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"PID is sensitive to NPA and therefore has a role in polar auxin transport (Benjamins et al., 2001). It also interacts with Ca2+ binding proteins, TOUCH3, a calmodulin-related protein, and PID-BINDING PROTEIN, an uncharacterized protein with Ca2+ binding motifs, suggesting a connection between auxin and Ca2+ signaling (Benjamins et al., 2003). This is consistent with a role for flavonoids in Ca2+ signaling (Lee et al., 2002; Montero et al., 2004)." - Erich Grotewold, The Science of Flavonoids (Get the book.) "In Arabidopsis, flavonol accumulations have been noted in regions where AtAPMl, AtPTENl, pid, and RCN1 are expressed (Deruere et al., 1999; Benjamins et al., 2001; Gupta et al., 2002; A. Murphy, unpublished). AtAPMl, a dual function protein containing both enzymatic and protein trafficking domains, is a homolog of the mammalian aminopeptidase M (APM)/insulin-responsive aminopeptidase (IRAP) and aminopeptidase N (APN) proteins (Murphy et al., 2002; Muday and Murphy, 2002)." - Erich Grotewold, The Science of Flavonoids (Get the book.) "Like pid, RCN1 may regulate polar auxin transport via MAPK activity (DeLong et al., 2002), and flavonoids have been shown to affect MAPK cascades in other systems (see Section 2.1). AtPTENl is a pollen-specific protein that is required for normal pollen development (Gupta et al., 2002). AtPTENl is a homolog of the mammalian PTEN protein that regulates cell division and polarization (Perandones et al., 2004; Waite et al., 2005). AtPTENl encodes a dual phosphatase acting on both phosphopeptides and phosphoinositol in vitro." - Erich Grotewold, The Science of Flavonoids (Get the book.)

"Ice packs over the pelvic region can reduce inflammation and pain in cases of acute pid. Cold or ice packs placed over the region of the uterus while putting the feet in a tub of hot water can further assist in reducing the inflammation, congestion, and pain in the pelvic area. Alternating hot and cold sitz baths can also be used to improve circulation in the pelvic area and improve the healing time from the infection." - Tori Hudson, N.D., Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness (Get the book.) "There are certain criteria for hospitalization of a woman with pid that include but are not limited to: • Concern about the ability of the patient to comply with treatment and to follow up • A fever greater than 101 degrees • Signs of an acute abdomen (acute onset of abdominal pain/tenderness/bloating, nausea, vomiting) • Lack of improvement within 72 hours If hospitalization occurs, a more complex regimen is administered with several combinations of IV antibiotics. After the patient leaves the hospital, two weeks of doxycycline is given." - Tori Hudson, N.D., Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness (Get the book.) "Treatment of a tubal ovarian abscess, which is a common complication of pid, is more complex. If the patient has a fever, with an acute abdomen, the first line of treatment is surgical drainage of the tubal ovarian abscess followed by multiple IV antibiotics. Sometimes, if a patient has minimal tenderness, does not have a fever, and is a good candidate for outpatient therapy, she can be given oral medications for two to three weeks and followed in the office." - Tori Hudson, N.D., Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness (Get the book.) "Women who suffer from pid and have strong opinions about not being treated with antibiotics should be fully educated and informed so that their decision to decline antibiotic therapy can be fully considered. A short course of antibiotic therapy is rarely detrimental to one's health. In this case, the benefit of the therapy far outweighs the risk of its use. Likewise, alternative practitioners should understand that the integration of antibiotic therapy for the benefit of the patient is not a failure of natural medicine." - Tori Hudson, N.D., Women's Encyclopedia of Natural Medicine: Alternative Therapies and Integrative Medicine for Total Health and Wellness (Get the book.)

"The bacteria that cause pid are often the same as those that cause gonorrhea and chlamydia. They move up the vagina to the cervix, uterus, and fallopian tubes, and sometimes into the ovaries. The symptoms of pid may include fever, abdominal pain, vaginal bleeding, foul-smelling vaginal discharge, nausea, and vomiting. If the infection breaks out of the reproductive system and spreads into the abdominal cavity, it can cause a severe infection called peritonitis. Doctors typically attack pelvic inflammatory disease with two antibiotics at once." - Frederic Vagnini, M.D. and Barry Fox, Ph.D., The Side Effects Bible: The Dietary Solution to Unwanted Side Effects of Common Medications (Get the book.)

