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"The withdrawal of Vioxx cast a cloud of suspicion over all COX-2 inhibitors, including Celebrex and another Pfizer drug, bextra. bextra was shown to increase the incidence of heart attacks and strokes by 219% in a study carried out by the American Heart Association. The cardiologist who presented the study, Dr Garret Fitzgerald, called bextra 'a time bomb waiting to go off.' Pfizer, however, did not move immediately to withdraw bextra or Celebrex, which are still prescribed with black box warnings imposed by the FDA. Pfizer plans to carry out major new trials of both drugs." - Martin J. Walker, HRT Licensed to Kill and Maim: The Unheard Voices of Women Damaged by Hormone Replacement Therapy (Get the book.)

"By 2004 bextra was a billion-dollar drug. Yet quietly, reports of injuries caused by bextra were flowing into government offices in Maryland. In April 2005 the FDA demanded that Pfizer, which had taken over Pharmacia, remove the drug from the market. Regulators said the risks of the drug exceeded its meager benefits. By then doctors had prescribed it to millions. All this was eerily reminiscent of another industry that attempted to create "science" to increase corporate sales." - Melody Petersen, Our Daily Meds: How the Pharmaceutical Companies Transformed Themselves into Slick Marketing Machines and Hooked the Nation on Prescription Drugs (Get the book.)

"Bextra is next. According to a study of more than 1,500 patients who had previously undergone cardiac surgery, those who were treated for pain with bextra were more likely to have heart and blood-clotting problems than those who received no drug at all. Stroke, heart attack, blood clots in the lung, deep vein blood clots in the leg, all can result just from taking this drug. Arthritis drugs have never been properly tested for safety. Vioxx, Celebrex, bextra, Aleve, and aspirin are just plain poisons. Another arthritis drug, infliximab (Remicade), is on alert for causing cancer." - Andreas Moritz, Timeless Secrets of Health & Rejuvenation: Unleash The Natural Healing Power That Lies Dormant Within You (Get the book.)

"The story of a pain reliever called bextra provides a case in point. Pharmacia, the drugs manufacturer, had asked the FDA in 2001 to approve bextra to treat both the chronic pain of arthritis and the more acute pain that follows surgery. The regulators agreed to approve the drug to treat arthritis but refused to allow the company to sell it for more intense pain. The regulators' decision upset Pharmacia's marketing plans." - Melody Petersen, Our Daily Meds: How the Pharmaceutical Companies Transformed Themselves into Slick Marketing Machines and Hooked the Nation on Prescription Drugs (Get the book.)

"The cardiologist who presented the study, Dr Garret Fitzgerald, called bextra 'a time bomb waiting to go off.' Pfizer, however, did not move immediately to withdraw bextra or Celebrex, which are still prescribed with black box warnings imposed by the FDA. Pfizer plans to carry out major new trials of both drugs. arrest and seizure are employed by the local authorities to detect and trace such cases, and there are mandatory, heavy fines and worse for miscreants." - Martin J. Walker, HRT Licensed to Kill and Maim: The Unheard Voices of Women Damaged by Hormone Replacement Therapy (Get the book.)

"Painkillers and Heart Disease Revelations in 2004 and 2005 that best-selling painkillers such as Vioxx, Celebrex, Aleve, and bextra increase the risk of heart attacks made big headlines. The news stunned millions of patients relying on these medications. Ongoing news about possible adverse cardiovascular effects from medication makes us very concerned about the widespread use of painkillers altogether." - Stephen Sinatra, M.D. and James C., M.D. Roberts, Reverse Heart Disease Now: Stop Deadly Cardiovascular Plaque Before It's Too Late (Get the book.)

