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"Included in the latter group would be the isothiocyanates from cruciferous vegetables, which are metabolized by GST, also resulting in their excretion [21]. Genetic variation in the pathway for a vitamin can affect the physiologic impact of intake of that vitamin. If a vitamin plays a role in cancer prevention, differences in the receptor for the vitamin could also affect the susceptibility of an individual to cancer. For example, there are commonly occurring genetic differences in the vitamin D receptor that may have functional significance." - Ann M. Coulston and Carol J. Boushey, Nutrition in the Prevention and Treatment of Disease (Get the book.)

"It was found that in the case of a heart attack, where aspirin is commonly prescribed, the isothiocyanates in wasabi had an immediate effect as opposed to thirty minutes for aspirin. MELANOMA: Eighty-two percent of lung tumors resulting from metastatic melanoma were reduced in mice who were administered a component of wasabi. BREAST CANCER: A human cell line study showed that a relatively small concentration of wasabi inhibited up to 50 percent of breast cancer cells. CANCER: Both wasabi and horseradish inhibited the growth of colon, lung, and stomach cancer cells in a human cell study." - David W. Grotto, RD, LDN, 101 Foods That Could Save Your Life! (Get the book.) "BACTERIA KILLER: Horseradish and wasabi root have components including isothiocyanates that are effective in killing H. pylori and other bacteria. Tips on Using Horseradish and Wasabi SELECTION AND STORAGE: Horseradish: • The vast majority of horseradish sold today is prepared horseradish that comes in jars, which will keep for a year unopened and for four months opened. Wasabi: Paste: • Wasabi will last up to two years if frozen. • Refrigerated opened shelf life is approximately 30 days. Rhizomes: • Keep refrigerated when not being used. • Wrap in damp paper towels." - David W. Grotto, RD, LDN, 101 Foods That Could Save Your Life! (Get the book.) "Cabbage, especially raw sauerkraut (cooking cabbage appears to reduce these helpful plant chemicals), is rich in the anti-cancer compounds indole-3-carbinole (I3C), isothiocyanates (a type of beneficial compound found in Brassica vegetables), and sulforaphane. These compounds help activate and stabilize the body's antioxidant and detoxification mechanisms, which, in turn, eliminate cancer-producing substances. Cabbage intake has been linked to a lower incidence of colon, lung, cervical, and breast cancer." - David W. Grotto, RD, LDN, 101 Foods That Could Save Your Life! (Get the book.) "Antiplatelet and anticancer isothiocyanates in fapanese domestic horseradish, wasabi. Biofactors. 2000;13(l-4):271-276. Nomura T et al. Selective sensitivity to wasabi-derived 6-(methylsulnnyl)hexyl isoth-iocyanate of human breast cancer and melanoma cell lines studied in vitro. Cancer Detect Prev. 2005;29(2):155-160. Ono H et al. 6-Methylsulfinylhexyl isothiocyanate and its homologues as food-originated compounds with antibacterial activity against Escherichia coli and Staphylococcus aureus. Biosci Biotechnol Biochem. 1998 Feb;62(2):363-365. Shin IS, Masuda H, Naohide K." - David W. Grotto, RD, LDN, 101 Foods That Could Save Your Life! (Get the book.)

"Sulforaphane is one of a class of chemicals called isothiocyanates. Sulforaphane and other isothiocyanates are antioxidants (page 467) and potent stimulators of natural detoxifying enzymes in the body. These compounds are believed to be responsible for the lowered risk of cancer that is associated with the consumption of broccoli and other cruciferous vegetables, such ascauliflower, cabbage, andkale.3-4-% 6-7-8'9 Feeding sulforaphane-rich broccoli-sprout extracts to laboratory rats exposed to a carcinogen dramatically reduced the frequency, size, and number of the rats' tumors." - Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D., The Natural Pharmacy: Complete A-Z Reference to Natural Treatments for Common Health Conditions (Get the book.)

"Constituents Isobutylmine, isothiocyanates, spilanthol, polygodi-al, eudesmanolide, essential oils (limonene, thymol, germacrene, myrcene) Energetic Correspondences • Flavor: pungent, salty • Temperature: warm • Moisture: dry • Polarity: yang • Planet: Mars • Element: fire Contraindications Spilanthes is nonpoisonous to humans, though toxic to cold-blooded organisms. Eating the plant can cause numbness in the mouth. The volatile isothiocyanates cause an intense pungent sensation in the mouth." - Brigitte Mars, A.H.G., The Desktop Guide to Herbal Medicine: The Ultimate Multidisciplinary Reference to the Amazing Realm of Healing Plants, in a Quick-study, One-stop Guide (Get the book.)

