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"I doubt the enthusiasm would be tempered by the brouhaha that now surrounds rosiglitazone, which is manufactured by glaxosmithkline (GSK) and marketed as Avandia. Steven Nissen is a cardiologist on the staff of the Cleveland Clinic who assumed the role of director of the clinic's contracted drug trials enterprise from Eric Topol after the latter became embroiled in the Vioxx controversy about which we have much to say in later chapters. Nissen and Wolski (2007) undertook a meta-analysis of forty-two treatment trials and concluded that rosiglitazone increased the risk of myocardial infarction." - Nortin M. Hadler MD, Worried Sick: A Prescription for Health in an Overtreated America (Get the book.)

"How did glaxosmithkline react to the jury verdict? Did the company remove Paxil from the market? GSK didn't blink. It didn't even put a warning in • For details of the bizarre outcome of the Wesbecker case, see chapter 18. its label and instead went on with business as usual, selling more and more Paxil to the public, while quietly settling additional cases as they came along. More recently, as we'll see, GSK felt compelled to issue a "Dear Healthcare Provider" letter warning that Paxil causes suicidality in children and adults." - Peter Breggin, Medication Madness: A Psychiatrist Exposes the Dangers of Mood-Altering Medications (Get the book.) "Several years earlier, when I gained access to sealed company records in a product-liability suit against glaxosmithkline, the manufacturer of Paxil, I investigated the relationship between akathisia and suicidal or violent behavior. Although the drug company systematically tried to avoid diagnosing patients with the dread disorder akathisia, a number of cases turned up in their European database. Working with my research assistant Ian Goddard, we found many correlations between akathisia and suicidal behavior, including completed suicides." - Peter Breggin, Medication Madness: A Psychiatrist Exposes the Dangers of Mood-Altering Medications (Get the book.) "When confronted with the question during a deposition against glaxosmithkline in early 2007,1 realized that there were no suicides in either the drug groups or the sugar pill groups. None of the depressed and vulnerable patients who participated in the trials committed suicide including those who were given placebo. Therefore, the lack of completed suicides had nothing to do with the antidepressants. My conclusion? Putting a depressed patient in a controlled clinical trial by itself probably protects against suicide. Why?" - Peter Breggin, Medication Madness: A Psychiatrist Exposes the Dangers of Mood-Altering Medications (Get the book.) "At that time I was asked by California attorney Don Farber to be the medical expert in a product-liability case that was brought by the family of Reynaldo Lacuzong (his real name) in California against the Paxil manufacturer, glaxosmithkline (GSK). The Lacuzong Case On the third day of taking Paxil 10 mg, the smallest available dose, Reynaldo drowned himself and his two small children in a bathtub. Before his death, Reynaldo received excellent evaluations as an employee at a high-tech firm. He had no prior history of mental problems, psychiatric treatment, or counseling." - Peter Breggin, Medication Madness: A Psychiatrist Exposes the Dangers of Mood-Altering Medications (Get the book.)

"Healthworld represents Wyeth Pharmaceuticals, together with Bayer, Bristol Myers Squibb, glaxosmithkline, Novartis, Pfizer, Roche and Schering. Shire Health represents Wyeth-Ayerst along with 21 other pharmaceutical companies.48 Healthworld Communications incorporates the Global Business Group, which, as well as representing various pharmaceutical compa- 48 These include: Abbott Laboratories, AstraZeneca, Bristol-Myers Squibb, glaxosmithkline, Janssen-Cilag, Johnson & Johnson, Merck Sharp & Dohme, Novartis, Novo Nordisk, Pfizer, Roche and Schering-Plough." - Martin J. Walker, HRT Licensed to Kill and Maim: The Unheard Voices of Women Damaged by Hormone Replacement Therapy (Get the book.)

"However, the site does mention that the two nonprofit organizations participating in this educational initiative have a number of "corporate partners," namely AstraZeneca, Aventis, Bristol-Myers Squibb, Eli Lilly, glaxosmithkline, Merck, Merck/Schering-Plough, Monarch, Novartis, Pfizer, and Wyeth. When corporate partners fund the flow of information, the message is likely to accentuate treatment strategies that are in their interest and downplay those that are not. For example, fewer than one-third of the diabetics in the United States get adequate exercise." - John Abramson, Overdosed America: The Broken Promise of American Medicine (P.S.) (Get the book.)

