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"There had previously been hope that the cox-2 inhibitors might reduce systemic inflammation, but they seem to exert more of a localized action in areas such as the joints, where they are used to combat the inflammation of arthritis. However, there have been many severe side effects from the cox-2 inhibitors, so it is probable that even if they had demonstrated effectiveness, they still would not be appropriate for long-term use by children. The best medications for long-term treatment of widespread inflammation are the nutraceuticals, accompanied by nutritional therapy." - Kenneth Bock, Healing the New Childhood Epidemics: Autism, ADHD, Asthma, and Allergies: The Groundbreaking Program for the 4-A Disorders (Get the book.)

"Anthocyanins act like natural cox-2 inhibitors. COX stands for cyclooxygenase, which is produced in the body in two major O O ? n c 73 m t/> flavors, COX-1 and COX-2. It's the latter that is responsible for signaling pain and inflammation. Aspirin tends to block both, but COX-1 has some valuable uses. Some years ago, a popular class of arthritis drugs was developed that were known as COX-2 inhibitors; they inhibited the pain-signaling COX-2 molecules without touching the non-inflammatory COX-Is." - Jonny Bowden, Ph.D., C.N.S., The Most Effective Natural Cures on Earth: The Surprising, Unbiased Truth about What Treatments Work and Why (Get the book.)

"Good riddance to a bad drug," he concluded, calling the entire story of cox-2 inhibitors "a debacle."46 That should have been the end of the story. Not so. On February 18, 2005, an advisory panel for the FDA voted unanimously that Vioxx and Celebrex can lead to serious heart problems. Most of the panel also recommended warning labels that detailed the drug's danger and also a ban on consumer advertising. The panel then voted 31-1 that Pfizer should be allowed to continue selling Celebrex, and 17-15 that Merck could sell Vioxx.47 "At least the pharmaceutical lawyers must be happy," I said. " - Gerald E. Markle and Frances B. McCrea, What If Medicine Disappeared? (Get the book.)

"For some time, physicians believed that the popular cox-2 inhibitors, which are used for rheumatoid inflammation, would help with neuroinflammation. However, they have not proven to be particularly effective. They appear to be more active peripherally than in the brain. Ultimately, as always, there is no single medication, supplement, food, or lifestyle alteration that can fully halt the force of inflammation. A comprehensive anti-inflammatory strategy, applied as part of a larger restorative program, is the only viable solution." - Kenneth Bock, Healing the New Childhood Epidemics: Autism, ADHD, Asthma, and Allergies: The Groundbreaking Program for the 4-A Disorders (Get the book.)

"Selective cox-2 inhibitors like Vioxx and Celebrex block only COX-2. Despite drug companies' highest hopes, it turns out that blocking only COX-2 doesn't eliminate the risk of GI bleeding. And, blocking only COX-2 affects the clotting of blood and flexibility of blood vessels in ways that bring about an increased risk of heart disease. In a nutshell, we know now that the newer cox-2 inhibitors are all likely to increase cardiovascular risk. Since this discovery, many of the older NSAIDS have been implicated in raising heart disease risk as well." - Hyla Cass, Supplement Your Prescription: What Your Doctor Doesn't Know About Nutrition (Get the book.) "The newest generation of NSAIDs, cox-2 inhibitors such as celecoxib (Celebrex), lumiracoxib (Prexige), valdecoxib (Bextra) are now the most widely used for arthritis. Many of the adverse effects seen with older NSAIDs are also seen with the COX-2 inhibitors—with the likely exception of increased risk of heart problems. Actions: All NSAIDs block the production of hormone-like substances in the body that produce inflammation and pain. Side effects: All NSAIDs carry significant risk of gastrointestinal erosion that can lead to GI bleeding." - Hyla Cass, Supplement Your Prescription: What Your Doctor Doesn't Know About Nutrition (Get the book.)