"To benefit from the most cancer-fighting substances in produce, like carotenoids, isothiocyanates, limonene, vitamin C, and folic acid, just think of the three Cs. / Color (the deeper the better) - Elaine Magee, Food Synergy: Unleash Hundreds of Powerful Healing Food Combinations to Fight Disease and Live Well (Get the book.)

"Anticarcinogenic activities of organic isothiocyanates: Chemistry and mechanisms. Cancer Res. 54, 1976s-1981s. 216. Svehlikova, V., Wang, S., Jakubikova, J., Williamson, G., Mithen, R., and Bao, Y. (2004). Interactions between sulfor-aphane and apigenin in the induction of UGT1A1 and GSTA1 in CaCo-2 cells. Carcinogenesis 25, 1629-1637. 217. Gerhauser, C, You, M., Liu, J., et al. (1997). Cancer che-mopreventive potential of sulforamate, a novel analogue of sulforaphane that induces phase 2 drug-metabolizing enzymes. Cancer Res. 57, 272-278. 218. Fahey, J. W., Zhang, Y., and Talalay, P." - Ann M. Coulston and Carol J. Boushey, Nutrition in the Prevention and Treatment of Disease (Get the book.) "Dietary isothiocyanates, glutathione S-transferase polymorphisms and colorectal cancer risk in the Singapore Chinese Health Study. Carcinogenesis 23, 2055-2061. 223. Frosst, P., Blom, H. J., Milos, R., et al. (1995). A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase. Nat. Genet. 10, 111-113. 224. Ulrich, C. M., Curtin, K., Potter, J. D?Bigler, L, Caan, B., and Slattery, M. L. (2005). Polymorphisms in the reduced folate carrier, thymidylate synthase, or methionine synthase and risk of colon cancer. Cancer Epidemiol. Biomarkers Prev." - Ann M. Coulston and Carol J. Boushey, Nutrition in the Prevention and Treatment of Disease (Get the book.)

"Methylsulfinylheptyl and 8-methylsulfinyloctyl isothiocyanates from watercress are potent inducers of phase II enzymes." Carcinogenesis, 2000 Nov;21(ll):1983-1988. Thomson, B. & Shaw, I. "A comparison of risk and protective factors for colorectal cancer in the diet of New Zealand Maori and non-Maori." Asian Pac J Cancer Prev, 2002;3(4):319-324. Yanamoto, I. Hydrobiologica, 1984;116/117:145." - Freedom Press, Natural Cancer Cures: The Definitive Guide to Using Dietary Supplements to Fight and Prevent Cancer (Get the book.)

"Several compounds in cruciferous vegetables, such as sulforaphane and other isothiocyanates, have been of interest because of their potential chemopreventive effects. Concentrations of these compounds and the metabolic derivatives of them can be measured in plasma and urine by liquid chroma-tography/mass spectrometry [18]." - Ann M. Coulston and Carol J. Boushey, Nutrition in the Prevention and Treatment of Disease (Get the book.)

"Several isothiocyanates have been shown to inhibit tumors induced by chemical carcinogens. Broccoli in particular contains a potent isothio-cyanate that is an inhibitor of mammary tumors. Why Women Should Eat More Broccoli The anticancer properties of broccoli are well established. Even the American Cancer Society recommends eating it and other cruciferous vegetables. Though there are many compounds responsible for its impact on our health, one that deserves special mention is the indoles." - Jonny Bowden, Ph.D., C.N.S., The 150 Healthiest Foods on Earth: The Surprising, Unbiased Truth About What You Should Eat and Why (Get the book.)

"Notes As with other members of the cabbage family such as mustard and horseradish, the pungent taste is due to isothiocyanates. The main compound in wasabi is sinigrin (also present in black mustard and horseradish). It is tasteless and only becomes pungent after enzymatic conversion to "mustard oils". Xanthosoma sagittifolium tannia • new cocoyam Tannia plant Tannia tubers Description A robust perennial herb with fleshy tubers and large leaves shaped like arrowheads." - Ben-Erik van Wyk, Food Plants of the World: An illustrated guide (Get the book.)

"To summarize, however, the World Cancer Research Fund's Report for 1997 lists the following compounds under continuing investigation in plant foods as having proven or potential cancer activity: dithiothiones, isothiocyanates, sulfuropanes, terpenoids, isoflavones, protease inhibitors, phytic acid, polyphenols, glucosinolates, indoles, flavonoids, plant sterols, saponins and coumarins." - Michael Gearin-Tosh, Living Proof: A Medical Mutiny (Get the book.)

