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"The cox-2 inhibitor Bextra was supposed to have more advantages than Vioxx in the treatment of osteoarthritis. The drug's manufacturer, Pfizer, argued that Bextra should have a lower risk of heart attacks than Vioxx. This claim has not been supported by research. In fact, Nussmeier and colleagues studied 1,671 patients randomized to parecoxib (Dynastat, a cox-2 inhibitor that is given intravenously to surgical patients) or valde-coxib (i.e., Bextra). Patients with parecoxib or valdecoxib showed a 3.7-fold increase in heart attack or stroke." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"More than 20 percent of the people taking this cox-2 inhibitor experienced kidney toxicity (fluid retention, high blood pressure, and kidney failure).81 If patients had some kidney impairment before the study started (a common situation in older people), the likelihood of kidney toxicityjumped to more than 50 percent! We assume other NSAIDs are likely to have a similar effect on kidney function. NSAID Survival Strategy By now it should be clear that nonsteroidal anti-inflammatory drugs, including the COX-2 inhibitors, can be trouble with a capital T!" - Joe Graedon, M.S. and Teresa Graedon, Ph.D., Best Choices From the People's Pharmacy (Get the book.)

"In fact, Nussmeier and colleagues studied 1,671 patients randomized to parecoxib (Dynastat, a cox-2 inhibitor that is given intravenously to surgical patients) or valde-coxib (i.e., Bextra). Patients with parecoxib or valdecoxib showed a 3.7-fold increase in heart attack or stroke.5 Curt Furberg, Bruce Patsy, and Garret Fitzgerald analyzed data from this study along with data made available by the FDA and also found a greater than threefold increased risk of heart attack and stroke.6 After these studies were published, Pfizer initially argued with the results." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.) "Celebrex (or celecoxib, the generic name), marketed by Pfizer and Pharmacia, is a cox-2 inhibitor still on the market in the U.S. In 2000, a large review of the drug, called the Celecoxib Long-term Arthritis Safety Study (CLASS), which was published in the Journal of the American Medical Association, reported a 50% reduction of ulcers and stomach bleeding with celecoxib as compared to NSAIDS.7 Patients taking aspirin lost the protection afforded by Celebrex. This study looked at one year of treatment, but only the results found after six months were published." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.) "In 2006 a review of cox-2 inhibitor safety from studies performed up to that time found a significant risk of cardiac events across the spectrum of COX-2 drugs.14 Overall there was a statistically significant 42% increase in vascular events and an 86% increase in heart attacks. The risks of taking COX-2 drugs were double that of taking naproxen. Diclofenac was also associated with a statistically significant 63% increase in the risk of vascular events. Naproxen had no risk, and ibuprofen had a 51% increase, which was not statistically significant." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"It is important to note, however, that cox-2 inhibitor NSAIDs pose a serious risk—they have been shown to increase the chance of heart attack by two to five times and are no more effective at relieving pain than aspirin or regular NSAIDs. Many brands of COX-2 inhibitors have been removed from the marketplace due to such serious side effects. I assured Louise that once she began faithfully following my McDougall Diet recommendations, she would most likely be able to discontinue all of her anti-inflammatory drugs." - John A. McDougall, Dr. McDougall's Digestive Tune-Up (Get the book.)

"Katz and his team at the Center for Holistic Urology found Zyflamend to inhibit COX-2 about as well as the potent cox-2 inhibitor drugs. "In our test-tube studies, Zyflamend doubled the apoptosis rate and significantly slowed the growth of prostate cancer cells," wrote Dr. Katz. Breast Cancer Researchers at the Medical College of Wisconsin, led by Ashwani Khanna, Ph.D., an associate professor of medicine, are studying the role inflammation may play in initiating breast cancer, specifically by looking at certain proteins known to affect inflammation and their presence in breast cancer." - Freedom Press, Natural Cancer Cures: The Definitive Guide to Using Dietary Supplements to Fight and Prevent Cancer (Get the book.)

