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"The panel's endorsement of both drugs will definitely help merck and Pfizer fend off the hundreds of lawsuits already filed by patients and their survivors." The panel's chairman, trying to put the whole debacle in perspective, made the unfortunate comment: "It would be a brave man or woman [physician] who started a patient with a clear history of heart disease on these drugs."48 "That's not brave," complained Fran. "It's either incompetent or negligent.!" What are the lessons of COX-2 Inhibitors for our book? We live in a hypermodern society. Everything happens at breakneck speed." - Gerald E. Markle and Frances B. McCrea, What If Medicine Disappeared? (Get the book.)

"POSSIBLE ADVERSE REACTIONS FROM HEALING PROGRAM SUPPLEMENTS • Vitamin A is a fat-soluble vitamin that can be toxic if taken in extremely high dosages. The merck Manual of Diagnosis and Therapy sets the level of toxicity at ingestion of300,000 international units per day, but I believe that significantly lower doses than this can cause at least subtle harm in some small children. Generally, children can safely take 2,500 to 10,000 i.u. per day, depending on their age, size, and their existing levels of vitamin A." - Kenneth Bock, Healing the New Childhood Epidemics: Autism, ADHD, Asthma, and Allergies: The Groundbreaking Program for the 4-A Disorders (Get the book.) "Merck Manual. Infants can suffer toxic reactions to 3,000 i.u. per day, if taken every day for an extended period. I usually recommend no more than approximately 800 i.u. per day for children. Similarly to vitamin A, I monitor vitamin D levels periodically to ensure that levels are within a safe, normal range. • Zinc can partially suppress immunity at extremely high dosages, although this is contrary to its typical effect of enhancing immunity at lower to moderate doses. I usually recommend doses in the 20- to 60-mg. range, with a maximum of about 90 to 100 mg. per day for children." - Kenneth Bock, Healing the New Childhood Epidemics: Autism, ADHD, Asthma, and Allergies: The Groundbreaking Program for the 4-A Disorders (Get the book.)

"The two largest pharmaceutical companies at that time, Johnson & Johnson and merck had, respectively, $204 and $1.5 million in prescription revenue. From I960 to 1980, prescription sales were fairly static; from 1980 to 2000, they tripled. Since 1980, the pharmaceutical industry has consistently ranked as the most profitable in the United States In 2002, worldwide prescription sales were about $400 billion, half of which come from the United States. In 1995, 2.12 billion prescriptions were filled in the United States; by 2002 that number had increased dramatically, almost 50%, to 3." - Gerald E. Markle and Frances B. McCrea, What If Medicine Disappeared? (Get the book.) "If it is true that merck, Pfizer, and other pharmaceutical companies knew the truth about cardiovascular dangers, then they are fully culpable in tens of thousands of deaths. "That's murder," whispered Fran. But what about pain relief? What about allowing people to "work, walk, garden, and do all the little things that make life worthwhile?" - Gerald E. Markle and Frances B. McCrea, What If Medicine Disappeared? (Get the book.)

"According to the merck Manual (the medical industry's standard text for the diagnosis and treatment of disease), the incidence of diverticulosis has increased dramatically over the last 40 years. It has gone from 10% of the adult population over the age of 45 who had this disease (according to an early 1950s edition) to an astounding, "every person has many" in the 1992 edition. In other words, virtually 100% of all American adults will eventually have diverticulosis of the large intestine if they live long enough. Why?" - Jon Barron, Lessons from The Miracle Doctors: A Step-by-Step Guide to Optimum Health and Relief from Catastrophic Illness (Get the book.)

"Following the publication of the APPROVe trial and the belated admission of increased heart attacks in ADVANTAGE, merck announced in September 2004 that it would pull Vioxx from the market, but not before considerable damage had been done. It has been estimated that Vioxx caused 88,000 to 139,000 heart attacks, with 30% to 40% of them fatal.4 The COX-2 inhibitor Bextra was supposed to have more advantages than Vioxx in the treatment of osteoarthritis. The drug's manufacturer, Pfizer, argued that Bextra should have a lower risk of heart attacks than Vioxx." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"Hyperimerck® 260 mg, hypericum extract. merck Generika GmbH, Darmstadt. 1997. Fachinformation. Remotiv®, hypericum extract. Bayer AG, Pharma Deutschland, Leverkusen. 1996. Fava M, Alpert J, Nierenberg AA, et al. A double-blind, randomized trial of St. John's wort,'fluoxetine, and placebo in major depressive disorder. J Clin Psychopharmacol; 25(5): 441-447. 2005. Ferko N, Levine MA. Evaluation of the Association between St. John's Wort and elevated thyroid-stimulating hormone. Pharmacotherapy 21 (12): 1574-1578. 2001. Gaster B, Holroyd J. St. John's Wort for depression: a systematic review." - Thomson Healthcare, Inc., PDR for Herbal Medicines, Fourth Edition (Get the book.)

