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"Folkers, leader of the merck research group, became so intrigued that he proceeded to spearhead pioneering studies into the biochemistry, action, and clinical aspects of this new discovery, now called coenzyme Qiq. Although sitting on the potential to investigate and develop coenzyme Qiq, merck dropped the ball at this point. Thus it was the Japanese, in 1963, who began testing the supplement on humans on an individual case basis. The first organized clinical trial of coenzyme Q10 in human subjects was performed by Dr. Y." - Stephen T. Sinatra, M.D., The Sinatra Solution Metabolic Cardiology (Get the book.)

"Merck Manual Home Edition Online www.merck.com/mmhe/index.html Myasthenia Gravis Foundation of America www.myasthenia.org National Adrenal Diseases Foundation www.nadf.us National Cancer Institute www.cancer.gov National Eye Institute www.nei.nih.gov National Graves' Disease Foundation www.ngdf.org National Heart, Lung, and Blood Institute www.nhlbi.nih.gov National Institute of Neurological Disorders and Stroke www.ninds.nih.gov National Institute of Arthritis and Musculoskeletal and Skin Diseases www.niams.nih.gov National Institute on Aging www.nia.nih." - Joan Liebmann-Smith, Ph. D., and Jacqueline Nardi Egan, Body Signs: From Warning Signs to False Alarms...How to Be Your Own Diagnostic Detective (Get the book.)

"Simply incomprehensible" is what the FDA's letter says about a press release issued by merck on May 22, 2001, titled, "Merck Confirms Cardiovascular Safety Profile of Vioxx." The warning letter adds: "Your misrepresentation of the safety profile for Vioxx is particularly troublesome because we have previously, in an untitled letter, objected to promotional materials for Vioxx that also misrepresented Vioxx's safety profile." The dose for over-the-counter tablets is slightly lower than that for prescription tablets: 440 mg (in two tablets) compared with 500 mg twice daily." - John Abramson, Overdosed America: The Broken Promise of American Medicine (P.S.) (Get the book.)

"Merck Manual online: www.merck.com/mmhe/sec02/ch019/ ch019l.html Mingrone G. Carnitine in type 2 diabetes. Ann NY Acad Sci 2004; 1033:99-107. Mingrone G et al. L-carnitine improves glucose disposal in type 2 diabetic patients./Aw Coll Nutr 1999; 77-82. Mita T et al. Eicosapentaenoic acid reduces the progression of carotid intima-media thickness in patients with type 2 diabetes. Atherosclerosis 2007 Mar; 191 (1): 162-67. Miura Y et al. Tea catechins prevent the development of atherosclerosis in apoprotein E-deficient mice. J Nutr 2001; 131(l):27-32. Montori V et al." - Steven V. Joyal, What Your Doctor May Not Tell You About Diabetes: An Innovative Program to Prevent, Treat, and Beat This Controllable Disease (Get the book.)

"Berkow, Robert ed. The merck Manual, Sixteenth Edition. New Jersey: merck Research Laboratories, 1992. Bernard, H., The Homeopathic Treatment of Constipation. New Delhi: B. Jain Publishers (P) Ltd., 2004. Bhanja, K.C. The Homeopathic Prescriber, Sixth Edition. Calcutta, N.K. Mitter at the Indian Press Pvt. Ltd., 1989. Blumenthal, Mark. The Complete German Commission E Monographs, Therapeutic Guide to Herbal Medicines. Boston Massachusetts: Integrative Medicine Communications, 1998. Boger, CM. Boenninghausen's Characteristics Materia Medica & Repertory with Word Index New Delhi: B." - Heather Caruso, Your Drug-Free Guide to Digestive Health (Get the book.)

"Merck, Sharpe, and Dohme Laboratories in New Jersey. Folkers confirmed Crane's discovery, TABLE 4.1. THE HISTORY OF COENZYME Qt0 1957 CoQ10 first isolated from beef heart by Frederick Crane. 1958 Karl Folkers at merck, Sharpe & Dohme determines the precise chemical structure. Mid-1960s Professor Yamamura (Japan) is the first to use CoQ7 (related compound) in congestive heart failure. 1972 Dr. Littarru (Italy) and Dr. Folkers (United States) document a CoQ10 deficiency in human heart disease." - Stephen T. Sinatra, M.D., The Sinatra Solution Metabolic Cardiology (Get the book.)

