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"Yet another ssri, Celexa, placed seventeenth in sales, grossing $1.5 billion. SSRIs were also third in prescription activity, 140 million in 2002, up 12.6% from 2001. It is generally believed that SSRIs are effective in the treatment of depression. Prescriptions are easy to get and millions of Americans take them. But, in this book, we repeatedly ask the question: Do they work? That is, are SSRIs effective treatments for depression? In the early 1990s, SSRIs were tested against so-called tricyclic antidepressants (TCA), the drugs they replaced." - Gerald E. Markle and Frances B. McCrea, What If Medicine Disappeared? (Get the book.) "The balance between benefit and harm of ssri for depression in childhood has yet to be shown to be favorable."41 We would rephrase: In the treatment of childhood depression, SSRIs do more harm than good. Harm, of course, includes many outcomes— one of which may be the worst of all. Does the use of SSRIs lead to suicide? Unfortunately, the research findings are confusing and contradictory. Still, we can come to three conclusions. In reverse order of causality, they are: First, there does not seem to be any relationship, or at least "no clear relationship," between SSRIs and suicide." - Gerald E. Markle and Frances B. McCrea, What If Medicine Disappeared? (Get the book.)

"The most common medication recommended for PMS/PMDD of moderate to severe intensity is an ssri. These medications can be used just on the severe-symptom days each month. They are effective the day they are taken, which suggests that SSRIs in this case are not helping by increasing neurotransmitters. They seem to work in PMS by altering the neurophysiology and electrical conduction in the brain. Several SSRIs have been used. Suggested doses are fluoxetine (20 mg a day) or the once-weekly tablet sertraline or paroxetine controlled-release (12.5 to 25.0 mg per day)." - Tori Hudson, N.D., Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness (Get the book.)

"Patients in this group knew that they were receiving the real ssri, as did their physicians, a condition which surely created expectations of maximum benefit—and made comparison with the other groups less meaningful. "The data do not support the TADS authors' optimistic conclusion. The balance between benefit and harm of ssri for depression in childhood has yet to be shown to be favorable."41 We would rephrase: In the treatment of childhood depression, SSRIs do more harm than good. Harm, of course, includes many outcomes— one of which may be the worst of all." - Gerald E. Markle and Frances B. McCrea, What If Medicine Disappeared? (Get the book.)

"A tendency to violence has been reported in 1 out of 16 ssri users • In 70% of all murder/suicides involving women and children, the women were on SSRIs The Columbine Tragedy, et al • Specialized testing during the autopsy of Eric Harris, one of the Colombine shooters, showed "therapeutic" levels of an ssri in his blood. In addition, he was also taking cough syrup." - Jon Barron, Lessons from The Miracle Doctors: A Step-by-Step Guide to Optimum Health and Relief from Catastrophic Illness (Get the book.)

"In this context, it is worth noting that there is some evidence of a 20 percent drop in ssri use among children from March to December 2004 (Rosack, 2005). This is likely a result of the risk scare that SSRIs may increase suicidalitv in children and adolescents (Jureidini et al., 2004), which prompted the British medical authority to ban SSRIs for children and the FDA to add a "black box" warning to the drug labels. It is unclear, however, whether this decline in use will be just a blip in the continual rise of ssri use with children and adolescents or if it will be a long-lasting trend." - Peter Conrad, The Medicalization of Society: On the Transformation of Human Conditions into Treatable Disorders (Get the book.)

"Twenty years later, it's evident that Prozac and its ssri daughters don't work for everyone, nor do antidepressants that target norepinephrine, dopamine, or any combination of the three. One of the issues is side effects. To take an example, a good portion of my patients on SSRIs develop problems with their sex lives after a few months. Some estimates suggest that more than 50 percent complain of sexual side effects, ranging from lack of interest to lack of functionality. (It says something that SSRIs are often used as a treatment for premature ejaculation and for sexual offenders." - John J. Ratey, MD, Spark: The Revolutionary New Science of Exercise and the Brain (Get the book.)

