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"These drugs, the selective serotonin reuptake inhibitors, or ssris, are known more commonly as antidepressants. In some people, 5-HTP has an effect that is similar to ssris, although ssris generally have stronger and more reliable actions. Some studies have indicated that 5-HTP can be effective for depression, anxiety, panic attacks, insomnia, and weight management. As a rule, it tends to cause fewer side effects than the ssris, which are typically applied to mood disorders. Although 5-HTP is generally well tolerated, some people experience the paradoxical effect of increased agitation." - Kenneth Bock, Healing the New Childhood Epidemics: Autism, ADHD, Asthma, and Allergies: The Groundbreaking Program for the 4-A Disorders (Get the book.)

"Kip Kinkle, who shot his parents and then shot his classmates in Oregon, was on ssris. • Brynn Hartmann, the actor Phil Hartmann's wife, was on ssris when she shot her husband and committed suicide. • In March of 1998, Matthew Beck went on a bloody rampage at his office, the Connecticut Lottery Corp. headquarters, killing four senior lottery officials before committing suicide. He was on 2 antidepressants, including Luvox. • Many children under the age of 3 have already been given Prozac. • Special "flavored" ssris are now in development just for children." - Jon Barron, Lessons from The Miracle Doctors: A Step-by-Step Guide to Optimum Health and Relief from Catastrophic Illness (Get the book.) "But not without cost. • ssris cause mania and delusions of grandeur in one out of every 25 children taking the drugs. • A tendency to violence has been reported in 1 out of 16 SSRI users • In 70% of all murder/suicides involving women and children, the women were on SSRIs The Columbine Tragedy, et al • Specialized testing during the autopsy of Eric Harris, one of the Colombine shooters, showed "therapeutic" levels of an SSRI in his blood. In addition, he was also taking cough syrup." - Jon Barron, Lessons from The Miracle Doctors: A Step-by-Step Guide to Optimum Health and Relief from Catastrophic Illness (Get the book.)

"The Committee on Safety of Medicines, a subagency of the MHPRA, found "the risks of treating depressive illness in under 18s with certain ssris outweigh the benefits of treatment."144 Long before Mosholder issued his report, FDA management scheduled him to speak before a February 2, 2004 meeting of the FDA advisory committee considering safety risks associated with the prescription of ssris to children. Mosholder's negative findings caused FDA management to reconsider whether Mosholder should be allowed to speak." - Jonathan W. Emord, The Rise of Tyranny (Get the book.)

"Brynn Hartmann, the actor Phil Hartmann's wife, was on ssris when she shot her husband and committed suicide. • In March of 1998, Matthew Beck went on a bloody rampage at his office, the Connecticut Lottery Corp. headquarters, killing four senior lottery officials before committing suicide. He was on 2 antidepressants, including Luvox. • Many children under the age of 3 have already been given Prozac. • Special "flavored" ssris are now in development just for children. The Herbal Solution For the vast majority of people bothered by stress or depression, there is a safe, effective solution." - Jon Barron, Lessons from The Miracle Doctors: A Step-by-Step Guide to Optimum Health and Relief from Catastrophic Illness (Get the book.)

"Among patients with Parkinson's disease treated with ssris, there were 16 cases of worsening parkinsonism. Patients who developed dystonia, parkinsonism, or tardive dyskinesia were older on average than patients with akathisia; 67.6% of affected patients were females. Fluoxetine, the most commonly prescribed SSRI to date, was implicated in 53 (74.6%) of cases of SSRI-induced EPS. Several reports (57.7%) were confounded by the concomitant use of other medications that can contribute to the development of EPS." - Gary Null and Amy McDonald, The Food-Mood Connection: Nutrition-based and Environmental Approaches to Mental Health and Physical Wellbeing (Get the book.)

"For major depression, ssris were "clearly beneficial" though as the authors are careful to note, the efficacy is most easily established "in carefully selected patients."33 SUICIDE AND MURDER A hearing about suicide, and a murder trial, frame our discussion. The suicide hearing: 15 September 2004—In a 15-8 vote, a panel of experts recommended that the FDA warn physicians and patients in the strongest possible terms that antidepressants fail in most cases to cure depression in children and teenagers; even worse, for every 100 patients given the drug, 2—3 will become suicidal. " - Gerald E. Markle and Frances B. McCrea, What If Medicine Disappeared? (Get the book.)