"Wyeth Five of them are located in the USA {Pfizer, merck, Johnson & Johnson, Abbott Laboratories, and Wyeth), two in England {GlaxoSmithKline and AstraZenca), one in France {Aventis) and two in Switzerland {Novartis and Hoffmann-La Roche). The exact ranking varies from year to year. Pfizer, the second biggest pharmaceutical giant, spends $17 billion every year for marketing alone and therefore belongs to the ten greatest advertisers in the USA.36 35 "Top 50 pharmaceutical companies," MedAdNews, September 2007 36 Der Spiegel 15/2005, p." - Kenneth W Thomas, Ron Gilbert, Gerd Schaller, Side Effects: The Hidden Agenda of the Pharmaceutical Drug Cartel (Get the book.) "The pharmaceutical giant merck, for example, rakes in $900 million every year. Since vaccinations still have an excellent image, it is easy to convince people to be inoculated. Billions of dollars are earned here. But guess who pays for those afflicted with adverse reactions? The taxpayer. And yet, new vaccinations are continuously researched and tested for; many are underway at this very moment as these lines are written. The authors of this book believe that the true danger of mass-vaccinations is not realized." - Kenneth W Thomas, Ron Gilbert, Gerd Schaller, Side Effects: The Hidden Agenda of the Pharmaceutical Drug Cartel (Get the book.)

"Merck Manual The online edition of your physician's standard medical reference book. www.merck.com Nutrient Data Laboratory Food Composition Type in nearly any food or food product, and you instantly get its nutritional breakdown per cup or 100 grams. www.nal.usda.gov/fnic/foodcomp USDA Data on Nutritional Deficiencies You can quickly look up the percentage of people nationally or in individual states who consume the basic recommended amounts of individual nutrients and, conversely, the appalling numbers of Americans who do not. This is the source of the data for the graph on page 208." - Jack Challem, Stop Prediabetes Now: The Ultimate Plan to Lose Weight and Prevent Diabetes (Get the book.)

"Vioxx had an unbelievable sales share of 20% in the total turnover of the merck & Co. group.' "There are more than fifty years of medical and scientific progress between Thalidomide and Vioxx. Well, this is cynical, but what has really changed? "Nevertheless, the pharmaceutical industry still has the nimbus of scientific nature and of progress, and those researching pharmaceutical companies justify their high prices with their high costs for research and development before these new medicinal products can finally be marketed to become a blockbuster." - Kenneth W Thomas, Ron Gilbert, Gerd Schaller, Side Effects: The Hidden Agenda of the Pharmaceutical Drug Cartel (Get the book.)

"Instead, the agency spent eighteen months wrangling with merck over the wording of a warning to be placed on the drug's label. By the time the company complied, the warning was so watered down it had virtually no effect on prescription rates. In 2004, in testimony before Congress, Graham said, "I would argue that the FDA, as currently configured, is incapable of protecting America against another Vioxx . . . Simply put, the FDA and its Center for Drug Evaluation and Research are broken." The pharmaceutical industry itself has come in for even harsher criticism." - Shannon Brownlee, Overtreated: Why Too Much Medicine Is Making Us Sicker and Poorer (Get the book.) "Thirty years ago, Henry Gadsden, the head of merck, told Fortune magazine he wanted his company to be more like the chewing gum maker Wrigley. It was his dream to make drugs not just for the truly sick but also for the healthy, so that he could "sell to everyone." - Shannon Brownlee, Overtreated: Why Too Much Medicine Is Making Us Sicker and Poorer (Get the book.) "Internal memos from merck obtained by Congress show that company scientists knew about the potential cardiac risk as early as 1997 and deliberately excluded patients who were already suffering from heart disease from clinical trials in an effort to reduce the chances of seeing a cardiovascular event. Other critics lay blame at the feet of doctors and insurance companies." - Shannon Brownlee, Overtreated: Why Too Much Medicine Is Making Us Sicker and Poorer (Get the book.)

