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"The phosphatidylserine used in this trial was obtained from cow brain. That product is not available in the United States, because of concern that an extract of cow brain could cause Creutzfeld-Jakob disease, the human variant of "mad cow" disease. The phosphatidylserine sold in the United States is manufactured from plant sources and cow-brain phosphatidylserine.49 Vitamin D (page 607) deficiency is common in Parkinson's disease. People with Parkinson's often get insufficient sun exposure and have reduced levels of activity that adversely affect calcium (page 483) metabolism." - Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D., The Natural Pharmacy: Complete A-Z Reference to Natural Treatments for Common Health Conditions (Get the book.)

"In a study of young adults, taking 300 mg of phosphatidylserine daily for one month led to fewer feelings of stress, better moods, and less neurotic behavior. Phosphatidylserine has also been shown to improve memory and to reverse age-related memory loss. In one of several studies, Thomas H. Crook, Ph.D., a clinical psychologist in Scottsdale, Arizona, gave 300 mg of phosphatidylserine daily to 149 patients with age-related memory impairment." - Jack Challem, The Food-Mood Solution: All-Natural Ways to Banish Anxiety, Depression, Anger, Stress, Overeating, and Alcohol and Drug Problems--and Feel Good Again (Get the book.)

"Nearly all of the good studies on phosphatidylserine used PS from the brains of cows. For obvious reasons—like concerns with viruses like mad cow disease—no one is using or selling PS from bovine sources anymore. The PS now on the market as a supplement comes from soy, and there is a huge controversy over whether it's as effective. Phosphatidylserine is basically a serine molecule attached to some fat, and the fat in a cow's brain is 7 percent omega-3, which is what the serine molecule likes to bind to. There's no omega-3 in the soy." - Jonny Bowden, Ph.D., C.N.S., The Most Effective Natural Cures on Earth: The Surprising, Unbiased Truth about What Treatments Work and Why (Get the book.)

"People with Parkinson's disease treated with L-dopa have been reported to have reduced levels of the neurotransmitter phosphatidylserine (page 569). In one trial, supplementing with phosphatidylserine (100 mg three times daily) improved the mood and mental function in patients with Parkinson's disease, but exerted no beneficial effects on muscle control.48 The phosphatidylserine used in this trial was obtained from cow brain." - Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D., The Natural Pharmacy: Complete A-Z Reference to Natural Treatments for Common Health Conditions (Get the book.)

"After twelve weeks, patients taking phosphatidylserine scored about 30 percent better in terms of learning and recalling names, faces, and numbers, compared with people taking placebos. Dosage: To optimize cognitive function, take 100 mg of phosphatidylserine one to three times daily. Protein and Individual Amino Acids That Improve Mood and Behavior Action plan: Protein consists of amino acids, which are the building blocks of neurotransmitters, so it's important to eat high-quality protein, such as fish, chicken, and turkey." - Jack Challem, The Food-Mood Solution: All-Natural Ways to Banish Anxiety, Depression, Anger, Stress, Overeating, and Alcohol and Drug Problems--and Feel Good Again (Get the book.)

"Phosphatidylserine If you want to About 70 percent of our cell membranes are made from this, and as we age, the level of phosphatidylserine drops, and the membranes become brittle. This supplement seems to strengthen cell membranes and the phospholipid sheathing around nerves, protecting the cables that transfer information from shorting out. Since risks are few, taking 200 milligrams daily is reasonable. This supplement has a beneficial effect in protecting against Parkinson's disease (a neural disease that can be caused by trauma, as in the case of boxers, or through viruses and genetics)." - Mehmet C. Oz., M.D. and Michael F. Roizen, M.D., You: Staying Young: The Owner's Manual for Extending Your Warranty (Get the book.)

"Afore: If your doctor is not familiar with phosphatidylserine, he or she may want to substitute L-acetyl choline, an amino acid, as a three-times-a-day supplement (500 to 1,000 mg in each dose). • Zinc Can Bring Mindful Zing When many people age, they suffer nutritional deficiencies for the first time. Either their eating habits decline somewhat, or their bodies are less efficient at processing and absorbing nutrients. That is one reason why federal researchers advise everyone—but especially older men and women—to think more about zinc." - Bottom Line Books, Uncommon Cures For Everyday Ailments (Get the book.)

