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"Andrew Mosholder, a psychiatrist at the FDA who reviewed data collected from ssri trials in childhood depression, became concerned about an increase in suicidal thoughts, but was specifically excluded by his superiors at the FDA from attending an FDA advisory panel meeting on drug treatment of childhood depression. As described in The Lancet (April 24, 2004, "Depressing Research"), after reviewing the evidence from clinical trials conducted by the drug companies, the Medicines and Healthcare Products Regulatory Agency (MHRA) of the United Kingdom (U.K." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"As you read further into the book you will see that due to the longterm accumulation of these drugs blocking of one receptor/passageway by an ssri or SNRI continues long after use of the drug. So, for instance, say a patient is given Prozac that closes one serotonin pathway out of the brain. Then they complain of side effects to the doctor who next gives them Zoloft. Then Zoloft is introduced into the brain shutting yet another door or pathway out of the brain for the serotonin." - Ann Blake Tracy, Ph.D., Prozac: Panacea or Pandora? The Rest of the Story on the New Class of ssri Antidepressants Prozac, Zoloft, Paxil, Lovan, Luvox & More (Get the book.)

"For the first part of the study, more than 700 adults who had not responded to Celexa or who could not tolerate this drug were randomly assigned to receive instead either sustained-release bupropion (Wellbutrin, not an ssri), Zoloft or venlafaxine (Effexor, not an ssri) for up to 14 weeks. Approximately 25% of the participants in the trial achieved total remission, regardless of the drug used. "Three different 'switch' medications were tested," says Dr. A." - Bottom Line Health, Bottom Line's Health Breakthroughs 2007 (Get the book.)

"And despite an FDA warning in 2004 of the increased risk of suicidal behavior for young people associated with ssri antidepressants and a great deal of public-relations bloodying of Big Pharma in 2006 and 2007, antidepressant use actually went up during that period. In 2006, 227 million antidepressant prescriptions were dispensed to Americans— more than any other class of medication—and up by 50 million prescriptions since 2002." - Charles Barber, Comfortably Numb: How Psychiatry Is Medicating a Nation (Get the book.) "But even within that context of the ongoing love affair of Americans with their substances, the ssri phenomenon has been exceptional in the rapidity of its penetration into the masses. Prozac was blessed by having a great opening act: Valium. Valium did what all great opening acts are supposed to do—set the stage, pave the way, and make the main event shine. Introduced in 1963 after being developed by the legendary Dr. Leo Sternbach of Hoffman-La Roche, Inc., Valium was one of the benzodiazepines, quick-acting antianxiety drugs which are, in effect, minor tranquilizers." - Charles Barber, Comfortably Numb: How Psychiatry Is Medicating a Nation (Get the book.)

"In the above study bipolar was triggered by ssri withdrawal in spite of the use of mood stabilizers normally used to counter a bipolar reaction. A study released in Am J Psychiatry, 1999 Sep; Vol; 156 (9), pp. 1417-20, "Elevated frequency of diabetes mellitus in hospitalized manic-depressive patients," clearly states what I have lectured and written about for the last ten years which is that bipolar is caused by blood sugar imbalance, "Disturbance in glucose homeostasis in psychiatric populations has been suggested since the early part of this century." - Ann Blake Tracy, Ph.D., Prozac: Panacea or Pandora? The Rest of the Story on the New Class of ssri Antidepressants Prozac, Zoloft, Paxil, Lovan, Luvox & More (Get the book.)

"Each year more and more Americans were taking psychiatric medications, particularly the ssri (selective serotonin reuptake inhibitor) antidepressants like Zoloft, Paxil, and Prozac. What started as a drip developed into a stream, a river, and then a torrent. Introduced to the market in 1988, Prozac appeared on the cover of Newsweek in 1990 ("A Breakthrough Drug for Depression"); was the subject of a best-selling and extremely influential book, Peter Kramer's Listening to Prozac in 1993; graced, again, in 1994 the Newsweek cover, this time with even greater claims ("Shy? Forgetful? Anxious?" - Charles Barber, Comfortably Numb: How Psychiatry Is Medicating a Nation (Get the book.)

