NaturalPedia > Retinoic Acid

Quotes about Retinoic Acid from the world's top natural health / natural living authors

Share

Tweet

Email to a friend   |  Click here for FREE email alerts

page 1 of 3 | Next ->

"Blocking activator protein-1 activity, but not activating retinoic acid response element, is required for the antitumor promotion effect of retinoic acid, Proc Natl Acad Sci USA, 94: 5826-5830. Huang, C, Schmid, P. C, Ma, W. Y., Schmid, H. H., and Dong, Z., 1997b, Phosphatidylinositol-3 kinase is necessary for 12-0-tetradecanoylphorbol-13-acetate-induced cell transformation and activated protein 1 activation, J Biol Chem, 272:4187-4194. Huang, C, Ma, W. Y., Young, M. R., Colburn, N., and Dong, Z." - Erich Grotewold, The Science of Flavonoids (Get the book.)

"Forms in the body: retinol, retinal, retinoic acid, retinyl palmitate, and beta-carotene. CERTAIN TYPES OF VITAMIN A CAN CAUSE BIRTH DEFECTS Excess preformed vitamin A from animal products or supplements taken during pregnancy is known to cause birth defects. Provitamin A carotenes are not known to cause birth defects. Intake levels by pregnant women below 10,000 IU daily have not been associated with an increase of birth defects. However, many foods are fortified with preformed vitamin A that can add to the other dietary sources of vitamin A." - Dr. Steve Blake, Vitamins and Minerals Demystified (Get the book.)

"Abu J, Batuwangala M, Herbert K, Symonds P. retinoic acid and retinoid receptors: potential chemopreventive and therapeutic role in cervical cancer. Lancet Oncol. 2005 Sep;6(9):712-720. Brown L, Rimm EB, Seddon JM, Giovannucci EL, Chasan-Taber L, Spiegelman D, Willett WC, Hankinson SE. A prospective study of carotenoid intake and risk of cataract extraction in US men. Am } Clin Nutr. 1999 Oct;70(4):431-432. Chu YF, Sun J, Wu X, Liu RH. Antioxidant and antiproliferative activities of common vegetables.} Agric Food Chem. 2002 Nov6;50(23):6910-6916. Kelemen et al." - David W. Grotto, RD, LDN, 101 Foods That Could Save Your Life! (Get the book.)

"This finding was replicated recently in a study of three different doses of topical retinoic acid in women with CIN 1 and 2.42 In my own research, vitamin A suppositories were applied topically as part of a multifactorial systemic and local treatment plan. (The protocol is described later in this chapter.) Vitamin E. Low levels of serum vitamin E have been associated with an increased risk of all stages of CIN and cervical cancer and high levels associated with a decreased risk." - Tori Hudson, N.D., Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness (Get the book.)

"Kerr's first step was to collaborate with other researchers at Columbia University who had succeeded in prompting mouse embryonic stem cells to become specialized motor neurons by adding growth factors—known as "retinoic acid" and "Sonic hedgehog proteins"—to undifferentiated stem cells to induce them to specialize into motor neuron cells, the same cells that, when we develop inside the womb, assume their proper place in the spinal cord and, from there, are responsible for the growth of our axonal nerves and the myelin that sheaths them." - Donna Jackson Nakazawa, The Autoimmune Epidemic (Get the book.)

"Regulation of the hormone testosterone. (c) retinoic acid activity in the eye. (d) Vitamin D activity. 3. Very high intakes of zinc can interfere with: (a) Magnesium absorption. (b) Copper absorption. (c) Vitamin A absorption. (d) Vitamin E absorption. 4. Signs of childhood zinc deficiency are: (a) Increased susceptibility to infectious diarrhea. (b) Increased susceptibility to infections. (c) Failure to grow. (d) All of the above. 5. The lowest content of dietary zinc is found in: (a) Fruit. (b) Legumes. (c) Dairy products. (d) Meats. 6." - Dr. Steve Blake, Vitamins and Minerals Demystified (Get the book.) "Some of the trans-retinol is converted to retinoic acid and is no longer available to bind to opsin to form rhodopsin. These losses must be replaced with vitamin A either from the diet or from vitamin A stored in the liver. Each cell in the retina contains about 30 million molecules containing forms of vitamin A—and there are over 100 million cells in the retina. If enough retinol is not available to the retina, this can result in night blindness. Vitamin A Deficiency and Blindness Severe vitamin A deficiency is one of the leading causes of blindness in children." - Dr. Steve Blake, Vitamins and Minerals Demystified (Get the book.) "Without sufficient retinoic acid, growth hormone may be limited in the developing fetus. Millions of red blood cells are made in the body every second. Red blood cells are derived from precursor cells called stem cells. These stem cells are dependent on vitamin A for normal differentiation into red blood cells. In addition, vitamin A facilitates the mobilization of iron from storage areas to the developing red blood cell for integration into hemoglobin. Hemoglobin is the oxygen carrier in red blood cells." - Dr. Steve Blake, Vitamins and Minerals Demystified (Get the book.)