"Phosphatidylserine (PS) phosphatidylserine belongs to a special category of fat-soluble substances called phospholipids. Phospholipids in general are essential components of cell membranes, and phosphatidylserine in particular is found in high concentrations in the brain. Found in only ttace amounts in a typical diet, PS is found in very small amounts in lecithin. The body manufactures it from phospholipid building blocks. Along with other phospholipids, PS safely and effectively supports memory, learning, concentration, word recall, and a wide range of othet cognitive brain functions." - Dianne Onstad, Whole Foods Companion: A Guide For Adventurous Cooks, Curious Shoppers, and lovers of natural foods (Get the book.)

"A large study in Italy titled Cognitive decline in the elderly: A double-blind, placebo-controlled multi-centered study on efficacy of phosphatidylserine administration followed 494 elderly subjects over six months, all of whom had moderate to severe mental decline. One group received 300 mg a day of PS, the other received a placebo. The PS group performed significantly better in both mental function and measures of behavior. Interestingly, symptoms of depression also improved, a finding that has been suggested by another study on elderly women. Steven Bratman, M.D." - Jonny Bowden, Ph.D., C.N.S., The Most Effective Natural Cures on Earth: The Surprising, Unbiased Truth about What Treatments Work and Why (Get the book.)

"The phosphatidylserine sold in the United States is manufactured from plant sources and cow-brain phosphatidylserine.49 Vitamin D (page 607) deficiency is common in Parkinson's disease. People with Parkinson's often get insufficient sun exposure and have reduced levels of activity that adversely affect calcium (page 483) metabolism.50 Low vitamin D levels in Parkinson's disease have been reported to increase the risk of hip fracture due to osteoporosis (page 333).51 This risk has been significantly reduced with the use of synthetic, activated vitamin D—a prescription drug." - Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D., The Natural Pharmacy: Complete A-Z Reference to Natural Treatments for Common Health Conditions (Get the book.)

"An impressive volume of research shows that phosphatidylserine, another modified amino acid, benefits acetylcholine deficiencies. We often recommend phosphatidylserine in our clinic when a patient is diagnosed with a memory disorder, early dementia, or depression. Multiple sclerosis patients may respond to phosphatidylserine as well. antioxidants Antioxidants are the ultimate brain food because they protect the membranes of brain cells by providing building blocks for those membranes." - Eric R. Braverman, The Edge Effect: Achieve Total Health and Longevity with the Balanced Brain Advantage (Get the book.)

"One final nutrient also bears discussion: phosphatidylserine. Classified as a phospholipid, it isn't, strictly speaking, an amino acid, but it does contain the amino acid serine. phosphatidylserine plays a critical role in the normal functioning of the cell membranes of neurons. It also helps the hypothalamus regulate the amount of Cortisol produced by the adrenals. This makes it a useful supplement for those who cannot sleep because of high Cortisol levels, usually caused by stress." - Herbert Ross, DC with Keri Brenner, L.Ac., Alternative Medicine Magazine's Definitive Guide to Sleep Disorders: 7 Smart Ways to Help You Get a Good Night's Rest (Get the book.)

"This double-blind, placebo-controlled study examined the effects of 300 mg per day of phosphatidylserine in cognitive impaired geriatric patients. Results showed the treatment had significant positive cognitive and behavioral effects relative to controls. Candida_ Antioxidant, Antimalarial and Antimicrobial Activities of Tannin-Rich Fractions, Ellagitannins and Phenolic Acids from Punica Granatum L. Reddy MK; Gupta SK; et al. Planta Medica, 2007 May, 73(5):461-467. Punica granatum L." - Gary Null and Amy McDonald, The Food-Mood Connection: Nutrition-based and Environmental Approaches to Mental Health and Physical Wellbeing (Get the book.) "Results of this study indicated that the oral administration of 300 mg per day of soybean transphosphatidylated phosphatidylserine can improve and/or prevent senile dementia. The Potent Free Radical Scavenger Alpha-lipoic Acid Improves Memory in Aged Mice. Stoll S; et al. Pharmacology Biochemistry and Behavior, 1995 October-December, 111(4): 6-8. Results of this study showed that alpha-lipoic acid improved memory in aged mice. Memory-improving Effect of Aqueous Extract of Astragalus Membranaceus (Fisch.) Bge. Hong GX; et al. Chung Kuo Chung Yap Tsa Chih, 1994 November, 19(ll):687-688." - Gary Null and Amy McDonald, The Food-Mood Connection: Nutrition-based and Environmental Approaches to Mental Health and Physical Wellbeing (Get the book.)