"Well, our old well-known "friends," merck, Smith-Kline-Beecham but 292 Tim O'Shea, p. 46 also Pasteur-Merieux-Connaught, and Bio cine-Sclav o and Wyeth-Lederle. AlphaVax, a large vaccine research company in the USA, can use public funds to develop new vaccinations. The market grew and grew. Up to 4 billion dollars, up to 5 billion dollars at the moment 10% each year. Twelve billion injections are given per year to keep the population of earth safe, says WHO, The World Health Organization." - Kenneth W Thomas, Ron Gilbert, Gerd Schaller, Side Effects: The Hidden Agenda of the Pharmaceutical Drug Cartel (Get the book.)

"In fact, the ongoing lawsuits against merck and Co. are a pretty good indication of what the pharmaceutical companies may expect should the tens of millions of antidepressant users seek relief through litigation. Vioxx, a treatment for pain and inflammation manufactured by merck, was approved by the FDA in 1999 and, by the time it was voluntarily pulled from the market in September 2004; at least 20 million Americans had taken the drug." - Kelly Patricia O'Meara, Psyched Out: How Psychiatry Sells Mental Illness and Pushes Pills That Kill (Get the book.)

"For example, Monsanto, a leading company of pesticides and genetically modified seeds, was owned by the Pharmacia Corporation, which sells prescription drugs. merck is a pharmaceutical company that also produces chemicals and precursors for pesticides and other neurotoxins. Remember that these pesticides, herbicides and fungicides kill farm workers, who experience high cancer rates. Why would you want to support such an industry?" - Susan E. Schenck, The Live Food Factor: The Comprehensive Guide to the Ultimate Diet for Body, Mind, Spirit & Planet (Get the book.)

"If you apply the risk-levels seen in the 2 merck trials, VIGOR and APPROVe, you obtain a more realistic and likely range of estimates for the number of excess cases in the U.S. This estimate ranges from 88,000 to 139,000 Americans. Of these, 30-40% probably died. For the survivors, their lives were changed forever. It's important to note that this range does not depend at all on the data from our Kaiser-FDA study. Indeed, Dr. Eric Topol. . ." - Jonathan W. Emord, The Rise of Tyranny (Get the book.)

"As an aside, the observations regarding aspirin and secondary prevention of colorectal cancer caused merck and Pfizer to see if Vioxx and Celebrex might provide such benefit with less risk. That led to the realization of the cardiotoxic-ity of Vioxx and the brouhaha I will discuss in chapter 9. However, aside from the cardiotoxicity, the Vioxx trial suggests some decrease in the likelihood of polyp formation. However, when the U.S." - Nortin M. Hadler MD, Worried Sick: A Prescription for Health in an Overtreated America (Get the book.) "Pharmacia (the Swedish pharmaceutical firm that was to be swallowed by Pfizer) and merck were breaking new ground in the escalating tendency of the pharmaceutical industry to market at the very edge of veracity. This is the impression one gets from the content of their numerous sponsored professional symposia, the dinner talks by "thought leaders," their advertising in professional journals, and their direct-to-consumer advertising. Direct-to-consumer (dtc) advertising has an interesting history." - Nortin M. Hadler MD, Worried Sick: A Prescription for Health in an Overtreated America (Get the book.)

"Vioxx, a treatment for pain and inflammation manufactured by merck, was approved by the FDA in 1999 and, by the time it was voluntarily pulled from the market in September 2004; at least 20 million Americans had taken the drug. Nearly 10,000 Americans have filed suit against the company claiming that early into the marketing of Vioxx the company was aware of data showing a twofold increase of heart attack and other cardiovascular risks. Although merck has set aside $1 billion to cover the Vioxx litigation costs, many experts believe the damages could run into the tens of billions of dollars." - Kelly Patricia O'Meara, Psyched Out: How Psychiatry Sells Mental Illness and Pushes Pills That Kill (Get the book.)

"I'm not one of the convinced, since the acknowledgment is based on a trivial difference, too small to measure reliably. But merck had a greater market in sight. In chapter 5, I discussed the hypothesis that nsaids might decrease the likelihood of colonic polyps. I also detailed the tenuous basis for someone to think polyps are meaningful harbingers of colon cancer. Nonetheless, Americans are told as much. It would follow that if nsaids blocked polyp formation, they would banish colon cancer from the aging population. If nsaids were safer, everyone would take them regardless of the cost." - Nortin M. Hadler MD, Worried Sick: A Prescription for Health in an Overtreated America (Get the book.)