"As reported in the New York Times on April 24, 2005, by Alex Berenson ("Evidence in Vioxx Suits Shows Intervention by merck Officials"), the publication of the study results in 2003 reported five cardiac deaths in patients taking Vioxx vs. one in patients taking naproxen. The article reported that in an e-mail exchange from 2000, merck officials pressured a company scientist to not determine that the death of a patient was cardiac related "so that we don't raise concerns." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"In 2001, merck reaped more than $7 billion in profits, and Pfizer $12 billion in 2003.3 Put another way: the $7 billion of profits Pfizer amassed in 2001 was greater than the Fortune 500 profits in the home building, apparel, railroad, and publishing industries combined. Merck's profits that year exceeded the combined profits of the Fortune 500-listed semiconductor, pipeline, food production, crude oil production, hotel, casino, and resort industries.4 The compensation given to the top executives is equally transcendent. Wlliam C. Steere Jr." - Charles Barber, Comfortably Numb: How Psychiatry Is Medicating a Nation (Get the book.)

"Helgesson, O., merck, C, and Bjorntorp, P. (1988). Adipose tissue distribution and female carcinomas. A 12-year follow-up of participants in the population study of women in Gothenburg, Sweden. Int. J. Obes. 12, 361-368. 248. Schapira, D. V., Kumar, N. B., Lyman, G. H., Cavanagh, D., Roberts, W. S., and LaPolla, J. (1991). Upper-body fat distribution and endometrial cancer risk. JAMA 266, 1808-1811. 249. Shu, X. O., Brinton, L. A., Zheng, W., et al. (1992). Relation of obesity and body fat distribution to endometrial cancer in Shanghai, China. Cancer Res. 52, 3865-3870. 250. Swanson, C. A." - Ann M. Coulston and Carol J. Boushey, Nutrition in the Prevention and Treatment of Disease (Get the book.)

"Unfortunately, the pharmaceutical company, merck, got to him first. They not only hired him, but had also placed him on a non-disclosure (basically a gag order). They would prefer to hide the information from the public, while searching desperately for a drug that might duplicate the benefits of the xanthones in mangosteen, (God's creation), which man can't possibly duplicate. Without a doubt, if merck (or any other drug company) could develop a symptom-free drug, with the cancer-fighting potential of mangosteen, it would definitely cost a fortune." - Dr. David W. Tanton; Ph.D., A Drug-Free Approach To Healthcare, Revised Edition (Get the book.)

"In a 2004 Lancet editorial, Richard Horton called Vioxx a "public health catastrophe" and accused merck and the FDA of "ruthless, shortsighted and irresponsible self-interest."43 He especially criticized the FDA for failing to act as early as 2001, and called for a complete restructuring of that agency. Strong words, indeed. In an interview, Eric Topol said that he had "never read a more powerful editorial in a medical journal." - Gerald E. Markle and Frances B. McCrea, What If Medicine Disappeared? (Get the book.)

"Merck Manuals Online Medical Library http://www.merck.com/mrkshared/mmanual/home.jsp • Excellent resource on health issues. National Center for Complementary and Alternative Medicine http://nccam.nih. gov/ • Resource on complementary and alternative medicine. New England Journal of Medicine http://content. nejm. org • Peer-reviewed medical journal online featuring current medical research information, reviews and articles for biomedical science and internal medicine. Nutra Ingredients http://www.nutraingredients-usa." - Jan Lovejoy, Get Balanced-the Natural Way to Better Health with Superfoods (Get the book.)

"Likewise, the NEJM review article did exactly what the FDA's Warning Letter cited merck for doing: minimizing the cardiovascular risk and the unfavorable safety profile of Vioxx. The FDA reviewers' reports posted on the Internet provide an unusual opportunity to compare the unprocessed data from the manufacturer-sponsored CLASS and VIGOR studies with the medical journal articles and "medical knowledge" that they subsequently became. Unlike the articles about statins and strokes that I investigated, this went beyond spin." - John Abramson, Overdosed America: The Broken Promise of American Medicine (P.S.) (Get the book.)

"Merck Manual The online edition of your physician's standard medical reference book. www.merck.com Nutrient Data Laboratory Food Composition Type in nearly any food or food product, and you instantly get its nutritional breakdown per cup or 100 grams. www.ars.usda.gov/ The Nutrition Reporter™ Dozens of articles on vitamins and minerals. www.nutritionreporter.com The Official No More Bad Moods Web Site www.foodmoodsolution.com Price-Pottenger Foundation A Web site dedicated to two twentieth-century nutritional pioneers. www.price-pottenger." - Jack Challem, The Food-Mood Solution: All-Natural Ways to Banish Anxiety, Depression, Anger, Stress, Overeating, and Alcohol and Drug Problems--and Feel Good Again (Get the book.)