"This case report shows that EPS can and does occur in youth with ssri. Clinicians should be aware of the SSRIs as a potential causative factor for EPS. Fluoxetine-induced tremor: clinical features in 21 patients. M. Serrano-Duenas - Servicio de Neurologia del Hospital Carlos Andrade Marin, Insti-tuto Ecuatoriano de Seguridad Social, Facultad de Medicina de la Pontificia, Universidad Catolica del Ecuador, Quito, Ecuador. Parkinsonism & Related Disorders Volume 8, Issue 5, June 2002, Pages 325-327 We report a cohort of 21 patients (12 females and nine males), with a mean age of 42." - Gary Null and Amy McDonald, The Food-Mood Connection: Nutrition-based and Environmental Approaches to Mental Health and Physical Wellbeing (Get the book.) "The proposed hypothesis for EPRs occurring with ssri use involves serotonin's inhibitory actions on extrapyramidal dopamine activity. Other possible contributing factors include pharmacokinetic interactions or drug-disease interactions. EPRs may include dystonias, dyskinesias, akathisia, parkinsonism, exacerbations of Parkinson's disease, and possibly the neuroleptic malignant syndrome. The majority of SSRI-related reactions appear to occur within the first month of treatment." - Gary Null and Amy McDonald, The Food-Mood Connection: Nutrition-based and Environmental Approaches to Mental Health and Physical Wellbeing (Get the book.)

"The second established that bone mineral density (BMD) among elderly male ssri users was about 4% lower at the hip bone and about 6% lower at the spine compared to those reporting no ssri use. Another investigation reported that SSRI-using adults over the age of 50 were twice as likely to fracture a bone and twice as likely to fall as those who did not use the drugs.75 These risks were dose-dependent, meaning that as the dosage of the drug increased, there was a accompanying increase in fractures and falling. The extraordinary story of Dr." - Marc Sorenson, Solar Power For Optimal Health (Get the book.)

"The other confounding factor here is the fact that not everybody responds in the same way to an ssri. Studies in healthy volunteers, people who have no signs or symptoms of depression, have found that some people feel terrific, even better than well, on an antidepressant. Many feel little or nothing. For others, SSRIs can trigger akathisia and suicidal thoughts. t Eli Lilly, the maker of Prozac, has data showing that 38 percent of people who take the drug become "activated," a term that includes varying degrees of agitation." - Shannon Brownlee, Overtreated: Why Too Much Medicine Is Making Us Sicker and Poorer (Get the book.)

"Glenmullen, an ssri pre-scriber, came to believe that Prozac and other SSRIs are not, as Solomon describes, "essentially benign cures." In Prozac Backlash, endorsed by a former president of the American Psychiatric Association, Glenmullen has this to say about Prozac and other SSRIs: "Withdrawal syndromes—which can be debilitating—are estimated to affect up to 50 percent of patients." - Bruce E. Levine, Surviving America's Depression Epidemic: How to Find Morale, Energy, and Community in a World Gone Crazy (Get the book.)

"When someone with medical symptoms other than pain also has depression, I usually start with drugs in the ssri class, such as esc-italopram (Lexapro). An added benefit of this particular ssri is that it can also relieve anxiety and sometimes improve sleep. When widespread pain and depression coexist, I choose to prescribe duloxetine (Cymbalta), a drug that alters both serotonin and norepinephrine. I will discuss Cymbalta further when I talk about how I manage severe nonmalignant pain in chapter 7." - Benjamin H. Natelson, M.D., Your Symptoms Are Real: What to Do When Your Doctor Says Nothing Is Wrong (Get the book.)