"Yet quietly, reports of injuries caused by bextra were flowing into government offices in Maryland. In April 2005 the FDA demanded that Pfizer, which had taken over Pharmacia, remove the drug from the market. Regulators said the risks of the drug exceeded its meager benefits. By then doctors had prescribed it to millions. All this was eerily reminiscent of another industry that attempted to create "science" to increase corporate sales." - Melody Petersen, Our Daily Meds: How the Pharmaceutical Companies Transformed Themselves into Slick Marketing Machines and Hooked the Nation on Prescription Drugs (Get the book.) "They pointed out that Scirex's conclusion that a dose of bextra worked longer than a single dose of Percocet was not meaningful. Patients rarely receive just one dose of Percocet because it is well known it wears off in four to six hours. One of those scientists, Dr. Eric Topol, then the chairman of the Cleveland Clinic's department of cardiovascular medicine, called the studies "a contrived comparison." He said he found it "quite disquieting" that Scirex was partly owned by an advertising firm. "If this is where clinical research is headed," Dr." - Melody Petersen, Our Daily Meds: How the Pharmaceutical Companies Transformed Themselves into Slick Marketing Machines and Hooked the Nation on Prescription Drugs (Get the book.)

"Vioxx (rofecoxib) and bextra (valdecoxib)—called COX-2 inhibitors left many osteoarthritis sufferers who took them skating on thin ice. COX-2 inhibitors are prescribed primarily to fight the pain and stiffness that accompanies osteoarthritis, a painful and disabling condition that affects 20 million people in the U.S. Osteoarthritis is caused by the destruction of cartilage in the joints that increases with age and is exacerbated or triggered by physical injury or wear and tear." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.) "In fact, Nussmeier and colleagues studied 1,671 patients randomized to parecoxib (Dynastat, a COX-2 inhibitor that is given intravenously to surgical patients) or valde-coxib (i.e., bextra). Patients with parecoxib or valdecoxib showed a 3.7-fold increase in heart attack or stroke.5 Curt Furberg, Bruce Patsy, and Garret Fitzgerald analyzed data from this study along with data made available by the FDA and also found a greater than threefold increased risk of heart attack and stroke.6 After these studies were published, Pfizer initially argued with the results." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.) "In January 2005 insurer Kaiser Perma-nente took bextra off its formulary, reasoning that the risks of the drug outweighed the benefits. Under a storm of controversy Pfizer finally pulled the drug from the market in April 2005. Celebrex (or celecoxib, the generic name), marketed by Pfizer and Pharmacia, is a COX-2 inhibitor still on the market in the U.S." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"According to a study of more than 1,500 patients who had previously undergone cardiac surgery, those who were treated for pain with bextra were more likely to have heart and blood-clotting problems than those who received no drug at all. Stroke, heart attack, blood clots in the lung, deep vein blood clots in the leg, all can result just from taking this drug. Arthritis drugs have never been properly tested for safety. Vioxx, Celebrex, bextra, Aleve, and aspirin are just plain poisons. Another arthritis drug, infliximab (Remicade), is on alert for causing cancer." - Andreas Moritz, Timeless Secrets of Health & Rejuvenation: Unleash The Natural Healing Power That Lies Dormant Within You (Get the book.)

"The Vioxx recall prompted the FDA to assemble an advisory panel during the third week of February 2005 to make a recommendation to the FDA about the entire group of Cox-2 inhibitors (Vioxx, Celebrex and bextra). Then something very surprising happened. By a very close vote (17-15) the panel of experts voted to allow Vioxx back on the market. They also voted not to remove Celebrex and bextra. The vote made headlines and seemed to say again that the safety concerns were overblown. The message seemed to be that, yes, there were risks, but they were so minimal even Merck was overreacting." - Dr. Timothy Scott, America Fooled: The Truth About Antidepressants, Antipsychotics and How We've Been Deceived (Get the book.)

"That's what SCIREX did for Pharmacia and Pfizer's jointly marketed bextra, originally approved by the FDA in November 2001 for treating pain from arthritis and menstrual cramps. The FDA rejected a plea that Bextra also be approved for acute pain. To encourage doctors to prescribe off-label for that purpose, the companies retained SCIREX. What happened next is spelled out in a lawsuit filed by the Congress of California Seniors: SCIREX recruited patients with impacted molars, gave them bextra, and then concluded that "the drug was effective in treating adults with acute pain." - Donald L. Barlett and James B. Steele, Critical Condition: How Health Care in America Became Big Business (Get the book.)