"The scientists at both companies were failing to prove that the new drugs, known as cox-2 inhibitors, relieved pain any better than the far cheaper standbys like over-the-counter ibuprofen. Also, patients taking Vioxx and Celebrex still suffered from ulcers, albeit at what appeared to be a lower rate than those using the older drugs. At Merck, scientists were troubled by something more: they feared Vioxx might harm the hearts of some patients as it relieved their pain. More than two years before Vioxx was approved for sale, Dr." - Melody Petersen, Our Daily Meds: How the Pharmaceutical Companies Transformed Themselves into Slick Marketing Machines and Hooked the Nation on Prescription Drugs (Get the book.) "Daily they swallowed their proton pump inhibitors and cox-2 inhibitors, tricyclics and analgesics, benzodiazepines and amphetamines, anticoagulants and antihypertensives, as well as their lipid reducers, serotonin escalators, and mood stabilizers. On average, each Iowan now picked up fourteen prescriptions a year from the pharmacy. Some of the highest users needed that many medicines every day. Local newspapers were the first to document the predicaments of those prescribed ever more pills." - Melody Petersen, Our Daily Meds: How the Pharmaceutical Companies Transformed Themselves into Slick Marketing Machines and Hooked the Nation on Prescription Drugs (Get the book.)

"Overall, cox-2 inhibitors are not recommended for cancer prevention in patients who do not have familial polyposis (even those with polyps found on routine colonoscopy) since polyps do not necessarily proceed to gastrointestinal cancer, and people on a coxib are five times more likely to have a cardiac event as they are to develop gastrointestinal cancer if they don't take a coxib." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.) "Efficacy: cox-2 inhibitors are no more effective for pain relief than nonspecific NSAIDS or aspirin. Side effects: COX-2s have even nastier (and in some cases fatal) side effects than those listed for older NSAIDS. While they may not cause stomach bleeding, they do seem to cause the most heart attacks, probably by increasing blood clotting. People with preexisting heart disease are most at risk." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.) "Vioxx and Friends It's worth spending some time looking at the stories of two cox-2 inhibitors that have been taken off the market, Vioxx and Bextra, as they help put in perspective the drugs still available (Celebrex, which I discuss later, is still available.) The stories of these drugs are also prime examples of why and how a rush to market can have devastating effects on the consumer." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"However, there have been many severe side effects from the cox-2 inhibitors, so it is probable that even if they had demonstrated effectiveness, they still would not be appropriate for long-term use by children. The best medications for long-term treatment of widespread inflammation are the nutraceuticals, accompanied by nutritional therapy. For information on this, review the appropriate sections in the chapters on supplementation therapy and nutritional therapy." - Kenneth Bock, Healing the New Childhood Epidemics: Autism, ADHD, Asthma, and Allergies: The Groundbreaking Program for the 4-A Disorders (Get the book.)

"The advertising campaigns suggested that a sufferer could enjoy relief with diminished risk of gastrointestinal toxicity, as was predicted by the test-tube studies of the cox-2 inhibitors. They convinced patients and physicians alike, though they had never generated data that convinced the fda ?or me. One has to wonder what possessed the fda to license coxibs in the first place, given that the agency was not convinced of either any advance in effectiveness or in safety over available drugs with long-term track records. I suspect outside influences were at play." - Nortin M. Hadler MD, Worried Sick: A Prescription for Health in an Overtreated America (Get the book.)

"Both of these—hormone replacement therapy for treatment of menopausal symptoms, and so-called cox-2 inhibitors, which are pain relievers—are medical morality tales from which we may learn many important lessons. Hormone Replacement Therapy We would like to think that the development of new drugs follows a prudent and rational procedure: that research protocols are carefully designed and evaluated, and that decisions about dosage and use are evidence-based, so that ultimately such drugs are both safe and effective." - Gerald E. Markle and Frances B. McCrea, What If Medicine Disappeared? (Get the book.) "Neither estrogens or cox-2 inhibitors are miracle drugs. The former do not accomplish much and in fact cause considerable morbidity and some mortality. The latter are no more effective in relieving pain than less powerful substances; what they do is kill people. Many of the presumed diseases treated by prescription drugs are not pathological, but rather clusters of symptoms, the origins of which are either social, psychological, or from the natural process of aging— or most likely, a combination of all three." - Gerald E. Markle and Frances B. McCrea, What If Medicine Disappeared? (Get the book.)

