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"Johann-Liang had called for a black box warning on the drug, FDA Commissioner von Eschenbach capitulated, announcing that black box warnings would be included on avandia labels.105 In July of 2007 the FDA convened a drug advisory committee meeting at which FDA's Dr. David J. Graham spoke. Graham recommended that avandia be removed from the market. Pressured to keep the product on the market despite the heart risks, the committee produced a schizophrenic result."
- Jonathan W. Emord, The Rise of Tyranny (Get the book.)

"Many of the diabetic drugs we have today are simply first cousins of those prescribed years ago. avandia?which rakes in 2.1 billion dollars in revenue per year - doesn't do anybody any good and has recently showed to dramatically increase risk of heart attacks." "Does this worsen their conditions? " Dr. Whitaker: "Yes. Diabetics are taking drugs that they don't need, which are most likely worsening the problem. Patients with hypertension are taking multiple medications they don't need. The safest and most effective anti-hypertensive drugs are low-dose diuretics."
- Kenneth W Thomas, Ron Gilbert, Gerd Schaller, Side Effects: The Hidden Agenda of the Pharmaceutical Drug Cartel (Get the book.)

"For example, the widely used diabetes drug avandia has recently been linked to a greater risk of heart attack and, possibly, death, according to the New England Journal of Medicine (May 21, 2007). An analysis pooling the results of several dozen studies, encompassing some 28,000 patients, showed that avandia, which is manufactured by GlaxoSmithKline, causes a 43 percent higher risk of heart attack. The U.S. government has issued a safety alert, but despite the enormous health risk imposed by the drug, the FDA has not requested a stronger warning label for the drug."
- Andreas Moritz, Timeless Secrets of Health & Rejuvenation: Unleash The Natural Healing Power That Lies Dormant Within You (Get the book.)

"Kathy Wolski, MPH, reported in 2007 in the New England Journal of Medicine a 43% increase in heart attacks with avandia compared to other treatments for diabetes. In other words, a drug given to prevent the consequences of diabetes (including cardiovascular events) actually increases them. GLITAZONES AND WEIGHT GAIN Weight gain is one of the most troubling side effects of medications for the treatment of type 2 diabetes. Studies have consistently shown that glitazones cause weight gain."
- J. Douglas Bremner, Before You Take that Pill: Why the Drug Industry May Be Bad for Your Health (Get the book.)

"New Scientist magazine reported in 2007 how a well-respected physician who had raised concerns about serious side effects associated with the diabetes drug avandia was attacked by the FDA, which sent news media organizations unsubstantiated allegations against the whistleblower. As a result of such tactics, scientists and physicians are often reluctant to publicize their concerns."
- Samuel S. Epstein, Randall Fitzgerald, Toxic Beauty: How Cosmetics and Personal Care Products Endanger Your Health . . . And What You Can Do about It (Get the book.)

"Topol was succeeded at Cleveland Clinic by Steven Nissen, whose avandia meta-analysis is discussed in the supplementary reading for chapter 3. Although the fda houses many a committed and honorable staffer, it is clear that its approach to safeguarding the consumer is a blunt instrument in the current climate. Reeling from the coxib canard, the fda turned to the Institute of Medicine (iom) in 2005. The iom is the most politicized of the National Academies of Science in that members can be anointed based on academic power rather than scholarly accomplishment."
- Nortin M. Hadler MD, Worried Sick: A Prescription for Health in an Overtreated America (Get the book.)

"The committee voted 20-3 that avandia increases cardiac ischemic risk in type 2 diabetics but nonetheless voted in favor of keeping the drug on the market.106 Vioxx FDA gave Merck & Co. approval to market Vioxx on May 20, 1999 without any labeling to warn physicians or consumers that the drug would increase heart attack risk. Prior to approving Vioxx, a study performed by Merck and submitted to the FDA revealed a seven-fold increase in the risk of heart attack from low dose Vioxx."
- Jonathan W. Emord, The Rise of Tyranny (Get the book.)

"On May 25, 1999, the FDA granted GlaxoSmithKline approval to market avandia. In February 2006, another FDA medical reviewer, Dr. Rosemary Johann-Liang, advocated a black box warning to inform physicians and patients of the drugs risks to the heart.100 Her recommendation was also ignored, and she was then subjected to managerial pressure.101 Johann-Liang's supervisor, Dr. Mark Avigan, told her that agency management was "upset with [her] recommendation" and "decided to act like the review never happened."102 On May 21, 2007, the New England Journal of Medicine published a meta-analysis by Drs."

- Jonathan W. Emord, The Rise of Tyranny (Get the book.)