"The reasoning was that the COX-1 inhibiting activity of naproxen makes platelets less "sticky" (like aspirin, but not to the same extent), potentially decreasing the risk of unwanted blood clots—a property not shared by Vioxx, which is a selective cox-2 inhibitor. Because of this possibility, the research plan called for serious "cardiovascular thrombotic or embolic" complications* to be examined by an independent committee to make sure that the study results were accurate and unbiased." - John Abramson, Overdosed America: The Broken Promise of American Medicine (P.S.) (Get the book.) "COX-2 inhibitor sales in the United States in 2003. Public hearings investigating the commercial bias in the 2001 update of the cholesterol guidelines would be similarly revealing." - John Abramson, Overdosed America: The Broken Promise of American Medicine (P.S.) (Get the book.)

"This focus should include not only due diligence in the drug-approval process and the regulation of supplements according to the Dietary Supplement Health and Education Act (DSHEA) guidelines, but also, and just as important, the implementation of quality post-market surveillance programs for both. The cox-2 inhibitor Problem One of the most glaring and disturbing examples of the FDA's need to refine its current post-market surveillance and regulation of the pharmaceutical industry involves a group of drugs known as COX-2 inhibitors." - Shari Lieberman, Alan Xenakis, Mineral Miracle: Stopping Cartilage Loss & Inflammation Naturally (Get the book.)

"Aspirin and colon cancer Aspirin, like the cox-2 inhibitor drugs, is often recommended for prevention of recurring polyps. One aspirin study showed no reduction in risk for cancerous polyps after 9 years of aspirin use, but the risk was almost cut in half by 20 years of use. What this means to older patients who haven't another 20 years to live, is unknown. Another study showed that aspirin reduced the occurrence of polyps from 27 to 17 % after 31 months of use. Another study showed little benefit, with aspirin reducing the incidence of polyps from 47 to 45 %." - Bill Sardi, You Don't Have to be Afraid of Cancer Anymore (Get the book.)

"At that time, cox-2 inhibitor drugs like Vioxx and Celebrex, a newer class of non-steroidal anti-inflammatory drugs (NSAIDs), were replacing the older NSAIDs like Naprosyn and Aleve, Motrin and Advil, and Voltaren, Athrotec, and Cataflam. The older NSAIDs were known to cause ulcers and internal bleeding, while the new "super aspirins" were supposed to reduce that risk. One day, Anna suddenly passed out and fell to the floor. She had the presence of mind, when she awoke, to call the paramedics using her Medic Alert pendant. She had begun bleeding from a gastric ulcer." - Hyla Cass, M.D., Supplement Your Prescription: What Your Doctor Doesn't Know About Nutrition (Get the book.) "NSAID-INDUCED NUTRIENT DEPLETIONS: FOLATE AND VITAMIN C Research clearly demonstrates that aspirin and other NSAIDs—including the cox-2 inhibitor Celebrex—deplete folate. Aspirin has also been found to deplete vitamin C. Supplementing with these nutrients while using any NSAID—all of which work by the same general mechanism— is advisable. The mechanism for folate depletion with these drugs is complex. Basically, the therapeutic effect of these drugs operates through a biochemical mechanism that also depletes folate in the bloodstream." - Hyla Cass, M.D., Supplement Your Prescription: What Your Doctor Doesn't Know About Nutrition (Get the book.)

"You may still take a cox-2 inhibitor if your doctor advises and monitors you. Or you may be advised to return to ibuprofen or naproxen. Glucosamine and chondroitin, sold without a prescription, are among the building blocks of cartilage. Some osteoarthritis sufferers say that these supplements help. With your doctor's approval, you can try them if you want. When meds no longer quell osteoarthritis pain, a trade-in may be the answer. Hip and knee replacement surgery, performed for more than 30 years, has advanced dramatically." - Bottom Line Health, Bottom Line's Health Breakthroughs 2007 (Get the book.) "A second-generation NSAID, such as the prescription cox-2 inhibitor celecoxib (Celebrex), is less likely to cause bleeding, but might increase the risk of heart attack and stroke. Your doctor should weigh the risks against the benefits before recommending treatment using anti-inflammatory medication. •Opioids. These medications are typically used to treat moderate to severe pain. Opioids include codeine, morphine, hydrocodone (Vico-din), fentanyl patches (Duragesic), oxycodone (OxyContin), and oxycodone combined with acetaminophen (Percocet)." - Bottom Line Health, Bottom Line's Health Breakthroughs 2007 (Get the book.)