"Vioxx, Celebrex, and bextra. The lead-up to the coxib debacle was long and colorful, dripping the familiar and the unfamiliar and worthy of summary. The coxib Canard The first multinational pharmaceutical firm was the Jesuit order. The miracle drug of the seventeenth century was "Peruvian bark," also known as "Jesuit bark" because it was imported from South America by the Jesuits. It was harvested from the chincona tree by indigenous South Americans who had been converted both to Catholicism and to the task of harvesting." - Nortin M. Hadler MD, Worried Sick: A Prescription for Health in an Overtreated America (Get the book.)

"He feared Graham's views concerning the lack of safety of bextra, SSRI antidepressants, Lotronex, and Rezulin would invite a general congressional inquiry into FDA's new drug approval process, revealing for the first time details long kept from public view through a combination of intimidation and character assassination. When efforts by Graham's supervisors at intimidating him into not testifying before the Senate Finance Committee proved unsuccessful, new efforts were undertaken to disparage him with Senator Grassley's office and with others." - Jonathan W. Emord, The Rise of Tyranny (Get the book.)

"In 2005 bextra was taken off the market.) While it's true that many drugs help people live longer and better lives, myriad others may be harmful in ways you're unaware of. Dr. Graham's testimony provided the public a fleeting glimpse of the knowledge that is normally hidden from view or frustratingly difficult for the average person to access." - J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"In chapter 9, I'll explore the canard that enveloped the coxibs Vioxx and bextra. In these instances, along with Redux, Paxil, Propulsid, Zyprexa, and others, we owe the plaintiff's bar a debt of gratitude for forcing the fda toward regulatory remedies. Before you assume that I applaud the plaintiff's bar indiscriminately, I can assure you that I am well aware of and wont to condemn its excesses. The reference that discusses the negative psychological effects of labeling a well person as hypercholesterolemic is by Brett (1991)." - Nortin M. Hadler MD, Worried Sick: A Prescription for Health in an Overtreated America (Get the book.)

"Methadone and other narcotics used for chronic pain control Celebrex, Vioxx, bextra, Naproxen, Arthrotec, Ibuprofen and other anti-inflammatories used for musculoskeletal pain and inflammation control or menstrual pain Ultram, Talwin, and other non-opioid pain preparations Midrin, Fioricet, Imitrex, Amerge, Maxalt, Zomig and other migraine headache preparations Lipitor, Zocor, Pravachol and other lipid-lowering agents." - Dr. David W. Tanton; Ph.D., A Drug-Free Approach To Healthcare, Revised Edition (Get the book.)

"Meanwhile, the marketing of Celebrex and Vioxx continues, joined by bextra and others. There is so much at stake, and so much money in play, that the marketing minions have marshalled forces that are a match for this fda setback following the class and vigor trials. An alarming number of physicians, including academicians, have assumed paid roles in the process of performing clinical trials and marketing drugs. Some trials are designed to be marketing exercises rather than attempts to test hypotheses as to risk/benefit ratios." - Nortin M. Hadler, The Last Well Person: How to Stay Well Despite the Health-Care System (Get the book.)

"Take the example of the arthritis drug VIOXX, or other painkillers, including CLELEBREX, ALEVE, and bextra. Isn't it astounding that these poisonous, expensive drugs could have passed all the supposedly rigorous, scientific safety tests and been sold to millions of unsuspecting arthritis sufferers, just to find out years later that they sharply increase the risk of heart attack and stroke? Could there be double standards for "rigorous testing" in the field of medical research, one for before and one for after introducing these drugs to the market?" - Andreas Moritz, Timeless Secrets of Health & Rejuvenation: Unleash The Natural Healing Power That Lies Dormant Within You (Get the book.)

"Over the years I was also prescribed multiple types of non-steroidal anti-inflammatory drugs including Vioxx, Celebrex and bextra, all of which have been proven to increase the risk of having a heart attack. During the time I took these three drugs, none of them helped. Ultimately, I made the decision to stop taking these medications. If you don't feel that you are getting results from a drug, why continue to take it? Yes, there are drugs that "take time" to get the benefit, and there are others that you cannot stop taking all at once without withdrawal symptoms or other health risks." - Craig Pepin-Donat, The Big Fat Health and Fitness Lie (Get the book.)