"The past decade has seen a litany of products that have fallen from grace—Vioxx, avandia, Rezulin, Seldane, Baycol, CETP inhibitors, Pre-marin, and more. Which drugs that millions consume today will be the fallen heroes of tomorrow? I am certainly not against medications or their intelligent use. But they should be used carefully, with full awareness of all their effects whether that's "drug action" or "side effects." Most medication is prescribed for conditions that are better treated by diet, nutritional therapies, and lifestyle changes."
- Mark Hyman MD, The UltraMind Solution: Fix Your Broken Brain by Healing Your Body First (Get the book.)

"I doubt the enthusiasm would be tempered by the brouhaha that now surrounds rosiglitazone, which is manufactured by GlaxoSmithKline (GSK) and marketed as avandia. Steven Nissen is a cardiologist on the staff of the Cleveland Clinic who assumed the role of director of the clinic's contracted drug trials enterprise from Eric Topol after the latter became embroiled in the Vioxx controversy about which we have much to say in later chapters. Nissen and Wolski (2007) undertook a meta-analysis of forty-two treatment trials and concluded that rosiglitazone increased the risk of myocardial infarction."
- Nortin M. Hadler MD, Worried Sick: A Prescription for Health in an Overtreated America (Get the book.)

"In February of that year, the manufacturers of avandia (rosi-glitazone) reported that in their study of more than 4,300 patients with type 2 diabetes, significantly more women who took rosiglitazone experienced fractures of the foot, hand, or upper arm than did women who were taking metformin or glyburide. More research into this complication is ongoing, but results are not expected until 2009. On May 21, 2007, the Food and Drug Administration issued a news release in which it stated that rosiglitazone was associated with an increased risk of heart attack and other heart-related conditions."
- Steven V. Joyal, What Your Doctor May Not Tell You About Diabetes: An Innovative Program to Prevent, Treat, and Beat This Controllable Disease (Get the book.)

"And a head-to-head study of Actos and avandia (a similar medication) þ ?? Metformin (Glucophage) Metformin improves insulin sensitivity. It may control blood sugar alone or be combined with other diabetes drugs to improve blood sugar control. Common side effects include diarrhea, nausea and vomiting, flatulence, fatigue, indigestion, and headache. Avoid guar gum in low-fat foods (salad dressing, frozen desserts, etc.), because it reduces metformin's absorption and effectiveness. Downside: Lactic acidosis, a rare reaction, requires emergency medical attention and can be fatal."
- Joe Graedon, M.S. and Teresa Graedon, Ph.D., Best Choices From the People's Pharmacy (Get the book.)

"In 2007, a study was released that found that avandia appears to increase risk of heart failure, heart attack, and death from heart attack. If these results are correct, as many as 60,000 to 100,000 heart attacks could be blamed on the effect of this drug. Another drug in this class, Rezulin (troglitazone), was found to cause liver damage and liver failure, and was withdrawn."
- Hyla Cass, Supplement Your Prescription: What Your Doctor Doesn't Know About Nutrition (Get the book.)

"COX-2 inhibitors (like Celebrex and Vioxx) Painkillers (Tylenol) Cholesterol-lowering drugs (like Mevacor, Zocor, Lipitor, and niacin) Diabetic medications (Precose, Actos, avandia, and sulfonylureas) Estrogens Anabolic steroids Antibiotics Antifungals Anticonvulsants Antidepressants Antiarthritic (methotrexate) Anti-acne (Accutane) Vitamin A (retinol) For a more complete listing of drugs that can cause liver damage, look through a Physicians' Desk Reference at your local library or bookstore."
- John A. McDougall, Dr. McDougall's Digestive Tune-Up (Get the book.)

"An analysis pooling the results of several dozen studies, encompassing some 28,000 patients, showed that avandia, which is manufactured by GlaxoSmithKline, causes a 43 percent higher risk of heart attack. The U.S. government has issued a safety alert, but despite the enormous health risk imposed by the drug, the FDA has not requested a stronger warning label for the drug. I dare raise these simple questions: "Is it any wonder that 80 percent of diabetics die of heart disease?" "And who benefits from downplaying these known and proven risks?"
- Andreas Moritz, Timeless Secrets of Health & Rejuvenation: Unleash The Natural Healing Power That Lies Dormant Within You (Get the book.)

"In 2007, a study was released that found that avandia appears to increase risk of heart failure, heart attack, and death from heart attack. If these results are correct, as many as 60,000 to 100,000 heart attacks could be blamed on the effect of this drug. Another drug in this class, Rezulin (troglitazone), was found to cause liver damage and liver failure, and was withdrawn."
- Hyla Cass, M.D., Supplement Your Prescription: What Your Doctor Doesn't Know About Nutrition (Get the book.)

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