"Executives at glaxosmithkline were talking about the company's new asthma drug called Advair, which was nothing more than a combination of two of the company's older medicines. The drugs had a new name and a fresh marketing campaign, but patients still had the same two drugs. Then there were the companies that tried to extend their rich monopolies by introducing what they said were new and improved versions of products that had become wildly successful. Schering-Plough was preparing to sell Clarinex, which it said was even better than its best-selling allergy drug Claritin." - Melody Petersen, Our Daily Meds: How the Pharmaceutical Companies Transformed Themselves into Slick Marketing Machines and Hooked the Nation on Prescription Drugs (Get the book.) "The drug companies also copied some of RJR's direct marketing techniques. glaxosmithkline, the maker of Wellbutrin, had "Racing for Life" trailers at the track where fans were screened for depression and other diseases. An added attraction at the trailer was a visit from Bobby Labonte, the driver of the No. 18 Wellbutrin car, and his crew chief, Michael "Fatback" McSwain. NASCAR lovers are among the most dedicated of sports fans. They are known to show their loyalty by buying the products sponsoring their favorite drivers. Mark Martin and his No." - Melody Petersen, Our Daily Meds: How the Pharmaceutical Companies Transformed Themselves into Slick Marketing Machines and Hooked the Nation on Prescription Drugs (Get the book.) "Only a little more than half the patients taking Imitrex, a triptan sold by glaxosmithkline, felt relief from their pain after two hours, according to trials the company performed to get the drug approved. Even the sugar pills worked well in these studies. About a quarter of the people getting the placebo were also relieved of their pain after two hours. Dr. Reed also did not talk about the triptans'possible side effects, which include rare heart attacks and strokes. If the risks were listed on one of her slides, she did not point them out, and they passed without notice." - Melody Petersen, Our Daily Meds: How the Pharmaceutical Companies Transformed Themselves into Slick Marketing Machines and Hooked the Nation on Prescription Drugs (Get the book.)

"An Indian medical journal complains that the country is becoming "the greatest source of human guinea pigs for the global drug industry."51 glaxosmithkline, Eli Lilly, Pfizer, and Novartis all run trials there. Why? Vast numbers of potential research subjects, cheaper costs, and the fact that the patient population is "treatment naive"—they are largely unexposed to drugs, which makes the evaluation of the effect of a given drag easier. India's other advantages include English-speaking medical personnel, lots of hospitals (700,000 specialty beds), and medical colleges (221)." - Charles Barber, Comfortably Numb: How Psychiatry Is Medicating a Nation (Get the book.) "The initiative came about as a result of gifts from Pfizer, Lilly, glaxosmithkline, AstraZeneca, Bayer, Procter & Gamble, and Wyeth-Ayerst.90 While the public, historically, has been innocently unaware of these details, they are starting to get wise. In the public's view, the pharmaceutical industry has recently joined the oil industry as the most exploitative and reviled sector of corporate America. The perception of manipulation and arrogance on the part of Big Pharma is starting to stick. A trust factor appears to have been violated." - Charles Barber, Comfortably Numb: How Psychiatry Is Medicating a Nation (Get the book.) "As part of an earlier campaign for "social anxiety disorder" ("Imagine Being Allergic to People" was the slogan), glaxosmithkline spent $92 million in one year to market Paxil—more than Nike spent to market its top shoes.100 The result of all this: Paxil passed Prozac and Zoloft and became the world's ninth best-selling drug.101 The marketing has been so excessive that the drug companies clearly took advantage of the events of September 11 for sales. Even Psychiatric News, a journal of the American Psychiatric Association, said that drug makers like Glaxo found 9/11 "a marketing opportunity." - Charles Barber, Comfortably Numb: How Psychiatry Is Medicating a Nation (Get the book.) "In response, Glaxo-SmithKline positioned Paxil as an antianxiety drug, and on April 16, 2001, got their prize: FDA approval as an agent for "generalized anxiety disorder," previously a little-known condition. glaxosmithkline cranked up an aggressive public relations campaign—an amalgam of profiles of generalized anxiety sufferers given out to local news programs, patient surveys meant to inform the populace of the hidden epidemic, expert testimony by eminent psychiatrists, a blizzard of newspaper articles, and, most pointedly, an onslaught of DTC ads on television." - Charles Barber, Comfortably Numb: How Psychiatry Is Medicating a Nation (Get the book.)

"Changes May Be Coming I discussed in the Tricks of the Trade chapter the lawsuit Eliot Spitzer brought against glaxosmithkline for hiding the results of studies which found their antidepressant to be associated with suicide. I did not mention that Mr. Spitzer was not just upset with glaxosmithkline. "Where has the FDA been all these years when clinical data has been hidden from public scrutiny? They have simply failed to confront the problem."59 It is truly remarkable what media attention can accomplish." - Dr. Timothy Scott, America Fooled: The Truth About Antidepressants, Antipsychotics and How We've Been Deceived (Get the book.)