"It did not inhibit COX-1, and as Gilmartin and his development executives saw it, such a cox-2 inhibitor would not only be profitable, but also conform to the new realities of pharmaco-economics: you could prove that its health benefits also saved health care plans money because they would not be paying for stomach and kidney problems, which were expensive to treat. Gilmartin turned up the heat on the team responsible for L-748, 731, named rofecoxib, or Vioxx." - Greg Critser, Generation Rx: How Prescription Drugs are Altering American Lives, Minds, and Bodies (Get the book.) "That's increasingly important during those times when the industry fails to disclose everything to the FDA and it comes back to bite us on the collective cox-2 inhibitor. Yet the use of congressional power over the industry has been inconsistent, disorganized, and often irresponsible, both on the right and left. It has been lorded over long enough by Henry Waxman, who is good at playing the hysteria card, and Orrin Hatch, who tries to trump him with the "let's keep America competitive" card." - Greg Critser, Generation Rx: How Prescription Drugs are Altering American Lives, Minds, and Bodies (Get the book.)

"Those ten experts voted 10-0 in favor of keeping Pfizer's two cox-2 inhibitor drugs on the market and 9-1 in favor of allowing Vioxx to be made available again. No one can prove that the financial ties influenced the votes of these panel members, and all of those willing to discuss it claimed it had no influence on their votes. However, none of us is as objective as we think we are. Those ten experts should have simply said they had a conflict of interest and felt it improper to vote. But then Vioxx would have been rejected by a vote of 8 to 14." - Dr. Timothy Scott, America Fooled: The Truth About Antidepressants, Antipsychotics and How We've Been Deceived (Get the book.)

"Topol was the first doctor to go public about the shortcomings of the cox-2 inhibitor drugs for pain relief, Vioxx and Celebrex, in an article in the New York Times in October 2004. He has personal experience of how doctors are discouraged from speaking out in the public interest. 'The world very much wants new drugs and medical devices to succeed,' he says. 'Anyone who speaks out is cast as a heretic standing in the way of progress.' The immediate effect of Topol's action in highlighting safety concerns about this hugely popular class of drug was to invite criticism from consultants." - Jacky Law, Big Pharma: Exposing the Global Healthcare Agenda (Get the book.)

"However, recent revelations show the FDA approved relatively unsafe drugs (Vioxx cox-2 inhibitor) and at least five other drugs and continues to do little to remove these drugs from the marketplace. Public Citizen, the Ralph Nader group, indicates 1 81 FDA-approved drugs should be recalled because they are not as safe as other drugs or are ineffective. An FDA drug reviewer, Dr. David Graham, had to publish his report on the hidden dangers of Vioxx outside of the country in the British Medical Journal." - Bill Sardi, You Don't Have to be Afraid of Cancer Anymore (Get the book.) "He also receives an anti-inflammatory drug, a cox-2 inhibitor, thought to be a colon cancer preventive agent. He is unaware that only 20% of cancer patients have colon/rectal tumors that are sensitive to 5-FU. For the remaining 80% of patients, 5-FU will be ineffective and the patients will endure suffering from side effects needlessly. Furthermore, colon cancer is a solid tumor, and all forms of chemotherapy cannot penetrate solid tumors and over time drug resistance will occur, rendering the treatment useless." - Bill Sardi, You Don't Have to be Afraid of Cancer Anymore (Get the book.) "Butyrate also works as a natural cox-2 inhibitor, working in a similar fashion to COX-2 inhibiting drugs, but without the cardiovascular side effects. [Biochemical Biophysical Research Communications 317: 463-71, 2004] þ Butyrate reduces the metastatic properties of colon cancer cells so they won't easily spread to the liver, which is a highly mortal sign. [Clinical Experimental Metastasis 21: 331-38, 2004] Published reports on the effectiveness of butyrate in inhibiting colon cancer are mixed." - Bill Sardi, You Don't Have to be Afraid of Cancer Anymore (Get the book.)