"And many classes of drugs—especially beta-blockers and the ssri class of antidepressants—list erectile dysfunction as one of the major side effects. (How's that for a trade-off? Take a drug to improve your mood, but risk cutting off your sexual interest and capabilities at the same time.) If you or your partner experience ED while taking a drug, tell your doc so she can switch you to another class that may not have as powerful an effect. For example, switching from an ssri to Wellbutrin (bupropion) seems to help alleviate arousal and interest issues that are common in people who take SSRIs." - Mehmet C. Oz., M.D. and Michael F. Roizen, M.D., You: Staying Young: The Owner's Manual for Extending Your Warranty (Get the book.)

"A meta-analysis of data on SSRI's submitted to the FDA indicates that placebos (sugar pills) are as effective as SSRI's in reducing depression; in other words, only drug companies benefit from SSRI's—not depression sufferers. And now the good news: serotonin levels relate directly to the availability of sunlight A study reported in the Lancet in 2002 found that brain serotonin levels were greater during the summer, and higher on sunny days than cloudy ones—the brighter the sunlight, the greater the production of serotonin." - Marc Sorenson, Solar Power For Optimal Health (Get the book.)

"In the Summer of 2003 Britain's Medicines and Healthcare Products Regulatory Agency prohibited the prescription of the ssri drug Paxil (sold in Britain under the name Seroxat) to depressed patients.142 In December of 2003 the MHPRA declared antidepressants Zoloft, Lexapro, Celexa, Luvox, Serzone, Remeron, and Paxil unsuitable for those under eighteen years of age.143 The Committee on Safety of Medicines, a subagency of the MHPRA, found "the risks of treating depressive illness in under 18s with certain SSRIs outweigh the benefits of treatment." - Jonathan W. Emord, The Rise of Tyranny (Get the book.)

"One study compared 5-HTP to fluvoxamine, an ssri like Prozac, Paxil, and Zoloft. In the study, subjects received either 5-HTP (100 mg) or fluvoxamine (50 mg) three times daily for six weeks. More patients felt better after using 5-HTP than fluvoxamine, and 5-HTP was quicker acting than the fluvoxamine. And in one other study, patients who were unresponsive to other antidepressant therapy showed significant improvement when using 5-HTP. Then there are headaches." - Jonny Bowden, Ph.D., C.N.S., The Most Effective Natural Cures on Earth: The Surprising, Unbiased Truth about What Treatments Work and Why (Get the book.)

"GULF WAR VETERANS: Captain Joyce Riley, who has headed the battle in exposing Gulf War Syndrome, has noted that approximately 80- 90% of the Gulf War vets are now on or have been offered one of the ssri antidepressants. As a result many have had their lives turned upside down with others committing suicide or murder/suicide. When you see one of these tragedies keep in mind that if the perpetrator was a Gulf War vet the chances he was on one of these medications is very high. This raises questions about Timothy McVeigh who bombed the federal building in Oklahoma City." - Ann Blake Tracy, Ph.D., Prozac: Panacea or Pandora? The Rest of the Story on the New Class of ssri Antidepressants Prozac, Zoloft, Paxil, Lovan, Luvox & More (Get the book.)

"The other confounding factor here is the fact that not everybody responds in the same way to an ssri. Studies in healthy volunteers, people who have no signs or symptoms of depression, have found that some people feel terrific, even better than well, on an antidepressant. Many feel little or nothing. For others, SSRIs can trigger akathisia and suicidal thoughts. t Eli Lilly, the maker of Prozac, has data showing that 38 percent of people who take the drug become "activated," a term that includes varying degrees of agitation." - Shannon Brownlee, Overtreated: Why Too Much Medicine Is Making Us Sicker and Poorer (Get the book.)