"EIGHT M oney, Drugs, and Lies Sometime in the early weeks of 2001, the giant pharmaceutical house merck realized it had a problem. Its flagship drug, the painkiller Vioxx, had been on the market for more than a year, and it had already reached blockbuster status, the term for drugs that sell more than a billion dollars annually. The company had recently published a massive study of Vioxx that showed the drug was safer than naproxen, a painkiller similar to ibuprofen, both of which can cause bleeds in the stomach and intestines, a rare but potentially deadly side effect." - Shannon Brownlee, Overtreated: Why Too Much Medicine Is Making Us Sicker and Poorer (Get the book.)

"Among his new clients were PhRMA, Pfizer, Eli Lilly and merck. Linda Fishman, from the majority side of the Finance Committee, left to become a lobbyist with the drug manufacturer Amgen. Pat Morrisey, chief of staff of the Energy and Commerce Committee, took a job lobbying for drug companies Novartis and Hoffman-La Roche. Jeremy Allen went to Johnson and Johnson. Kathleen Weldon went to lobby for Biogen, a Bio-tech company. Jim Barnette left to lobby for Hoffman-La Roche." - Jonathan W. Emord, The Rise of Tyranny (Get the book.) "Merck & Co., Inc., makers of Vioxx, and the Pharmaceutical Research and Manufacturers of 67 America. In 2006, the Union of Concerned Scientists confidentially surveyed 997 FDA scientists. Sixty-one percent responded affirmatively to the question of whether they knew of cases in which HHS or FDA "political appointees [had] inappropriately injected themselves into FDA determinations or actions." - Jonathan W. Emord, The Rise of Tyranny (Get the book.) "In November 2000, another merck clinical trial named VIGOR found a 5-fold increase in heart attack risk with high-dose Vioxx. The company said the drug was safe and that the comparison drug naproxen was protective. In 2002, a large epidemiologic study reported a 2-fold increase in heart attack risk with high-dose Vioxx and another study reported that naproxen did not affect heart attack risk. About 18 months after the VIGOR results were published, FDA made a labeling change about heart attack risk with high-dose Vioxx, but did not place this in the "Warnings" section." - Jonathan W. Emord, The Rise of Tyranny (Get the book.)

"How many thousands of people needed to die (death dramatically raises the stakes for expensive law suits) before the drug producer merck "volunteered" to withdraw the drug from the market? Likewise, how can powerful antidepressants be given to unhappy children, when it has been demonstrated that these drugs increase the risk of suicide? These are questions that reflect physic's "uncertainty principle" which turns the use of medical drugs into a gamble with one's life. The stamp of scientific approval is perhaps one of the most dangerous tools employed by the medical industry today." - Andreas Moritz, Timeless Secrets of Health & Rejuvenation: Unleash The Natural Healing Power That Lies Dormant Within You (Get the book.)

"Merck Doctor Likely to Testify in Vioxx Trial." Wall Street Journal,]\i\y 18, 2005:B1. 21 Hipisley-Cox,J., and Coupland, C. "Risk of Myocardial Infarction in Patients Taking Cyclo-Oxygenase-2 Inhibitors or Conventional Non-Steroidal Anti-Inflammatory Drugs: Population Based Nested Case-Control Analysis." BM/2005;330:1366-1373. 22 Temple, R. Personal Communication, November 18, 2004. Teicher, M. H., et al. "Emergence of Intense Suicidal Preoccupation During Fluoxetine Treatment." Am. J. Psychiatry 1990;147:207-210. 24 "FDA Reviews Data for Antidepressant Use in Adults." - Joe Graedon, M.S. and Teresa Graedon, Ph.D., Best Choices From the People's Pharmacy (Get the book.) "When merck discovered that Cholestin was being sold over the counter as a dietary supplement, the pharmaceutical giant complained to the FDA. The agency agreed that Pharmanex was selling an unapproved new drug, even though it has been used for hundreds of years in China to flavor and color meat and fish. Lengthy legal battles ultimately resulted in Pharmanex taking red yeast rice off the market and substituting policosanol in its Cholestin sold in the United States." - Joe Graedon, M.S. and Teresa Graedon, Ph.D., Best Choices From the People's Pharmacy (Get the book.)

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