"Many of the brain-supportive nutrients, including amino acids like tyrosine, special fats like phosphatidylserine, or parts of our normal biochemistry such ! as coenzyme Q10, acetyl-L-carnitine, alpha lipoic acid, and others, fall into this category While not everyone may need them, many of us do, particularly if we are in the category of the 162 million with chronic illness." - Mark Hyman MD, The UltraMind Solution: Fix Your Broken Brain by Healing Your Body First (Get the book.)

"The phosphatidylserine sold in the United States is manufactured from plant sources and cow-brain phosphatidylserine.49 Vitamin D (page 607) deficiency is common in Parkinson's disease. People with Parkinson's often get insufficient sun exposure and have reduced levels of activity that adversely affect calcium (page 483) metabolism.50 Low vitamin D levels in Parkinson's disease have been reported to increase the risk of hip fracture due to osteoporosis (page 333).51 This risk has been significantly reduced with the use of synthetic, activated vitamin D—a prescription drug." - Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D., The Natural Pharmacy: Complete A-Z Reference to Natural Treatments for Common Health Conditions (Get the book.)

"Young, healthy adults with higher than average neuroticism scores reported feeling less stressed when asked to perform a difficult mental arithmetic task after taking 300 mg of phosphatidylserine daily. Kava Extract for Anxiety. Journal of Clinical Psychopharmacology, 2000, 20:1, 84-89. A literature review and expert analysis revealed that kava extract is superior to placebo as a symptomatic treatment for anxiety. Inositol Treatment of Obsessive-Compulsive Disorder. Fux M; et al. American Journal of Psychiatry, 1996 September, 153 (9): 1219-21." - Gary Null and Amy McDonald, The Food-Mood Connection: Nutrition-based and Environmental Approaches to Mental Health and Physical Wellbeing (Get the book.)

"Phospholipids (choline from egg yolks, soybeans, peanuts, lentils, sesame seeds, flaxseeds): fats that contain phosphorous,phosphatidylcholine (PC) and phosphatidylserine (PS) are the two most important. 3. Cholesterol (from eggs, shrimp, poultry): glue between molecules (see,you need cholesterol). 4. Protein (from legumes, whole grains, nuts, seeds, eggs, poultry, meat, and dairy): receptors, transporters, gates, signal transducers, etc. This is where all the communication signals from other parts of the body and the environment get processed." - Mark Hyman MD, The UltraMind Solution: Fix Your Broken Brain by Healing Your Body First (Get the book.)

"At bedtime she took three capsules of phosphatidylserine (100 mg each) to lower her high nighttime Cortisol, with tryptophan (200 mg). Her sleep deepened almost immediately, and she gradually started sleeping normally. Interestingly, after a few months, she was able to tolerate melatonin 1 mg without side effects and she slowly withdrew the other supports. Caution: Dangerous Interactions with Melatonin Melatonin by itself is safe and effective, but there are some interactions to be aware of. It should not be used if you are pregnant or breast-feeding." - Phuli Cohan, The Natural Hormone Makeover: 10 Steps to Rejuvenate Your Health and Rediscover Your Inner Glow (Get the book.)

"That's the belief of doctors who have studied age-related declines in memory. phosphatidylserine is a nutritional supplement, not a drug; as such, it is more widely known in alternative than in conventional medicinal circles. In short, it is a fatty substance that may halt memory declines and even bring memory improvements (at least among those who have already suffered some decline). You may see results over the course of two or three months. It is too soon to tell whether this supplement, available at health food stores, can help prevent memory decline from occurring in the first place." - Bottom Line Books, Uncommon Cures For Everyday Ailments (Get the book.)

"In addition, I prescribed phosphatidylserine (100 mg three times daily with meals) to help regulate her Cortisol. The first night she slept deeper, but felt drugged and headachy. She decided to see what a double dose would be like the next night. On this she had horrible dreams about demons and blood and woke feeling even more drugged and hung over than the previous day. Needless to say, she stopped everything and was discouraged. She was clearly not tolerating melatonin, even though she had used it successfully in the past for jet lag." - Phuli Cohan, The Natural Hormone Makeover: 10 Steps to Rejuvenate Your Health and Rediscover Your Inner Glow (Get the book.)

"Q10 (coQio) dehydroepiandrosterone (DHEA) dimethylaminoethanol (DMAE) essential fatty acids (EFAs) glycerylphosphorylcholine (CPC) hydergine lecithin phosphatidylcholine phosphatidylserine (PS) 1,000 mg 100-300 mgwith meals 25-50 mg 150 mg Must be prescribed by health practitioner. Individuals with hormone-related cancers should not take DHEA. May be overstimulating for some people. Headaches, muscle tension, and irritability may occur. Do not take if you have epilepsy, a history of convulsions, or bipolar disorder." - Gary Null and Amy McDonald, The Food-Mood Connection: Nutrition-based and Environmental Approaches to Mental Health and Physical Wellbeing (Get the book.)