"Mood-stabilizing agents, which include valproic acid (Valproate), carbamazepine (Tegretol), topiramate (Topomax), lamotrigine (Lamictal), phenytoin (Dilantin), and neurontin (Gabapentin), are commonly used in clinical practice, often in combination with ssri medications, since psychiatrists commonly add psychotropic medications from different classes of drugs if patients don't respond to treatment. Valproate can cause potentially fatal liver failure, although it very rarely does so." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"An added benefit of this particular ssri is that it can also relieve anxiety and sometimes improve sleep. When widespread pain and depression coexist, I choose to prescribe duloxetine (Cymbalta), a drug that alters both serotonin and norepinephrine. I will discuss Cymbalta further when I talk about how I manage severe nonmalignant pain in chapter 7. The nice thing about using Lexapro is that the starting dose (10 mg) is very often the active dose. If depression remains, it's only one step to the maximum suggested dose of 20 mg." - Benjamin H. Natelson, M.D., Your Symptoms Are Real: What to Do When Your Doctor Says Nothing Is Wrong (Get the book.)

"The doctor's natural response these days, more frequently than not, may be to get out a prescription pad and write a scrip for an ssri. In the past decade there has been a dramatic shift from the psychiatrist and appropriate therapy to Prozac as the "mind drug" of the general practitioner. Clearly there are a number of situations where a wait-and-see approach or a referral for counseling or psychotherapy would be the preferred approach. Dr." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"Most fatal ODs involved an ssri taken concomitantly with benzodiazepines, tricyclic antidepressants, narcotics, alcohol, or diphenhydramine." P450IID6 LIVER ENZYME SYSTEM: While the book goes into this issue in detail, it is important to know several things. To quickly review this is the liver system that is genetically impaired in 7 - 10% of the population. This leaves them unable to break down the serotonergic drugs leaving them vulnerable to the toxic reactions of the drugs." - Ann Blake Tracy, Ph.D., Prozac: Panacea or Pandora? The Rest of the Story on the New Class of ssri Antidepressants Prozac, Zoloft, Paxil, Lovan, Luvox & More (Get the book.)

"John's-wort to the ssri paroxetine showed that it was better in reducing symptoms of depression in patients with severe major depression: 71% of St.-John's-wort-treated patients experienced a 50% reduction in symptoms compared with 60% of those on paroxetine.27 Headache was the only side effect with St.-John's-wort that was more common than with placebo. A second study funded by the NIH and performed by the Hypericum Depression Trial Study Group (HDTSG) showed that St.-John's-wort was no more effective than placebo but no worse than an antidepressant comparison." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"Information from available case reports does not strongly support any consistent risk factor, although some worth considering may include total ssri daily dose, rapid dose escalation strategies, increased age, female gender, concurrent psychotropics known to also precipitate EPRs, and concurrent disease states such as Parkinson's disease." - Gary Null and Amy McDonald, The Food-Mood Connection: Nutrition-based and Environmental Approaches to Mental Health and Physical Wellbeing (Get the book.) "Although many case reports describe this association, few report the effect of rechallenge with another ssri. We present a case of an elderly patient who developed hyponatremia with sertraline and SIADH when rechallenged with fluoxetine. Muscle changes in the neuroleptic malignant syndrome. Behan WM, Madigan M, Clark BJ, Goldberg J, McLellan DR. - University Department of Pathology, Western Infirmary, Glasgow, UK. wmblq@clin-med.gla.ac.uk. J Clin Pathol. 2000 Mar;53(3):223-7. AIMS: To characterise the skeletal muscle changes in the neuroleptic malignant syndrome (NMS)." - Gary Null and Amy McDonald, The Food-Mood Connection: Nutrition-based and Environmental Approaches to Mental Health and Physical Wellbeing (Get the book.)

"Specifically, studies show that anywhere from 60 to 70 percent of people using these ssri antidepressants have diminished interest in sex, and patients commonly report that their SSRIs and other antidepressants cause memory and concentration difficulties. Simply put, psychotropics (including antidepressants, antianxieties, antipsychotics, alcohol, and marijuana) take the edge off pain—but that's not the only thing these drugs take the edge off. I understand why people reach for psychotropic drugs. At times, I've grabbed a beer or a glass of wine to take the edge off." - Bruce E. Levine, Surviving America's Depression Epidemic: How to Find Morale, Energy, and Community in a World Gone Crazy (Get the book.)

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