"For relief from the pain, many reach for remedies like the prescription drugs in the category known as cox-2 inhibitors (Celebrex and Vioxx are famous examples), or pain relievers such as acetaminophen (Tylenol) and nonsteroidal anti-inflammatory drugs (Aleve). These drugs do offer immediate relief, but they're hardly without problems (witness the class-action suits over Vioxx). O Keep in mind that none of them address 03 the underlying cause of the joint pa.n." - Jonny Bowden, Ph.D., C.N.S., The Most Effective Natural Cures on Earth: The Surprising, Unbiased Truth about What Treatments Work and Why (Get the book.) "Some years ago, a popular class of arthritis drugs was developed that were known as COX-2 inhibitors; they inhibited the pain-signaling COX-2 molecules without touching the non-inflammatory COX-Is. The problem was, there were some really serious side effects with some of these drugs—such as the increased risk of blood clotting and heart attack—and at least one, Vioxx, was taken off the market. But anthocyanins produce a similar effect with none of the side effects. Cherries (and raspberries) have the highest yields of pure anthocyanins." - Jonny Bowden, Ph.D., C.N.S., The Most Effective Natural Cures on Earth: The Surprising, Unbiased Truth about What Treatments Work and Why (Get the book.)

"Cox-2 Inhibitors With the discovery of two forms of cyclooxygenase, and the belief that only Cox-2 was involved in inflammation, several pharmaceutical companies began massive research projects to develop a new generation of cox-2 inhibitors. In theory, these drugs would stop inflammation by suppressing Cox-2 activity, but avoid gastrointestinal side effects associated with inhibition of Cox-1. Celebrex and Vioxx were the first "selective" cox-2 inhibitors. But the new generation of cox-2 inhibitors (often referred to as "coxibs") was only 20 percent selective for Cox-2." - Jack Challem, The Inflammation Syndrome: The Complete Nutritional Program to Prevent and Reverse Heart Disease, Arthritis, Diabetes, Allergies, and Asthma (Get the book.)

"A new class of NSAIDs called cox-2 inhibitors was developed to reduce this side effect. However, a number of large studies have found that these newer drugs have a higher rate of potentially lethal side effects, such as heart attack or stroke, than the old fashioned NSAIDs. Two of them—Vioxx and Bextra—have been taken off the market. Although Celebrex is still available, I think its risk for people taking it chronically outweighs any potential benefit over ibuprofen. Whether these toxicities extend to the older class of NSAIDs is currently not known but is a question undergoing research." - Benjamin H. Natelson, M.D., Your Symptoms Are Real: What to Do When Your Doctor Says Nothing Is Wrong (Get the book.)

"Easier on the stomach: cox-2 inhibitors, which are selective NSAIDs that block prostaglandins—hormones that cause inflammation of the joints. Cox-2 inhibitors—rofecoxib (Vioxx, withdrawn from the market in 2004), celecoxib (Celebrex) and valdecoxib (Bextra, withdrawn from the market in 2005)—were welcomed with open arms in the late 1990s until a few patients had heart attacks or strokes. You may still take a Cox-2 inhibitor if your doctor advises and monitors you. Or you may be advised to return to ibuprofen or naproxen." - Bottom Line Health, Bottom Line's Health Breakthroughs 2007 (Get the book.)

"Selective cox-2 inhibitors like Vioxx and Celebrex block only COX-2. Despite drug companies' highest hopes, it turns out that blocking only COX-2 doesn't eliminate the risk of GI bleeding. And, blocking only COX-2 affects the clotting of blood and flexibility of blood vessels in ways that bring about an increased risk of heart disease. In a nutshell, we know now that the newer cox-2 inhibitors are all likely to increase cardiovascular risk. Since this discovery, many of the older NSAIDS have been implicated in raising heart disease risk as well." - Hyla Cass, M.D., Supplement Your Prescription: What Your Doctor Doesn't Know About Nutrition (Get the book.) "The newest generation of NSAIDs, cox-2 inhibitors such as celecoxib (Celebrex), lumiracoxib (Prexige), valdecoxib (Bextra) are now the most widely used for arthritis. Many of the adverse effects seen with older NSAIDs are also seen with the COX-2 inhibitors—with the likely exception of increased risk of heart problems. Actions: All NSAIDs block the production of hormone-like substances in the body that produce inflammation and pain. Side effects: All NSAIDs carry significant risk of gastrointestinal erosion that can lead to GI bleeding." - Hyla Cass, M.D., Supplement Your Prescription: What Your Doctor Doesn't Know About Nutrition (Get the book.)