"When vitamin A is digested, the beta-carotene is converted to retinoic acid, which has biological effects. For example, Arctic explorers in the ninteenth century who lived almost exclusively on polar bear liver, an extremely rich source of vitamin A, developed symptoms of confusion and psychosis. Large doses of vitamin A can have a number of other neurological and mental effects, including fatigue, decreased interest, headache, double vision, aggression, personality changes, depression, psychosis, and a swelling of the brain, called pseudotumor cerebri, that can be fatal." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.) "Both vitamin A and the beta-carotenes are sold as vitamins or supplements, respectively; however, they both are converted in the body to the physiologically active form of vitamin A, retinoic acid, which is the version of vitamin A that actually has an effect on the body. Since vitamin A has antioxidant properties, it has long been assumed to have protective effects on diseases related to oxidation, like heart disease and cancer. However, years of research and large studies with tens of thousands of patients have shown that vitamins do not prevent heart disease or cancer." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"Besides the IFABP, this family also includes the heart, epidermal, brain, and liver fatty acid binding proteins, testicular, myelin, adipocyte, and ileal lipid binding proteins, and cellular retinol and retinoic acid binding proteins [166, 167]. The IFBP gene (FABP2) is located in 4q28-q31 and has the conserved four exons and three introns characteristic of this family of genes; its expression is under nutritional control [168]." - Ann M. Coulston and Carol J. Boushey, Nutrition in the Prevention and Treatment of Disease (Get the book.) "Correlation of retinoid binding affinity to retinoic acid receptor alpha with retinoid inhibition of growth of estrogen receptor-positive MCF-7 mammary carcinoma cells. Cancer Res. 55, 4446-4451. 127. Prakash, P., Krinsky, N. I., and Russell, R. M. (2000). Retinoids, carotenoids, and human breast cancer cell cultures: A review of differential effects. Nutr. Rev. 58, 170-176. 128. Rock, C. L., Kusluski, R. A., Galvez, M. M., and Ethier, S. P. (1995). Carotenoids induce morphological changes in human mammary epithelial cell cultures. Nutr. Cancer 23, 319-333. 129. Sumantran, V. N., Zhang, R." - Ann M. Coulston and Carol J. Boushey, Nutrition in the Prevention and Treatment of Disease (Get the book.) "Differential regulation of apoptosis in normal versus transformed mammary epithelium by lutein and retinoic acid. Cancer Epidemiol. Biomarkers Prev. 9, 257-263. 130. Fowke, J. H., Longcope, C, and Hebert, J. R. (2000). Bras-sica vegetable consumption shifts estrogen metabolism in healthy postmenopausal women. Cancer Epidemiol. Biomarkers Prev. 9, 773-779. 131. Smith-Warner, S. A., Spiegelman, D., Yaun, S. S., et al. (1998). Alcohol and breast cancer in women: A pooled analysis of cohort studies. JAMA 279, 535-540. 132. Ginsburg, E. S. (1999). Estrogen, alcohol and breast cancer risk. J." - Ann M. Coulston and Carol J. Boushey, Nutrition in the Prevention and Treatment of Disease (Get the book.) "In 18 nonrandomized patients with small cell lung cancer, supplementation with multiple antioxidants along with chemotherapy or radiation therapy resulted in increased survival times. retinoic acid and interferon enhanced the effect of radiation on locally advanced cervical adenoma, again improving survival times [119]." - Ann M. Coulston and Carol J. Boushey, Nutrition in the Prevention and Treatment of Disease (Get the book.)

"Conventional treatment for acne includes topical application of benzoyl peroxide or retinoic acid (Retin-A, a vitamin A derivative), and topical or oral administration of antibiotics. In severe cases, the drug Accutane (another vitamin A derivative) is sometimes used. However, this drug can cause birth defects (if taken by pregnant women), as well as other significant side effects. DR. WRIGHT'S CASE STUDY Jason Jeffries didn't look happy, and didn't say much, so his mother spoke first. "You can see Jason has a bad case of acne," she said. "It started when he was 12, and he's 15 now." - Jonathan V. Wright, M.D. and Alan R. Gaby, M.D., Natural Medicine, Optimal Wellness: The Patient's Guide to Health and Healing (Get the book.)

"That's important, because retinoic acid is the substance that can communicate with a skin cell to tell it to function normally (Sources: Skin Pharmacology and Physiology, May-June 2004, pages 124-128; European Journal of Pharmaceutics and Biopharmaceutics, May 2000, pages 211-218; and Journal of Investigative Dermatology, September 1997, pages 301-305). One more ingredient that stands out is prasterone (dehydroepiandrosterone, DHEA), a naturally occurring pro-hormone rhat in the body is converted primarily to androgens (male steroids) and to a lesser degree estrogens." - Paula Begoun and Bryan Barron, Don't Go to the Cosmetics Counter Without Me, 7th Edition (Get the book.)