"For example, switching from an ssri to Wellbutrin (bupropion) seems to help alleviate arousal and interest issues that are common in people who take SSRIs. So does switching from a beta-blocker for high blood pressure to an angiotensin receptor blocker such as losartan or valsartan. YOU Tip: Drink This. Research shows that Rhodiola rosea, when consumed as a tea or with a light alcohol like vodka, can aid with erectile dysfunction and improve prostate function. To make tea: Cut fine 5 grams of Rhodiola rosea roots." - Mehmet C. Oz., M.D. and Michael F. Roizen, M.D., You: Staying Young: The Owner's Manual for Extending Your Warranty (Get the book.)

"Fifty-five percent of patients with depression showed improvement when they tried with an ssri alone; 52 percent got better with CBT alone; but 85 percent showed improvement when both treatments were used. In the same way that CBT improves treatment of depression with antidepressants, I strongly believe that CBT improves treatment of medically unexplained pain and fatigue. I will discuss in more detail a simple version of CBT in chapter 8 because it is extremely useful in helping people cope with chronic illness, even in the absence of depression." - Benjamin H. Natelson, M.D., Your Symptoms Are Real: What to Do When Your Doctor Says Nothing Is Wrong (Get the book.)

"In a landmark study affectionately called SMILE (Standard Medical Intervention and Long-term Exercise), James Blumenthal and his colleagues pitted exercise against the ssri sertraline (Zoloft) in a sixteen-week trial. They randomly divided 156 patients into three groups: Zoloft, exercise, or a combination of the two. The exercise group was assigned to supervised walking or jogging, at 70 to 85 percent of their aerobic capacity, for thirty minutes (not including a ten-minute warm-up and a five-minute cool-down) three times a week. The results?" - John J. Ratey, MD, Spark: The Revolutionary New Science of Exercise and the Brain (Get the book.) "I insisted that he try an antidepressant, and I put him on the ssri escitalopram (Lexapro). He had a severe reaction—he felt nauseated and started throwing up — and said he didn't want to try another. He'd been physically active in the past, and I told him that he should really be exercising every day. I'd been talking about it all along, but after the Lexapro episode, I explained what an enormous effect exercise has on the brain, and I gave him several relevant studies in an appeal to his professional sensibility. Two weeks later, he looked like a different man." - John J. Ratey, MD, Spark: The Revolutionary New Science of Exercise and the Brain (Get the book.)

"No one ssri seems to be more beneficial than another, but the atypical ssri mirtazapine has the side effect of increasing appetite. Lifestyle modifications: Eat a high-protein diet that excludes processed foods and is low sugar and caffeine. This can help to increase the effectiveness of other therapies. Winter holidays, or in extreme cases, relocation to a sunnier area may be advisable if possible. St." - Marshall Editions, 1000 Cures for 200 Ailments: Integrated Alternative and Conventional Treatments for the Most Common Illnesses (Get the book.)

"Genie was working as a pharmaceutical representative for Eli Lilly in 1987 when the company launched the first ssri, Prozac. During sales meetings, she was instructed to target ob-gyns and sell them on Prozac as a cure for the symptoms of premenstrual syndrome (PMS), such as depression, mood swings, bloating, and anxiety. Evidently, the recommended sales technique worked. Prozac soon accounted for one-quarter of Lilly's revenues, with annual sales reaching $2.6 billion." - C. W. Randolph, M.D., From Belly Fat to Belly FLAT: How Your Hormones Are Adding Inches to Your Waistline and Subtracting Years from Your Life (Get the book.)

"For the first part of the study, more than 700 adults who had not responded to Celexa or who could not tolerate this drug were randomly assigned to receive instead either sustained-release bupropion (Wellbutrin, not an ssri), Zoloft or venlafaxine (Effexor, not an ssri) for up to 14 weeks. Approximately 25% of the participants in the trial achieved total remission, regardless of the drug used. "Three different 'switch' medications were tested," says Dr. A." - Bottom Line Health, Bottom Line's Health Breakthroughs 2007 (Get the book.)