"This panel also supported the continued use of other cox-2 drugs, such as Celebrex and bextra, for arthritis, despite their known cardiovascular risks, so long as they also carry a black-box warning. Given the evidence that arthritis can often be successfully treated with vitamins B-3 and C or other nutrients, these decisions raise many interesting ethical issues. Vitamin B-3 is not a drug. Drugs are developed to treat a single condition. Arthritis is not a single disease. It is caused by many factors, including toxic responses to foods." - Dr. Abram Hoffer, MD, FRCP (C) and Dr. Harold D. Foster, PhD, Feel Better, Live Longer with Vitamin B-3 (Get the book.)

"He alleged GlaxoSmithKline's asthma drug Serevent; AstraZeneca's statin, Crestor; Pfizer's latest Cox-2 inhibitor, Bextra; Roche's acne drug, Accutane; and Abbott Laboratories' slimming drug Meridia (Reductil in the UK), as all having had the same whitewash treatment to present their best side, rather than the warts-and-all version people need if they are to live in what can be considered a civilized society. The stock market responded to Graham's remarks, with the share prices of all five companies concerned falling, some quite significantly." - Jacky Law, Big Pharma: Exposing the Global Healthcare Agenda (Get the book.)

"Ten panel members had financial ties with either Pfizer (maker of Celebrex and bextra) or Merck. Those ten experts voted 10-0 in favor of keeping Pfizer's two Cox-2 inhibitor drugs on the market and 9-1 in favor of allowing Vioxx to be made available again. No one can prove that the financial ties influenced the votes of these panel members, and all of those willing to discuss it claimed it had no influence on their votes. However, none of us is as objective as we think we are. Those ten experts should have simply said they had a conflict of interest and felt it improper to vote." - Dr. Timothy Scott, America Fooled: The Truth About Antidepressants, Antipsychotics and How We've Been Deceived (Get the book.)

"Progress Drug Research 60: 59-92, 2003] Therefore, can we assume that the use of anti-inflammatory drugs like aspirin, ibuprofen, and COX-2 inhibitors like Vioxx and bextra, will reduce the risk for cancer? A lot of doctors think so. But recent studies don't bear this out: ¦ A large study of 77,413 women could not find a preventive effect for aspirin or non-steroidal anti-inflammatory drugs against breast cancer." - Bill Sardi, You Don't Have to be Afraid of Cancer Anymore (Get the book.)

"Pfizer's bextra, one of its COX-2 inhibitors, remained on the market for another six months, until the FDA ordered its removal in April 2005. Pfizer's other coxib, Celebrex, remains on the market despite deeply troubling signs that it too is a harmful drug. What about the two classes of drugs specifically created by the industry to extend the life and health of the heart? How have they fared — and how have we fared under them?" - Greg Critser, Generation Rx: How Prescription Drugs are Altering American Lives, Minds, and Bodies (Get the book.)

"Vioxx, Celebrex, bextra, Aleve, and aspirin are just plain poisons. Another arthritis drug, infliximab (Remicade), is on alert for causing cancer. Amazingly, many people have been so blinded by clever advertising campaigns and brainwashing that they have no clue they are being methodically poisoned in order to support and sustain the most lucrative business in the world besides oil, the pharma-medical industry. An investigation made public by CNN on 26 September 2007 discovered that 56 million prescriptions each year are handed out by doctors for drugs that are not even approved by the FDA." - Andreas Moritz, Timeless Secrets of Health & Rejuvenation: Unleash The Natural Healing Power That Lies Dormant Within You (Get the book.)

"Others noted that coxibs like Vioxx (as well as Pfizer's Celebrex and bextra) posed something of a therapeutic dilemma. By selectively inhibiting only the COX-2 enzyme, they were able to alleviate pain without causing gastric problems (the COX-1 enzyme is responsible for gastro-protection). But as it turned out, COX-1 was also responsible for raised levels of blood clotting — it was good to inhibit it, especially if you were older or inclined to heart problems. Increased blood clotting was often the cause of heart attacks." - Greg Critser, Generation Rx: How Prescription Drugs are Altering American Lives, Minds, and Bodies (Get the book.)

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