"Vaginal discharge is usually the first symptom of pid, and may be followed by tension in the anal area, fever, nausea, pain along the midline of the abdomen, and vaginal bleeding. Women infected with chlamydia or gonorrhea often experience pain when leaning the trunk to the left or right. pid infections often are so mild that they go undetected until they are discovered as the cause of infertility, which occurs when scar tissue forms in the fallopian tubes. PID is conventionally treated with antibiotics after the infectious agent is identified. (Surgery may be necessary to remove abscesses." - Phyllis A. Balch, CNC, Prescription for Herbal Healing: An Easy-to-Use A-Z Reference to Hundreds of Common Disorders and Their Herbal Remedies (Get the book.)

"Avoid birth control pids, anti-hypertensives, antidepressants, hormone replacement therapy in pid form (toxic to the liver), and do not take Tamoxifen preventively; get the full data on those drugs; check them out first on the Internet and at www.preventcancer.com. 22. Do not invest your savings and RSPs in known cancer source poduters such as Dofasco, Stelco, Algoma Steel, Domtar, Bayer Rubber, Shed, Nora Chemicals, Imperial Oil (these are just some of the worst offenders) .Inform yourself about Ethical Mutual Funds, etc. Doing Something Constructive about Cancer 1." - Helke Ferrie, Dispatches From the War Zone of Environmental Health (Get the book.)

"As of 1995, pid was one of the most common causes of infertility and tubal pregnancies in North American women. The National Institute of Child Health and Human Development reports that women who smoke, especially those who smoke ten or more cigarettes a day, are twice as likely to develop pid as those who don't. Most cases of pid are the result of chlamydia, with the sexually transmitted disease gonorrhea a close second." - Kathi Keville, Herbs for Health and Healing (Get the book.)

"Heading Off Trouble Preventing a recurrence of pid is largely in your control. Here's how. Waste the weed. "One thing you can do for yourself is to quit smoking," says Polly Marchbanks, Ph.D., an epidemiologist and chief of the Centers for Disease Control and Prevention (CDC) Epidemic Intelligence Service in Atlanta. Surprised? Almost everyone knows that cigarette smoking increases cancer risk to lungs and throat. Fewer people may realize that smoking can also cause cancer in the bladder, pancreas and cervix. Dr." - the Editors of PREVENTION Magazine Health Books, Symptoms: Their Causes & Cures : How to Understand and Treat 265 Health Concerns (Get the book.) "Researchers at the Center for Reproductive Health Policy Research at the University of California in San Francisco offer this reminder: Mutual monogamy is safest; acquiring new partners increases your risk for pid. Protect yourself. Both mechanical and chemical barriers are highly effective in preventing pid. These include latex condoms, diaphragms and spermicides. Don't ignore infections. Prompt treatment for symptoms suggesting vaginal infections is an important ally against pid, the researchers say. And remember to abstain from sex during treatment." - the Editors of PREVENTION Magazine Health Books, Symptoms: Their Causes & Cures : How to Understand and Treat 265 Health Concerns (Get the book.)

"About 20 percent of the 850,000 women who contracted pid in the United States each year between 1977 and 1980 suffered pid as a result of underlying gonorrhea infection. A woman who survived a case of pid without obvious lasting effects was ten times more likely to suffer subsequent ectopic pregnancies—which could be life-threatening—due to infectious damage to her reproductive tract. The ectopic pregnancy rate in the United States soared from 19,300 cases in 1971 to 42,000 in 1978." - Laurie Garrett, The Coming Plague: Newly Emerging Diseases in a World Out of Balance (Get the book.)

"Native Americans used these two herbs for women recovering from pid. Take 500 milligrams of nettle and 250 to 500 milligrams of yellow dock twice daily for one week. HOMEOPATHY PID is a complicated and potentially serious problem that should not be self-diagnosed or self-treated. We strongly advise that you see a homeopathic practitioner for a constitutional remedy. The following remedies may serve to help alleviate some of the acute symptoms in the meantime. ¦ Apis mellifica may help relieve a burning pain that is worse on the right side, possibly accompanied by a swollen abdomen." - Janet Zand, LAc, OMD, Allan N. Spreed, MD, CNC, James B. LaValle, RPh, ND, Smart Medicine for Healthier Living : Practical A-Z Reference to Natural and Conventional Treatments for Adults (Get the book.)