"All-trans retinoic acid has recently been recommended for approval for treating patients with acute myelogenous leukemia. Breitman and He, 1990; reviewed by Linder, 1991:494 Vitamin D3 The active metabolite of vitamin D3, 1,2 5-dihydroxy vitamin D3 (l,25-diOHD3), induces differentiation in a variety of cell lines. However, like retinoic acid, it can be toxic at high levels. retinoic acid appears to up-regulate vitamin D3 receptors and, in this manner, the two compounds may act synergistically." - John Boik, Cancer & Natural Medicine: A Textbook of Basic Science and Clinical Research (Get the book.) "However, the concentration of DMSO required to induce differentiation in vivo may be lower than that required in vitro due to the presence of retinoic acid in the plasma. Trans-retinoic acid and DMSO act synergisti-cally in inducing differentiation of human HL-60 leukemia cells. In the presence of normal plasma levels of retinoic acid (30 nM), the concentration of DMSO required to induce differentiation in vitro is reduced by as much as 400% (Breitman and He, 1990). The process by which DMSO and other compounds induce differentiation is unknown, although numerous theories have been postulated." - John Boik, Cancer & Natural Medicine: A Textbook of Basic Science and Clinical Research (Get the book.)

"Preliminary research into the potential of beta-carotene, folic acid, retinoic acid, vitamin C, vitamin E, and minerals as inhibitors of skin cancer is encouraging. Q Garlic may be effective in fighting basal cell carcinoma by boosting the body's immune response. Q A worldwide rise in the incidence of skin cancer has been linked to the destruction of the earth's ozone layer. The ozone layer acts as a protective atmospheric sunscreen. As it becomes thinner and holes develop in it, more of the sun's harmful rays reach the earth." - Phyllis A. Balch, CNC, Prescription for Nutritional Healing, 4th Edition: A Practical A-to-Z Reference to Drug-Free Remedies Using Vitamins, Minerals, Herbs & Food Supplements (Get the book.) "These include antibiotics, antidepressants, diuretics, antihistamines, sedatives, estrogen, and acne medications such as retinoic acid. Ask your health care provider or pharmacist if any medication that you take might have such an effect. Q A study reported in the Journal of the American Academy of Dermatology found that well-educated white-collar men have the highest risk of developing melanoma." - Phyllis A. Balch, CNC, Prescription for Nutritional Healing, 4th Edition: A Practical A-to-Z Reference to Drug-Free Remedies Using Vitamins, Minerals, Herbs & Food Supplements (Get the book.) "Retinoic acid, a form of vitamin A that smoothes skin, promotes cell renewal, and improves circulation to the skin. • Sage, an herb with astringent properties that can help relieve dry, itchy skin. • Witch hazel, a natural astringent that tones the skin. • Yarrow, an astringent herb that acts as an antiinflammatory and tightens and firms saggy skin. Q There are many excellent home facial treatments that can help with specific skin problems. Some of the best include: • To add color to sallow skin, mash V2 cup or so of strawberries in a blender and apply them to your face." - Phyllis A. Balch, CNC, Prescription for Nutritional Healing, 4th Edition: A Practical A-to-Z Reference to Drug-Free Remedies Using Vitamins, Minerals, Herbs & Food Supplements (Get the book.)

"Vitamin A, also known as retinoic acid in scientific terms, promotes the maturation of embryonic cells into any of the 200 types of cells in the body, thus preventing cancer. In a laboratory dish, vitamin A demonstrates the ability to slow cancer cell growth and induce tumor cell death. [Prostate 61: 142-52, 2004] One of the reasons why vitamin A may have not met its promise to prevent or cure cancer is because it works in tandem with vitamin C." - Bill Sardi, You Don't Have to be Afraid of Cancer Anymore (Get the book.)

"It's a natural pigment found in abundance in many green and yellow vegetables. retinoic acid, on the other hand, is derived from vitamin A rather than being used to make it. Both forms of the vitamin help the body's cells, particularly those in the protective linings (of arteries, The difference between for instance), grow and mature properly. But vitamin beta-carotene and A has two other important functions—maintaining retinoic acid. normal vision and reproductive cells—in which retinoic acid plays no known role. Q." - Prevention Magazine Editors, The Complete Book of Vitamins & Minerals for Health (Get the book.)