"Normally, the brain can manufacture sufficient levels of phosphatidylserine, but if there is a deficiency of folic acid and vitamin B12, or of essential fatty acids, the brain may not be able to make sufficient phosphatidylserine. Low levels of phosphatidylserine in the brain are associated with impaired mental function and depression in the elderly. The primary use of phosphatidylserine is in the treatment of depression and/or impaired mental function in the elderly, including Alzheimer's disease patients." - Michael T. Murray, N.D., Joseph E. Pizzorno, N.D., Encyclopedia of Natural Medicine, Revised Second Edition (Get the book.)

"If Cortisol control is poor, with rises too early or too late, I usually recommend using a supplement known as phosphatidylserine or phosphoserine (100 to 300 mg throughout the day or at bedtime). To help you understand, look at the Cortisol curves shown above. DHEA DHEA is the most abundant hormone in your body. It is important for stabilizing mood, helping to activate thyroid hormone, building bone, deepening sleep, and improving memory and sex drive." - Phuli Cohan, The Natural Hormone Makeover: 10 Steps to Rejuvenate Your Health and Rediscover Your Inner Glow (Get the book.)

"Vitamin B12 100 meg 1,000 meg 1,667% Folic Acid 1 mg 10 mg 250% Other Ingredients: Trimethylglycine, Gingko Biloba, MSM, phosphatidylserine, de-ionized water, vegetable glycerine, aloe vera, trace minerals, natural flavors, grapefruit seed extract, potassium sorbate. • ><><>00<><<><>OOOC<><><>^ SAM-e Essential food for Every Healthy Living Cell SAM-e stands for S-adenosyl-l-methionine. It is one of the most innovative and multifunctional food supplements on the market. SAM-e is a substance produced by our own body. It plays a central part in almost all body processes." - Robert Redfern, The Miracle Enzyme Is Serrapeptase (Get the book.)

"Low levels of phosphatidylserine in the brain are associated with impaired mental function and depression in the elderly. The primary use of phosphatidylserine is in the treatment of depression and/or impaired mental function in the elderly, including Alzheimer's disease patients. To date, eleven double-blind studies have been completed using phosphatidylserine in the treatment of age-related cognitive decline, Alzheimer's disease, or depression. Good results have been obtained in these studies." - Michael T. Murray, N.D., Joseph E. Pizzorno, N.D., Encyclopedia of Natural Medicine, Revised Second Edition (Get the book.)

"Amaducci L. phosphatidylserine in the treatment of Alzheimer's disease: results of a multicenter study. Psychopharmacol Bull 1988; 24: 1030-1034 53. Nerozzi D, Aceti F, Melia E et al. phosphatidylserine in age-related disturbance of memory. Clin Terapeutica 1987; 120: 399-404 54. Palmieri G, Palmieri R, Inzoll MR et al. Double-blind controlled trial of phosphatidylserine in patients with senile mental deterioration. Clin Trials J 1987; 24: 73-83 55. Villardita C, Grioli S, Slameri G et al." - Michael T. Murray, ND, Textbook of Natural Medicine 2nd Edition Volume 2 (Get the book.)

"Also take 300 mg of phosphatidylserine a day; it is found in high concentrations in brain cells and helps them function properly. Herbs: Drink chamomile tea, made by pouring boiling water over 2-3 heaped tsp of flowers and steeping them for 10 minutes, to calm the nervous and digestive systems. Chamomile tinctures and pills should be taken according to the directions on the pack. Alcoholic tincture may be the most potent form for internal use. Kava kava has been used traditionally as a nervine, a substance that balances the nervous system." - Marshall Editions, 1000 Cures for 200 Ailments: Integrated Alternative and Conventional Treatments for the Most Common Illnesses (Get the book.)

"Memory-Boosting Supplement The US Food and Drug Administration (FDA) allows phosphatidylserine (PS) makers to claim that their products can reduce the risk of both dementia and cognitive dysfunction in the elderly. If you want to try PS supplements, start with a dose of 300 milligrams (mg) per day— the amount used in many studies. After a few months, you may be able to reduce this to a dose of 100 mg per day. Caution: Pregnant or nursing women should not take PS before discussing it with an obstetrician or pediatrician. Thomas H." - Bottom Line Health, Bottom Line's Health Breakthroughs 2007 (Get the book.)

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