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"DOSAGE AND ADMINISTRATION Body builders and athletes—typically male—who use chrysin take about one gram daily during training. HOW SUPPLIED Capsules — 250 mg Extended Release Tablets — 250 mg LITERATURE Capasso A, Piacente S, Pizza C, Sorrentino L. Flavonoids reduce morphine withdrawal in vitro. J Pharm Pharmacol. 1998; 50:561-564. Galijatovic A, Otake Y, Walle UK, Walle T. Extensive metabolism of the flavonoid chrysin by human Caco-2 and Hep G2 cells. Xenobiotica. 1999; 29:1241-1256. Jeong HJ, Shin YG, Kim IH, Pezzuto JM. Inhibition of aromatase activity by flavonoids. Arch Pharm Res."
- Sheldon Saul Hendler and David Rorvik, PDR for Nutritional Supplements (Get the book.)

"INTERACTIONS Aromatase inhibitors: chrysin may be addictive to the effects of such aromatase inhibitors as aminoglutethimide, anastrozole and letrozole. OVERDOSAGE There are no reports of overdosage. DOSAGE AND ADMINISTRATION Body builders and athletes—typically male—who use chrysin take about one gram daily during training. HOW SUPPLIED Capsules — 250 mg Extended Release Tablets — 250 mg LITERATURE Capasso A, Piacente S, Pizza C, Sorrentino L. Flavonoids reduce morphine withdrawal in vitro. J Pharm Pharmacol. 1998; 50:561-564. Galijatovic A, Otake Y, Walle UK, Walle T."

- Sheldon Saul Hendler and David Rorvik, PDR for Nutritional Supplements (Get the book.)

"Active principles and pharmacology The plant is reported to contain alpha-amyrin, campesterol, beta-sitosterol, its palmitate, chrysin and flavonoid glucosides from heartwood. These constituents justify the traditional use of the herb in the South; also its equation with Paashaanabheda. Pharmacological studies have confirmed that the roots possess diuretic, antiinflammatory, anthelmintic, antibacterial and mild analgesic effects."
- C. P. Khare, Indian Herbal Remedies: Rational Western Therapy, Ayurvedic and Other Traditional Usage, Botany (Get the book.)

"Bark of the root gave chrysin, baicalein and oroxylin. Bark also contained dihydrobaicalcein. A decoction of bark showed good diuretic activity in rats, comparing favourably with potassium acetate, and being more potent than urea. 50 % ethanolic extract of the fruit showed spasmogenic action on isolated guinea-pig ileum, whereas the root, stem and stembark extracts had no such effects."

- C. P. Khare, Indian Herbal Remedies: Rational Western Therapy, Ayurvedic and Other Traditional Usage, Botany (Get the book.)

"A 1993 study published in the Journal of Steroid Biochemical Molecular Biology compares chrysin and ten other flavonoids to an aromatase-inhibiting drug (aminoglutethimide). chrysin was not only shown to be the most potent of these aromatase inhibitors, it was found to be similar in effectiveness to the aromatase-inhibiting drug. The scientists conducting the study conclude that the aromatase-inhibiting effects of certain flavonoids may contribute to the cancer-preventive effects of plant-based diets."
- Gary Null, Gary Null's Power Aging (Get the book.)

"However, it's been shown that a pepper extract called piperine may significantly enhance chrysin's function. Pilot studies find that when chrysin is combined with piperine, reductions in serum estrogen (estradiol) and increases in total and free testosterone result in thirty days. Aromatase-inhibiting drugs are also used to treat women with estrogen-dependent breast cancers. The rationale for this therapy is that if they can halt the aromatasation process, and hence the production of the estrogen, they can slow the course of the cancer."

- Gary Null, Gary Null's Power Aging (Get the book.)

"Low testosterone or low androstenedione: Use transdermal androstenedione with augmenting nutrients such as chrysin, Tribulus ter-restris, saw palmetto extract, damiana extract, selenium, zinc, and grapeseed extract to prevent conversion of testosterone into DHT. Apply daily. High estrogen: Use progesterone (10 mg) applied twice daily. Low DHEA: Use DHEA cream, 15 mg twice daily, or 25 mg oral DHEA twice a day. (Oral doses are higher than topical doses because the liver converts some oral DHEA into inactive metabolites."
- Vincent Giampapa, Ronald Pero, and Marcia Zimmerman, The Anti-Aging Solution: 5 Simple Steps to Looking and Feeling Young (Get the book.)

"Chrysin was the most potent aromatase-inhibitor, and was shown to be similar in potency and effectiveness to the aromatase-inhibiting dmg. The scientists conducting the study concluded by stating that the aromatase-inhibiting effects of certain flavonoids may contribute to the cancer preventive effects of plant-based diets. Two studies have identified specific mechanisms by which chrysin inhibits aromatase in human cells."
- The Life Extension Editorial Staff, Disease Prevention and Treatment (Get the book.)

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