"In fact the SUV story and ssri story have remarkable similarities: both grew into iconic products of their age, and both represent in their respective industries the most extraordinary kind of overkill, or what marketers call "overperformance," the gap, or disconnect, between a product's maximal capabilities and what is needed for everyday, real-world use.8 SUVs may well be able to pull three tons up the Himalayas, but most people need them only to get to Wal-Mart at three in the afternoon." - Charles Barber, Comfortably Numb: How Psychiatry Is Medicating a Nation (Get the book.)

"He feared Graham's views concerning the lack of safety of Bextra, ssri antidepressants, Lotronex, and Rezulin would invite a general congressional inquiry into FDA's new drug approval process, revealing for the first time details long kept from public view through a combination of intimidation and character assassination. When efforts by Graham's supervisors at intimidating him into not testifying before the Senate Finance Committee proved unsuccessful, new efforts were undertaken to disparage him with Senator Grassley's office and with others." - Jonathan W. Emord, The Rise of Tyranny (Get the book.)

"As well, "it is estimated that between 10% and 25% of ssri users experience akathisia,119 often in conjunction with suicidal thoughts, hostility and violent behavior." As if that isn't bad enough, antidepressants can accumulate in the lungs, so that if a second antidepressant is prescribed, they may be released in toxic levels.120 Anti-hypertensive medications are blood-pressure reduction pills. Non-steroidal anti-inflammatory medications are those that reduce joint pain, used in the treatment of gout, arthritis and other inflammations." - Kenneth W Thomas, Ron Gilbert, Gerd Schaller, Side Effects: The Hidden Agenda of the Pharmaceutical Drug Cartel (Get the book.)

"Finally one of the physicians noted in the record that Melvin was "exquisitely ssri sensitive." Eventually they subdued him with antipsychotic and mood-stabilizing drugs, and then added yet another risky, stimulating antidepressant, Wellbutrin. PSYCHIATRY'S COMPULSION TO DO "MORE OF THE SAME" MUCH LIKE MELVIN WORTHY, patients are often continued on the medications that have driven them over the edge. Sometimes it seems as if the doctors become defiant." - Peter Breggin, Medication Madness: A Psychiatrist Exposes the Dangers of Mood-Altering Medications (Get the book.)

"Actually this is true for the majority of people, but in some less common cases it may take up to five weeks to work, about the same as a pharmaceutical antidepressant in the ssri class, which includes Prozac, Paxil, and Zoloft.) A review of eleven research papers on SAMe, published in Clinical Investigative Medicine in June 2005, concluded that "there appears to be a role for SAMe in the treatment of major depression in adults." Note the qualifier "major." - Jonny Bowden, Ph.D., C.N.S., The Most Effective Natural Cures on Earth: The Surprising, Unbiased Truth about What Treatments Work and Why (Get the book.)

"SSRI: (selective serotonin reuptake inhibitor) a class of drugs, such as fluoxetine or sertraline, that inhibit the uptake of serotonin by neurons of the central nervous system and are primarily used in the treatment of depression and obsessive compulsive disorder. 146 Minutes of the meeting convened by the Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research held on February 2, 2004. http://www.fda.gov/ohrms/dockets/ac/04/transcripts/4006Tl. htm pp. 12 - 13 147 http://www.fda.gov/ohrms/dockets/ac/04/transcripts/4006Tl.htmp." - Kenneth W Thomas, Ron Gilbert, Gerd Schaller, Side Effects: The Hidden Agenda of the Pharmaceutical Drug Cartel (Get the book.)

