BPharm, MRPharmS, ND, The Natural Medicine Guide to the 50 Most Common Medicinal Herbs (Get the book.) "In a review article, Beuscher comments on a study using a combination product containing both black cohosh and an extract of st john's wort (Hypericum perforatum L., Clusiaceae). In this multi-center trial conducted over 12 weeks with women (n=812) suffering from psycho-vegetative symptoms of menopause (including irritability, poor concentration, fear, insomnia, depression), 90% of patients noted an improvement.2 It should be noted that standardized extracts of St. John's Wort have now been shown to be effective in the management of mild-moderate depression when given as a single agent." - Heather Boon, BScPhm, PhD and Michael Smith, BPharm, MRPharmS, ND, The Natural Medicine Guide to the 50 Most Common Medicinal Herbs (Get the book.)

"In a study published in 1996 in the British Medical Journal, researchers from Germany and America analysed the results of 23 clinical trials that looked at st john's wort in the treatment of depression.8 The trials involved 1757 patients with mild to moderately severe depression. They specifically investigated whether st john's wort was more effective than a placebo, whether it was as effective as standard antidepressant drugs, and whether it had fewer side effects than those drugs." - Nicola Reavley, The New Encyclopedia of Vitamins, Minerals, Supplements and Herbs (Get the book.) "When the results of the trials were put together, they showed that st john's wort extracts were significantly better than placebo. Fifty-five per cent of patients given st john's wort found that their symptoms improved, whereas only 22 per cent of patients in the placebo group showed improvement. Other herbs that can be used to treat depression and strengthen the nervous system include vervain (Verbena officinalis), oat straw (Avena sativa), skullcap (Scutellaria laterifolia) and lemon balm (Melissa officinalis). Kava (Piper methysticum) has been used to treat anxiety." - Nicola Reavley, The New Encyclopedia of Vitamins, Minerals, Supplements and Herbs (Get the book.)

"The main anthraquinone-containing plants are cascara sagrada [Rbamnus purshiana), senna, rhubarb, aloes, dock and st john's wort. Rheum-emodin is a typical simple anthraquinone from rhubarb root [Rheum palmatum). oh o oh rheum-emodin As anthraquinones are yellow-brown pigments many have been used historically as dyes for textiles, for example dyer's madder (Rubia tinctoria). They are also known as anthracene glycosides, since anthracene was the first compound isolated, by French chemists Dumas and Lambert, in 1832." - Andrew Pengelly, The Constituents of Medicinal Plants: An Introduction to the Chemistry and Therapeutics of Herbal Medicine (Get the book.)

"The pharmacokinetic profile of simvastatin after repeated administration of st john's wort or its placebo in a double-blind, crossover study was reported by Sugimoto et al.35 In this study, St. John's wort significantly decreased plasma simvastatin hydroxy acid. However, the therapeutic manifestation of coadministration of St. John's wort was not determined. St. John's wort may reduce the cholesterol-lowering effect of simvastatin, demonstrating the critical effects that herbal preparations may have on drug pharmacokinetics in the GI tract. Further study is needed to address this issue." - Amarjit S. Basra, Handbook of Medicinal Plants (Get the book.) "C, Antibacterial activity of hyperforin from st john's wort, against multiresistant Staphylococcus aureus and gram-positive bacteria. Lancet 1999, .353, (9170), 2129. 72. Amaro-Luis. J. M.; Adrian, M.; Diaz, C, Isolation, identification and antimicrobial activity of ombuoside from Stevia triflora. Ann Pharm Fr 1997, 55, (6), 262-268. 73. Mitscher, L. A.; Telikepalli, H., Bioassay-directed discovery of natural product leads. Antibacterials and antifungals from unusual sources. In Advances in natural product chemistry, ed. Atta-ur-Rahman. Harwood Academic Publishers: Basel, 1992, pp. 281-310." - Amarjit S. Basra, Handbook of Medicinal Plants (Get the book.)

"A double-blind, placebo-controlled, three-way crossover trial investigated a valerian and st john's wort extract combination and st john's wort extract for their effects on safety-related performance in 12 volunteers tested over 10 days. The two herbal products were shown to be harmless and comparable to placebo with respect to safety regarding performance and well-being. The effects after simultaneous intake of alcohol were not greater than those of alcohol on its own." - Simon Mills and Kerry Bone, Principles and Practice of Phytotherapy: Modern Herbal Medicine (Get the book.)

"Different effects of st john's wort on the pharmacokinetics of simvastatin and pravastatin, Clinical Pharmacology and Therapeutics, 70: 518-524. 36. Ernst, E., 1997, Complementary AIDS therapies: the good, the bad, and the ugly, Int. J. STDAIDS, 8: 281-285. 37. Piscitelli, S.C., Burstein, A.H., Welden, N., Gallicano, K.D., and Falloon, J., 2002, The effect of garlic supplements on the pharmacokinetics of saquinavir, Clin. Infect. Dis., 34: 234-238. 38." - Amarjit S. Basra, Handbook of Medicinal Plants (Get the book.)

"Most products containing standardized extracts of st john's wort are still standardized on hypericin content, as hyperforin is fairly unstable. STIMULANTS CNS stimulants are now rarely employed therapeutically, with the exception of caffeine, although they were important in the treatment of barbiturate poisoning (e.g. picro-toxin) or as a tonic (strychnine). Cola nut extract is used in many herbal tonics and, of course, in the ubiquitous soft drink of the same name. Guarana is an ingredient of some 'energy' drinks and 'healthy' nutritional products." - Dr. Michael Heinrich, Joanne Barnes, Simon Gibbons and Elizabeth M. Williamson, Fundamentals of Pharmacognosy and Phytotherapy (Get the book.)