"Merck, with its new cox-2 inhibitor, Vioxx, (an expensive one-pill-a-day treatment for arthritis) was then engaged in a head-to-head competition with Pfizer over Pfizer's cox-2 inhibitor, Celebrex. In the interview with Adams, Dr. Field bragged that he sometimes participated in these events twice in one day, that he had gone to such events as often as five times in one week, that he had accepted two Christmas trees courtesy of a company, and that he estimated that he had attended 150 to 200 such events in the course of two years." - Jerome P. Kassirer, On the Take: How Medicine's Complicity with Big Business Can Endanger Your Health (Get the book.)

"Years later, we find out that the cox-2 inhibitor drugs are actually killing people and have fatal side effects. Then everybody says, "Oops, maybe we shouldn't have been taking those all along." The important thing to note here is that people were effectively seduced and manipulated into either taking the drugs or prescribing them. It's just one example of the many ways in which Americans are easily influenced and seduced by messages from the mainstream media, figures of authority, announcements from the FDA and drug company propaganda." - Mike Adams, Spam Filters for Your Brain (Get the book.)

"Having found ginger to be a cox-2 inhibitor, Schulick, a master herbalist with twenty-five years of experience, scoured all the available medical databases, including the National Library of Medicine and the U.S. Department of Agriculture, for premiere herbal candidates to combat inflammation generated by cancer." - David Steinman, Safe Trip to Eden: Ten Steps to Save Planet Earth from the Global Warming Meltdown (Get the book.) "One of the first test tube studies on the product, titled "Zyflamend, an Herbal cox-2 inhibitor with In Vitro Anti-Prostate Cancer Activity," was presented at the December 13, 2002, meeting of the Society of Urologic Oncology at the National Institutes of Health in Bethesda, Maryland. (This meeting was cosponsored by the National Cancer Institute.) The formula suppressed the growth of prostate cancer cells and caused many more to commit apoptosis, or cellular suicide." - David Steinman, Safe Trip to Eden: Ten Steps to Save Planet Earth from the Global Warming Meltdown (Get the book.)

"At that time, cox-2 inhibitor drugs like Vioxx and Celebrex, a newer class of non-steroidal anti-inflammatory drugs (NSAIDs), were replacing the older NSAIDs like Naprosyn and Aleve, Motrin and Advil, and Voltaren, Athrotec, and Cataflam. The older NSAIDs were known to cause ulcers and internal bleeding, while the new "super aspirins" were supposed to reduce that risk. One day, Anna suddenly passed out and fell to the floor. She had the presence of mind, when she awoke, to call the paramedics using her Medic Alert pendant. She had begun bleeding from a gastric ulcer." - Hyla Cass, Supplement Your Prescription: What Your Doctor Doesn't Know About Nutrition (Get the book.)

"Furthermore, after Vioxx's life-threatening side effects became public in 2004, an FDA safety panel recommended that Vioxx and other cox-2 inhibitor drugs be allowed to return to the marketplace. There was one stipulation—the packaging had to contain a "black box" warning of the drug's implication in heart attack and stroke. (It was later revealed that more than half of the panel's eighteen members—all of whom voted in favor of the black box warnings instead of censuring the drug companies in any way—had current or former financial ties to the manufacturers of the assessed drugs." - Shari Lieberman, Alan Xenakis, Mineral Miracle: Stopping Cartilage Loss & Inflammation Naturally (Get the book.)

"NSAID-INDUCED NUTRIENT DEPLETIONS: FOLATE AND VITAMIN C Research clearly demonstrates that aspirin and other NSAIDs—including the cox-2 inhibitor Celebrex—deplete folate. Aspirin has also been found to deplete vitamin C. Supplementing with these nutrients while using any NSAID—all of which work by the same general mechanism?is advisable. The mechanism for folate depletion with these drugs is complex. Basically, the therapeutic effect of these drugs operates through a biochemical mechanism that also depletes folate in the bloodstream." - Hyla Cass, Supplement Your Prescription: What Your Doctor Doesn't Know About Nutrition (Get the book.)

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