"The symptoms of pid may include fever, abdominal pain, vaginal bleeding, foul-smelling vaginal discharge, nausea, and vomiting. If the infection breaks out of the reproductive system and spreads into the abdominal cavity, it can cause a severe infection called peritonitis. Doctors typically attack pelvic inflammatory disease with two antibiotics at once. The idea is to make sure that at least one (but preferably both) will kill the offending bacteria and knock the infection out ASAP. Ofloxacin destroys bacteria by interfering with their ability to repair and replicate their DNA." - Frederic Vagnini, M.D. and Barry Fox, Ph.D., The Side Effects Bible: The Dietary Solution to Unwanted Side Effects of Common Medications (Get the book.)

"Sexually transmitted disease is the most likely cause of pid, but other types of infection may also be to blame. In some cases, your doctor may be able to pinpoint the cause of the pain as soon as you describe its nature and location. If pid is your problem, for example, you'll hurt on both sides of the pelvis. On the other hand, pain from a ruptured ovarian cyst comes on suddenly, more on one side than the other. Endometriosis—a growth of the uterine lining outside of the uterus—causes chronic pelvic pain, painful periods and painful intercourse." - the Editors of PREVENTION Magazine Health Books, Symptoms: Their Causes & Cures : How to Understand and Treat 265 Health Concerns (Get the book.) "Both mechanical and chemical barriers are highly effective in preventing pid. These include latex condoms, diaphragms and spermicides. Don't ignore infections. Prompt treatment for symptoms suggesting vaginal infections is an important ally against pid, the researchers say. And remember to abstain from sex during treatment. If your doctor says your type of infection can be sexually transmitted, be sure to refer your partner for treatment as well. See also Stomach Pain; Vaginal Itching Penile Discharge when to see your doctor • Any unusual discharge needs to be discussed with your doctor." - the Editors of PREVENTION Magazine Health Books, Symptoms: Their Causes & Cures : How to Understand and Treat 265 Health Concerns (Get the book.)

"Among current douchers, pid was related to the frequency of douching. Those who douched three or more times per month were 3.6 times more likely to get pid than those who douched less than once per month. A much larger study surveyed 6,984 women over the age of 18 and found that 32% said they had douched within the past week, and 13% reported regular douching more than once a week.70 Intercourse during menses Intercourse during menses is not recommended unless a condom is used." - Michael T. Murray, ND, Textbook of Natural Medicine 2nd Edition Volume 2 (Get the book.)

"Although pid itself is not sexually transmitted, it is most often a complication of a sexually transmitted disease such as chlamydia or gonorrhea. A pelvic infection of this type can also develop after miscarriage or induced abortion. pid is most common among sexually active young women and women who have been fitted with intrauterine devices (IUDs) for contraception. It seldom occurs in women who have passed menopause. Symptoms include a heavy, rank-smelling vaginal discharge; fever; pain and tenderness in the lower abdomen; backache; and abnormal bleeding." - Janet Zand, LAc, OMD, Allan N. Spreed, MD, CNC, James B. LaValle, RPh, ND, Smart Medicine for Healthier Living : Practical A-Z Reference to Natural and Conventional Treatments for Adults (Get the book.)

"Often, the onset of menses corresponds with the onset of an episode of pid. Infections occurring around the menses tend to be GC rather than CT, a clinical curiosity which may ultimately illuminate more about the etiology. One hypothesis is that menstrual regurgitation facilitates the inflammatory response by carrying sloughed endometrial epithelium which may have attached GC or intracellular CT. These organisms are then able to proliferate in the tubal epithelium or on peritoneal surfaces.9,31 Human sperm has proved an interesting and multi-faceted variable in the precipitation of pid." - Michael T. Murray, ND, Textbook of Natural Medicine 2nd Edition Volume 2 (Get the book.)

"If you have never had pid and develop unexplained pelvic pain or vaginal discharge, see your doctor immediately. Treatment and Preventive Measures CONVENTIONAL MEDICAL TREATMENT • If pid is diagnosed, antibiotics should be taken as prescribed. Both doxycycline or ciprofloxacin and metronidazole are commonly prescribed together. Chronic or recurring symptoms may be treated with antibiotics as well. DIETARY RECOMMENDATIONS • Eat a whole-foods diet, including plenty of fresh vegetables and fruits." - Ralph Golan, M.D., Optimal Wellness (Get the book.)