"A double-blind, placebo-controlled, three-way crossover trial investigated a valerian and st john's wort extract combination and st john's wort extract for their effects on safety-related performance in 12 volunteers tested over 10 days. The two herbal products were shown to be harmless and comparable to placebo with respect to safety regarding performance and well-being. The effects after simultaneous intake of alcohol were not greater than those of alcohol on its own." - Simon Mills and Kerry Bone, Principles and Practice of Phytotherapy: Modern Herbal Medicine (Get the book.)

"Strong Nettle tea - pain killer. (3) st john's wort oil. (4) Aloe Vera - cut off piece of leaf and pulp; or, gel. (5) Slippery Elm -Powder mixed with little milk to form a paste. (6) Pierce Vitamin E capsule and anoint area. (7) Distilled extract of Witch Hazel. (8) Cod liver oil. Compress. Apply piece of suitable material steeped in teas of any of the following: Chamomile, Chickweed, Comfrey, Cucumber, Elderflowers, Marigold, Plantain, st john's wort. Alcohol should not be taken. Supplementation. Vitamins A, B-complex, C, D, E. Potassium. Zinc. BURR-MARIGOLD. Water Agrimony." - Thomas Bartram, Bartram's Encyclopedia of Herbal Medicine: The Definitive Guide (Get the book.)

"One of the most significant series of herb-drug interactions observed in recent years has been that of st john's wort, currently popular for self-treatment of minor depression. Some of these interactions have been so severe as to cause the Committee on Safety of Medicines to issue warnings about the use of this herb with a series of prescription medicines, including the contraceptive pill, digoxin, HIV protease inhibitors, selective serotonin reuptake inhibitors, theophylline and warfarin (Barnes et al 2001)." - Dr. Michael Heinrich, Joanne Barnes, Simon Gibbons and Elizabeth M. Williamson, Fundamentals of Pharmacognosy and Phytotherapy (Get the book.)

"Gordon J (1998) SSRIs and St John's wort: possible toxicity? Am Fam Physician 62: 31. Greenson JM, Sanford B, Monti DA (2001) St. John's Wort (Hypericum perforatum): a review of the current pharmacolocical, toxicological and clinical literature. Psychopharmacology 153: 402-14. Gulick RM, McAuliffe V, Holden-Wiltse J et al.: Phase I studies of hypericin, the active compound in St. John's Wort, as an antiretroviral agent in HIV-infected adults. Ann Intern Med 130: 510-514,1999. Halama P (1991) Wirksamkeit des Johanniskrautextraktes LI 160 bei depressiver Verstimmung." - volker schulz and Rudolf Hansel, Rational Phytotherapy: A Reference Guide for Physicians and Pharmacists (Get the book.)

"However, since 1996, there has been a significant increase in the publication of randomized clinical trials on herbs, such as echinacea, garlic, ginkgo and st john's wort. Although some of these clinical trials are flawed by methodological weaknesses, there can be no doubt that clinical interest in medicinal herbs is growing. Use of herb extracts or isolated active principles The focus on the isolation of active principles from herbs in the past has led to the view that each individual herb must have an active principle(s)." - Dr. Michael Heinrich, Joanne Barnes, Simon Gibbons and Elizabeth M. Williamson, Fundamentals of Pharmacognosy and Phytotherapy (Get the book.) "REFERENCES American Herbal Pharmacopeia 1997 st john's wort (Hypericum perforatum L.). In: American herbal pharmacopeia and therapeutic compendium. AHP, Santa Cruz American Herbal Pharmacopoeia 1999 Valerian root (Valeriana officinalis). In: American herbal pharmacopeia and therapeutic compendium." - Dr. Michael Heinrich, Joanne Barnes, Simon Gibbons and Elizabeth M. Williamson, Fundamentals of Pharmacognosy and Phytotherapy (Get the book.)

"St John's wort (Hypericum perforatum L.): A review of its chemistry, pharmacology and clinical properties, Journal of Pharmacy and Pharmacology, 53: 583-600. 20. Hypericum Depression Trial Study Group, 2002, Effect of Hypericum perforatum (St. John's wort) in major depressive disorder, Journal of the American Medical Association, 287: 1807-1814. 21. Di Carlo et al., 2001, St. John's wort. 22. Palevitch. D., 1997, Feverfew (Tanacetum parthenium) as a prophylactic treatment for migraine: A double-blind, placebo-controlled study, Phytotherapy Research. 11: 508-511; Murphy, J.J." - Amarjit S. Basra, Handbook of Medicinal Plants (Get the book.)

"The main advantage of st john's wort extract over antidepressant drugs was not so much a difference in therapeutic outcome, but rather a significant advantage in terms of side-effects, cost and patient. For example, in a study of 102 patients there were slightly better results obtained with maprotiline (a tetracyclic) in the HAM-D, D-S, and CGI, but when side-effects and patient tolerance were added to the equation, st john's wort was considered superior.100 Maprotiline treatment resulted in the typical side-effects of tricyclics, e.g. tiredness, mouth dryness, and heart complaints." - Michael T. Murray, ND, Textbook of Natural Medicine 2nd Edition Volume 2 (Get the book.)

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