"One of the other doctors practicing in her office had received payments from glaxosmithkline and three other drug companies. There was nothing unusual about this. It was simply an example of a tiny strand of the ubiquitous web of doctors that the drug companies had created to promote their products even when they were not around. I rummaged through my files to find the brochure Dr. Reed had handed out to the women at the mall. Called the Headache Impact Test, it included six brief questions to use to rate the severity of headaches." - Melody Petersen, Our Daily Meds: How the Pharmaceutical Companies Transformed Themselves into Slick Marketing Machines and Hooked the Nation on Prescription Drugs (Get the book.)

"On May 25, 1999, the FDA granted glaxosmithkline approval to market Avandia. In February 2006, another FDA medical reviewer, Dr. Rosemary Johann-Liang, advocated a black box warning to inform physicians and patients of the drugs risks to the heart.100 Her recommendation was also ignored, and she was then subjected to managerial pressure.101 Johann-Liang's supervisor, Dr. Mark Avigan, told her that agency management was "upset with [her] recommendation" and "decided to act like the review never happened."102 On May 21, 2007, the New England Journal of Medicine published a meta-analysis by Drs." - Jonathan W. Emord, The Rise of Tyranny (Get the book.)

"Resveratrol derivatives or extracts are powerful mitochondrial energy boosters and are in drug development now (Sirtris was just purchased by glaxosmithkline). 4. Your doctor may prescribe additional energy-boosting treatments and exercises such as interval training. KEY #7: CALM YOUR MIND Most of us were never trained to calm ourselves. Unless, of course, we do it with a big jelly doughnut or a glass of chardonnay. A runaway stress response has become a part of our daily lives, but most of us are unaware that we are in a perpetual state of alarm. It is just how we are." - Mark Hyman MD, The UltraMind Solution: Fix Your Broken Brain by Healing Your Body First (Get the book.)

"Indeed, according to a 2003 report in the New York Times, "GlaxoSmithKline and Bayer, the comarketers of Levitra, boldly admit that they are focusing on men who may have successful sexual relationships but who simply want to improve the quality or duration of their erections." This statement upset the makers of Viagra so much that Pfizer spokeswoman Janice Lipsky told Times reporter Gardiner Harris that Levitra had benefited from "false claims and public relations in which they inaccurately state that Levitra works faster and is better, neither of which is true." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"On April 17, 2008, drug giant glaxosmithkline submitted a petition to the FDA, joined by its compatriots the American Dietetic Association and the Obesity Society, among others. Glaxo asked FDA to ban all claims that a dietary supplement "promote[s], assist[s], or otherwise help[s] in weight loss." If overweight status is a contributing factor to a host of diseases, Glaxo argues, then claims concerning weight loss are drug claims that may be censored under Whitaker III. Glaxo's bias and interest are apparent to industry observers, albeit undisclosed in the petition." - Jonathan W. Emord, The Rise of Tyranny (Get the book.) "Misbin reported to his FDA supervisors that a glaxosmithkline drug for type 2 diabetes then under review, Avandia (rosiglitazone), appeared to increase the incidence of congestive heart failure in study participants. In an April 2, 1999 internal FDA report on Avandia, Misbin warned: "My concern about deleterious long term effects on the heart should be addressed by requiring the Sponsor to provide adequate information in the label about changes in weight and lipids. A postmarketing study to address these issues needs to be a condition of approval." - Jonathan W. Emord, The Rise of Tyranny (Get the book.)

"That year, New York's then—attorney general, Elliot Spitzer, sued glaxosmithkline (SmithKline merged with Glaxo in 2001) for concealing data on the drug's potential to cause suicide. Internal company documents that became public included a memo to company sales reps that instructed them specifically not to discuss the potential suicide risk with physicians. Other company research suggested that as many as one in four patients on Paxil suffer withdrawal symptoms if they abruptly stop taking the drug." - Shannon Brownlee, Overtreated: Why Too Much Medicine Is Making Us Sicker and Poorer (Get the book.)

"These mergers instead turned out to be team-wrecking, momentum-slowing, lab-shattering experiences in most big companies, glaxosmithkline chief among them. There, the cupboards were bare. Lab heads are at odds, and such high-tech industry cure-alls as high-throughput screening — computerized drug candidate testing — have been major and costly disappointments. Yet instead of focusing on this core of issues, the industry has gone into reengineering mode. Expensive "big think" consultants are drafted by the score. Internal "change initiatives," led by overpaid managerial whizfolk, abound." - Greg Critser, Generation Rx: How Prescription Drugs are Altering American Lives, Minds, and Bodies (Get the book.)