"Some children develop racing thoughts, "electric head," or a feeling of lightning bolts in the head several weeks into treatment with ssris. This side effect can be associated with suicidal thoughts, and appears to be more common in children and young adults. It may be a form of what is called akathisia, an internal restlessness associated with psychotropic medication use, which can be treated successfully with benzodiazepine medications like diazepam (Valium)." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.) "Children and young adults treated with ssris should be watched carefully for signs of suicidal thoughts or akathisia, and a one-week course of benzodiazepines should be started if necessary. Antipsychotic Medications and Children Over the past two decades there has been a stunning increase in the use of antipsychotic medications for children. In the U.S., doctor visits for antipsychotic treatment increased from 201,000 in 1993 to 1,224,000 in 2002." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.) "There was no difference, however, between ssris and the older tricyclic antidepressants, suggesting that all antidepressant medications may carry an increased risk of suicide. Questions about suicidal thinking with antidepressants have been around for years, and occurred with the tricyclics. Some doctors, including my father (who is a retired psychiatrist), offer the explanation that the increase in energy that antidepressants experience often gives the suicidal patient enough stamina to go through with the act." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.) "This has become a particular issue in the case of treating childhood depression with ssris. Parents may take their kids into the general practitioner if they are sad about a breakup with a boyfriend or girlfriend or are having trouble fitting in at school. The doctor's natural response these days, more frequently than not, may be to get out a prescription pad and write a scrip for an SSRI. In the past decade there has been a dramatic shift from the psychiatrist and appropriate therapy to Prozac as the "mind drug" of the general practitioner." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"John's Wort It's the largest selling antidepressant in Germany, and does indeed work on mild to moderate depression by elevating the levels of serotonin in the brain, much like the ssris such as Lexapro and Prozac. You'll recall that sugar increases serotonin levels, making us temporarily less depressed; conversely, dieters get grouchy because their serotonin levels fall. When supplementing with St. John's Wort, some of my patients—and I-report diminished sugar urges; others didn't notice such an effect." - Dr. Steven R. Gundry, Dr. Gundry's Diet Evolution: Turn Off the Genes That Are Killing You - And Your Waistline - And Drop the Weight for Good (Get the book.)

"New labeling on ssris reflect recent findings that in rare cases, ssris increase suicidal and violent thinking and behavior. Nutrients depleted: None reported. ATYPICAL ANTIDEPRESSANTS: bupropion (Wellbutrin, Zyban), duloxetine (Ariclaim, Cymbalta, Xeristar, Yentreve), venlafaxine (Effexor, Effexor XR) Atypical antidepressants are a more modern class of antidepressant, used when a patient is more withdrawn due to a lack of norepinephrine (besides being anxious from a lack of serotonin), and needs to have more of the activating neurotransmitters." - Hyla Cass, Supplement Your Prescription: What Your Doctor Doesn't Know About Nutrition (Get the book.)

"The newer ssris were the most frequent culprits but older antidepressants were also involved in causing mania and psychosis. Two of the patients heard voices (hallucinations) commanding them to kill themselves. Physicians too often mistakenly believe that antidepressants can only cause mania in especially vulnerable people who have already displayed manic tendencies or have some hidden vulnerability to do so. As these and many other studies9 confirm, that is simply untrue." - Peter Breggin, Medication Madness: A Psychiatrist Exposes the Dangers of Mood-Altering Medications (Get the book.)

"CONCLUSIONS: Clinicians should be aware of the possible effects of fluoxetine (and possibly other ssris) on memory. Fluoxetine-induced extrapyramidal symptoms in an adolescent: a case report. Diler RS, Yolga A, Avci A. Swiss Med Wkly 2002;132:125-126. We present a 15-year-old girl with depression, an obsessive compulsive disorder and conduct disorder, who developed EPS (torticollis, bradykinesia and cogwheel rigidity) while on fluoxetine. No other cause of EPS was present. The patient responded well to benztropine but re-experienced EPS when benztropine was stopped." - Gary Null and Amy McDonald, The Food-Mood Connection: Nutrition-based and Environmental Approaches to Mental Health and Physical Wellbeing (Get the book.)