"Many cabbage family members prevent cancer with two nutrients called indoles and isothiocyanates. Recently, scientists from Finland For tastier greens, discovered that the fermentation cook them with process used to turn white cabbage spices. Add mustard into ^aikraat a]so creates isothioseed to broccoli, mar- , joram to kale, or dill cymates in the sauerkrautto brussels sprouts. Some researchers think you need to eat an awful lot of sauerkraut to get real protection, but you don't have to just eat sauerkraut all day. You can also get cancer defense from these other cabbage family members." - The Editors of FC&A, Unleash the Inner Healing Power of Foods (Get the book.)

"A Glucosinolates: glucocheiroline, glucoiberin, which yield the isothiocyanates cheiroline and iberin Fatty oil (in the seeds) EFFECTS The drug has cardiac effects similar to digitaloid drugs, due to the cardenolide glycosides. Its application for constipation is plausible because of the inhibition of Na+ and H2O absorption and the stimulating effect on the smooth muscles of the gastrointestinal tract. indications and usage Unproven Uses: Wallflower is used for cardiac insufficiency, as a laxative, and to encourage menstruation. Homeopathic Uses: The herb is used for wisdom tooth pain." - Thomson Healthcare, Inc., PDR for Herbal Medicines, Fourth Edition (Get the book.) "Efficacy for rheumatism seems plausible because of the stimulating effect of the isothiocyanates. Efficacy for the other indications has not yet been proved. BEHENSEEDS Unproven Uses: Folk medicine indications for internal use are constipation, warts, and worms (Central America); for diarrhea (Chad); for splenomegaly, colic, dyspepsia, fever, inflammation of the skin, edema, diabetes, abdominal tumors, paralyses, and lumbago (Saudi Arabia). The seeds are used externally for dandruff in Nigeria. Indian Medicine: Behen seeds are used for fever and as an aphrodisiac." - Thomson Healthcare, Inc., PDR for Herbal Medicines, Fourth Edition (Get the book.)

"In a study published in the October 23, 2002, Journal of Agricultural and Food Chemistry, Finnish researchers reported that fermenting cabbage produces compounds known as isothiocyanates, shown in laboratory studies (in test tubes and animals) to prevent the growth of cancer. Sulforaphane, a particularly potent member of the isothiocyanate family, increases the production of certain enzymes known as phase-2 enzymes, which can "disarm" damaging free radicals and help fight carcinogens. It's believed that phase-2 enzymes may reduce the risk of prostate cancer." - Jonny Bowden, Ph.D., C.N.S., The 150 Healthiest Foods on Earth: The Surprising, Unbiased Truth About What You Should Eat and Why (Get the book.)

"In all cases, the freed aglycone is unstable and is chemically restructured to an isothiocyanate. isothiocyanates have a pungent odor and taste and are irritating to both the skin and the mucous membranes that line the gastrointestinal tract. They may also cause liver and kidney damage. Isothiocyanates inhibit the uptake of iodine in the thyroid. However, the small amounts of isothiocyanates consumed in cabbage and related edible plants are not believed to cause thyroid problems in humans." - David Hoffman, FNIMH, AHG, Medical Herbalism: The Science Principles and Practices Of Herbal Medicine (Get the book.)

"Brussels sprouts are high in isothiocyanates and sulforaphane, which are compounds known to help fight cancer by inhibiting cell proliferation, neutralizing carcinogens, and helping to detoxify nasty environmental toxins. Sulforaphane, a particularly potent member of the isothiocyanate family, increases the production of certain enzymes known as "phase-2 enzymes," which can "disarm" damaging free radicals and help fight carcinogens. It's believed that phase-2 enzymes may reduce the risk of prostate cancer." - Jonny Bowden, Ph.D., C.N.S., The 150 Healthiest Foods on Earth: The Surprising, Unbiased Truth About What You Should Eat and Why (Get the book.) "It's one of a class of chemicals in plants called isothiocyanates and is a potent antioxidant and stimulator of natural detoxifying enzymes in the body. How Does Cauliflower Fight Cancer? Here's how it works: Within minutes of being eaten, sulforaphane enters the bloodstream and turbocharges the body's antioxidant defense systems. When it reaches the cells, it activates phase-2 detoxification enzymes in the liver, which then "disarm" carcinogenic molecules and help remove them from the cells." - Jonny Bowden, Ph.D., C.N.S., The 150 Healthiest Foods on Earth: The Surprising, Unbiased Truth About What You Should Eat and Why (Get the book.)

"The glucosinolates are a group of compounds that are enzymatically converted to volatile and pungent isothiocyanates when chewed or processed. There is evidence that regular consumption of glucosinolates may offer protection against cancer. Tannins are astringent substances that are considered to be detrimental to good digestion, at least in animals." - Ben-Erik van Wyk, Food Plants of the World: An illustrated guide (Get the book.)