"The TMAP drug lists and guidelines were developed and approved in Texas while Bush was Governor, through an "expert opinion consensus" by a panel of medical professionals chosen by the pharmaceutical sponsors of the program that included Janssen Pharmaceutical, Eli Lilly, Johnson & Johnson, AstraZeneca, Pfizer, Novartis, Janssen-Ortho-McNeil, glaxosmithkline, Abbott, Bristol Myers Squibb, Wyeth-Ayerst and Forrest Laboratories." - Dr David W Tanton, Ph.D., Antidepressants, Antipsychotics, And Stimulants - Dangerous Drugs on Trial (Get the book.) "Apparently Merck has also tunneled money through "Women in Government", an advocacy group made up of female state legislators around the country, sponsored by many pharmaceutical companies, including Abbott laboratories, AstraZeneca, Bristol-Myers Squibb, glaxosmithkline, Johnson & Johnson, Merck, Novartis, Wyeth, Pfizer, PhRMA, and Eli Lilly! In fact, their website boasts EIGHTY-ONE different "sponsors", including such contributors as ExxonMobil, Anheuser-Busch Companies, Inc., and Wholesale Beer Distributors of Arkansas, Inc., (clearly mentioned on their website at http://www." - Dr David W Tanton, Ph.D., Antidepressants, Antipsychotics, And Stimulants - Dangerous Drugs on Trial (Get the book.)

"The young companies with the freshest ideas want research contracts with a Pfizer or a Merck or a glaxosmithkline, just as a young starlet longs to hook up with a Hollywood major - and for the same reasons: so their full potential can be given the opportunity to shine on the global stage. These small companies work to pharma's rules, which largely set the standards for what is researched. The most important of these is that a drug, from the moment of conception, must have a market." - Jacky Law, Big Pharma: Exposing the Global Healthcare Agenda (Get the book.) "But it had built up so much free cash-flow by then that when glaxosmithkline was stung for a $5 billion tax demand by the US authorities in 2003/4, one analyst brushed it aside, saying, 'The company is just a cash-machine. A bill like this is just an ant on the back of an elephant.'20 The arguments that ensued over this particular tax demand revealed how global reach can increase and sustain extraordinary profitability. In the words of one columnist: In the wonderful world of pharmaceuticals, lateral thinking is prized as highly in tax planning as in the lab." - Jacky Law, Big Pharma: Exposing the Global Healthcare Agenda (Get the book.)

"GlaxoSmithKline, the company that makes Paxil. Below is their questionnaire for depression. In this case there are 11 questions and they provide you the following directions at the bottom of it, "If you answered 'yes' to 5 or more of these questions, print out this self test and bring it to your doctor." Chances are, your doctor has had the same criteria provided to her, along with plenty of incentives to prescribe Paxil, of course. As with the anxiety sheets, there are some things on here that genuinely require attention if a person is experiencing them." - Fred A. Baughman, Jr., M.D. and Craig Hovey, The ADHD Fraud: How Psychiatry Makes "Patients" of Normal Children (Get the book.) "Then, in the mid-90s glaxosmithkline, the maker of the antidepressant Paxil, got their drug approved for double duty as an anti-anxiety agent and hired a public relations firm to launch a major promotional campaign. It was hugely successful. Stories in the media about social anxiety disorder leapt from 50 in 1997-98 to over 1 billion references in just 1999. Almost every story mentioned Paxil as the first and only FDA-approved drug for treatment of it." - Fred A. Baughman, Jr., M.D. and Craig Hovey, The ADHD Fraud: How Psychiatry Makes "Patients" of Normal Children (Get the book.)

"Eli Lilly, Ancile, Roche, Novartis, and Organon; has received research support from the National Institute of Mental Health, Pfizer, Solvay, Eli Lilly, glaxosmithkline, Wyeth-Ayerst, Organon, Forest Pharmaceuticals, Inc., PureWorld, Allergan, and Nutrition 2 . . . and has received royalties from MultiHealth Systems, Inc., Guilford Publications and the American Psychiatric Association.56 The Specialty Which Refuses to Disclose Financial Conflicts of Interest I hope you were startled by the research I shared a few pages back (p." - Dr. Timothy Scott, America Fooled: The Truth About Antidepressants, Antipsychotics and How We've Been Deceived (Get the book.)

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