"Drug therapy with a synthetic, prescription form of vitamin A (page 595) (known as Accutane, isotretinoin, and 13-cis retinoic acid) has been reported to be more effecrive than treatment with 50,000 IU per day of beta-carotene.14 However, because of the potential toxicity of the vitamin A-like drug, it may be preferable to treat leukoplakia with beta-carotene, which is much safer. Before the research on beta-carotene was published, vitamin A was used to treat leukoplakia." - Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D., The Natural Pharmacy: Complete A-Z Reference to Natural Treatments for Common Health Conditions (Get the book.)

"David Schubert points out that "a GM plant making vitamin A precursor, such as 'golden rice,' might also produce retinoic acid derivatives." He says these might result in "direct toxicity or abnormal embryonic development."34 In addition, one gene inserted into the rice comes from daffodils. It is possible that it will also transfer known allergens from the flower.35 Biotech proponents also admit that to persuade people to eat yellow rice may require an educational campaign." - Jeffrey M. Smith, Genetic Roulette: The Documented Health Risks of Genetically Engineered Foods (Get the book.)

"Functions of vitamin D, retinoic acid, and dexamethasone in mouse adipose-derived mesenchymal cells." Tissue Eng. 2006 Jul;12(7):2031-40. Children's Surgical Research Program, Department of Surgery, Stanford University School of Medicine, Stanford, California 94305, USA. Cockayne, S.; Adamson, J.; Lanham-New, S.; Shearer, M.J.; Gilbody, S.; Torgerson, D.J. "Vitamin K and the prevention of fractures: systematic review and meta-analysis of randomized controlled trials." Arch Intern Med. 2006 Jun 26; 166(12): 1256-61." - Jan Lovejoy, Get Balanced-the Natural Way to Better Health with Superfoods (Get the book.)

"It now appears that the retinoid metabolites responsible for hormone-like signaling are all-trans retinoic acid and 9-cis retinoic acid. This signaling is mediated through specific nuclear receptors in cells of effector organs (Figure 4). Thus, because of retinoic acid's hydrophobic nature, it is able to penetrate the cell membrane and bind to nuclear receptors. Once activated, these nuclear receptors regulate gene expression by binding to short DNA segments near target genes (hormone-specific response elements), and they modulate transcription by mechanisms not well understood (Figure 4)." - Reginald C. Tsang, Nutrition During Infancy: Principles and Practice (Get the book.)

"The patient's high intake of carotenoids and retinoids may also be a relevant factor, since it is known that retinoic acid induces apoptosis in Myeloma cell lines by once again downmodulating IL-6R expression.99 As a general consideration the fact that the therapies appear to have boosted the patient's immunity, as evinced by his relatively low incidence of infection, may also be of relevance here. Infections equal inflammation which means high levels of IL-6 and CRR Thus protection against infections may itself also protect against promotion and proliferation in Myeloma." - Michael Gearin-Tosh, Living Proof: A Medical Mutiny (Get the book.)

"The aldehyde form of all-trans retinol is commonly designated retinaldehyde or retinal, while the acidic form is termed retinoic acid. It has been suggested that retinol serves only as a precursor to these two active forms of vitamin A - retinal being primarily involved with vision and reproduction, while retinoic acid is important in other somatic functions, such as growth and differentiation. Synthetic derivatives of retinoic acid have been developed to treat many dermatological conditions and, more recently, certain forms of cancer." - Michael T. Murray, ND, Textbook of Natural Medicine 2nd Edition Volume 1 (Get the book.)

page 1 of 3 | Next ->

FAIR USE NOTICE: The research quoted here is provided under the protection of Fair Use provisions and published by the 501(c)3 non-profit Consumer Wellness Center for the purposes of public comment and education. Authors / publishers may submit books for consideration of inclusion here.

TERMS OF USE: Read full terms of use. Citations of text from NaturalPedia must include: 1) Full credit to the original author and book title. 2) Secondary credit to the Natural News Naturalpedia as a research resource and a link to www.NaturalPedia.com

This unique compilation of research is copyright (c) 2008, 2009 by the non-profit Consumer Wellness Center.

ABOUT THE CREATOR OF NATURALPEDIA: Mike Adams, the creator of NaturalPedia, is the editor of NaturalNews.com, the internet's top natural health news site, creator of the Honest Food Guide (www.HonestFoodGuide.org), a free downloadable consumer food guide based on natural health principles, author of Grocery Warning, The 7 Laws of Nutrition, Natural Health Solutions, and many other books available at www.TruthPublishing.com, creator of the earth-friendly EcoLEDs company (www.EcoLEDs.com) that manufactures energy-efficient LED lighting products, founder of Arial Software (www.ArialSoftware.com), a permission e-mail technology company, creator of the CounterThink Cartoon series (www.NaturalNews.com/index-cartoons.html) and author of over 1,500 articles, interviews, special reports and reference guides available at www.NaturalNews.com. Adams' personal philosophy and health statistics are available at www.HealthRanger.org.