"The pungent taste and tear-producing properties of mustard seeds are a result of nitrogen-and sulfur-containing compounds called isothiocyanates. These compounds are formed from glucosides called sini-grin (in brown mustard) and sinalbin (in white mustard), which are normally present in ground mustard seeds when the seeds are dry; once water is added, special enzymes (myrosin, for example), also present in the seeds, break down these glucosides to form isothiocyanates. That is why dry mustard powder lacks pungent odor but develops it only shortly after water or vinegar is added." - Dianne Onstad, Whole Foods Companion: A Guide For Adventurous Cooks, Curious Shoppers, and lovers of natural foods (Get the book.)

"Bok choy guards you with its isothiocyanates and pack of indoles. • Cauliflower. Cauliflower's glucosinolates help your body use estrogen safely — and that may reduce your risk. Cauliflower gives you indoles, too. For a sweeter taste, try broccoflower, a bright green version of cauliflower. • Brussels sprouts. Chow down on brussels sprouts to arm your body with indoles and a cancer repelling isothio-cyanate called sulphorophane. Pack in some parsley. Skip out on parsley and you'll miss two anti-cancer nutrients, vitamin C and the flavonoid, apigenin." - The Editors of FC&A, Unleash the Inner Healing Power of Foods (Get the book.)

"The volatile isothiocyanates cause an intense pungent sensation in the mouth. Range and Appearance Spilanthes acmella is native to northern Africa, China, and the Indian subcontinent, while S. oler-acea is native to South America. The leaves are opposite. The small yellow flowers grow on terminal stalks. STAR ANISE Botanical Name lllicium verum Family Illiciaceae (lllicium Family) Etymology The genus name, lllicium, is Latin for "that which entices," in reference to the tree's pleasant scent. The species name, verum, is Latin for "true." - Brigitte Mars, A.H.G., The Desktop Guide to Herbal Medicine: The Ultimate Multidisciplinary Reference to the Amazing Realm of Healing Plants, in a Quick-study, One-stop Guide (Get the book.)

"Applied as a cataplasm, it triggers local hyperemias due to the irritating effect of the isothiocyanates. Dried extracts of the root are abortive and contraceptive in their effect." - Thomson Healthcare, Inc., PDR for Herbal Medicines, Fourth Edition (Get the book.)

"Sulforaphane and other isothiocyanates are antioxidants (page 467) and potent stimulators of natural detoxifying enzymes in the body. These compounds are believed to be responsible for the lowered risk of cancer that is associated with the consumption of broccoli and other cruciferous vegetables, such ascauliflower, cabbage, andkale.3-4-% 6-7-8'9 Feeding sulforaphane-rich broccoli-sprout extracts to laboratory rats exposed to a carcinogen dramatically reduced the frequency, size, and number of the rats' tumors." - Alan R. Gaby, M.D., Jonathan V. Wright, M.D., Forrest Batz, Pharm.D. Rick Chester, RPh., N.D., DipLAc. George Constantine, R.Ph., Ph.D. Linnea D. Thompson, Pharm.D., N.D., The Natural Pharmacy: Complete A-Z Reference to Natural Treatments for Common Health Conditions (Get the book.)

"Scottish researchers have reported that indoles and isothiocyanates from cruciferous vegetables protect DNA from damage and stimulate apoptosis in colon cancer cells. Health gurus have been maintaining the colon health benefits of eating cabbage and sauerkraut for many years. The active component was called "cabbagen" before it was identified as a complex of indoles and isothiocyanates. Cruciferous vegetables, garlic, and onions release their sulfur compounds when they are bruised, mashed, or cooked. In nature, one bite into green foods was enough to send many predators packing." - Vincent Giampapa, Ronald Pero, and Marcia Zimmerman, The Anti-Aging Solution: 5 Simple Steps to Looking and Feeling Young (Get the book.)

"Eating three or more 54-cup servings of vegetables daily, particularly those rich in beta-carotene and cruciferous vegetables containing indoles and isothiocyanates (substances that have been found to reduce the number of tumors in mice treated with carcinogens) is highly recommended. Cruciferous vegetables that have been found to contain indoles and isothiocyanates are broccoli, brussels sprouts, cabbage, and cauliflower. Other cruciferous vegetables that are presumed to contain indoles and isothiocyanates include bok choy, collards, kale, kohlrabi, mustard greens, rutabaga, and turnips." - Earl Mindell and Hester Mundis, Dr. Earl Mindell's Unsafe at Any Meal: How to Avoid Hidden Toxins in Your Food (Get the book.)

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