"Rates of pediatric prescriptions for the stimulant Ritalin, which is used to treat attention deficit hyperactivity disorder, have been going up dramatically along with rates of * For anyone who has found relief from depression by taking an ssri, the fact that the drugs have proved no more effective than a sugar pill in clinical trials undoubtedly seems more than a little strange. The problem is the "placebo effect," the ability of placebos to make people feel better, a mysterious but common occurrence in medicine." - Shannon Brownlee, Overtreated: Why Too Much Medicine Is Making Us Sicker and Poorer (Get the book.) "Paxil sales, most of which were for social anxiety disorder, hit three billion dollars in 2002, putting it ahead of Zoloft, the nation's number-two ssri. Some might reasonably argue that Cohn and Wolfe's marketing campaign was indeed a public service to people who did not realize that their debilitating shyness was actually a mental disorder, that help was available. It undoubtedly brought some social-phobes into a doctor's office for treatment." - Shannon Brownlee, Overtreated: Why Too Much Medicine Is Making Us Sicker and Poorer (Get the book.)

"Combining an ssri with an MAOI can cause sudden severe high blood pressure. 4. After stopping MAOIs, you should wait 4 weeks before taking any ssri, either the prescription drug or hypericum. Scientists don't know for sure (research hasn't been done) if there is a serious problem between the two, but the warning has been issued because of what is known about SSRIs and MAOIs. Unfortunately, the best way to make the change from one of the SSRIs (Prozac, Paxil, Zoloft, or Effexor) to St. John's wort isn't known, either." - Carol Turkington, The Hypericum Handbook: Nature's Antidepressant (Get the book.)

"This may help persons who have failed to benefit from selective serotonin reuptake inhibitors (SSRI) and may also prove of value to those who have had side effects from ssri therapy. Powdered packets of 4 grams and effervescent delivery systems are also available. Inositol is safe and readily available in health food stores and from Natural Health Team 800-416-2806. Anxiety Kava Many individuals are in great stress in our modem society. Conventional psychoactive drugs have the problems of addiction and side effects." - James A. Howenstine, A Physician's Guide to Natural Health Products That Work (Get the book.)

"Nonetheless, unlike in Britain, the FDA kept the ssri antidepressants available for pediatric prescription. The list of drugs above is but a small subset of the universe of drugs FDA has approved over safety objections from its own medical reviewers." - Jonathan W. Emord, The Rise of Tyranny (Get the book.) "Graham recalls the turn of events: [I]n early 2004, FDA suppressed another FDA scientist [referring to Mosholder] who had concluded that ssri antidepressants increased the risk of suicidality in children. FDA held an advisory committee meeting where it hid this information from the public and from its own advisory committee. This suppression of important safety information was leaked to the press by people within FDA and this embarrassed the agency. My supervisor ordered an internal criminal investigation to identify and imprison the perpetrators.145 In a March 15, 2004 memo from Dr." - Jonathan W. Emord, The Rise of Tyranny (Get the book.)

"Published studies show that treatment with the new ssri (selective seratonin reuptake inhibitor) antidepressants provides significant benefit to people suffering from both of these conditions. An exquisitely designed study (sponsored—to give credit where credit is due—by Pfizer, the manufacturer of Zoloft) randomized people suffering from social anxiety disorder into four groups: two of the groups were treated with Zoloft for 24 weeks and two with a placebo." - John Abramson, Overdosed America: The Broken Promise of American Medicine (P.S.) (Get the book.)

"When taking ssri antidepressants such as Prozac, Zoloft, Paxil, and Celexa—and more commonly during withdrawal from the drugs—individuals frequently cite indescribable mental and physical pain inside their heads as their greatest source of unendurable distress. Because most of these antidepressants are relatively short acting, more than half the drug is eliminated from the body in less than a day, so that people can go into withdrawal between doses." - Peter Breggin, Medication Madness: A Psychiatrist Exposes the Dangers of Mood-Altering Medications (Get the book.) "I ques: oned whether the FDA might have rejected Prozac and that the entire ssri onslaught might never have gotten started if the president and vice president of the United States had not been so closely affiliated with Eli Lilly. APPLYING THE SUICIDE WARNING TO ADULTS TAKING ANTIDEPRESSANTS BENEATH THE BLACK BOX, the FDA mandated another new section entitled, "warnings: Clinical Worsening and Suicide Risk," that applies to children and to adults." - Peter Breggin, Medication Madness: A Psychiatrist Exposes the Dangers of Mood-Altering Medications (Get the book.)

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