"The merck Manual of Medical Information—Second Home Edition Online. "Gas and Chemical Exposure." http://www.merck.com/mmhe/sec04/ch049/ch049j.html. Mercola.com. "The Secret Dangers of Splenda (Sucralose), an Artificial Sweetener." http://www .mercola.eom/2000/dec/3/sucralose_dangers.htm. Metcalfe, Ed. "Sweet Talking." Ecologist 30, No. 4 (June, 2000). Mindell, Earl. Earl Mindell's Vitamin Bible for the 21st Century. New York: Warner Books, 1999. Misner, Scottie. "Sugar Substitutes: Are They Safe?" May 2001. http://ag.arizona.edu/pubs/health/ azl229.pdf. Mission Possible." - Connie Bennett, C.H.H.C. with Stephen T. Sinatra, M.D., Sugar Shock!: How Sweets and Simple Carbs Can Derail Your Life-- and How YouCan Get Back on Track (Get the book.)

"If you go to the website sponsored by merck, the manufacturer of Fosamax, you will be advised to "know your T score" and told that "If your T score is less than -1.0, talk to your doctor about treatment options." (Remember, on a statistical basis, half of women in their early fifties have a T score of-1.0 or less, but treating these women with drugs does not decrease, and may actually increase, their risk of fractures.) The information you find on the National Osteoporosis Society website won't be free of commercial influence, either." - John Abramson, Overdosed America: The Broken Promise of American Medicine (P.S.) (Get the book.) "The next drug to take center stage in direct-to-consumer advertising was Vioxx. merck spent more than $160 million to advertise this new and supposedly "improved" arthritis drug to consumers in 2000—half again more than its closest rival and $20 million more than the previous record set by Claritin in 1999. Overcoming the lack of scientific evidence that Vioxx provides better relief or is safer for most patients than its less expensive competitors, sales of Vioxx grew more than any other drug in 2000, to $1.1 billion." - John Abramson, Overdosed America: The Broken Promise of American Medicine (P.S.) (Get the book.)

"Today, according to the merck Manual, 100% of all Americans will have many—if they live long enough. • Thirty years ago, colorectal cancer was virtually unknown. Today, it is the single most prevalent cancer among men and women combined. • The number of Americans who suffer from Asthma, according to the Centers for Disease Control, has risen by an astounding 75% in just the last 20 years. • Breast cancer rates are up 30% in just the last 15 years. • And on . . . and on . . ." - Jon Barron, Lessons from The Miracle Doctors: A Step-by-Step Guide to Optimum Health and Relief from Catastrophic Illness (Get the book.)

"On September 30, 2004, merck withdrew the painkiller Vioxx from the market after it was linked to cardiovascular deaths, leading to congressional investigations. The FDA then came under fire from Congress for its handling of SSRI-induced suicidality, especially in children and youth.27 Then in the September 23, 2006, headline on the front page of The New York Times reported criticism of the agency in general: study condemns f.d.a.'s handling of drug safety: sweeping cflanges urged." - Peter Breggin, Medication Madness: A Psychiatrist Exposes the Dangers of Mood-Altering Medications (Get the book.)

"Put another way: the $7 billion of profits Pfizer amassed in 2001 was greater than the Fortune 500 profits in the home building, apparel, railroad, and publishing industries combined. Merck's profits that year exceeded the combined profits of the Fortune 500-listed semiconductor, pipeline, food production, crude oil production, hotel, casino, and resort industries.4 The compensation given to the top executives is equally transcendent. Wlliam C. Steere Jr., Pfizer's chairman, made $40 million in 2000 as Pfizer's chairman." - Charles Barber, Comfortably Numb: How Psychiatry Is Medicating a Nation (Get the book.)

"New Jersey: merck Research Laboratories, 1992. Bernard, H., The Homeopathic Treatment of Constipation. New Delhi: B. Jain Publishers (P) Ltd., 2004. Bhanja, K.C. The Homeopathic Prescriber, Sixth Edition. Calcutta, N.K. Mitter at the Indian Press Pvt. Ltd., 1989. Blumenthal, Mark. The Complete German Commission E Monographs, Therapeutic Guide to Herbal Medicines. Boston Massachusetts: Integrative Medicine Communications, 1998. Boger, CM. Boenninghausen's Characteristics Materia Medica & Repertory with Word Index New Delhi: B. Jain Publishers (P) Ltd., 1996. Calbom, Cherie, Keane, Maureen." - Heather Caruso, Your Drug-Free Guide to Digestive Health (Get the book.)

"Karl Folkers at merck, Sharpe & Dohme determines the precise chemical structure. Mid-1960s Professor Yamamura (Japan) is the first to use CoQ7 (related compound) in congestive heart failure. 1972 Dr. Littarru (Italy) and Dr. Folkers (United States) document a CoQ10 deficiency in human heart disease. Mid-1970s Japanese perfect industrial technology of fermentation to produce pure CoQ10 in significant quantities. 1976 CoQ10 is placed on formulary in Japanese hospitals. 1977 Peter Mitchell receives Nobel Prize for CoQ,0 and energy transfer." - Stephen T. Sinatra, M.D., The Sinatra Solution Metabolic Cardiology (Get the book.)