"The ssris do just what the term says— they inhibit the action of the cleanup crew that "mops up" serotonin from the brain, thus allowing serotonin to hang around longer. The more serotonin, goes the reasoning, the happier the camper. Enter 5-HTP. Your body makes serotonin from an amino acid known as L-tryptophan. L-tryptophan comes in foods like turkey and seafood. The body then turns it into a metabolite called 5-HTP (5-hydroxytryptophan) and then, with the help of vitamin B6, into 5-HT (5-hydroxytryptamine), better known to all of us as plain old serotonin." - Jonny Bowden, Ph.D., C.N.S., The Most Effective Natural Cures on Earth: The Surprising, Unbiased Truth about What Treatments Work and Why (Get the book.)

"Since SSRI-related EPRs have occurred in different situations with different possible contributing factors, clinical pharmacy practitioners and other healthcare providers should remain aware of these reactions and carefully consider educating and monitoring their patients accordingly CONCLUSIONS: The use of ssris may be associated with the development of EPRs; therefore, appropriate monitoring should be considered for patients so that optimal pharmaceutical care may be provided. Recognition and management of acute neuroleptic-induced extrapyramidal motor and mental syndromes.Dose M." - Gary Null and Amy McDonald, The Food-Mood Connection: Nutrition-based and Environmental Approaches to Mental Health and Physical Wellbeing (Get the book.) "Conventional treatment of anxiety disorders involves medications—including antidepressants (primarily the newer selective serotonin reuptake inhibitors, or ssris), antianxietry drugs, and beta-blockers—as well as psychotherapy, particularly cognitive behavior therapy. In cognitive behavior therapy, the goal is to change a person's thinking pattern and the way he or she reacts to situations that provoke anxiety. From the perspective of orthomolecular psychiatry, practically any nutritional deficiency that affects the mind—and almost all do in one way or another—can cause anxiety." - Gary Null and Amy McDonald, The Food-Mood Connection: Nutrition-based and Environmental Approaches to Mental Health and Physical Wellbeing (Get the book.)

"As a rule, it tends to cause fewer side effects than the ssris, which are typically applied to mood disorders. Although 5-HTP is generally well tolerated, some people experience the paradoxical effect of increased agitation. This may be due to the fact that these people already have an excess of serotonin. An excess of serotonin can cause mood disorders, just as a deficiency can. Serotonin, like all neurotransmitters, works best in a limited bandwidth. I often recommend 5-HTP for insomnia, depression, and irritability. It may also help reduce carbohydrate cravings." - Kenneth Bock, Healing the New Childhood Epidemics: Autism, ADHD, Asthma, and Allergies: The Groundbreaking Program for the 4-A Disorders (Get the book.)

"Consistent with what we find throughout this book, the increased rate of suicide on ssris occurred during the first month of treatment and "suicides of a violent nature were distinctly more common during SSRI therapy." Members of the "public" were allowed to make three-minute presentations.21 In my presentation, I politely told the FDA that it was playing with junk when it tried to analyze the suicidality data produced by drug companies. I emphasized that the drug companies cannot be trusted to deliver accurate data from their clinical trials." - Peter Breggin, Medication Madness: A Psychiatrist Exposes the Dangers of Mood-Altering Medications (Get the book.) "They focused on studies conducted on ssris such as Prozac, Zoloft, and Paxil, and concluded that these drugs "do not have a clinically meaningful advantage over placebo." As this book goes to press, a research team led by Kirsch (2008) has once again produced a meta-analysis of the scientific literature demonstrating the ineffectiveness of antidepressants. It is a sad, ironic, and tragic tale: It's impossible to prove that antidepressants actually relieve depression but it's relatively easy to demonstrate that they can worsen depression and cause mania, murder, and suicide." - Peter Breggin, Medication Madness: A Psychiatrist Exposes the Dangers of Mood-Altering Medications (Get the book.) "Prozac was followed by several competing ssris, including Paxil, which Harry Henderson was taking when driven in an anguished, suicidal state. All of the SSRI antidepressants have very similar and often identical adverse effects, so that as of early January 2005, the FDA has required the identical black-box warning for all of them concerning drug-induced suicide and mental deterioration in children and youth age eighteen and younger, which was then expanded to include young adults (see chapter 3). Did Emily know the potential risks involved in taking Prozac?" - Peter Breggin, Medication Madness: A Psychiatrist Exposes the Dangers of Mood-Altering Medications (Get the book.)