"The National Institute of Child Health and Human Development reports that women who smoke, especially those who smoke ten or more cigarettes a day, are twice as likely to develop pid as those who don't. Most cases of pid are the result of chlamydia, with the sexually transmitted disease gonorrhea a close second. Gonorrhea was on the wane in the 1970s, thanks to antibiotics, but has come back during the last decade because it has developed new, drug-resistant strains that the old antibiotics cannot kill. As new, stronger drugs are created, tougher strains of gonorrhea are appearing." - Kathi Keville, Herbs for Health and Healing (Get the book.)

"PID infections often are so mild that they go undetected until they are discovered as the cause of infertility, which occurs when scar tissue forms in the fallopian tubes. PID is conventionally treated with antibiotics after the infectious agent is identified. (Surgery may be necessary to remove abscesses.) However, about 20 percent of women treated with standard antibiotics do not respond to treatment. These are the women who can benefit most from herbal treatment. BENEFICIAL HERBS FORM AND DOSAGE COMMENTS Barberry1 or coptis1 or goldenseal1 or Oregon grape root1 Tincture." - Phyllis A. Balch, CNC, Prescription for Herbal Healing: An Easy-to-Use A-Z Reference to Hundreds of Common Disorders and Their Herbal Remedies (Get the book.) "FORMULAS FORMULA COMMENTS Dong Quai and A traditional Chinese herbal formula used to prevent mis-Peony Powder carriage in women who have had pid. Eight-Ingredient A traditional Chinese herbal formula that relaxes the walls of Pill with Rehmannia the bladder and increases urination, effectively flushing PID (Rehmannia-Eight organisms (which have a very short life span) out of the Combination) genitourinary tract before they can cause damage." - Phyllis A. Balch, CNC, Prescription for Herbal Healing: An Easy-to-Use A-Z Reference to Hundreds of Common Disorders and Their Herbal Remedies (Get the book.)

"At this stage, a woman is usually diagnosed as suffering from pelvic inflammatory disease, or pid, caused by the gonococcal bacteria. Gonorrhea that is not properly treated can spread to other parts of the body. In men, it can cause an inflamed prostate or inflammation of the testes, and may affect fertility. A woman who develops pid can suffer damage to the ovaries and/or fallopian tubes, resulting in infertility. The bacteria can also cause gonococcal arthritis, which results in pain and swelling of the joints around the body. This condition may be misdiagnosed as simple arthritis." - Janet Zand, LAc, OMD, Allan N. Spreed, MD, CNC, James B. LaValle, RPh, ND, Smart Medicine for Healthier Living : Practical A-Z Reference to Natural and Conventional Treatments for Adults (Get the book.)

"By 1980, pid was the reason for 30 percent of all gynecological visits in Ugandan cities; 26.5 percent in Zambia; 30 percent in Ethiopia; Nigeria, 30 percent; Kenya, 40 percent; and Zimbabwe, 44 percent.28 Ectopic pregnancy rates were also rising, and in some countries were responsible for up to a third of all maternal deaths.29 Most pid was due to either gonorrhea or chlamydia, both of which were out of control in the majority of cities in developing countries." - Laurie Garrett, The Coming Plague: Newly Emerging Diseases in a World Out of Balance (Get the book.)

"If You Have It Doctors are finding pid to be the cause of so much infertility that they're beginning to treat it more seriously. "In the past," Dr. Sansone says, "we started treatment only when there was fever and considerable pain. Now, if you have mild pain, especially during intercourse, a slight discharge and a slight tenderness in the pelvic area, we'll treat you for pid." Treatment is aggressive. The doctor will take cultures, but he won't wait for the results before putting you on antibiotics. " - Matthew Hoffman and William Legro, Disease Free: How to Prevent, Treat and Cure More Than 150 Illnesses and Conditions (Get the book.)

"The result was a device that provided a safe conduit for bacteria into a uterus already torn, or even perforated, by the action of the prongs, thus creating a fertile breeding ground for pelvic inflammatory disease, or pid. The consequence of pid is often a hysterectomy, and even when that procedure is not required, infertility often results.4 In October 1969, Davis submitted a study of the Dalkon Shield to the American Journal of Obstetrics and Gynecology." - Herbert Burkholz, The FDA Follies (Get the book.)

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