"Almost four years after Virginia died, merck pulled Vioxx from pharmacy shelves, saying that a study had shown that Vioxx doubled the risk of heart attacks and strokes in patients who took it for eighteen months or longer. "When they pulled the drug," Rosemary said, "I grieved again." Rosemary knows her sister might not have had a long life. Virginia had smoked, and even though a doctor never diagnosed her with heart disease, the coroner found her arteries filled with plaque. But Rosemary believes Virginia would have lived years longer if she had never taken Vioxx. " - Melody Petersen, Our Daily Meds: How the Pharmaceutical Companies Transformed Themselves into Slick Marketing Machines and Hooked the Nation on Prescription Drugs (Get the book.) "To prepare its salespeople for the increasing number of questions about the drug, merck created a training exercise called Dodge Ball Vioxx. Each of the first dozen pages of this training document listed an "obstacle" the salespeople might encounter, like a doctor who tells them, "I am concerned about the cardiovascular effects of Vioxx." Another possible "obstacle" was described as a physician who says, "I am concerned with dose-related increases in hypertension with Vioxx." - Melody Petersen, Our Daily Meds: How the Pharmaceutical Companies Transformed Themselves into Slick Marketing Machines and Hooked the Nation on Prescription Drugs (Get the book.) "Some of the companies, including merck and the drugmaker Squibb, promised to keep their new laboratories separate from their corporate interest of making money. When the Indianapolis-based drugmaker Eli Lilly and Company dedicated its new laboratory at a ceremony in the 1930s, Dr. George Henry Alexander Clowes, the company's director of research, told the audience that the firm was dedicated to fundamental science. The company's leaders, Josiah K." - Melody Petersen, Our Daily Meds: How the Pharmaceutical Companies Transformed Themselves into Slick Marketing Machines and Hooked the Nation on Prescription Drugs (Get the book.) "But inside the walls of merck and Pharmacia, scientists were worried. They were struggling to generate the scientific data that supported the "superaspirin" buzz being stirred up by their marketing colleagues. The scientists at both companies were failing to prove that the new drugs, known as Cox-2 inhibitors, relieved pain any better than the far cheaper standbys like over-the-counter ibuprofen. Also, patients taking Vioxx and Celebrex still suffered from ulcers, albeit at what appeared to be a lower rate than those using the older drugs." - Melody Petersen, Our Daily Meds: How the Pharmaceutical Companies Transformed Themselves into Slick Marketing Machines and Hooked the Nation on Prescription Drugs (Get the book.)

"The article reported that in an e-mail exchange from 2000, merck officials pressured a company scientist to not determine that the death of a patient was cardiac related "so that we don't raise concerns." However, the FDA had reviewed the study results in 2001 and determined that in this case (and those of two others reported in the paper) the deaths were cardiac related, making the increase in cardiac deaths a statistically significant increase of eight with Vioxx compared to one with naproxen." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"McClung is among several consultants for merck and has received a number of "grants" from the firm. McClung is in good company ?or at least he has prominent fellow travelers publishing similar conclusions in invited commentaries in similarly prominent journals (Rosen 2005; Raisz table 12. Incidence of Vertebral Fractures (vf) over Four Years of Treatment with Alendronate versus Placebo Outcomes Percentage of Incidence with Alendronate Percentage of Incidence with Placebo Number Needed to Treat Clinical VF with baseline VF 0.3 0.9 185 Clinical VF without baseline VF 0.3 0." - Nortin M. Hadler MD, Worried Sick: A Prescription for Health in an Overtreated America (Get the book.)

"Although sitting on the potential to investigate and develop coenzyme Qiq, merck dropped the ball at this point. Thus it was the Japanese, in 1963, who began testing the supplement on humans on an individual case basis. The first organized clinical trial of coenzyme Q10 in human subjects was performed by Dr. Y. Yamamura and his colleagues at Osaka University in 1965, where the nutrient was given to patients with heart disease. In 1971, Drs." - Stephen T. Sinatra, M.D., The Sinatra Solution Metabolic Cardiology (Get the book.)

"And it's not just the CEOs: in 2000, the average unexercised stock options of the top executives at merck were $73 million; at Bristol-Myers Squibb, $65 million; at Pfizer, $54 million; at Eli Lilly, $33 million.5 Even after the woes that Big Pharma experienced between 2004 and 2007—the withdrawal of Vioxx from the market, the loss of half of the injectable flu vaccines because of quality control problems, and a growing public awareness of profiteering and an all-too-cozy relationship with the Bush administration—no one should worry unduly about the industry's fortunes." - Charles Barber, Comfortably Numb: How Psychiatry Is Medicating a Nation (Get the book.)

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