"The mechanisms of COX-2 inhibition that led to the development of the cox-2 inhibitors were discovered at a university by researchers supported by taxpayers' dollars. In order to keep making money, drug companies are under enormous pressure to create new drugs they can patent and sell without competition for twenty years, after which patents run out and generic (cheaper) versions go to market. In fact, there really aren't a lot of truly new drugs being developed these days." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"How else can we explain the widespread agreement that statins or the new antidepressants or the cox-2 inhibitors are genuine breakthroughs that will preserve and restore our health in ways never before possible? These are our myths, merging science and hope into our shared belief. It is exactly myths such as these that Thomas Kuhn was referring to in his groundbreaking book The Structure of Scientific Revolutions, published in 1962. Kuhn coined the term "paradigm" to describe the unspoken professional values, beliefs, and techniques shared by a community of scientists or professionals." - John Abramson, Overdosed America: The Broken Promise of American Medicine (P.S.) (Get the book.)

"We repeat two scientific findings: first, cox-2 inhibitors really do hospitalize and even kill people; second, amazingly, they are no better at relieving pain than over-the-counter medications, a finding which was published a full year before the Pfizer CEO's rhapsody.49 THE AMERICAN PHARMACY Remember the millennial article in the New England Journal from the first page of this book. "Medicine is one of the few spheres of human activity," wrote the Journals editors, "in which the purposes are unambiguously altruistic." - Gerald E. Markle and Frances B. McCrea, What If Medicine Disappeared? (Get the book.)

"The theoretical advantage of the new selective cox-2 inhibitors is that they can block inflammation without causing irritation of the stomach lining. As I got into the review of the scientific evidence, I became increasingly puzzled. The authors praised both drugs, stating that they cause "significantly fewer serious gastrointestinal adverse events than does treatment with non-selective NSAIDs." I pulled the "Dear Healthcare Provider" letter out of my files to make sure that my recollection of its wording was accurate. It was." - John Abramson, Overdosed America: The Broken Promise of American Medicine (P.S.) (Get the book.)

"COX-2 inhibitors COX-2 enzymes cause pain and inflammation. cox-2 inhibitors restrain that enzyme, while ignoring the COX-i enzyme, which helps protect the lining of the stomach. cox-2 inhibitors have fewer side effects than NSAIDs. There are currently two COX-2 inhibitor drugs for arthritis: Celebrex and Vioxx. A third drug, Mobic, has been used in Europe for several years and has recently received FDA approval. tnf inhibitors These are some of the newest drugs in the arthritis arsenal. TNF stands for tumor necrosis factor, which is a cytokine." - Garcia Oz, Sharyn Kolberg, The Healthy High-tech Body (Get the book.)

"Anthocyanins act like natural cox-2 inhibitors. "COX" stands for cyclooxygenase, which is produced in the body in two or more forms, called COX-1 and COX-2. COX-2 is used for signaling pain and inflammation. The popularity of arthritis drugs like Vioxx and Celebrex was based on their unique ability to block only the pain and inflammation messages of COX-2 while leaving the noninflammatory COX-1 alone. Unfortunately, there were some really unpleasant side effects associated with Vioxx, and it was taken off the market. But anthocyanins produce a similar effect with none of the problems of drugs." - Jonny Bowden, Ph.D., C.N.S., The 150 Healthiest Foods on Earth: The Surprising, Unbiased Truth About What You Should Eat and Why (Get the book.)

"This included high doses of MSM of up to 10 to 15 grams per day, as well as glucosamine and natural herbal cox-2 inhibitors such as tumeric and curcumin extracts. On particularly bad days, I would even use Celebrex, although I mostly avoided drugs because of their potential side effects. My nutritional regimen helped take the edge off of my back and hip pain, but still did not provide me with the degree of relief I was looking for. Then I learned about SierraSil and, based on the studies I read, I started to take it." - Shari Lieberman, Alan Xenakis, Mineral Miracle: Stopping Cartilage Loss & Inflammation Naturally (Get the book.)

"Recently, a new class of drugs known as cox-2 inhibitors has been introduced. Although these drugs are being promoted as a safer alternative to NSAIDs, reports of adverse effects are already beginning to appear. DR. WRIGHT'S CASE STUDY "T 1 know there arent any cures for rheumatoid arthritis," Teresa Clancy said. "And I don't expect that some of my joints will ever look normal again." She held up her hands. " - Jonathan V. Wright, M.D. and Alan R. Gaby, M.D., Natural Medicine, Optimal Wellness: The Patient's Guide to Health and Healing (Get the book.)

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