"It's also well known in the medical community that excessively elevated serotonin levels (from Prozac or other ssris) can cause suicidal depression the same way too low of a level of serotonin can. Which begs the question: Could some of the suicides blamed on these antidepressants have been prevented with simple genetic testing for the gene that's responsible for the detox enzyme? I personally think so. Interestingly, on the other hand, some folks make too much of this enzyme (as well as other enzymes) and require higher doses of drugs for the therapeutic benefit." - Brenda Watson and Leonard Smith, The Detox Strategy: Vibrant Health in 5 Easy Steps (Get the book.)

"The primary way ssris are thought to work is by increasing the amount of serotonin available to parts of the brain that are not receiving enough of this brain-active chemical. The success of this class of drugs in treating depression supports the underlying assumption responsible for their existence: that a lack of serotonin produces the symptoms of depression. However, brain-active chemicals besides serotonin can also affect mood. Altering levels of a different neurotransmitter called norepinephrine (also called noradrenaline) can also alter mood." - Benjamin H. Natelson, M.D., Your Symptoms Are Real: What to Do When Your Doctor Says Nothing Is Wrong (Get the book.)

"Newer medications, such as the selective serotonin reuptake inhibitors, or ssris, are helping. (See Categories of Antidepressant Drugs on page 356.) ssris generally produce fewer side effects than the older drugs, making it easier for people, including older adults, to adhere to treatment. Both generations of medication are effective in relieving depression, although any given individual may respond to one type of drug and not another. It is difficult to predict which people will respond to which drug, or who will experience what side effects." - Phyllis A. Balch, CNC, Prescription for Nutritional Healing, 4th Edition: A Practical A-to-Z Reference to Drug-Free Remedies Using Vitamins, Minerals, Herbs & Food Supplements (Get the book.)

"Low levels of serotonin are associated with depression, anxiety, and sleep disorders. ssris prevent the brain cells from using up serotonin too quickly, thereby causing a deficiency. 5-Hydroxytryptophan (5-HTP) is a hot new supplement that does what the ssris cannot: increase the cells' production of serotonin to boost serotonin levels. When tested against standard ssris, 5-HTP has proved to be an equally effective antidepressant but without any of the negative side effects associated with ssris, such as dry mouth, reduced libido, heart palpitations, tremors, and anxiety." - Earl Mindell, R.Ph., Ph.D., Earl Mindell's Supplement Bible: A Comprehensive Guide to Hundreds of NEW Natural Products that Will Help You Live Longer, Look Better, Stay Heathier, ... and Much More! (Get the book.)

"New labeling on ssris reflect recent findings that in rare cases, ssris increase suicidal and violent thinking and behavior. Nutrients depleted: None reported. atypical antidepressants: bupropion (Wellbutrin, Zyban), duloxetine (Ariclaim, Cymbalta, Xeristar, Yentreve), venlafaxine (Effexor, Effexor XR) Atypical antidepressants are a more modern class of antidepressant, used when a patient is more withdrawn due to a lack of norepinephrine (besides being anxious from a lack of serotonin), and needs to have more of the activating neurotransmitters." - Hyla Cass, M.D., Supplement Your Prescription: What Your Doctor Doesn't Know About Nutrition (Get the book.)

"On balance, the side effects are certainly outweighed by the most serious consequences of depression, but they get in the way for a lot of people. Now ssris carry a warning that they may increase the risk of suicidal thoughts and actions in children and adolescents, a finding that is still in question. And stories are coming out about the difficulty of withdrawing from this class of drugs, especially from venlafaxine (Effexor). Recently, I started treating a successful entrepreneur whose life was a mess." - John J. Ratey, MD, Spark: The Revolutionary New Science of Exercise and the Brain (Get the book.)

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